AU2014209346B2 - Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid - Google Patents

Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid Download PDF

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Publication number
AU2014209346B2
AU2014209346B2 AU2014209346A AU2014209346A AU2014209346B2 AU 2014209346 B2 AU2014209346 B2 AU 2014209346B2 AU 2014209346 A AU2014209346 A AU 2014209346A AU 2014209346 A AU2014209346 A AU 2014209346A AU 2014209346 B2 AU2014209346 B2 AU 2014209346B2
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AU
Australia
Prior art keywords
pharmaceutical composition
aqueous pharmaceutical
corticosteroid
enhancing agent
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Application number
AU2014209346A
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English (en)
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AU2014209346A1 (en
Inventor
Mahendra G. Shah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Semnur Pharmaceuticals Inc
Original Assignee
Semnur Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Semnur Pharmaceuticals Inc filed Critical Semnur Pharmaceuticals Inc
Publication of AU2014209346A1 publication Critical patent/AU2014209346A1/en
Application granted granted Critical
Publication of AU2014209346B2 publication Critical patent/AU2014209346B2/en
Priority to AU2019200649A priority Critical patent/AU2019200649B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2014209346A 2013-01-23 2014-01-23 Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid Active AU2014209346B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2019200649A AU2019200649B2 (en) 2013-01-23 2019-01-31 Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361755723P 2013-01-23 2013-01-23
US61/755,723 2013-01-23
US201361776617P 2013-03-11 2013-03-11
US61/776,617 2013-03-11
PCT/US2014/012824 WO2014116876A1 (en) 2013-01-23 2014-01-23 Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019200649A Division AU2019200649B2 (en) 2013-01-23 2019-01-31 Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid

Publications (2)

Publication Number Publication Date
AU2014209346A1 AU2014209346A1 (en) 2015-07-23
AU2014209346B2 true AU2014209346B2 (en) 2018-11-15

Family

ID=50097866

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2014209346A Active AU2014209346B2 (en) 2013-01-23 2014-01-23 Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid
AU2019200649A Active AU2019200649B2 (en) 2013-01-23 2019-01-31 Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2019200649A Active AU2019200649B2 (en) 2013-01-23 2019-01-31 Pharmaceutical formulation comprising an insoluble corticosteroid and a soluble corticosteroid

Country Status (13)

Country Link
US (4) US9833460B2 (enExample)
EP (1) EP2948182B1 (enExample)
JP (1) JP6215354B2 (enExample)
KR (1) KR102055937B1 (enExample)
CN (1) CN105073138B (enExample)
AU (2) AU2014209346B2 (enExample)
BR (1) BR112015017246B1 (enExample)
CA (1) CA2897467C (enExample)
IL (1) IL239791B (enExample)
MX (1) MX366654B (enExample)
NZ (1) NZ709620A (enExample)
TW (1) TWI624262B (enExample)
WO (1) WO2014116876A1 (enExample)

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AU2006249866B2 (en) 2005-05-26 2011-10-13 Aldeyra Therapeutics, Inc. Compositions and methods of treating retinal disease
CA2782015C (en) 2009-12-11 2020-08-25 Neuron Systems, Inc. Topical ophthalmic compositions and methods for the treatment of macular degeneration
CN111135171B (zh) 2013-01-23 2023-09-08 奥尔德拉医疗公司 与毒性醛相关的疾病和治疗
JP6215354B2 (ja) 2013-01-23 2017-10-18 セムヌール ファーマシューティカルズ， インコーポレイテッド 不溶性コルチコステロイドおよび可溶性コルチコステロイドを含む医薬処方物
TWI772659B (zh) 2015-01-21 2022-08-01 美商桑紐爾製藥公司 醫藥配方
US11857554B2 (en) * 2015-06-02 2024-01-02 Intravital Pty Ltd. Drug delivery device with pre-assembled cartridge
CN118724806A (zh) 2015-08-21 2024-10-01 奥尔德拉医疗公司 氘化化合物和其用途
CN109152774A (zh) 2016-05-09 2019-01-04 奥尔德拉医疗公司 眼部炎性病症和疾病的组合治疗
CN111356451A (zh) 2017-10-10 2020-06-30 奥尔德拉医疗公司 炎性病症的治疗
CN112714762A (zh) 2018-08-06 2021-04-27 奥尔德拉医疗公司 多晶型化合物及其用途
JP2022511030A (ja) * 2018-12-05 2022-01-28 アルデイラ セラピューティクス， インコーポレイテッド 注射可能な製剤
US12098132B2 (en) 2019-05-02 2024-09-24 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
CN113784954A (zh) 2019-05-02 2021-12-10 奥尔德拉医疗公司 多晶型化合物和其用途
US11382863B2 (en) * 2020-03-04 2022-07-12 Somerset Therapeutics Llc Injectable suspension comprising an insoluble corticosteroid and a soluble corticosteroid
WO2021231792A1 (en) 2020-05-13 2021-11-18 Aldeyra Therapeutics, Inc. Pharmaceutical formulations and uses thereof
JP2023546445A (ja) * 2020-10-22 2023-11-02 ファイザー・インク コルチコステロイドの非経口投与のためのｐｅｇフリー水性懸濁液
JP2026502695A (ja) * 2023-01-26 2026-01-23 インシグニア・ファーマシューティカルズ・リミテッド・ライアビリティ・カンパニー 変形性関節症の処置のための医薬組成物

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US3962430A (en) * 1974-08-07 1976-06-08 Merck & Co., Inc. Sterilization of solid non-electrolyte medicinal agents employing sodium chloride
WO2009129148A2 (en) * 2008-04-18 2009-10-22 Medtronic, Inc. Methods and compositions for treating intervertebral disc herniations
WO2009139924A2 (en) * 2008-05-14 2009-11-19 Otonomy, Inc. Controlled release corticosteroid compositions and methods for the treatment of otic disorders

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IL25251A (en) 1965-07-20 1969-11-12 Merck & Co Inc Aqueous mixtures for ophthalmology based on hydroxyethylcellulose and a method for their preparation
US4304765A (en) * 1980-10-14 1981-12-08 Alza Corporation Ocular insert housing steroid in two different therapeutic forms
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US20050101582A1 (en) * 2003-11-12 2005-05-12 Allergan, Inc. Compositions and methods for treating a posterior segment of an eye
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JP2007001926A (ja) * 2005-06-24 2007-01-11 Ltt Bio-Pharma Co Ltd 吸入・噴霧用ステロイド製剤
JP4969812B2 (ja) 2005-07-22 2012-07-04 久光製薬株式会社 ハイドロゲル組成物
US20070099882A1 (en) * 2005-10-27 2007-05-03 Gurney Harry C Methods and compositions for prolonged alleviation of articular joint pain
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US20110281834A1 (en) * 2008-11-10 2011-11-17 Friden Phillip M Pharmaceutical Formulations for Iontophoretic Delivery of a Corticosteroid
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UA111162C2 (uk) 2010-08-04 2016-04-11 Флекшен Терап'Ютікс, Інк. Ін'єкційна композиція ацетоніду триамцинолону для лікування болю
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JP6215354B2 (ja) 2013-01-23 2017-10-18 セムヌール ファーマシューティカルズ， インコーポレイテッド 不溶性コルチコステロイドおよび可溶性コルチコステロイドを含む医薬処方物
TWI772659B (zh) 2015-01-21 2022-08-01 美商桑紐爾製藥公司 醫藥配方

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962430A (en) * 1974-08-07 1976-06-08 Merck & Co., Inc. Sterilization of solid non-electrolyte medicinal agents employing sodium chloride
WO2009129148A2 (en) * 2008-04-18 2009-10-22 Medtronic, Inc. Methods and compositions for treating intervertebral disc herniations
WO2009139924A2 (en) * 2008-05-14 2009-11-19 Otonomy, Inc. Controlled release corticosteroid compositions and methods for the treatment of otic disorders

Also Published As

Publication number Publication date
WO2014116876A8 (en) 2015-08-20
KR20150114505A (ko) 2015-10-12
KR102055937B1 (ko) 2019-12-13
JP6215354B2 (ja) 2017-10-18
BR112015017246A8 (pt) 2019-10-29
TWI624262B (zh) 2018-05-21
EP2948182B1 (en) 2020-09-30
AU2014209346A1 (en) 2015-07-23
CN105073138A (zh) 2015-11-18
IL239791A0 (en) 2015-08-31
US20220370476A1 (en) 2022-11-24
MX2015009455A (es) 2016-01-12
MX366654B (es) 2019-07-17
HK1218074A1 (zh) 2017-02-03
US9833460B2 (en) 2017-12-05
TW201442713A (zh) 2014-11-16
BR112015017246A2 (pt) 2017-07-11
US20180235980A1 (en) 2018-08-23
US20210052605A1 (en) 2021-02-25
AU2019200649B2 (en) 2020-02-27
BR112015017246B1 (pt) 2022-11-29
US11364251B2 (en) 2022-06-21
US10744144B2 (en) 2020-08-18
CA2897467A1 (en) 2014-07-31
US20140356434A1 (en) 2014-12-04
JP2016510329A (ja) 2016-04-07
CN105073138B (zh) 2018-06-05
WO2014116876A1 (en) 2014-07-31
NZ709620A (en) 2020-07-31
US12016867B2 (en) 2024-06-25
CA2897467C (en) 2020-09-22
AU2019200649A1 (en) 2019-02-21
IL239791B (en) 2020-11-30
EP2948182A1 (en) 2015-12-02

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