AU2012288865B2 - Bicyclic pyrimidone compounds - Google Patents

Bicyclic pyrimidone compounds Download PDF

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Publication number
AU2012288865B2
AU2012288865B2 AU2012288865A AU2012288865A AU2012288865B2 AU 2012288865 B2 AU2012288865 B2 AU 2012288865B2 AU 2012288865 A AU2012288865 A AU 2012288865A AU 2012288865 A AU2012288865 A AU 2012288865A AU 2012288865 B2 AU2012288865 B2 AU 2012288865B2
Authority
AU
Australia
Prior art keywords
esi
pyrimido
chloro
pyrimidin
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2012288865A
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English (en)
Other versions
AU2012288865A1 (en
Inventor
Kai Long
Zehong Wan
Haihua YU
Xiaomin Zhang
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Glaxo Group Ltd
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Glaxo Group Ltd
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Publication of AU2012288865A1 publication Critical patent/AU2012288865A1/en
Application granted granted Critical
Publication of AU2012288865B2 publication Critical patent/AU2012288865B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2012288865A 2011-07-27 2012-07-25 Bicyclic pyrimidone compounds Ceased AU2012288865B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2011077702 2011-07-27
CNPCT/CN2011/077702 2011-07-27
PCT/EP2012/064598 WO2013014185A1 (en) 2011-07-27 2012-07-25 Bicyclic pyrimidone compounds

Publications (2)

Publication Number Publication Date
AU2012288865A1 AU2012288865A1 (en) 2014-02-13
AU2012288865B2 true AU2012288865B2 (en) 2015-10-01

Family

ID=46579034

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012288865A Ceased AU2012288865B2 (en) 2011-07-27 2012-07-25 Bicyclic pyrimidone compounds

Country Status (12)

Country Link
US (2) US9273054B2 (enExample)
EP (1) EP2736908A1 (enExample)
JP (1) JP2014521625A (enExample)
KR (1) KR20140059204A (enExample)
AR (1) AR087309A1 (enExample)
AU (1) AU2012288865B2 (enExample)
BR (1) BR112014001634A2 (enExample)
CA (1) CA2843102A1 (enExample)
RU (1) RU2014107486A (enExample)
TW (1) TW201321382A (enExample)
UY (1) UY34216A (enExample)
WO (1) WO2013014185A1 (enExample)

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EP2925730A1 (en) 2012-11-27 2015-10-07 Basf Se Substituted 2-[phenoxy-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds and their use as fungicides
US20150313229A1 (en) 2012-11-27 2015-11-05 Basf Se Substituted [1,2,4] Triazole Compounds
CN104968665A (zh) * 2013-01-25 2015-10-07 葛兰素史密斯克莱知识产权发展有限公司 作为lp-pla2抑制剂的双环嘧啶酮化合物
RU2015135806A (ru) * 2013-01-25 2017-03-03 Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Соединения
JP2016505053A (ja) * 2013-01-25 2016-02-18 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｌｐ‐ＰＬＡ２の阻害剤としての二環式ピリミドン化合物
US9630896B2 (en) 2013-11-22 2017-04-25 Tansna Therapeutics, Inc. 2,5-dialkyl-4-H/halo/ether-phenol compounds
WO2016012917A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
CN106536521B (zh) 2014-07-22 2018-08-03 葛兰素史密斯克莱知识产权发展有限公司 化合物
WO2016012916A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
CN105777653A (zh) 2014-12-26 2016-07-20 中国科学院上海药物研究所 用作Lp-PLA2抑制剂的嘧啶酮类化合物及其药物组合物
CN106188063A (zh) * 2015-05-08 2016-12-07 中国科学院上海药物研究所 用作Lp-PLA2抑制剂的双环类化合物、其制备方法及医药用途
WO2017040877A1 (en) * 2015-09-04 2017-03-09 Lysosomal Therapeutics Inc. Heterobicyclic pyrimidinone compounds and their use in the treatment of medical disorders
GB201522179D0 (en) * 2015-12-16 2016-01-27 Autifony Therapeutics Ltd Novel compounds
EP3752503A1 (en) 2018-02-16 2020-12-23 Boehringer Ingelheim International GmbH Inhibitors of trpc6
CN112574221B (zh) * 2019-09-30 2022-03-04 上海纽思克生物科技有限公司 四环嘧啶酮类化合物、其制备方法、其组合物和用途
MX2022005615A (es) 2019-11-09 2022-07-27 Shanghai Simr Biotechnology Co Ltd Derivado triciclico de dihidroimidazopirimidona, metodo de preparacion del mismo, composicion farmaceutica y uso del mismo.
WO2021228159A1 (zh) * 2020-05-13 2021-11-18 上海纽思克生物科技有限公司 桥环嘧啶酮类化合物、其制备方法、其组合物和用途
CN113912622B (zh) * 2020-07-10 2023-12-01 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途

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Also Published As

Publication number Publication date
US20140179716A1 (en) 2014-06-26
UY34216A (es) 2013-02-28
AR087309A1 (es) 2014-03-12
TW201321382A (zh) 2013-06-01
KR20140059204A (ko) 2014-05-15
US9273054B2 (en) 2016-03-01
CA2843102A1 (en) 2013-01-31
RU2014107486A (ru) 2015-09-10
JP2014521625A (ja) 2014-08-28
WO2013014185A1 (en) 2013-01-31
BR112014001634A2 (pt) 2017-02-14
AU2012288865A1 (en) 2014-02-13
EP2736908A1 (en) 2014-06-04
US20130030012A1 (en) 2013-01-31

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Legal Events

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FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired