AU2013262991A1 - Methods of using (4S,4aS,5aR,12aS)-4- dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide - Google Patents

Methods of using (4S,4aS,5aR,12aS)-4- dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide Download PDF

Info

Publication number
AU2013262991A1
AU2013262991A1 AU2013262991A AU2013262991A AU2013262991A1 AU 2013262991 A1 AU2013262991 A1 AU 2013262991A1 AU 2013262991 A AU2013262991 A AU 2013262991A AU 2013262991 A AU2013262991 A AU 2013262991A AU 2013262991 A1 AU2013262991 A1 AU 2013262991A1
Authority
AU
Australia
Prior art keywords
methyl
salt
mono
crystalline
naphthacene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2013262991A
Other languages
English (en)
Inventor
Catherine COULTER
Sean M. Johnston
Farzaneh Seyedi
Tina M. Devries
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Paratek Pharmaceuticals Inc
Warner Chilcott Co LLC
Original Assignee
Paratek Pharmaceuticals Inc
Warner Chilcott Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paratek Pharmaceuticals Inc, Warner Chilcott Co LLC filed Critical Paratek Pharmaceuticals Inc
Publication of AU2013262991A1 publication Critical patent/AU2013262991A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2013262991A 2012-05-14 2013-05-14 Methods of using (4S,4aS,5aR,12aS)-4- dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide Abandoned AU2013262991A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261646754P 2012-05-14 2012-05-14
US61/646,754 2012-05-14
PCT/US2013/040933 WO2013173326A1 (en) 2012-05-14 2013-05-14 Methods of using (4s,4as,5ar,12as)-4- dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

Publications (1)

Publication Number Publication Date
AU2013262991A1 true AU2013262991A1 (en) 2014-12-04

Family

ID=49548796

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013262991A Abandoned AU2013262991A1 (en) 2012-05-14 2013-05-14 Methods of using (4S,4aS,5aR,12aS)-4- dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide

Country Status (6)

Country Link
US (1) US20130302442A1 (enExample)
EP (1) EP2849757A4 (enExample)
JP (1) JP2015517524A (enExample)
AU (1) AU2013262991A1 (enExample)
CA (1) CA2873412A1 (enExample)
WO (1) WO2013173326A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012155146A1 (en) * 2011-05-12 2012-11-15 Paratek Pharmaceuticals, Inc. Crystalline salts of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide and methods of using the same
EP4268897A3 (en) * 2015-03-24 2024-01-03 Paratek Pharmaceuticals, Inc. Minocycline compounds for biodefense
US12297161B2 (en) * 2018-04-06 2025-05-13 Almirall, Llc Process for making sarecycline hydrochloride

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0375068A1 (en) * 1988-12-23 1990-06-27 Gist-Brocades N.V. Combining bismuth compounds and tetracyclines
US7871793B2 (en) * 2004-02-20 2011-01-18 Burnham Institute For Medical Research Antimicrobial carbohydrates and methods of using same
AU2007338681B2 (en) * 2006-12-21 2013-09-26 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of inflammatory skin disorders
ES2548261T3 (es) * 2006-12-21 2015-10-15 Paratek Pharmaceuticals, Inc. Derivados de tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias
JP5944825B2 (ja) * 2009-08-28 2016-07-05 テトラフェース ファーマシューティカルズ，インコーポレイテッド テトラサイクリン化合物
WO2012021829A1 (en) * 2010-08-12 2012-02-16 Tetraphase Pharmaceuticals, Inc. Methods of treating bacterial infections
WO2012155146A1 (en) * 2011-05-12 2012-11-15 Paratek Pharmaceuticals, Inc. Crystalline salts of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide and methods of using the same

Also Published As

Publication number Publication date
EP2849757A1 (en) 2015-03-25
US20130302442A1 (en) 2013-11-14
WO2013173326A1 (en) 2013-11-21
CA2873412A1 (en) 2013-11-21
EP2849757A4 (en) 2015-11-18
JP2015517524A (ja) 2015-06-22

Similar Documents

Publication Publication Date Title
JP6876082B2 (ja) （４ｓ，４ａｓ，５ａｒ，１２ａｓ）−４−ジメチルアミノ−３，１０，１２，１２ａ−テトラヒドロキシ−７−［（メトキシ（メチル）アミノ）−メチル］−１，１１−ジオキソ−１，４，４ａ，５，５ａ，６，１１，１２ａ−オクタヒドロ−ナフタセン−２−カルボン酸アミドの結晶塩及びそれを使用する方法
EA013835B1 (ru) Замещенные соединения тетрациклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния субъекта
CN101128114B (zh) 18元环大环化合物及其类似物
EP3154534A1 (en) Small molecule efflux pump inhibitors
CN109071456A (zh) 作为myc调节剂的max结合剂及其用途
US20130302442A1 (en) Methods of using (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide
WO2010082019A1 (en) Actagardine derivatives, and pharmaceutical use thereof
JP2021521175A (ja) ベンズアミド抗菌剤
CN111116707A (zh) 一种Rakicidins氨基甲酸酯类衍生物及其制备方法与应用
CN115340538B (zh) 8-苯亚胺基甲基小檗碱型衍生物及其制备药物的应用
JP5825217B2 (ja) １８員大環状化合物及びその類似化合物
HK1194659A (en) Crystalline salts of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide and methods of using the same
HK1194659B (en) Crystalline salts of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide and methods of using the same
EP3522896A2 (en) Ketolides having antibacterial activity
HK1174260A (en) 18-membered macrocycles and analogs thereof

Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period