AU2013225721B2 - Expansion of alloantigen-reactive regulatory T cells - Google Patents

Expansion of alloantigen-reactive regulatory T cells Download PDF

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Publication number
AU2013225721B2
AU2013225721B2 AU2013225721A AU2013225721A AU2013225721B2 AU 2013225721 B2 AU2013225721 B2 AU 2013225721B2 AU 2013225721 A AU2013225721 A AU 2013225721A AU 2013225721 A AU2013225721 A AU 2013225721A AU 2013225721 B2 AU2013225721 B2 AU 2013225721B2
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cells
tregs
donor
reactive
treg
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AU2013225721A1 (en
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Jeffrey A. Bluestone
Qizhi Tang
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University of California San Diego UCSD
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University of California Berkeley
University of California San Diego UCSD
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    • AHUMAN NECESSITIES
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/0005Vertebrate antigens
    • A61K39/001Preparations to induce tolerance to non-self, e.g. prior to transplantation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00Cellular immunotherapy
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    • A61K40/22Immunosuppressive or immunotolerising
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    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41Vertebrate antigens
    • A61K40/418Antigens related to induction of tolerance to non-self
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • C12N5/0637Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20Cytokines; Chemokines
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    • C12N2502/30Coculture with; Conditioned medium produced by tumour cells

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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2013225721A 2012-03-02 2013-03-01 Expansion of alloantigen-reactive regulatory T cells Ceased AU2013225721B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2018219968A AU2018219968B2 (en) 2012-03-02 2018-08-20 Expansion of alloantigen-reactive regulatory t cells

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261606329P 2012-03-02 2012-03-02
US61/606,329 2012-03-02
PCT/US2013/028734 WO2013131045A1 (en) 2012-03-02 2013-03-01 Expansion of alloantigen-reactive regulatory t cells

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AU2013225721A1 AU2013225721A1 (en) 2014-10-09
AU2013225721B2 true AU2013225721B2 (en) 2018-06-14

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US (2) US9801911B2 (https=)
EP (2) EP2820125B1 (https=)
JP (1) JP6422344B2 (https=)
CN (1) CN104245923B (https=)
AU (2) AU2013225721B2 (https=)
CA (1) CA2866116C (https=)
ES (1) ES2675317T3 (https=)
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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101697473B1 (ko) 2014-11-26 2017-01-18 주식회사 녹십자랩셀 T 세포를 이용한 자연살해세포의 배양방법
IL258935B2 (en) * 2015-10-28 2024-08-01 Life Tech As Selective expansion of different subpopulations of t cells by the alteration of cell surfacing signals and signal ratio
CN105420190B (zh) * 2016-01-08 2018-07-31 无锡药明生基医药科技有限公司 B27添加剂及其类似物在利用无血清培养基培养淋巴细胞中的应用
EP3216861A1 (en) * 2016-03-11 2017-09-13 Fropharm GmbH Immunoregulatory cells and methods for their production
EP3633029A4 (en) 2017-05-26 2021-06-09 Green Cross Lab Cell Corporation METHOD OF DEVELOPING A NATURAL KILLER CELL USING A T-CELL
WO2018231803A1 (en) * 2017-06-12 2018-12-20 The Trustees Of Columbia University In The City Of New York Methods for generating polyclonal regulatory t cells
TWI793151B (zh) 2017-08-23 2023-02-21 瑞士商諾華公司 3-(1-氧異吲哚啉-2-基)之氫吡啶-2,6-二酮衍生物及其用途
KR102232321B1 (ko) * 2018-03-23 2021-03-26 주식회사 녹십자랩셀 자연살해세포의 제조방법
BR122022012697B1 (pt) 2018-07-10 2023-04-04 Novartis Ag Usos de derivados de 3-(5-hidróxi-1-oxoisoindolin-2-il)piperidina-2,6- diona, e kit
AR116109A1 (es) 2018-07-10 2021-03-31 Novartis Ag Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos
AU2019381526B2 (en) 2018-11-14 2023-02-23 Green Cross Lab Cell Corporation Method for culturing cord blood-derived natural killer cells using transformed T-cells
MX2021013227A (es) * 2019-04-30 2022-01-06 Univ California Expansion ex-vivo sin microesferas de celulas t reguladoras humanas.
CN110195041B (zh) * 2019-06-20 2023-04-25 威海正生生物科技有限公司 利用ASC三维培养体系获得高活性Tregs细胞的方法
WO2021007396A2 (en) 2019-07-09 2021-01-14 The Children's Mercy Hospital Engineered regulatory t cells
PL238336B1 (pl) * 2019-08-22 2021-08-09 Gdanski Univ Medyczny Sposób otrzymywania in vitro antygenowo-specyficznych limfocytów T regulatorowych
WO2022182763A1 (en) * 2021-02-23 2022-09-01 KSQ Therapeutics, Inc. Methods for expanding regulatory t cells
WO2025081193A1 (en) * 2023-10-13 2025-04-17 Northwestern University Antigen specific expansion of regulatory t cells
JP7627920B1 (ja) 2023-12-11 2025-02-07 浩 宮内 移植材料の評価方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010129770A1 (en) * 2009-05-07 2010-11-11 The University Of Utah Research Foundation Methods for expanding human t regulatory cells and uses of same

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5540926A (en) 1992-09-04 1996-07-30 Bristol-Myers Squibb Company Soluble and its use in B cell stimulation
US7541184B2 (en) 2000-02-24 2009-06-02 Invitrogen Corporation Activation and expansion of cells
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
AU2001253400B2 (en) 2000-04-11 2007-03-01 University Of Southern California A method to prevent graft rejection using tgf-beta to induce t suppressor cells
US6746670B2 (en) 2000-08-15 2004-06-08 Schering Corporation Regulatory T cells; methods
US6670146B2 (en) 2000-10-04 2003-12-30 Schering Corporation Regulatory T cells; methods
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
US7494812B2 (en) 2003-04-01 2009-02-24 University Of Southern California Generation of human regulatory T cells by bacterial toxins for the treatment of inflammatory disorders
US7651855B2 (en) 2003-04-17 2010-01-26 The Trustees Of The University Of Pennsylvania Regulatory T cells and their use in immunotherapy and suppression of autoimmune responses
FR2856700B1 (fr) 2003-06-24 2007-06-08 Txcell Procede d'identification de lymphocytes tr1 regulateurs par la presence et la surexpression de molecules specifiques et ses applications
AU2005206746B2 (en) 2004-01-08 2008-08-28 Regents Of The University Of California Regulatory t cells suppress autoimmunity
ES2686593T3 (es) * 2006-05-31 2018-10-18 The Regents Of The University Of California Expresión de CD127 que correlaciona inversamente con FoxP3 y la función supresora de Treg CD4+
CA2706458A1 (en) 2007-11-30 2009-06-11 Therakos, Inc. Process for reducing effects of graft versus host disease using ex vivo expanded cd4+cd25+ regulatory t cells
US8658159B2 (en) 2008-06-30 2014-02-25 Versitech Limited Method to induce and expand therapeutic alloantigen-specific human regulatory T cells in large-scale

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010129770A1 (en) * 2009-05-07 2010-11-11 The University Of Utah Research Foundation Methods for expanding human t regulatory cells and uses of same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Amy L.Putnam, "Expansion of human regulatory T-cells from patients with type 1 diabetes", Diabetes, (2008-12-15), vol. 58, no. 3, pages 652-662 *
Q. TANG ET AL, "CD4+Foxp3+ regulatory T cell therapy in transplantation", JOURNAL OF MOLECULAR CELL BIOLOGY, (2011-12-14), vol. 4, no. 1, doi:10.1093/jmcb/mjr047, ISSN 1674-2788, pages 11 - 21 *

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AU2018219968A1 (en) 2018-09-06
CN104245923A (zh) 2014-12-24
CA2866116C (en) 2021-06-15
US9801911B2 (en) 2017-10-31
CA2866116A1 (en) 2013-09-06
JP6422344B2 (ja) 2018-11-14
EP2820125B1 (en) 2018-05-09
AU2013225721A1 (en) 2014-10-09
WO2013131045A1 (en) 2013-09-06
CN104245923B (zh) 2018-04-20
AU2018219968B2 (en) 2020-09-17
EP2820125A1 (en) 2015-01-07
JP2015513403A (ja) 2015-05-14
ES2675317T3 (es) 2018-07-10
EP2820125A4 (en) 2015-07-29
US20180036345A1 (en) 2018-02-08
EP3366768B1 (en) 2020-07-08
EP3366768A1 (en) 2018-08-29
US20150110761A1 (en) 2015-04-23

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