AU2013249111B2 - Aminosteroids for the treatment of a PTP1B associated disease - Google Patents

Aminosteroids for the treatment of a PTP1B associated disease Download PDF

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Publication number
AU2013249111B2
AU2013249111B2 AU2013249111A AU2013249111A AU2013249111B2 AU 2013249111 B2 AU2013249111 B2 AU 2013249111B2 AU 2013249111 A AU2013249111 A AU 2013249111A AU 2013249111 A AU2013249111 A AU 2013249111A AU 2013249111 B2 AU2013249111 B2 AU 2013249111B2
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AU
Australia
Prior art keywords
available
compound
pharmaceutically acceptable
ptp1b
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2013249111A
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English (en)
Other versions
AU2013249111A1 (en
Inventor
W. Lee Maloy
Michael Mclane
Inez Ruiz-White
Henry R. Wolfe
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Depymed Inc
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Depymed Inc
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Publication date
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Publication of AU2013249111A1 publication Critical patent/AU2013249111A1/en
Application granted granted Critical
Publication of AU2013249111B2 publication Critical patent/AU2013249111B2/en
Priority to AU2018256561A priority Critical patent/AU2018256561B2/en
Priority to AU2020203736A priority patent/AU2020203736B2/en
Assigned to DEPYMED INC. reassignment DEPYMED INC. Request for Assignment Assignors: OHR PHARMACEUTICAL, INC.
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2013249111A 2012-04-20 2013-04-19 Aminosteroids for the treatment of a PTP1B associated disease Active AU2013249111B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2018256561A AU2018256561B2 (en) 2012-04-20 2018-10-31 Aminosteroids for the treatment of a PTP1B associated disease
AU2020203736A AU2020203736B2 (en) 2012-04-20 2020-06-05 Aminosteroids for the treatment of a PTP1B associated disease

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261636252P 2012-04-20 2012-04-20
US61/636,252 2012-04-20
PCT/US2013/037330 WO2013158970A2 (en) 2012-04-20 2013-04-19 Aminosteroids for the treatment of a ptp1b associated disease

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2018256561A Division AU2018256561B2 (en) 2012-04-20 2018-10-31 Aminosteroids for the treatment of a PTP1B associated disease

Publications (2)

Publication Number Publication Date
AU2013249111A1 AU2013249111A1 (en) 2014-11-06
AU2013249111B2 true AU2013249111B2 (en) 2018-08-09

Family

ID=48325893

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2013249111A Active AU2013249111B2 (en) 2012-04-20 2013-04-19 Aminosteroids for the treatment of a PTP1B associated disease
AU2018256561A Active AU2018256561B2 (en) 2012-04-20 2018-10-31 Aminosteroids for the treatment of a PTP1B associated disease
AU2020203736A Active AU2020203736B2 (en) 2012-04-20 2020-06-05 Aminosteroids for the treatment of a PTP1B associated disease

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2018256561A Active AU2018256561B2 (en) 2012-04-20 2018-10-31 Aminosteroids for the treatment of a PTP1B associated disease
AU2020203736A Active AU2020203736B2 (en) 2012-04-20 2020-06-05 Aminosteroids for the treatment of a PTP1B associated disease

Country Status (15)

Country Link
US (6) US9546194B2 (https=)
EP (2) EP2838907B1 (https=)
JP (4) JP6165843B2 (https=)
KR (3) KR101963312B1 (https=)
AU (3) AU2013249111B2 (https=)
CA (1) CA2870671C (https=)
DK (1) DK2838907T3 (https=)
ES (1) ES2736310T3 (https=)
HR (1) HRP20191348T1 (https=)
HU (1) HUE044769T2 (https=)
MX (2) MX367255B (https=)
PL (1) PL2838907T3 (https=)
PT (1) PT2838907T (https=)
TR (1) TR201911039T4 (https=)
WO (1) WO2013158970A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2736310T3 (es) * 2012-04-20 2019-12-27 Ohr Pharmaceutical Inc Aminoesteroides para el tratamiento de una enfermedad asociada a PTP1B
US10040817B2 (en) 2013-10-03 2018-08-07 Enterin Laboratories, Inc. Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or conditions related to the same
GB201700567D0 (en) 2017-01-12 2017-03-01 Genagon Therapeutics Ab Therapeutic agents
MA50094A (fr) * 2017-09-08 2020-07-15 Enterin Inc Méthodes de traitement des troubles du sommeil, des perturbations du sommeil et de symptômes associés à l'aide de compositions d'aminostérol
CN107802626B (zh) * 2017-10-11 2020-01-21 南昌大学 降血糖组合物及其制备方法、用途
CN111801102B (zh) * 2017-11-06 2024-05-28 冷泉港实验室 用于形成含铜络合物的方法和组合物及其用途
KR20200146038A (ko) * 2018-03-27 2020-12-31 엔테린, 인코포레이티드 환각 및 이와 관련된 상태를 치료하는 방법 및 조성물
AU2019308311B2 (en) * 2018-07-20 2024-12-05 Cold Spring Harbor Laboratory (pyridinylmethyl)butanediamine derivatives that chelate copper
WO2021025974A1 (en) * 2019-08-02 2021-02-11 Enterin, Inc. Human squalamine derivatives, related compositions comprising the same, and methods of using the same
EP4007764B1 (en) * 2019-08-02 2026-01-21 Enterin, Inc. Human aminosterol ent-03 compounds, related compositions comprising the same, and methods of using the same
WO2023230593A1 (en) 2022-05-27 2023-11-30 Cold Spring Harbor Laboratory Ptp1b inhibitors for treating lung injury

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040151A1 (en) * 1995-06-07 1996-12-19 Magainin Pharmaceuticals Inc. Use of squalamine for the manufacture of a medicament for inhibiting nhe
WO2001042273A2 (en) * 1999-12-09 2001-06-14 Genaera Corporation Asthma associated factors as targets for treating atopic allergies including asthma and related disorders
WO2009032321A2 (en) * 2007-09-06 2009-03-12 Genaera Corporation A method for treating diabetes

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2403683A (en) * 1942-04-25 1946-07-09 Relchstein Tadeus Compounds of the cyclopentanopolyhydrophenanthrene series and process of making same
US3636210A (en) * 1968-02-02 1972-01-18 Merck & Co Inc Cholanic acid and cholenic acid compositions and method of treatment
IT1255450B (it) * 1992-06-30 1995-10-31 Montefarmaco Spa Uso di acidi biliari come agenti antivirali
WO1994019366A1 (en) * 1993-02-26 1994-09-01 Magainin Pharmaceuticals Inc. Chemical synthesis of squalamine
DE69412596T2 (de) * 1993-03-10 1999-03-04 Magainin Pharmaceuticals Inc., Plymouth Meeting, Pa. Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel
US5856535A (en) 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
ATE259375T1 (de) * 1995-06-07 2004-02-15 Genaera Corp Aminosterinverbindungen als inhibitoren der natrium/proton-pump, pharmazeutische methoden und präparaten davon
US7410959B1 (en) * 2000-07-13 2008-08-12 Genaera Corporation Therapeutic uses for aminosterol compounds
EP1214060A2 (en) 1999-09-10 2002-06-19 Novo Nordisk A/S Method of inhibiting protein tyrosine phosphatase 1b and/or t-cell protein tyrosine phosphatase and/or other ptpases with an asp residue at position 48
AU6985300A (en) 1999-09-10 2001-04-17 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (ptpases)
JP2003509429A (ja) 1999-09-10 2003-03-11 ノボ ノルディスク アクティーゼルスカブ タンパク質チロシンホスファターゼ（ｐｔｐアーゼ）のモジュレーター
AU2003292939A1 (en) * 2002-12-24 2004-07-22 The University Of British Columbia Angiogenic compounds and uses thereof
JP2006165843A (ja) * 2004-12-06 2006-06-22 Matsushita Electric Ind Co Ltd 画像処理装置
US20080058300A1 (en) * 2006-04-21 2008-03-06 Mclane Michael Induction of weight loss and the selective inhibition of PTP1B
KR101260221B1 (ko) * 2011-12-01 2013-05-06 주식회사 엘지화학 마스크
ES2736310T3 (es) * 2012-04-20 2019-12-27 Ohr Pharmaceutical Inc Aminoesteroides para el tratamiento de una enfermedad asociada a PTP1B

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040151A1 (en) * 1995-06-07 1996-12-19 Magainin Pharmaceuticals Inc. Use of squalamine for the manufacture of a medicament for inhibiting nhe
WO2001042273A2 (en) * 1999-12-09 2001-06-14 Genaera Corporation Asthma associated factors as targets for treating atopic allergies including asthma and related disorders
WO2009032321A2 (en) * 2007-09-06 2009-03-12 Genaera Corporation A method for treating diabetes

Also Published As

Publication number Publication date
KR101963312B1 (ko) 2019-03-28
JP2021073250A (ja) 2021-05-13
MX2014012619A (es) 2015-01-15
AU2020203736A1 (en) 2020-06-25
TR201911039T4 (tr) 2019-08-21
JP6165843B2 (ja) 2017-07-19
US20230203088A1 (en) 2023-06-29
DK2838907T3 (da) 2019-08-05
US9546194B2 (en) 2017-01-17
JP2015514781A (ja) 2015-05-21
MX2019009539A (es) 2019-09-26
EP3556765A1 (en) 2019-10-23
AU2018256561B2 (en) 2020-03-05
EP2838907A2 (en) 2015-02-25
US20190202858A1 (en) 2019-07-04
EP2838907B1 (en) 2019-05-22
KR102057812B1 (ko) 2019-12-19
HRP20191348T1 (hr) 2019-10-18
US20250002525A1 (en) 2025-01-02
US20170129914A1 (en) 2017-05-11
WO2013158970A2 (en) 2013-10-24
HK1205516A1 (en) 2015-12-18
KR20150003798A (ko) 2015-01-09
US10556923B2 (en) 2020-02-11
AU2020203736B2 (en) 2021-12-02
PL2838907T3 (pl) 2019-12-31
AU2018256561A1 (en) 2018-11-22
MX367255B (es) 2019-08-12
US20200270300A1 (en) 2020-08-27
HUE044769T2 (hu) 2019-11-28
JP6457010B2 (ja) 2019-01-23
JP2019059781A (ja) 2019-04-18
CA2870671C (en) 2020-05-12
KR20190034685A (ko) 2019-04-02
CA2870671A1 (en) 2013-10-24
US11434257B2 (en) 2022-09-06
JP2017178951A (ja) 2017-10-05
US20150099727A1 (en) 2015-04-09
EP3556765B1 (en) 2022-02-23
WO2013158970A3 (en) 2013-12-12
AU2013249111A1 (en) 2014-11-06
PT2838907T (pt) 2019-08-05
ES2736310T3 (es) 2019-12-27
KR20160091435A (ko) 2016-08-02

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FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: DEPYMED INC.

Free format text: FORMER OWNER(S): OHR PHARMACEUTICAL, INC.