AU2015209481C1 - Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema - Google Patents

Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema Download PDF

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Publication number
AU2015209481C1
AU2015209481C1 AU2015209481A AU2015209481A AU2015209481C1 AU 2015209481 C1 AU2015209481 C1 AU 2015209481C1 AU 2015209481 A AU2015209481 A AU 2015209481A AU 2015209481 A AU2015209481 A AU 2015209481A AU 2015209481 C1 AU2015209481 C1 AU 2015209481C1
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antibody
plasma kallikrein
binding
ser
plasma
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AU2015209481A
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AU2015209481B2 (en
AU2015209481A1 (en
Inventor
Burt Adelman
Joseph BIEDENKAPP
Yung CHYUNG
Ryan Faucette
Ryan Iarrobino
Jon A. Kenniston
Daniel J. Sexton
Christopher Tenhoor
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Publication of AU2015209481A1 publication Critical patent/AU2015209481A1/en
Publication of AU2015209481B2 publication Critical patent/AU2015209481B2/en
Priority to AU2020244370A priority Critical patent/AU2020244370B2/en
Application granted granted Critical
Publication of AU2015209481C1 publication Critical patent/AU2015209481C1/en
Assigned to TAKEDA PHARMACEUTICAL COMPANY LIMITED reassignment TAKEDA PHARMACEUTICAL COMPANY LIMITED Request for Assignment Assignors: DYAX CORP.
Priority to AU2024203436A priority patent/AU2024203436A1/en
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/03—Phosphotransferases with a nitrogenous group as acceptor (2.7.3)
    • C12Y207/03002—Creatine kinase (2.7.3.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21034—Plasma kallikrein (3.4.21.34)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AU2015209481A 2014-01-21 2015-01-21 Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema Active AU2015209481C1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2020244370A AU2020244370B2 (en) 2014-01-21 2020-09-28 Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema
AU2024203436A AU2024203436A1 (en) 2014-01-21 2024-05-23 Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201461929716P 2014-01-21 2014-01-21
US61/929,716 2014-01-21
US201461944361P 2014-02-25 2014-02-25
US61/944,361 2014-02-25
US201462021397P 2014-07-07 2014-07-07
US62/021,397 2014-07-07
PCT/US2015/012212 WO2015112578A1 (en) 2014-01-21 2015-01-21 Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2020244370A Division AU2020244370B2 (en) 2014-01-21 2020-09-28 Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema

Publications (3)

Publication Number Publication Date
AU2015209481A1 AU2015209481A1 (en) 2016-08-25
AU2015209481B2 AU2015209481B2 (en) 2020-07-30
AU2015209481C1 true AU2015209481C1 (en) 2020-10-29

Family

ID=53681890

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2015209481A Active AU2015209481C1 (en) 2014-01-21 2015-01-21 Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema
AU2020244370A Active AU2020244370B2 (en) 2014-01-21 2020-09-28 Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema
AU2024203436A Pending AU2024203436A1 (en) 2014-01-21 2024-05-23 Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2020244370A Active AU2020244370B2 (en) 2014-01-21 2020-09-28 Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema
AU2024203436A Pending AU2024203436A1 (en) 2014-01-21 2024-05-23 Plasma kallikrein binding proteins and uses thereof in treating hereditary angioedema

Country Status (18)

Country Link
US (2) US11084884B2 (enExample)
EP (2) EP3848057B1 (enExample)
JP (4) JP6845012B2 (enExample)
KR (3) KR102424183B1 (enExample)
CN (2) CN116585468A (enExample)
AU (3) AU2015209481C1 (enExample)
BR (1) BR112016016916B1 (enExample)
CA (1) CA2937329C (enExample)
DK (1) DK3096798T3 (enExample)
EA (1) EA038532B1 (enExample)
ES (1) ES2856076T3 (enExample)
IL (3) IL246864B (enExample)
MX (2) MX387753B (enExample)
NZ (2) NZ723369A (enExample)
PL (1) PL3096798T3 (enExample)
PT (1) PT3096798T (enExample)
WO (1) WO2015112578A1 (enExample)
ZA (2) ZA201605342B (enExample)

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