AU2015220762B2 - Method for in situ inhibition of regulatory T cells - Google Patents

Method for in situ inhibition of regulatory T cells Download PDF

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AU2015220762B2
AU2015220762B2 AU2015220762A AU2015220762A AU2015220762B2 AU 2015220762 B2 AU2015220762 B2 AU 2015220762B2 AU 2015220762 A AU2015220762 A AU 2015220762A AU 2015220762 A AU2015220762 A AU 2015220762A AU 2015220762 B2 AU2015220762 B2 AU 2015220762B2
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cell
antigen
cells
engineered
nucleic acid
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AU2015220762A1 (en
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Philippe Duchateau
Laurent Poirot
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Cellectis SA
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/41—Vertebrate antigens
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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    • C12N2510/00—Genetically modified cells

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AU2015220762A 2014-02-21 2015-02-20 Method for in situ inhibition of regulatory T cells Active AU2015220762B2 (en)

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Application Number Priority Date Filing Date Title
DKPA201470088 2014-02-21
DKPA201470088 2014-02-21
PCT/EP2015/053592 WO2015124715A1 (en) 2014-02-21 2015-02-20 Method for in situ inhibition of regulatory t cells

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AU2015220762A1 AU2015220762A1 (en) 2016-07-28
AU2015220762B2 true AU2015220762B2 (en) 2019-05-02

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US (2) US10196608B2 (enExample)
EP (1) EP3107552B1 (enExample)
JP (1) JP6665102B2 (enExample)
AU (1) AU2015220762B2 (enExample)
CA (1) CA2939711C (enExample)
WO (1) WO2015124715A1 (enExample)

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