AU2012370450B2 - Cyclic diaminopyrimidine derivatives - Google Patents

Cyclic diaminopyrimidine derivatives Download PDF

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AU2012370450B2
AU2012370450B2 AU2012370450A AU2012370450A AU2012370450B2 AU 2012370450 B2 AU2012370450 B2 AU 2012370450B2 AU 2012370450 A AU2012370450 A AU 2012370450A AU 2012370450 A AU2012370450 A AU 2012370450A AU 2012370450 B2 AU2012370450 B2 AU 2012370450B2
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disease
formula
conditions
compound
denotes
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AU2012370450A1 (en
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Lizbeth Celeste DESELM
Henry Yu
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Merck Patent GmbH
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Merck Patent GmbH
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
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    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
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AU2012370450A 2012-02-21 2012-12-18 Cyclic diaminopyrimidine derivatives Active AU2012370450B2 (en)

Applications Claiming Priority (3)

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US201261601101P 2012-02-21 2012-02-21
US61/601,101 2012-02-21
PCT/US2012/070252 WO2013126132A1 (en) 2012-02-21 2012-12-18 Cyclic diaminopyrimidine derivatives

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AU2012370450A1 AU2012370450A1 (en) 2014-10-02
AU2012370450B2 true AU2012370450B2 (en) 2017-02-02

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EP (1) EP2817306B1 (es)
JP (1) JP6059260B2 (es)
CN (1) CN104254531B (es)
AR (1) AR090103A1 (es)
AU (1) AU2012370450B2 (es)
CA (1) CA2865040C (es)
ES (1) ES2552518T3 (es)
IL (1) IL233986A (es)
WO (1) WO2013126132A1 (es)

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CN106999561A (zh) 2014-07-18 2017-08-01 阿德瓦希斯股份有限公司 用于治疗前列腺癌的pd‑1拮抗剂和基于李斯特菌的疫苗的组合
IL292677A (en) 2016-12-22 2022-07-01 Calithera Biosciences Inc Preparations and methods for inhibiting arginase activity
CN114364798A (zh) 2019-03-21 2022-04-15 欧恩科斯欧公司 用于治疗癌症的Dbait分子与激酶抑制剂的组合
AU2020378630A1 (en) 2019-11-08 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2023025912A1 (en) 2021-08-25 2023-03-02 Alesta Therapeutics BV Use of gcn2 inhibitors in treating cancer
WO2023174948A2 (en) * 2022-03-14 2023-09-21 TRx Biosciences Limited Compositions having improved bioavailability of therapeutics and uses thereof
WO2024017251A1 (zh) * 2022-07-18 2024-01-25 江苏恒瑞医药股份有限公司 抑制并诱导egfr降解的大环类化合物、其制备方法及其在医药上的应用

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CA2865040C (en) 2020-07-14
EP2817306A1 (en) 2014-12-31
ES2552518T3 (es) 2015-11-30
WO2013126132A1 (en) 2013-08-29
US20150025066A1 (en) 2015-01-22
AR090103A1 (es) 2014-10-22
US9073944B2 (en) 2015-07-07
CN104254531B (zh) 2017-05-03
JP6059260B2 (ja) 2017-01-11
JP2015508099A (ja) 2015-03-16
EP2817306B1 (en) 2015-09-16
IL233986A (en) 2017-10-31
CN104254531A (zh) 2014-12-31
AU2012370450A1 (en) 2014-10-02
CA2865040A1 (en) 2013-08-29

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