AU2013209580B2 - Enhanced glycemic control using Ad36E4orf1 and AKT1 inhibitor - Google Patents

Enhanced glycemic control using Ad36E4orf1 and AKT1 inhibitor Download PDF

Info

Publication number
AU2013209580B2
AU2013209580B2 AU2013209580A AU2013209580A AU2013209580B2 AU 2013209580 B2 AU2013209580 B2 AU 2013209580B2 AU 2013209580 A AU2013209580 A AU 2013209580A AU 2013209580 A AU2013209580 A AU 2013209580A AU 2013209580 B2 AU2013209580 B2 AU 2013209580B2
Authority
AU
Australia
Prior art keywords
individual
e4orfl
adenovirus
protein
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2013209580A
Other languages
English (en)
Other versions
AU2013209580A1 (en
Inventor
Nikhil Dhurandhar
Rashmi KRISHNAPURAM
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Louisiana State University
Original Assignee
Louisiana State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Louisiana State University filed Critical Louisiana State University
Publication of AU2013209580A1 publication Critical patent/AU2013209580A1/en
Application granted granted Critical
Publication of AU2013209580B2 publication Critical patent/AU2013209580B2/en
Assigned to BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE reassignment BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE Amend patent request/document other than specification (104) Assignors: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE, DHURANDHAR, NIKHIL, Rashmi, Krishnapuram
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10333—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2013209580A 2012-01-20 2013-01-18 Enhanced glycemic control using Ad36E4orf1 and AKT1 inhibitor Ceased AU2013209580B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261588959P 2012-01-20 2012-01-20
US61/588,959 2012-01-20
PCT/US2013/022126 WO2013109876A1 (en) 2012-01-20 2013-01-18 Enhanced glycemic control using ad36e4orf1 and akt1 inhibitor

Publications (2)

Publication Number Publication Date
AU2013209580A1 AU2013209580A1 (en) 2014-08-07
AU2013209580B2 true AU2013209580B2 (en) 2017-11-30

Family

ID=47664431

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2013209580A Ceased AU2013209580B2 (en) 2012-01-20 2013-01-18 Enhanced glycemic control using Ad36E4orf1 and AKT1 inhibitor

Country Status (7)

Country Link
US (1) US9433659B2 (enExample)
EP (1) EP2804616B1 (enExample)
JP (1) JP6175076B2 (enExample)
AU (1) AU2013209580B2 (enExample)
BR (1) BR112014017683A2 (enExample)
CA (1) CA2865202A1 (enExample)
WO (1) WO2013109876A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025080777A1 (en) * 2023-10-10 2025-04-17 Texas Tech University System Ad36e4orf1 peptide fragments as anti-diabetic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1954131B1 (en) * 2005-11-30 2014-04-02 Board of Supervisors of Louisiana State University and Agricultural and Mechanical College Adenovirus 36 e4 orf 1 gene and protein and their uses
AR064010A1 (es) 2006-12-06 2009-03-04 Merck & Co Inc Inhibidores de la actividad de la akt

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
EMILY J. DHURANDHAR ET AL, "E4orf1: A Novel Ligand That Improves Glucose Disposal in Cell Culture", PLOS ONE, (20110823), vol. 6, no. 8, doi:10.1371/journal.pone.0023394, page e23394 *
M. WAN ET AL, "Loss of Akt1 in Mice Increases Energy Expenditure and Protects against Diet-Induced Obesity", MOLECULAR AND CELLULAR BIOLOGY, (20120101), vol. 32, no. 1, doi:10.1128/MCB.05806-11, ISSN 0270-7306, pages 96 - 106 *
R. KRISHNAPURAM ET AL, "Template to improve glycemic control without reducing adiposity or dietary fat", AJP: ENDOCRINOLOGY AND METABOLISM, (20110501), vol. 300, no. 5, doi:10.1152/ajpendo.00703.2010, ISSN 0193-1849, pages E779 - E789 *

Also Published As

Publication number Publication date
CA2865202A1 (en) 2013-07-25
EP2804616B1 (en) 2018-07-18
BR112014017683A2 (pt) 2017-06-27
US9433659B2 (en) 2016-09-06
US20150038412A1 (en) 2015-02-05
EP2804616A1 (en) 2014-11-26
HK1204449A1 (en) 2015-11-20
JP2015505535A (ja) 2015-02-23
JP6175076B2 (ja) 2017-08-02
WO2013109876A1 (en) 2013-07-25
AU2013209580A1 (en) 2014-08-07

Similar Documents

Publication Publication Date Title
EP1799826B1 (en) siRNA-MEDIATED GENE SILENCING OF ALPHA SYNUCLEIN
DK2968602T3 (en) SYNTHETIC METHYLMALONYL-COA MUTASE TRANSGEN TO TREAT MUT-CLASS METHYLMALONACIDEMIA (MMA)
WO2018089901A2 (en) Exosome delivery system
US20250195610A1 (en) Methods for regulating free fatty acid flux using fat specific protein 27 (fsp27) compositions
US20070281041A1 (en) Compositions and Methods Involving MDA-7 for the Treatment of Cancer
US20240384245A1 (en) Method for treating a disease
Zhong et al. Ciliary neurotrophic factor overexpression protects the heart against pathological remodelling in angiotensin II-infused mice
AU2013209580B2 (en) Enhanced glycemic control using Ad36E4orf1 and AKT1 inhibitor
US20190111154A1 (en) Treatment of neuropathy with dna construct expressing hgf isoforms with reduced interference from gabapentinoids
JP5965397B2 (ja) 非アルコール性脂肪肝疾患の予防および治療のためのアデノウイルスａｄ３６ｅ４ｏｒｆ１タンパク質
EP3220901B1 (en) Means and methods for treatment of early-onset parkinson&#39;s disease
CN106267235B (zh) miR-451作为调节血糖的靶标的用途
CN108926713A (zh) 钙调磷酸酶调节蛋白1.4或其类似物在制备抑制肝癌的药物中的应用
EP4524250A1 (en) Nucleic acid construct comprising utr and use thereof
HK1204449B (en) Enhanced glycemic control using ad36e4orf1 and akt1 inhibitor
US20230235403A1 (en) Long non-coding rna as therapeutic target in cardiac disorders and cardiac regeneration
CN1948483B (zh) 抑制人RabJ基因表达的siRNA及其应用
KR20200052294A (ko) Setd2의 저해에 의한 암의 치료 방법
US20220233648A1 (en) Compositions for use in the treatment of insulin deficiency conditions
CN105709217A (zh) Psat1及其产物在制备调节胰岛素敏感性的药物中的用途
WO2025055577A1 (en) USE OF RGMb AS A TARGET FOR TREATMENT OF KIDNEY DISEASES
CN117089548A (zh) 编码瘦素的核酸分子、组合物及应用
CN118043085A (zh) 用于治疗疾病的方法

Legal Events

Date Code Title Description
HB Alteration of name in register

Owner name: BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY

Free format text: FORMER NAME(S): BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE; DHURANDHAR, NIKHIL; RASHMI, KRISHNAPURAM

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired