AU2012324644B2 - Device for the aseptic expansion of cells - Google Patents
Device for the aseptic expansion of cells Download PDFInfo
- Publication number
- AU2012324644B2 AU2012324644B2 AU2012324644A AU2012324644A AU2012324644B2 AU 2012324644 B2 AU2012324644 B2 AU 2012324644B2 AU 2012324644 A AU2012324644 A AU 2012324644A AU 2012324644 A AU2012324644 A AU 2012324644A AU 2012324644 B2 AU2012324644 B2 AU 2012324644B2
- Authority
- AU
- Australia
- Prior art keywords
- vessel
- cells
- port
- vent
- orifice
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000007789 gas Substances 0.000 claims abstract description 42
- 239000007788 liquid Substances 0.000 claims abstract description 27
- 238000012258 culturing Methods 0.000 claims abstract description 16
- 239000012530 fluid Substances 0.000 claims abstract description 14
- 230000001225 therapeutic effect Effects 0.000 claims abstract description 13
- 230000005484 gravity Effects 0.000 claims abstract description 12
- 238000004891 communication Methods 0.000 claims abstract description 8
- 230000010261 cell growth Effects 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 22
- 238000003306 harvesting Methods 0.000 claims description 14
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 9
- 235000015097 nutrients Nutrition 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 6
- 238000004113 cell culture Methods 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims 17
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 238000011287 therapeutic dose Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 27
- 238000012545 processing Methods 0.000 abstract description 5
- 238000002560 therapeutic procedure Methods 0.000 abstract description 3
- 239000000463 material Substances 0.000 description 28
- 239000012528 membrane Substances 0.000 description 11
- 239000000047 product Substances 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 7
- 230000008901 benefit Effects 0.000 description 5
- 238000001802 infusion Methods 0.000 description 5
- 238000011109 contamination Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 230000001413 cellular effect Effects 0.000 description 3
- 239000002609 medium Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 239000004417 polycarbonate Substances 0.000 description 3
- 229920000515 polycarbonate Polymers 0.000 description 3
- 238000005086 pumping Methods 0.000 description 3
- 238000011052 biological reactivity test Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000011081 inoculation Methods 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 229920001169 thermoplastic Polymers 0.000 description 2
- 239000004416 thermosoftening plastic Substances 0.000 description 2
- 241000283073 Equus caballus Species 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000012777 commercial manufacturing Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
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- 238000000605 extraction Methods 0.000 description 1
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- 230000012010 growth Effects 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000005476 soldering Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/08—Flask, bottle or test tube
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/24—Gas permeable parts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/20—Degassing; Venting; Bubble traps
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
- C12M37/02—Filters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
- C12M37/04—Seals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Immunology (AREA)
- Clinical Laboratory Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550246P | 2011-10-21 | 2011-10-21 | |
| US61/550,246 | 2011-10-21 | ||
| PCT/GB2012/052587 WO2013057500A1 (en) | 2011-10-21 | 2012-10-19 | Device for the aseptic expansion of cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2012324644A1 AU2012324644A1 (en) | 2014-05-22 |
| AU2012324644B2 true AU2012324644B2 (en) | 2014-08-28 |
Family
ID=47116088
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012324644A Ceased AU2012324644B2 (en) | 2011-10-21 | 2012-10-19 | Device for the aseptic expansion of cells |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US9315774B2 (enExample) |
| EP (1) | EP2768939B1 (enExample) |
| JP (1) | JP5698421B2 (enExample) |
| KR (1) | KR101499929B1 (enExample) |
| AU (1) | AU2012324644B2 (enExample) |
| DK (1) | DK2768939T3 (enExample) |
| ES (1) | ES2598055T3 (enExample) |
| HU (1) | HUE031348T2 (enExample) |
| PL (1) | PL2768939T3 (enExample) |
| WO (1) | WO2013057500A1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2768939T3 (en) * | 2011-10-21 | 2016-11-07 | Cell Medica Ltd | Device for aseptic expansion of cells |
| CN102517210B (zh) * | 2011-12-08 | 2014-05-14 | 湖北民族学院 | 一种全波长可控光源的生物反应装置 |
| AU2014302589B2 (en) | 2013-06-24 | 2020-05-14 | Wilson Wolf Manufacturing, LLC | Closed system device and methods for gas permeable cell culture process |
| EP3059301A4 (en) * | 2013-10-16 | 2017-08-30 | Medican Inc. | Apparatus and method for continuous cell culture |
| US20170044496A1 (en) | 2014-04-10 | 2017-02-16 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Enhanced Expansion of Tumor-Infiltrating Lymphocytes for Adoptive Cell Therapy |
| SG11201900138TA (en) | 2016-07-07 | 2019-02-27 | Iovance Biotherapeutics Inc | Programmed death 1 ligand 1 (pd-l1) binding proteins and methods of use thereof |
| US20210292696A1 (en) * | 2016-09-22 | 2021-09-23 | Corning Incorporated | Gravity flow cell culture devices, systems, and methods of use thereof |
| AU2017347851B2 (en) | 2016-10-26 | 2024-03-07 | Iovance Biotherapeutics, Inc. | Restimulation of cryopreserved tumor infiltrating lymphocytes |
| TWI788307B (zh) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | 用於擴增腫瘤浸潤性淋巴細胞之工程化人造抗原呈現細胞 |
| WO2018094167A1 (en) | 2016-11-17 | 2018-05-24 | Iovance Biotherapeutics, Inc. | Remnant tumor infiltrating lymphocytes and methods of preparing and using the same |
| CA3049165A1 (en) | 2017-01-06 | 2018-07-12 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
| JOP20190224A1 (ar) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
| US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| USD846733S1 (en) * | 2017-04-04 | 2019-04-23 | Arc Medical Design Limited | Specimen trap |
| USD846732S1 (en) * | 2017-04-04 | 2019-04-23 | Arc Medical Design Limited | Specimen trap |
| USD820085S1 (en) | 2017-05-19 | 2018-06-12 | Pura Stainless Llc | Fluid container spout with straw |
| IL322309A (en) | 2017-05-24 | 2025-09-01 | Novartis Ag | IL2 antibody grafted proteins and methods of use in cancer treatment |
| US11819517B2 (en) * | 2017-06-05 | 2023-11-21 | Iovance Biotherapeutics, Inc. | Methods of using tumor infiltrating lymphocytes in double-refractory melanoma |
| USD848023S1 (en) * | 2017-11-09 | 2019-05-07 | 3088081 Canada Inc. | Sample vial |
| JP2021509586A (ja) | 2018-01-08 | 2021-04-01 | アイオバンス バイオセラピューティクス,インコーポレイテッド | 腫瘍抗原特異的t細胞について濃縮されたtil製品を生成するためのプロセス |
| US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
| US10889792B2 (en) | 2018-02-09 | 2021-01-12 | Global Life Sciences Solutions Usa Llc | Cell expansion vessel systems and methods |
| DE102018103634B3 (de) * | 2018-02-19 | 2019-07-04 | Sartorius Stedim Biotech Gmbh | Medienfiltrationsvorrichtung und Verfahren zur Medienfiltration |
| USD842105S1 (en) * | 2018-02-20 | 2019-03-05 | Paw Bioscience Products, Llc | Connector cap for tubes |
| TWI831776B (zh) | 2018-04-27 | 2024-02-11 | 美商艾歐凡斯生物治療公司 | 腫瘤浸潤性淋巴細胞之基因編輯和彼於免疫治療之用途 |
| US12473532B2 (en) | 2018-05-10 | 2025-11-18 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
| USD912247S1 (en) * | 2018-05-17 | 2021-03-02 | Dwk Life Sciences Gmbh | Connection cap device |
| WO2020096988A2 (en) | 2018-11-05 | 2020-05-14 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
| AU2020205031B2 (en) | 2019-01-04 | 2025-10-02 | Oribiotech Ltd | Cell processing unit, cell processing system and methods of use thereof |
| CN113423811B (zh) * | 2019-03-25 | 2024-04-05 | 泰尔茂株式会社 | 用于在洁净度高的空间中制备细胞培养物的容器及套件 |
| JP7352146B2 (ja) * | 2019-07-23 | 2023-09-28 | 住友ベークライト株式会社 | 分離器及び培養システム |
| USD895421S1 (en) * | 2019-10-31 | 2020-09-08 | Rodney Laible | Dual straw container insert |
| USD899925S1 (en) * | 2019-10-31 | 2020-10-27 | Rodney Laible | Dual draw cap adapter |
| USD932048S1 (en) * | 2020-04-07 | 2021-09-28 | Rodney Laible | Four port cap adapter |
| IL297442A (en) | 2020-04-22 | 2022-12-01 | Iovance Biotherapeutics Inc | Systems and methods for coordinating production of cells for patient-specific immunotherapy |
| CN115768879A (zh) | 2020-04-28 | 2023-03-07 | 莱尔免疫制药公司 | 用于培养细胞的方法 |
| USD964553S1 (en) | 2020-05-29 | 2022-09-20 | Keymed (Medical & Industrial Equipment) Limited | Medical instrument |
| EP4206311A4 (en) * | 2020-08-26 | 2025-08-20 | Shimadzu Corp | CELL CULTURE VESSEL AND CELL CULTURE SYSTEM |
| EP4225897A1 (en) * | 2020-10-09 | 2023-08-16 | VBC Holdings LLC | Closed-system method and kit of disposable assemblies for isolating mesenchymal stromal cells from lipoaspirate |
| US11718819B2 (en) | 2021-09-22 | 2023-08-08 | Shanghai Longevity Co., Ltd. | Cell proliferation bioreactor |
| CA3248034A1 (en) | 2022-04-15 | 2023-10-19 | Iovance Biotherapeutics Inc | METHODS FOR EXPANSION OF TIL CELLS BY MEANS OF SPECIFIC CYTOKINE COMBINATIONS AND/OR AKT INHIBITOR TREATMENT |
| EP4587549A2 (en) * | 2022-09-15 | 2025-07-23 | Life Technologies Corporation | Bioreactors operable in static and dynamic modes and methods of use |
| WO2024227265A1 (en) * | 2023-05-03 | 2024-11-07 | Volumina Medical Sa | Devices and methods for preparing and conditioning biological assemblies for minimally invasive delivery for tissue engineering, cell therapies and other therapeutic applications |
| USD1103765S1 (en) * | 2023-08-09 | 2025-12-02 | Molecular Devices (Austria) GmbH | Interface flange for a bottle |
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| WO2005035728A2 (en) * | 2003-10-08 | 2005-04-21 | Wilson Wolf Manufacturing Corporation | Cell culture methods and devices utilizing gas permeable materials |
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| AU2010353739B2 (en) * | 2010-05-17 | 2014-03-27 | Pall Corporation | System for seeding cells onto three dimensional scaffolds |
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| USD667959S1 (en) * | 2011-01-25 | 2012-09-25 | Steve Lin | Multiple configuration cap |
| USD678544S1 (en) * | 2011-08-02 | 2013-03-19 | Sartorius Weighing Technology Gmbh | Cell culturing vessel |
| DK2768939T3 (en) * | 2011-10-21 | 2016-11-07 | Cell Medica Ltd | Device for aseptic expansion of cells |
| USD674505S1 (en) * | 2012-03-12 | 2013-01-15 | Genx International, Inc. | Specimen culturing dish |
| US8945383B2 (en) * | 2012-03-16 | 2015-02-03 | Kx Technologies Llc | Filtration system |
| USD690826S1 (en) * | 2012-04-12 | 2013-10-01 | Becton Dickinson And Company | Vessel assembly |
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| USD744857S1 (en) * | 2013-03-15 | 2015-12-08 | Mccormick & Company, Incorporated | Bottle with cap |
| USD698940S1 (en) * | 2013-04-25 | 2014-02-04 | Vitrolife Kft | Culture dish |
| USD728123S1 (en) * | 2013-07-12 | 2015-04-28 | D. Roy Cullimore | Storage device for microorganisms |
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| USD767162S1 (en) * | 2015-11-03 | 2016-09-20 | Timothy Schimmel | Culture dish |
| USD767161S1 (en) * | 2015-11-03 | 2016-09-20 | Timothy Schimmel | Culture dish |
| USD767160S1 (en) * | 2015-11-03 | 2016-09-20 | Timothy Schimmel | Culture dish |
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2012
- 2012-10-19 DK DK12780267.6T patent/DK2768939T3/en active
- 2012-10-19 WO PCT/GB2012/052587 patent/WO2013057500A1/en not_active Ceased
- 2012-10-19 ES ES12780267.6T patent/ES2598055T3/es active Active
- 2012-10-19 EP EP12780267.6A patent/EP2768939B1/en not_active Not-in-force
- 2012-10-19 PL PL12780267T patent/PL2768939T3/pl unknown
- 2012-10-19 KR KR1020147013014A patent/KR101499929B1/ko not_active Expired - Fee Related
- 2012-10-19 AU AU2012324644A patent/AU2012324644B2/en not_active Ceased
- 2012-10-19 US US14/353,170 patent/US9315774B2/en not_active Expired - Fee Related
- 2012-10-19 HU HUE12780267A patent/HUE031348T2/hu unknown
- 2012-10-19 JP JP2014536331A patent/JP5698421B2/ja not_active Expired - Fee Related
-
2014
- 2014-03-14 US US29/485,083 patent/USD820996S1/en active Active
-
2016
- 2016-03-18 US US15/075,048 patent/US10221391B2/en active Active
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| US5693537A (en) * | 1994-06-28 | 1997-12-02 | Wilson; John R. | Compartmentalized tissue culture flask |
| WO1996040876A1 (en) * | 1995-06-07 | 1996-12-19 | Novartis Ag | Method of expanding hematopoietic stem cells, reagents and bioreactors for use therein |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2768939A1 (en) | 2014-08-27 |
| PL2768939T3 (pl) | 2017-02-28 |
| JP2014530618A (ja) | 2014-11-20 |
| KR101499929B1 (ko) | 2015-03-06 |
| DK2768939T3 (en) | 2016-11-07 |
| EP2768939B1 (en) | 2016-08-17 |
| KR20140097174A (ko) | 2014-08-06 |
| ES2598055T3 (es) | 2017-01-25 |
| US9315774B2 (en) | 2016-04-19 |
| JP5698421B2 (ja) | 2015-04-08 |
| US10221391B2 (en) | 2019-03-05 |
| HK1201289A1 (zh) | 2015-08-28 |
| USD820996S1 (en) | 2018-06-19 |
| US20160201021A1 (en) | 2016-07-14 |
| HUE031348T2 (hu) | 2017-07-28 |
| AU2012324644A1 (en) | 2014-05-22 |
| US20140273077A1 (en) | 2014-09-18 |
| WO2013057500A1 (en) | 2013-04-25 |
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