AU2013326231B2 - Cyclic depsipeptide compounds and their uses - Google Patents

Cyclic depsipeptide compounds and their uses Download PDF

Info

Publication number
AU2013326231B2
AU2013326231B2 AU2013326231A AU2013326231A AU2013326231B2 AU 2013326231 B2 AU2013326231 B2 AU 2013326231B2 AU 2013326231 A AU2013326231 A AU 2013326231A AU 2013326231 A AU2013326231 A AU 2013326231A AU 2013326231 B2 AU2013326231 B2 AU 2013326231B2
Authority
AU
Australia
Prior art keywords
meleu
leu
methyl
hiv
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013326231A
Other languages
English (en)
Other versions
AU2013326231A1 (en
Inventor
Hans Georg Fliri
Rhonan Lee Ford
Antonio Kuok Keong Vong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cypralis Ltd
Original Assignee
Cypralis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cypralis Ltd filed Critical Cypralis Ltd
Publication of AU2013326231A1 publication Critical patent/AU2013326231A1/en
Application granted granted Critical
Publication of AU2013326231B2 publication Critical patent/AU2013326231B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
AU2013326231A 2012-10-02 2013-10-02 Cyclic depsipeptide compounds and their uses Ceased AU2013326231B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1217560.0A GB201217560D0 (en) 2012-10-02 2012-10-02 Novel cyclic depsipeptide compounds and their uses
GB1217560.0 2012-10-02
PCT/GB2013/052570 WO2014053834A1 (en) 2012-10-02 2013-10-02 Cyclic depsipeptide compounds and their uses

Publications (2)

Publication Number Publication Date
AU2013326231A1 AU2013326231A1 (en) 2015-04-09
AU2013326231B2 true AU2013326231B2 (en) 2017-06-29

Family

ID=47225510

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013326231A Ceased AU2013326231B2 (en) 2012-10-02 2013-10-02 Cyclic depsipeptide compounds and their uses

Country Status (8)

Country Link
US (3) US9382295B2 (enExample)
EP (1) EP2904001A1 (enExample)
JP (1) JP6263541B2 (enExample)
CN (1) CN104768968B (enExample)
AU (1) AU2013326231B2 (enExample)
CA (1) CA2885940A1 (enExample)
GB (1) GB201217560D0 (enExample)
WO (1) WO2014053834A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201639873A (zh) 2015-01-08 2016-11-16 歐樂根公司 Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物
US11046730B2 (en) 2016-04-15 2021-06-29 The Regents Of The University Of California Antimicrobial compositions
CN111449050A (zh) 2019-01-20 2020-07-28 睿诺医疗科技（上海）有限公司 环孢菌素类似物及其用途
CN109821020B (zh) * 2019-01-28 2021-07-30 温州医科大学 一种制备干眼症药物的应用及治疗干眼症的方法
CN116870135A (zh) 2019-10-12 2023-10-13 睿诺医疗科技（上海）有限公司 肾毒素诱发的肾损伤的治疗和预防
EP4043478A4 (en) * 2019-11-07 2024-01-03 Chugai Seiyaku Kabushiki Kaisha CYCLIC PEPTIDE COMPOUND HAVING KRAS INHIBITING ACTION
CA3172535A1 (en) 2020-03-26 2021-09-30 Ching-Pong Mak Cyclophilin inhibitors and uses thereof
AU2021256222A1 (en) 2020-04-15 2022-10-06 Farsight Medical Technology (Shanghai) Co., Ltd. Prevention and treatment of organ injuries
CN115636872B (zh) * 2022-06-24 2026-02-24 中国农业科学院生物技术研究所 木糖酸肽类化合物及其在抗寄生虫药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010052559A1 (en) * 2008-11-06 2010-05-14 Debio Recherche Pharmaceutique S.A. Cycloundecadepsipeptide compounds and use of said compounds as a medicament

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE110784T1 (de) * 1987-06-19 1994-09-15 Sandoz Ag Zyklische peptolide.
US5595756A (en) * 1993-12-22 1997-01-21 Inex Pharmaceuticals Corporation Liposomal compositions for enhanced retention of bioactive agents
JP2008526816A (ja) 2005-01-10 2008-07-24 デビオファーム ソシエテ アノニム 心筋虚血状態の間の投与のための薬剤の製造のための環状ウンデカペプチドの使用
US8623814B2 (en) * 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
WO2011141891A1 (en) * 2010-05-12 2011-11-17 Debio Recherche Pharmaceutique S.A. Use of cycloundecadepsipeptide compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010052559A1 (en) * 2008-11-06 2010-05-14 Debio Recherche Pharmaceutique S.A. Cycloundecadepsipeptide compounds and use of said compounds as a medicament

Also Published As

Publication number Publication date
JP2016500653A (ja) 2016-01-14
US9895412B2 (en) 2018-02-20
US20150259386A1 (en) 2015-09-17
CN104768968B (zh) 2019-04-05
CA2885940A1 (en) 2014-04-10
AU2013326231A1 (en) 2015-04-09
EP2904001A1 (en) 2015-08-12
US9382295B2 (en) 2016-07-05
CN104768968A (zh) 2015-07-08
WO2014053834A1 (en) 2014-04-10
US20170007664A1 (en) 2017-01-12
JP6263541B2 (ja) 2018-01-17
US20180153958A1 (en) 2018-06-07
GB201217560D0 (en) 2012-11-14

Similar Documents

Publication Publication Date Title
US9895412B2 (en) Cyclic depsipeptide compounds and their uses
KR102305423B1 (ko) 아미노산 1 및 3에서 변형된 사이클로스포린 유사체 분자
EP2627664B1 (en) Cyclosporin analogs
CA2893935C (en) Novel pharmaceutical formulations and their use in the treatment of periodontal disease
JP5726733B2 (ja) 非免疫抑制性シクロスポリン類似体分子
EP2627663B1 (en) Cyclosporin analogs
ES2408190T3 (es) Microorganismo productor de un compuesto cíclico
ES2464723T3 (es) Compuesto cíclico y sal del mismo
CN101868149A (zh) 抗真菌剂
HK1161277A (en) Nonimmunosuppressive cyclosporine analogue molecules
HK1189898A (en) Cyclosporin analogs

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired