AU2014345599B2 - Salts of 1-(3-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)-2,4-dioxo-3-[(1R)- 4-(trifluormethyl)-2,3-dihydro-1H-inden-1-yl]-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid - Google Patents

Salts of 1-(3-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)-2,4-dioxo-3-[(1R)- 4-(trifluormethyl)-2,3-dihydro-1H-inden-1-yl]-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid Download PDF

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AU2014345599B2
AU2014345599B2 AU2014345599A AU2014345599A AU2014345599B2 AU 2014345599 B2 AU2014345599 B2 AU 2014345599B2 AU 2014345599 A AU2014345599 A AU 2014345599A AU 2014345599 A AU2014345599 A AU 2014345599A AU 2014345599 B2 AU2014345599 B2 AU 2014345599B2
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salt
compound
dihydro
oxo
dioxo
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AU2014345599A1 (en
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Jens Ackerstaff
Chantal Furstner
Martin-Holger Hinz
Mario Jeske
Birgit Keil
Britta Olenik
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Bayer Pharma AG
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Bayer Pharma AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/26—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one amino group bound to the carbon skeleton, e.g. lysine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2014345599A 2013-11-08 2014-11-05 Salts of 1-(3-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)-2,4-dioxo-3-[(1R)- 4-(trifluormethyl)-2,3-dihydro-1H-inden-1-yl]-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid Active AU2014345599B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13192177.7 2013-11-08
EP13192177 2013-11-08
PCT/EP2014/073801 WO2015067652A1 (de) 2013-11-08 2014-11-05 Salze von 1 -(3-methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)-2,4-dioxo-3-[(1 r)-4-(trifluormethyl)-2,3-dihydro-1h-inden-1 -yl]-1,2,3,4-tetrahydropyrimidin-5-carbonsäure

Publications (2)

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AU2014345599A1 AU2014345599A1 (en) 2016-05-19
AU2014345599B2 true AU2014345599B2 (en) 2019-02-14

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AU2014345599A Active AU2014345599B2 (en) 2013-11-08 2014-11-05 Salts of 1-(3-Methyl-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)-2,4-dioxo-3-[(1R)- 4-(trifluormethyl)-2,3-dihydro-1H-inden-1-yl]-1,2,3,4-tetrahydropyrimidin-5-carboxylic acid

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US (1) US9926305B2 (enExample)
EP (1) EP3066097B1 (enExample)
JP (1) JP6446051B2 (enExample)
KR (1) KR102351418B1 (enExample)
CN (1) CN105658647B (enExample)
AP (1) AP2016009181A0 (enExample)
AU (1) AU2014345599B2 (enExample)
BR (1) BR112016010253A8 (enExample)
CA (1) CA2929780C (enExample)
CL (1) CL2016001096A1 (enExample)
CY (1) CY1119520T1 (enExample)
DK (1) DK3066097T3 (enExample)
EA (1) EA033132B1 (enExample)
ES (1) ES2645480T3 (enExample)
HR (1) HRP20171603T1 (enExample)
HU (1) HUE035021T2 (enExample)
IL (1) IL245407B (enExample)
LT (1) LT3066097T (enExample)
MA (1) MA39020A1 (enExample)
ME (1) ME02907B (enExample)
MX (1) MX366848B (enExample)
MY (1) MY190108A (enExample)
NO (1) NO3066097T3 (enExample)
PH (1) PH12016500853B1 (enExample)
PL (1) PL3066097T3 (enExample)
PT (1) PT3066097T (enExample)
RS (1) RS56509B1 (enExample)
SA (1) SA516371082B1 (enExample)
SI (1) SI3066097T1 (enExample)
TN (1) TN2016000170A1 (enExample)
UA (1) UA117686C2 (enExample)
WO (1) WO2015067652A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3338780A1 (de) 2016-12-20 2018-06-27 Bayer Pharma Aktiengesellschaft Verwendung von chymaseinhibitoren zur behandlung von endometriose, post-operativer fibrose und erkrankungen die durch fibrosebildung gekennzeichnet sind
CA3061444A1 (en) * 2017-04-27 2018-11-01 Bayer Aktiengesellschaft Selective adrenoreceptor .alpha.2c receptor antagonists alone, or in combination with chymase inhibitors for use in the treatment and/or prophylaxis of peripheral artery diseases (pad)
WO2022135502A1 (zh) * 2020-12-25 2022-06-30 广东东阳光药业有限公司 多取代的尿嘧啶衍生物及其用途
TW202404601A (zh) * 2022-04-05 2024-02-01 加拿大商索科普拉健康與人類科學兩合公司 用於選擇性消退血栓性或血栓栓塞性疾病中血栓的凝乳酶抑制劑

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040019068A1 (en) * 2000-10-19 2004-01-29 Mizuo Miyazaki Novel remedies or preventives for angiostenosis
WO2013167495A1 (de) * 2012-05-09 2013-11-14 Bayer Pharma Aktiengesellschaft Bicyclisch-substituierte uracile und ihre verwendung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT511788A1 (de) 2011-07-29 2013-02-15 Georg Dr Gaul Vorrichtung zur vorgebbaren anordnung eines stents
CA2866184A1 (en) * 2012-03-05 2013-09-12 Gratuk Technologies Pty Ltd Dietary supplement
CA2929763A1 (en) * 2013-11-08 2015-05-14 Bayer Pharma Aktiengesellschaft Substituted uracils as chymase inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040019068A1 (en) * 2000-10-19 2004-01-29 Mizuo Miyazaki Novel remedies or preventives for angiostenosis
WO2013167495A1 (de) * 2012-05-09 2013-11-14 Bayer Pharma Aktiengesellschaft Bicyclisch-substituierte uracile und ihre verwendung

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Publication number Publication date
LT3066097T (lt) 2018-02-12
MY190108A (en) 2022-03-29
BR112016010253A2 (pt) 2017-08-08
HUE035021T2 (en) 2018-03-28
NO3066097T3 (enExample) 2018-01-13
AU2014345599A1 (en) 2016-05-19
KR102351418B1 (ko) 2022-01-17
CY1119520T1 (el) 2018-03-07
JP2016535096A (ja) 2016-11-10
EA033132B1 (ru) 2019-08-30
JP6446051B2 (ja) 2018-12-26
HRP20171603T1 (hr) 2017-12-01
CN105658647A (zh) 2016-06-08
MX2016005971A (es) 2016-08-11
US9926305B2 (en) 2018-03-27
EA201600381A1 (ru) 2016-10-31
MA39020A1 (fr) 2017-04-28
ME02907B (me) 2018-04-20
PH12016500853B1 (en) 2021-03-24
HK1222171A1 (zh) 2017-06-23
PH12016500853A1 (en) 2016-06-20
CA2929780A1 (en) 2015-05-14
AP2016009181A0 (en) 2016-04-30
CL2016001096A1 (es) 2016-12-23
SI3066097T1 (sl) 2017-12-29
IL245407B (en) 2019-10-31
US20160289220A1 (en) 2016-10-06
DK3066097T3 (da) 2017-11-06
TN2016000170A1 (en) 2017-10-06
MX366848B (es) 2019-07-26
WO2015067652A1 (de) 2015-05-14
KR20160078980A (ko) 2016-07-05
BR112016010253A8 (pt) 2021-06-22
SA516371082B1 (ar) 2019-05-16
PT3066097T (pt) 2017-11-10
NZ719532A (en) 2021-06-25
RS56509B1 (sr) 2018-02-28
UA117686C2 (uk) 2018-09-10
ES2645480T3 (es) 2017-12-05
IL245407A0 (en) 2016-06-30
EP3066097A1 (de) 2016-09-14
EP3066097B1 (de) 2017-08-16
PL3066097T3 (pl) 2018-01-31
CN105658647B (zh) 2019-09-06
CA2929780C (en) 2022-03-22

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