AU2013318146B2 - Drug delivery systems and methods for treatment of bladder voiding dysfunction|and other lower urinary tract disorders by using trospium - Google Patents
Drug delivery systems and methods for treatment of bladder voiding dysfunction|and other lower urinary tract disorders by using trospium Download PDFInfo
- Publication number
- AU2013318146B2 AU2013318146B2 AU2013318146A AU2013318146A AU2013318146B2 AU 2013318146 B2 AU2013318146 B2 AU 2013318146B2 AU 2013318146 A AU2013318146 A AU 2013318146A AU 2013318146 A AU2013318146 A AU 2013318146A AU 2013318146 B2 AU2013318146 B2 AU 2013318146B2
- Authority
- AU
- Australia
- Prior art keywords
- trospium
- bladder
- medicament
- urine
- treatment period
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229960001491 trospium Drugs 0.000 title claims abstract description 52
- OYYDSUSKLWTMMQ-JKHIJQBDSA-N trospium Chemical compound [N+]12([C@@H]3CC[C@H]2C[C@H](C3)OC(=O)C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CCCC1 OYYDSUSKLWTMMQ-JKHIJQBDSA-N 0.000 title claims abstract description 52
- 238000000034 method Methods 0.000 title claims abstract description 14
- 238000012377 drug delivery Methods 0.000 title claims abstract 7
- 208000026723 Urinary tract disease Diseases 0.000 title 1
- 230000004064 dysfunction Effects 0.000 title 1
- 208000014001 urinary system disease Diseases 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract description 32
- 210000002700 urine Anatomy 0.000 claims abstract description 27
- 230000002459 sustained effect Effects 0.000 claims abstract 11
- 206010069632 Bladder dysfunction Diseases 0.000 claims abstract 6
- 210000005068 bladder tissue Anatomy 0.000 claims abstract 3
- 230000001225 therapeutic effect Effects 0.000 claims abstract 3
- RVCSYOQWLPPAOA-CVPHZBIISA-M [(5s)-spiro[8-azoniabicyclo[3.2.1]octane-8,1'-azolidin-1-ium]-3-yl] 2-hydroxy-2,2-diphenylacetate;chloride Chemical compound [Cl-].[N+]12([C@H]3CCC2CC(C3)OC(=O)C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CCCC1 RVCSYOQWLPPAOA-CVPHZBIISA-M 0.000 claims description 15
- 229960001530 trospium chloride Drugs 0.000 claims description 15
- 206010020853 Hypertonic bladder Diseases 0.000 claims 7
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims 3
- 208000020629 overactive bladder Diseases 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 206010036018 Pollakiuria Diseases 0.000 claims 2
- 208000000921 Urge Urinary Incontinence Diseases 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 206010029446 nocturia Diseases 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 206010046494 urge incontinence Diseases 0.000 claims 2
- 208000022934 urinary frequency Diseases 0.000 claims 2
- 230000036318 urination frequency Effects 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 230000014759 maintenance of location Effects 0.000 claims 1
- 210000003708 urethra Anatomy 0.000 claims 1
- 229940079593 drug Drugs 0.000 abstract description 11
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
- XIQVNETUBQGFHX-UHFFFAOYSA-N Ditropan Chemical compound C=1C=CC=CC=1C(O)(C(=O)OCC#CCN(CC)CC)C1CCCCC1 XIQVNETUBQGFHX-UHFFFAOYSA-N 0.000 description 10
- 229960005434 oxybutynin Drugs 0.000 description 10
- 241000700159 Rattus Species 0.000 description 6
- 229920001296 polysiloxane Polymers 0.000 description 6
- YYSCJLLOWOUSHH-UHFFFAOYSA-N 4,4'-disulfanyldibutanoic acid Chemical compound OC(=O)CCCSSCCCC(O)=O YYSCJLLOWOUSHH-UHFFFAOYSA-N 0.000 description 4
- 230000001022 anti-muscarinic effect Effects 0.000 description 4
- 230000010412 perfusion Effects 0.000 description 4
- 229960004045 tolterodine Drugs 0.000 description 4
- OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 description 4
- 229960003553 tolterodine tartrate Drugs 0.000 description 4
- BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 description 4
- 230000036724 intravesical pressure Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- ZKNJEOBYOLUGKJ-ALCCZGGFSA-N (z)-2-propylpent-2-enoic acid Chemical compound CCC\C(C(O)=O)=C\CC ZKNJEOBYOLUGKJ-ALCCZGGFSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000003929 acidic solution Substances 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229960002016 oxybutynin chloride Drugs 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 210000003741 urothelium Anatomy 0.000 description 2
- 206010048994 Bladder spasm Diseases 0.000 description 1
- 241001631457 Cannula Species 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 239000008351 acetate buffer Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000013265 extended release Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000003149 muscarinic antagonist Substances 0.000 description 1
- 230000001473 noxious effect Effects 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Anesthesiology (AREA)
- Gynecology & Obstetrics (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261702576P | 2012-09-18 | 2012-09-18 | |
| US61/702,576 | 2012-09-18 | ||
| PCT/US2013/060479 WO2014047221A1 (en) | 2012-09-18 | 2013-09-18 | Drug delivery systems and methods for treatment of bladder voiding dysfunction|and other lower urinary tract disorders by using trospium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2013318146A1 AU2013318146A1 (en) | 2015-03-19 |
| AU2013318146B2 true AU2013318146B2 (en) | 2018-05-10 |
Family
ID=49301639
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2013318146A Active AU2013318146B2 (en) | 2012-09-18 | 2013-09-18 | Drug delivery systems and methods for treatment of bladder voiding dysfunction|and other lower urinary tract disorders by using trospium |
Country Status (13)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8721621B2 (en) | 2009-09-10 | 2014-05-13 | Taris Biomedical, Inc. | Systems and methods for deploying devices to genitourinary sites |
| CN104640549B (zh) | 2012-08-31 | 2018-09-07 | 塔里斯生物医药公司 | 用于治疗膀胱癌的药物递送系统和方法 |
| AU2013308465B2 (en) | 2012-08-31 | 2018-05-17 | Taris Biomedical Llc | Drug delivery systems and methods for treatment of prostate disease comprising gemicitabine |
| WO2014047221A1 (en) * | 2012-09-18 | 2014-03-27 | Taris Biomedical, Inc. | Drug delivery systems and methods for treatment of bladder voiding dysfunction|and other lower urinary tract disorders by using trospium |
| US10912933B2 (en) | 2014-08-19 | 2021-02-09 | The Regents Of The University Of California | Implants for localized drug delivery and methods of use thereof |
| GB201506526D0 (en) | 2015-04-17 | 2015-06-03 | Uropharma Ltd And Synesis Llc | Medicinal composition |
| CN106706832A (zh) * | 2015-08-06 | 2017-05-24 | 舒泰神（北京）生物制药股份有限公司 | 一种测定曲司氯铵含量的方法 |
| CA3052148A1 (en) * | 2017-02-01 | 2018-08-09 | Taris Biomedical Llc | In vivo drug delivery devices and methods for drug delivery |
| SG11201913251VA (en) | 2017-07-25 | 2020-01-30 | Taris Biomedical Llc | Methods of treating tumor metastasis |
| TWI841554B (zh) | 2018-03-21 | 2024-05-11 | 丹麥商珍美寶股份有限公司 | 以鉑為主之劑與抗組織因子抗體－藥物共軛物的組合治療癌症之方法 |
| BR112020022642A2 (pt) | 2018-05-07 | 2021-02-17 | Genmab A/S | método para tratar câncer em um indivíduo, e, estojo |
| CA3107461A1 (en) * | 2018-08-01 | 2020-02-06 | Taris Biomedical Llc | Methods of treating overactive bladder using trospium |
| EP3962449A1 (en) * | 2019-04-30 | 2022-03-09 | Trigone Pharma Ltd | Formulations and methods for drug instillation into the bladder and treatment of bladder ailments |
| US11338119B2 (en) | 2020-03-20 | 2022-05-24 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
| US11344526B2 (en) | 2020-03-20 | 2022-05-31 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
| US11173291B2 (en) | 2020-03-20 | 2021-11-16 | The Regents Of The University Of California | Implantable drug delivery devices for localized drug delivery |
| KR102596697B1 (ko) | 2021-05-20 | 2023-11-01 | 김정우 | 바위솔 추출물을 유효성분으로 포함하는 화장품 조성물 및 그 제조 방법 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998430A (en) * | 1996-11-27 | 1999-12-07 | Dr. R. Pfleger Chemische Fabrik Gmbh | Use of trospium chloride and 2-component system for the same |
| WO2006101954A2 (en) * | 2005-03-17 | 2006-09-28 | Indevus Pharmaceuticals, Inc. | Interstitial cystitis treatment |
| US20120203203A1 (en) * | 2011-02-04 | 2012-08-09 | Taris Biomedical, Inc. | Implantable device for controlled dissolution and diffusion of low solubility drug |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1424079A1 (en) * | 2002-11-27 | 2004-06-02 | Boehringer Ingelheim International GmbH | Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine |
| US20060058777A1 (en) * | 2002-12-11 | 2006-03-16 | Pia Norup Nielsen | Urinary catheter device with a pharmaceutically active composition |
| WO2004064789A2 (en) | 2003-01-16 | 2004-08-05 | University Of Rochester | Quaternary antimuscarinic compounds for the treatment of bladder diseases |
| ATE427108T1 (de) | 2004-08-11 | 2009-04-15 | Boehringer Ingelheim Pharma | Anticholinergika enthaltende arzneimittel zur behandlung von krankheiten der ableitenden harnwege |
| US7390816B2 (en) | 2005-06-21 | 2008-06-24 | Bridge Pharma, Inc. | Methods for treating urinary incontinence in patients suffering from memory disorders |
| US8801694B2 (en) | 2005-08-11 | 2014-08-12 | Massachusetts Institute Of Technology | Intravesical drug delivery device |
| EP1967202A1 (en) | 2007-03-05 | 2008-09-10 | AEterna Zentaris GmbH | Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity |
| MX348005B (es) | 2007-12-11 | 2017-05-23 | Massachusetts Inst Technology | Dispositivo implantable de liberación de fármacos y métodos para tratar la vejiga y otras vesículas o lúmenes corporales. |
| WO2010019507A2 (en) | 2008-08-09 | 2010-02-18 | Massachusetts Institute Of Technology | Implantable drug delivery device and methods of treating male genitourinary and surrounding tissues |
| ES2401007T3 (es) | 2009-06-26 | 2013-04-16 | Taris Biomedical, Inc. | Dispositivos de administración de fármaco implantables y procedimientos de fabricación de los mismos |
| US9017312B2 (en) | 2009-09-10 | 2015-04-28 | Taris Biomedical Llc | Implantable device for controlled drug delivery |
| US8721621B2 (en) | 2009-09-10 | 2014-05-13 | Taris Biomedical, Inc. | Systems and methods for deploying devices to genitourinary sites |
| RS61980B1 (sr) | 2009-12-17 | 2021-07-30 | Taris Biomedical Llc | Implantabilni uređaj sa intravezikalnom tolerancijom |
| US20110218488A1 (en) | 2010-03-05 | 2011-09-08 | Taris Biomedical, Inc. | Systems and Methods for Implanting Devices in the Bladder and Other Genitourinary Sites |
| US8690840B2 (en) | 2010-10-06 | 2014-04-08 | Taris Biomedical, Inc. | Time-selective bioresorbable or collapsible drug delivery systems and methods |
| US9457176B2 (en) | 2010-10-06 | 2016-10-04 | Taris Biomedical Llc | Implantable drug delivery device with bladder retention feature |
| JP2014503554A (ja) | 2011-01-10 | 2014-02-13 | タリス バイオメディカル，インコーポレイテッド | 膀胱痛及び刺激性排尿の持続的治療の使用のためのリドカインレジメン |
| WO2014047221A1 (en) * | 2012-09-18 | 2014-03-27 | Taris Biomedical, Inc. | Drug delivery systems and methods for treatment of bladder voiding dysfunction|and other lower urinary tract disorders by using trospium |
| SG10201708522SA (en) | 2013-03-15 | 2017-12-28 | Taris Biomedical Llc | Drug delivery devices with drug-permeable component and methods |
-
2013
- 2013-09-18 WO PCT/US2013/060479 patent/WO2014047221A1/en active Application Filing
- 2013-09-18 CN CN202010161062.6A patent/CN111450093A/zh active Pending
- 2013-09-18 CN CN201380046758.2A patent/CN104684556A/zh active Pending
- 2013-09-18 EP EP13771696.5A patent/EP2897616A1/en active Pending
- 2013-09-18 AU AU2013318146A patent/AU2013318146B2/en active Active
- 2013-09-18 RU RU2015112196A patent/RU2670749C9/ru active
- 2013-09-18 BR BR112015005351A patent/BR112015005351A2/pt not_active Application Discontinuation
- 2013-09-18 JP JP2015532177A patent/JP6600256B2/ja active Active
- 2013-09-18 MX MX2015003110A patent/MX379066B/es unknown
- 2013-09-18 KR KR1020157008403A patent/KR102141433B1/ko active Active
- 2013-09-18 SG SG11201502104YA patent/SG11201502104YA/en unknown
- 2013-09-18 CA CA2883855A patent/CA2883855C/en active Active
-
2015
- 2015-03-02 IL IL237498A patent/IL237498B/en active IP Right Grant
- 2015-03-11 MX MX2020002465A patent/MX2020002465A/es unknown
- 2015-03-16 US US14/658,699 patent/US10500200B2/en active Active
-
2018
- 2018-02-02 JP JP2018017300A patent/JP2018080208A/ja active Pending
-
2019
- 2019-12-06 US US16/706,009 patent/US11850244B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5998430A (en) * | 1996-11-27 | 1999-12-07 | Dr. R. Pfleger Chemische Fabrik Gmbh | Use of trospium chloride and 2-component system for the same |
| WO2006101954A2 (en) * | 2005-03-17 | 2006-09-28 | Indevus Pharmaceuticals, Inc. | Interstitial cystitis treatment |
| US20120203203A1 (en) * | 2011-02-04 | 2012-08-09 | Taris Biomedical, Inc. | Implantable device for controlled dissolution and diffusion of low solubility drug |
Non-Patent Citations (2)
| Title |
|---|
| MICHAELI W et al:, ANNUAL TECHNICAL CONFERENCE - ANTEC 2009, , SOCIETY OF PLASTICS ENGINEERS USA, 2009, Vol. 5, pages 2951-2956, * |
| VON WALTER M et al: " TROSPIUM CHLORIDE RELEASED FROM INTRAVESICALLY APPLIED PLGA-BASED CARRIERS DECREASES BLADDER CONTRACTILITY IN AN ISOLATED WHOLE PIG BLADDER MODEL", EUROPEAN UROLOGY SUPPLEMENTS, 2009, 230, Vol. 8, no. 4, page 178 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014047221A1 (en) | 2014-03-27 |
| US11850244B2 (en) | 2023-12-26 |
| KR102141433B1 (ko) | 2020-08-05 |
| BR112015005351A2 (pt) | 2017-07-04 |
| CA2883855C (en) | 2020-09-15 |
| RU2015112196A (ru) | 2016-11-10 |
| IL237498A0 (en) | 2015-04-30 |
| EP2897616A1 (en) | 2015-07-29 |
| KR20150058271A (ko) | 2015-05-28 |
| RU2670749C9 (ru) | 2018-12-13 |
| RU2670749C2 (ru) | 2018-10-25 |
| US20150182516A1 (en) | 2015-07-02 |
| US20200108057A1 (en) | 2020-04-09 |
| JP2018080208A (ja) | 2018-05-24 |
| MX2020002465A (es) | 2020-07-13 |
| JP6600256B2 (ja) | 2019-10-30 |
| AU2013318146A1 (en) | 2015-03-19 |
| CN111450093A (zh) | 2020-07-28 |
| JP2015529688A (ja) | 2015-10-08 |
| MX379066B (es) | 2025-03-04 |
| MX2015003110A (es) | 2015-06-05 |
| IL237498B (en) | 2018-01-31 |
| WO2014047221A9 (en) | 2015-05-21 |
| US10500200B2 (en) | 2019-12-10 |
| CA2883855A1 (en) | 2014-03-27 |
| CN104684556A (zh) | 2015-06-03 |
| SG11201502104YA (en) | 2015-05-28 |
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| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) |