AU2012285786B2 - TNF -alpha antigen- binding proteins with increased FcRn binding - Google Patents

TNF -alpha antigen- binding proteins with increased FcRn binding Download PDF

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Publication number
AU2012285786B2
AU2012285786B2 AU2012285786A AU2012285786A AU2012285786B2 AU 2012285786 B2 AU2012285786 B2 AU 2012285786B2 AU 2012285786 A AU2012285786 A AU 2012285786A AU 2012285786 A AU2012285786 A AU 2012285786A AU 2012285786 B2 AU2012285786 B2 AU 2012285786B2
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AU
Australia
Prior art keywords
seq
antigen binding
binding protein
tnf
variant
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Ceased
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AU2012285786A
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English (en)
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AU2012285786A1 (en
Inventor
Jonathan Henry Ellis
Michael J. Molloy
Tejash SHAH
Ian M. Tomlinson
Ahmed YASIN
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Glaxo Group Ltd
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Glaxo Group Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
AU2012285786A 2011-07-19 2012-07-19 TNF -alpha antigen- binding proteins with increased FcRn binding Ceased AU2012285786B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1112429.4A GB201112429D0 (en) 2011-07-19 2011-07-19 Antigen-binding proteins with increased FcRn binding
GB1112429.4 2011-07-19
PCT/EP2012/064129 WO2013011076A2 (en) 2011-07-19 2012-07-19 Antigen-binding proteins with increased fcrn binding

Publications (2)

Publication Number Publication Date
AU2012285786A1 AU2012285786A1 (en) 2014-02-06
AU2012285786B2 true AU2012285786B2 (en) 2016-05-12

Family

ID=44586854

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012285786A Ceased AU2012285786B2 (en) 2011-07-19 2012-07-19 TNF -alpha antigen- binding proteins with increased FcRn binding

Country Status (22)

Country Link
US (1) US20130243764A1 (enExample)
EP (2) EP3009450A1 (enExample)
JP (1) JP2014524748A (enExample)
KR (1) KR20140054085A (enExample)
CN (1) CN103748110A (enExample)
AU (1) AU2012285786B2 (enExample)
BR (1) BR112014000341A2 (enExample)
CA (1) CA2841105A1 (enExample)
CL (1) CL2014000134A1 (enExample)
CO (1) CO6862106A2 (enExample)
CR (1) CR20140029A (enExample)
DO (1) DOP2014000007A (enExample)
EA (1) EA201391789A1 (enExample)
ES (1) ES2600854T3 (enExample)
GB (1) GB201112429D0 (enExample)
MA (1) MA35345B1 (enExample)
MX (1) MX2014000739A (enExample)
PE (1) PE20141660A1 (enExample)
PH (1) PH12014500167A1 (enExample)
SG (1) SG10201601154QA (enExample)
WO (1) WO2013011076A2 (enExample)
ZA (1) ZA201400062B (enExample)

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Also Published As

Publication number Publication date
EP2734548B1 (en) 2016-08-17
MA35345B1 (fr) 2014-08-01
KR20140054085A (ko) 2014-05-08
ES2600854T3 (es) 2017-02-13
MX2014000739A (es) 2014-02-19
CN103748110A (zh) 2014-04-23
CO6862106A2 (es) 2014-02-10
PE20141660A1 (es) 2014-11-21
CL2014000134A1 (es) 2014-07-25
GB201112429D0 (en) 2011-08-31
DOP2014000007A (es) 2014-04-30
EP3009450A1 (en) 2016-04-20
BR112014000341A2 (pt) 2017-02-14
WO2013011076A2 (en) 2013-01-24
AU2012285786A1 (en) 2014-02-06
CA2841105A1 (en) 2013-01-24
NZ618897A (en) 2016-02-26
WO2013011076A3 (en) 2013-04-04
EA201391789A1 (ru) 2014-06-30
JP2014524748A (ja) 2014-09-25
PH12014500167A1 (en) 2019-03-22
US20130243764A1 (en) 2013-09-19
EP2734548A2 (en) 2014-05-28
ZA201400062B (en) 2017-08-30
CR20140029A (es) 2014-03-05
SG10201601154QA (en) 2016-03-30

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