AU2012305807B2 - Dengue-virus serotype neutralizing antibodies - Google Patents
Dengue-virus serotype neutralizing antibodiesInfo
- Publication number
- AU2012305807B2 AU2012305807B2 AU2012305807A AU2012305807A AU2012305807B2 AU 2012305807 B2 AU2012305807 B2 AU 2012305807B2 AU 2012305807 A AU2012305807 A AU 2012305807A AU 2012305807 A AU2012305807 A AU 2012305807A AU 2012305807 B2 AU2012305807 B2 AU 2012305807B2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161532671P | 2011-09-09 | 2011-09-09 | |
| US201161532605P | 2011-09-09 | 2011-09-09 | |
| US61/532,605 | 2011-09-09 | ||
| US61/532,671 | 2011-09-09 | ||
| PCT/JP2012/005699 WO2013035345A2 (fr) | 2011-09-09 | 2012-09-07 | Anticorps neutralisant les sérotypes du virus de la dengue |
Publications (3)
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| AU2012305807A1 AU2012305807A1 (en) | 2014-02-20 |
| AU2012305807A8 AU2012305807A8 (en) | 2014-03-13 |
| AU2012305807B2 true AU2012305807B2 (en) | 2015-08-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012305807A Active AU2012305807B2 (en) | 2011-09-09 | 2012-09-07 | Dengue-virus serotype neutralizing antibodies |
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|---|---|
| AU (1) | AU2012305807B2 (fr) |
| MY (1) | MY170725A (fr) |
| SG (1) | SG11201400100SA (fr) |
| WO (1) | WO2013035345A2 (fr) |
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| SG11201606624WA (en) | 2014-02-11 | 2016-09-29 | Visterra Inc | Antibody moleules to dengue virus and uses thereof |
| CN105137068B (zh) * | 2015-07-24 | 2017-03-01 | 鲁东大学 | 氟苯尼考现场检测试纸及其制备、使用方法 |
| CN105004860B (zh) * | 2015-07-24 | 2016-09-21 | 鲁东大学 | 氟苯尼考快速检测试剂盒及其制备、使用方法 |
| WO2017165736A1 (fr) | 2016-03-25 | 2017-09-28 | Visterra, Inc. | Formulations de molécules d'anticorps contre le virus de la dengue |
| CN109929033B (zh) * | 2019-03-15 | 2020-06-02 | 中国人民解放军军事科学院军事医学研究院 | 一种特异性结合四种血清型登革病毒的人源抗体 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010043977A2 (fr) * | 2008-10-13 | 2010-04-22 | Institute For Research In Biomedicine | Anticorps de neutralisation du virus de la dengue et leurs utilisations |
| WO2010093335A1 (fr) * | 2009-02-10 | 2010-08-19 | Nanyang Technological University | Anticorps destinés au diagnostic et au traitement d'infections flavivirales |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4450150A (en) | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5169939A (en) | 1985-05-21 | 1992-12-08 | Massachusetts Institute Of Technology & Pres. & Fellows Of Harvard College | Chimeric antibodies |
| GB8800077D0 (en) | 1988-01-05 | 1988-02-10 | Ciba Geigy Ag | Novel chimeric antibodies |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
| CA2078539C (fr) | 1991-09-18 | 2005-08-02 | Kenya Shitara | Procede de fabrication de chimere d'anticorps humain |
| EP0617706B1 (fr) | 1991-11-25 | 2001-10-17 | Enzon, Inc. | Proteines multivalentes de fixation aux antigenes |
| US6042828A (en) | 1992-09-07 | 2000-03-28 | Kyowa Hakko Kogyo Co., Ltd. | Humanized antibodies to ganglioside GM2 |
| DE69329503T2 (de) | 1992-11-13 | 2001-05-03 | Idec Pharma Corp | Therapeutische Verwendung von chimerischen und markierten Antikörpern, die gegen ein Differenzierung-Antigen gerichtet sind, dessen Expression auf menschliche B Lymphozyt beschränkt ist, für die Behandlung von B-Zell-Lymphoma |
| DE4337197C1 (de) | 1993-10-30 | 1994-08-25 | Biotest Pharma Gmbh | Verfahren zur selektiven Herstellung von Hybridomazellinien, die monoklonale Antikörper mit hoher Zytotoxizität gegen humanes CD16-Antigen produzieren, sowie Herstellung bispezifischer monoklonaler Antikörper unter Verwendung derartiger monoklonaler Antikörper und des CD30-HRS-3-Antikörpers zur Therapie menschlicher Tumore |
| AU8755798A (en) | 1997-04-04 | 1998-11-13 | Biosite Diagnostics Incorporated | Polyvalent and polyclonal libraries |
| AU2004215125B2 (en) * | 2003-02-26 | 2011-01-06 | Institute For Research In Biomedicine | Monoclonal antibody production by EBV transformation of B cells |
| KR101429254B1 (ko) * | 2006-04-13 | 2014-08-18 | 가부시키가이샤 이가쿠세이부츠가쿠겐큐쇼 | 융합 파트너 세포 |
| US8337854B2 (en) * | 2007-04-04 | 2012-12-25 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Monoclonal antibodies against dengue and other viruses with deletion in Fc region |
| JP5780762B2 (ja) * | 2008-12-25 | 2015-09-16 | 国立大学法人大阪大学 | 抗ヒトインフルエンザウイルス・ヒト型抗体 |
-
2012
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- 2012-09-07 MY MYPI2014700529A patent/MY170725A/en unknown
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010043977A2 (fr) * | 2008-10-13 | 2010-04-22 | Institute For Research In Biomedicine | Anticorps de neutralisation du virus de la dengue et leurs utilisations |
| WO2010093335A1 (fr) * | 2009-02-10 | 2010-08-19 | Nanyang Technological University | Anticorps destinés au diagnostic et au traitement d'infections flavivirales |
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201400100SA (en) | 2014-06-27 |
| WO2013035345A3 (fr) | 2013-09-06 |
| AU2012305807A8 (en) | 2014-03-13 |
| MY170725A (en) | 2019-08-27 |
| AU2012305807A1 (en) | 2014-02-20 |
| WO2013035345A2 (fr) | 2013-03-14 |
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