AU2013288265B2 - Tetrahydroquinazolinone derivatives as PARP inhibitors - Google Patents

Tetrahydroquinazolinone derivatives as PARP inhibitors Download PDF

Info

Publication number
AU2013288265B2
AU2013288265B2 AU2013288265A AU2013288265A AU2013288265B2 AU 2013288265 B2 AU2013288265 B2 AU 2013288265B2 AU 2013288265 A AU2013288265 A AU 2013288265A AU 2013288265 A AU2013288265 A AU 2013288265A AU 2013288265 B2 AU2013288265 B2 AU 2013288265B2
Authority
AU
Australia
Prior art keywords
compound
cyclopropane
spiro
quinazolin
piperazin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013288265A
Other languages
English (en)
Other versions
AU2013288265A1 (en
Inventor
Arun Rangnath Jagdale
Gourhari Jana
Rajender Kumar Kamboj
Gagan Kukreja
Sanjay Pralhad Kurhade
Venkata P. Palle
Neelima Sinha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lupin Ltd
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of AU2013288265A1 publication Critical patent/AU2013288265A1/en
Application granted granted Critical
Publication of AU2013288265B2 publication Critical patent/AU2013288265B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2013288265A 2012-07-09 2013-07-09 Tetrahydroquinazolinone derivatives as PARP inhibitors Ceased AU2013288265B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN762KO2012 2012-07-09
IN762/KOL/2012 2012-07-09
PCT/IB2013/055618 WO2014009872A1 (en) 2012-07-09 2013-07-09 Tetrahydroquinazolinone derivatives as parp inhibitors

Publications (2)

Publication Number Publication Date
AU2013288265A1 AU2013288265A1 (en) 2015-01-29
AU2013288265B2 true AU2013288265B2 (en) 2017-04-06

Family

ID=48906465

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013288265A Ceased AU2013288265B2 (en) 2012-07-09 2013-07-09 Tetrahydroquinazolinone derivatives as PARP inhibitors

Country Status (8)

Country Link
US (1) US9359367B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP2870140B8 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU2013288265B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2877826C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2595240T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN2015MN00002A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO2014009872A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA201409497B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2944801C (en) * 2014-04-10 2019-02-12 Hubei Bio-Pharmaceutical Industrial Technological Institute Inc. Analogs of 4h-pyrazolo[1,5-a]benzimidazole compounds as parp inhibitors
WO2016012956A1 (en) * 2014-07-24 2016-01-28 Lupin Limited Isoquinolinone derivatives as parp inhibitors
WO2017013593A1 (en) 2015-07-22 2017-01-26 Lupin Limited Isoquinolinone derivatives as parp inhibitors
CA2991232A1 (en) * 2015-08-17 2017-02-23 Lupin Limited Heteroaryl derivatives as parp inhibitors
CN108822115B (zh) * 2017-04-21 2022-08-12 上海迪诺医药科技有限公司 一种抑制parp活性的化合物的制备方法及其中间体
SMT202300113T1 (it) 2017-12-21 2023-05-12 Ribon Therapeutics Inc Chinazoline come inibitori di parp14.
CN111269216A (zh) * 2018-12-05 2020-06-12 中国医学科学院药物研究所 含有哌嗪酮的喹唑啉二酮盐类化合物、其制备方法、药物组合物和用途
WO2021041573A2 (en) * 2019-08-27 2021-03-04 The Johns Hopkins University Biomarkers for neurodegenerative disorders
TWI749881B (zh) * 2019-11-21 2021-12-11 大陸商深圳信立泰藥業股份有限公司 二氧代哌類衍生物、其製備方法及其在醫藥上的應用
CN112608303B (zh) * 2020-12-25 2021-10-26 华南理工大学 一种哌嗪类中间体及其制备方法与应用
CN114044769B (zh) * 2021-11-25 2023-12-12 中山大学 一种β-吲哚喹唑啉酮衍生物及其制备方法和应用
GB2634233A (en) * 2023-10-02 2025-04-09 Duke Street Bio Ltd PARP1 inhibitor compounds
WO2025091346A1 (en) * 2023-11-01 2025-05-08 Suzhou Eoc Medical Research Co., Ltd. Parp inhibitors and uses thereof
WO2025101854A1 (en) * 2023-11-09 2025-05-15 University Of Kentucky Research Foundation Opioid compounds

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2027645A1 (de) 1970-06-05 1971-12-09 Byk Gulden Lomberg Chemische Fa bnk GmbH, 7750 Konstanz Piperazinylalkyl chinazolon (4) den vate, Verfahren zu deren Herstellung und sie enthaltende Arzneimittel
BE503170A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-09-02
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US5019369A (en) 1984-10-22 1991-05-28 Vestar, Inc. Method of targeting tumors in humans
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
IL90858A (en) 1988-07-07 1994-08-26 Rhone Poulenc Sante Derivatives of (AZA) naphthalensultam, their preparation and compositions containing them
DE4312832C1 (de) 1993-04-20 1994-10-20 Boehringer Ingelheim Kg Verfahren zur Herstellung enantiomerenreiner Ketale der (S)- und (R)-3-Oxocyclopentancarbonsäure
DE4316576A1 (de) 1993-05-18 1994-11-24 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 1,3-Dipropyl-8-(3-Oxocyclopentyl)-xanthin
US5589489A (en) 1993-12-15 1996-12-31 Zeneca Limited Cyclic amide derivatives for treating asthma
GB9904275D0 (en) 1999-02-24 1999-04-21 Cancer Res Campaign Tech Anti-cancer compounds
AU2001249262A1 (en) 2000-03-20 2001-10-03 Sepracor, Inc. Therapeutic compounds for the treatment of asthma and allergy, and methods of use thereof
DK1178047T3 (da) 2000-08-03 2004-05-24 Pfizer Prod Inc Diazabicyclooctanderivater og terapeutiske anvendelser deraf
AUPR201600A0 (en) 2000-12-11 2001-01-11 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivative
JPWO2002094790A1 (ja) 2001-05-23 2004-09-09 三菱ウェルファーマ株式会社 縮合ヘテロ環化合物およびその医薬用途
PL368052A1 (en) 2001-07-11 2005-03-21 Elan Pharmaceuticals, Inc. N-(3-amino-2-hydroxy-propyl) substituted alkylamide compounds
AUPR975601A0 (en) 2001-12-24 2002-01-31 Fujisawa Pharmaceutical Co., Ltd. Quinazolinone derivatives
AUPS019702A0 (en) 2002-01-29 2002-02-21 Fujisawa Pharmaceutical Co., Ltd. Condensed heterocyclic compounds
JP2005536553A (ja) 2002-08-21 2005-12-02 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
GB0317466D0 (en) 2003-07-25 2003-08-27 Univ Sheffield Use
CN1266155C (zh) 2003-08-01 2006-07-26 浙江震元制药有限公司 6－氯－4－羟基－2－甲基－2H－噻吩并（2，3－e）－1，2－噻嗪－1，1－二氧化物－3－羧酸酯的合成方法
US7767683B2 (en) 2003-08-18 2010-08-03 H. Lundbeck A/S Hydrogen succinate salts of trans-4-((1R, 3S)-6-chloro-3-phenylindan-1-YL)-1,2,2-trimethylpiperazine and the use as a medicament
US20050065178A1 (en) 2003-09-19 2005-03-24 Anwer Basha Substituted diazabicycloakane derivatives
NZ547984A (en) 2003-12-01 2009-03-31 Kudos Pharm Ltd DNA damage repair inhibitors for treatment of cancer
US9016221B2 (en) 2004-02-17 2015-04-28 University Of Florida Research Foundation, Inc. Surface topographies for non-toxic bioadhesion control
US7799775B2 (en) 2004-02-26 2010-09-21 Aska Pharmaceutical Co., Ltd. Pyrimidine derivatives
US7381822B2 (en) 2004-03-31 2008-06-03 The General Hospital Corporation Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process
US20050245534A1 (en) 2004-04-29 2005-11-03 Link James T Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
ZA200609259B (en) 2004-04-30 2008-07-30 Takeda Pharmaceutical Heterocyclic amide compound and use thereof as an mmp-13 inhibitor
WO2006003150A1 (en) 2004-06-30 2006-01-12 Janssen Pharmaceutica N.V. Substituted 2-alkyl quinazolinone derivatives as parp inhibitors
US20060079510A1 (en) 2004-09-30 2006-04-13 Kristoffer Hellstrand Use of PARP-1 inhibitors for protecting tumorcidal lymphocytes from apoptosis
JPWO2006051851A1 (ja) 2004-11-10 2008-05-29 わかもと製薬株式会社 ２，３，４，５−テトラヒドロ−１ｈ−１，５−ベンゾジアゼピン誘導体、及び、医薬組成物
AU2005315392B2 (en) 2004-12-17 2010-03-11 Astrazeneca Ab 4- (4- (imidazol-4-yl) pyrimidin-2-ylamino) benzamides as CDK inhibitors
AU2006226018B2 (en) 2005-03-23 2012-07-12 Idorsia Pharmaceuticals Ltd Hydrogenated benzo (C) thiophene derivatives as immunomodulators
US20090226412A1 (en) 2005-06-24 2009-09-10 Ono Pharmaceutical Co., Ltd., Agent for reduction of bleeding in cerebrovascular disorder
US7300947B2 (en) 2005-07-13 2007-11-27 Banyu Pharmaceutical Co., Ltd. N-dihydroxyalkyl-substituted 2-oxo-imidazole derivatives
WO2007011623A1 (en) 2005-07-15 2007-01-25 Schering Corporation Quinazoline derivatives useful in cancer treatment
US20090170860A1 (en) 2005-11-25 2009-07-02 Pharma Mar, S.A., Sociedad Unipersonal Use of PARP-1 Inhibitors
US20070197509A1 (en) 2005-12-21 2007-08-23 Painceptor Pharma Corporation Compositions and methods for modulating gated ion channels
WO2007076055A2 (en) 2005-12-22 2007-07-05 Entremed, Inc. Compositions and methods comprising proteinase activated receptor antagonists
US8349850B2 (en) 2006-03-28 2013-01-08 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
JP5546240B2 (ja) 2006-04-26 2014-07-09 ジェネンテック， インコーポレイテッド 医薬化合物
WO2008080824A1 (en) 2006-12-29 2008-07-10 F. Hoffmann-La Roche Ag Aromatic sulfonated ketals
WO2009038064A1 (ja) 2007-09-19 2009-03-26 Institute Of Medicinal Molecular Design, Inc. Ｉ型１１βヒドロキシステロイド脱水素酵素阻害活性を有する複素環誘導体
JP2009096804A (ja) 2007-09-26 2009-05-07 Santen Pharmaceut Co Ltd キナゾリノン誘導体又はキノキサリン誘導体を有効成分として含む角結膜障害の予防又は治療剤
WO2009041566A1 (ja) 2007-09-26 2009-04-02 Santen Pharmaceutical Co., Ltd. キナゾリノン誘導体又はキノキサリン誘導体を有効成分として含有する後眼部疾患の予防又は治療剤
JP2011507910A (ja) 2007-12-21 2011-03-10 ユニバーシティー オブ ロチェスター 真核生物の寿命を変更するための方法
FR2926221A1 (fr) 2008-01-14 2009-07-17 Tassin Thomas Compositions permettant la reproduction artificielle des conditions pharmacologiques de la dependance aux drogues addictives telles que opiaces, psychostimulants, tabac et alcool, par la combinaison de nicotine et d'un ligand.
WO2009114459A2 (en) 2008-03-10 2009-09-17 The Trustees Of The University Of Pennsylvania Anti-neoplastic combination therapeutic regimen involving co-disruption of parp pathway and mre11/rad50/nbs1 complex and compositons useful therein
AU2009324210A1 (en) 2008-12-05 2010-06-10 F. Hoffmann-La Roche Ag Pyrrolopyrazinyl urea kinase inhibitors
WO2010082813A1 (en) 2009-01-13 2010-07-22 Academisch Medisch Centrum Bij De Universiteit Van Amsterdam Method of treating cancer
NZ628298A (en) 2010-03-25 2015-11-27 Abbvie Inc Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
AU2011298423B2 (en) 2010-09-03 2015-11-05 Bayer Intellectual Property Gmbh Substituted fused pyrimidinones and dihydropyrimidinones

Also Published As

Publication number Publication date
US9359367B2 (en) 2016-06-07
US20150152118A1 (en) 2015-06-04
EP2870140A1 (en) 2015-05-13
ES2595240T3 (es) 2016-12-28
EP2870140B1 (en) 2016-07-27
WO2014009872A1 (en) 2014-01-16
EP2870140B8 (en) 2016-09-28
CA2877826A1 (en) 2014-01-16
AU2013288265A1 (en) 2015-01-29
IN2015MN00002A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2015-10-16
ZA201409497B (en) 2015-12-23
CA2877826C (en) 2016-08-16

Similar Documents

Publication Publication Date Title
AU2013288265B2 (en) Tetrahydroquinazolinone derivatives as PARP inhibitors
AU2018255300B2 (en) Bicyclic compounds and their use in the treatment of cancer
JP7540998B2 (ja) αｖβ６インテグリンの阻害
EP3337802A1 (en) Heteroaryl derivatives as parp inhibitors
CA2829188C (en) Dispiropyrrolidine derivatives
JP7166028B2 (ja) 高活性ｓｔｉｎｇタンパク質アゴニスト化合物
WO2020045334A1 (ja) 光学活性なアザビシクロ環誘導体
CA3054604A1 (en) Inhibitors of .alpha.v.beta.6 integrin
CA3026983A1 (en) Chemical compounds
JP2023529908A (ja) Ｂｒｍ標的化化合物及び関連する使用方法
CA3110436C (en) High activity sting protein agonist
US20250136582A1 (en) Select kras g12c inhibitors and uses thereof
EP3844162B1 (en) Inhibitors of alpha v beta6 integrin
WO2016012956A1 (en) Isoquinolinone derivatives as parp inhibitors
WO2024238633A2 (en) Kras g12s and g12c inhibitors
WO2017013593A1 (en) Isoquinolinone derivatives as parp inhibitors
KR102852841B1 (ko) αvβ6 인테그린 억제
EP4547676A1 (en) Cyclic boronic esters and their uses
OA18697A (en) Heteroaryl derivatives as PARP inhibitors
HK40021223B (en) Bicyclic compounds and their use in the treatment of cancer
GB2558975A (en) New compounds

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired