AU2013350817A1 - Assays for detecting neutralizing autoantibodies to biologic therapy - Google Patents

Assays for detecting neutralizing autoantibodies to biologic therapy Download PDF

Info

Publication number
AU2013350817A1
AU2013350817A1 AU2013350817A AU2013350817A AU2013350817A1 AU 2013350817 A1 AU2013350817 A1 AU 2013350817A1 AU 2013350817 A AU2013350817 A AU 2013350817A AU 2013350817 A AU2013350817 A AU 2013350817A AU 2013350817 A1 AU2013350817 A1 AU 2013350817A1
Authority
AU
Australia
Prior art keywords
drug
tnfa
labeled
neutralizing
autoantibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2013350817A
Other languages
English (en)
Inventor
Scott Hauenstein
Sharat Singh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nestec SA
Original Assignee
Nestec SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/802,117 external-priority patent/US20130266963A1/en
Application filed by Nestec SA filed Critical Nestec SA
Publication of AU2013350817A1 publication Critical patent/AU2013350817A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/525—Tumor necrosis factor [TNF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2013350817A 2012-11-30 2013-11-27 Assays for detecting neutralizing autoantibodies to biologic therapy Abandoned AU2013350817A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261732251P 2012-11-30 2012-11-30
US61/732,251 2012-11-30
US13/802,117 US20130266963A1 (en) 2011-07-06 2013-03-13 Assay for detecting neutralizing autoantibodies to biologic therapy
US13/802,117 2013-03-13
PCT/IB2013/060458 WO2014083520A2 (en) 2012-11-30 2013-11-27 Assays for detecting neutralizing autoantibodies to biologic therapy

Publications (1)

Publication Number Publication Date
AU2013350817A1 true AU2013350817A1 (en) 2015-06-11

Family

ID=50828561

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013350817A Abandoned AU2013350817A1 (en) 2012-11-30 2013-11-27 Assays for detecting neutralizing autoantibodies to biologic therapy

Country Status (13)

Country Link
EP (1) EP2926136A2 (zh)
JP (1) JP2016502091A (zh)
KR (1) KR20150088890A (zh)
CN (1) CN105074461A (zh)
AU (1) AU2013350817A1 (zh)
BR (1) BR112015012482A2 (zh)
CA (1) CA2892766A1 (zh)
HK (1) HK1215969A1 (zh)
IL (1) IL238995A0 (zh)
MX (1) MX2015006852A (zh)
RU (1) RU2015125739A (zh)
SG (2) SG11201504097PA (zh)
WO (1) WO2014083520A2 (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX343328B (es) 2009-10-26 2016-11-01 Nestec Sa Analisis para la deteccion de farmacos anti-tnf y anticuerpos.
BR112013009376A2 (pt) 2010-10-18 2016-07-26 Nestec Sa métodos para determinar isótipos de anticorpos antifármacos
SG10201605516YA (en) 2011-07-06 2016-08-30 Nestec Sa Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha
SG11201704200SA (en) 2014-12-05 2017-06-29 Nestec Sa Indirect homogeneous mobility shift assays for the detection of biologics in patient samples
WO2016110595A1 (en) 2015-01-09 2016-07-14 Atonomics A/S A UNIVERSAL ASSAY FOR DETERMINING THE QUANTITY OF TNFα INHIBITORY DRUGS AND THEIR CORRESPONDING ANTI-DRUG-ANTIBODIES
US11119096B2 (en) 2016-07-08 2021-09-14 W. Health L.P. Universal assay for determining the quantity of therapeutic monoclonal antibodies and their corresponding anti-drug-antibodies in samples
SG11201908154RA (en) * 2017-03-31 2019-10-30 Ablynx Nv Improved immunogenicity assays
CN111024958B (zh) * 2020-03-11 2020-06-23 同昕生物技术（北京）有限公司 用于检测单抗药物和抗单抗药物抗体的试剂及其应用
CN112730846B (zh) * 2020-12-18 2023-12-15 安渡生物医药(杭州)有限公司 一种用于小鼠血样检测免疫复合物的方法
CN114047343B (zh) * 2022-01-13 2022-05-31 美迪西普亚医药科技(上海)有限公司 双耐受型抗IgE单抗药物的免疫原性分析试剂盒及其使用方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX343328B (es) * 2009-10-26 2016-11-01 Nestec Sa Analisis para la deteccion de farmacos anti-tnf y anticuerpos.
EP2564202B1 (en) * 2010-04-29 2015-07-01 Theradiag SA Methods for detecting anti-drug antibodies
BR112013009376A2 (pt) * 2010-10-18 2016-07-26 Nestec Sa métodos para determinar isótipos de anticorpos antifármacos
ES2530175T3 (es) * 2011-02-17 2015-02-26 Nestec S.A. Ensayos para la detección de autoanticuerpos contra fármacos anti-TNF
SG10201605516YA (en) * 2011-07-06 2016-08-30 Nestec Sa Assays for detecting neutralizing autoantibodies to biologic therapy with tnf alpha

Also Published As

Publication number Publication date
HK1215969A1 (zh) 2016-09-30
SG11201504097PA (en) 2015-06-29
RU2015125739A (ru) 2017-01-13
SG10201703210XA (en) 2017-06-29
IL238995A0 (en) 2015-07-30
CA2892766A1 (en) 2014-06-05
JP2016502091A (ja) 2016-01-21
BR112015012482A2 (pt) 2017-07-11
EP2926136A2 (en) 2015-10-07
WO2014083520A3 (en) 2014-07-31
MX2015006852A (es) 2015-09-16
WO2014083520A2 (en) 2014-06-05
CN105074461A (zh) 2015-11-18
KR20150088890A (ko) 2015-08-03

Similar Documents

Publication Publication Date Title
US10794906B2 (en) Assays for detecting neutralizing autoantibodies to biologic therapy
AU2017213584B2 (en) Assays for the detection of anti-TNF drugs and autoantibodies
AU2013350817A1 (en) Assays for detecting neutralizing autoantibodies to biologic therapy
US20130266963A1 (en) Assay for detecting neutralizing autoantibodies to biologic therapy
US20140051184A1 (en) Mobility shift assays for detecting anti-tnf alpha drugs and autoantibodies thereto

Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period