AU2012250568B2 - Cochleate compositions and methods of making and using same - Google Patents

Cochleate compositions and methods of making and using same Download PDF

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Publication number
AU2012250568B2
AU2012250568B2 AU2012250568A AU2012250568A AU2012250568B2 AU 2012250568 B2 AU2012250568 B2 AU 2012250568B2 AU 2012250568 A AU2012250568 A AU 2012250568A AU 2012250568 A AU2012250568 A AU 2012250568A AU 2012250568 B2 AU2012250568 B2 AU 2012250568B2
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Prior art keywords
cochleate
lipid
cochleates
composition
cation
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AU2012250568A
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AU2012250568A1 (en
Inventor
Ruying Lu
Raphael Mannino
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Rutgers State University of New Jersey
Matinas Biopharma Nanotechnologies Inc
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Rutgers State University of New Jersey
Matinas Biopharma Nanotechnologies Inc
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Assigned to RUTGERS, THE STATE OF UNIVERSITY OF NEW JERSEY, MATINAS BIOPHARMA NANOTECHNOLOGIES, INC. reassignment RUTGERS, THE STATE OF UNIVERSITY OF NEW JERSEY Request for Assignment Assignors: COORDINATED PROGRAM DEVELOPMENT, LLC, UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A—HUMAN NECESSITIES
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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    • C12N2740/10011—Retroviridae
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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
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    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16141—Use of virus, viral particle or viral elements as a vector
    • C12N2760/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
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AU2012250568A 2011-05-05 2012-05-04 Cochleate compositions and methods of making and using same Active AU2012250568B2 (en)

Applications Claiming Priority (17)

Application Number Priority Date Filing Date Title
US201161482996P 2011-05-05 2011-05-05
US61/482,996 2011-05-05
US201161534075P 2011-09-13 2011-09-13
US61/534,075 2011-09-13
US201161547325P 2011-10-14 2011-10-14
US61/547,325 2011-10-14
US201161570067P 2011-12-13 2011-12-13
US61/570,067 2011-12-13
US201261590531P 2012-01-25 2012-01-25
US61/590,531 2012-01-25
US201261608272P 2012-03-08 2012-03-08
US61/608,272 2012-03-08
US201261620656P 2012-04-05 2012-04-05
US61/620,656 2012-04-05
US201261636793P 2012-04-23 2012-04-23
US61/636,793 2012-04-23
PCT/US2012/036576 WO2012151517A1 (en) 2011-05-05 2012-05-04 Cochleate compositions and methods of making and using same

Publications (2)

Publication Number Publication Date
AU2012250568A1 AU2012250568A1 (en) 2013-11-07
AU2012250568B2 true AU2012250568B2 (en) 2017-06-29

Family

ID=47108070

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Application Number Title Priority Date Filing Date
AU2012250568A Active AU2012250568B2 (en) 2011-05-05 2012-05-04 Cochleate compositions and methods of making and using same

Country Status (7)

Country Link
US (1) US20140220108A1 (https=)
EP (1) EP2704688B1 (https=)
JP (2) JP6347743B2 (https=)
AU (1) AU2012250568B2 (https=)
CA (1) CA2834788C (https=)
ES (1) ES2741282T3 (https=)
WO (1) WO2012151517A1 (https=)

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EP2704688B1 (en) * 2011-05-05 2019-07-10 Matinas BioPharma Nanotechnologies, Inc. Cochleate compositions and methods of making and using same
KR102115718B1 (ko) * 2012-07-30 2020-05-28 마티나스 바이오파마 나노테크놀로지스, 인코포레이티드 대두 포스파티딜세린으로 제조된 코클리에이트
US20150147382A1 (en) * 2013-09-23 2015-05-28 Exir Nano Sina Company Topical liposomal compositions for delivering hydrophobic drugs and methods preparing same
CN104398745A (zh) * 2014-12-07 2015-03-11 王月水 一种治疗颈肩腰腿痛、腰椎间盘突出症的中药药浴及其制备方法
CA2978308C (en) 2015-03-03 2024-02-13 Matinas Biopharma Nanotechnologies, Inc. Cochleates and methods of using the same to enhance tissue penetration of pharmacologically active agent
AU2016252885B2 (en) * 2015-04-22 2021-05-20 Matinas Biopharma Nanotechnologies, Inc. Compositions and methods for treating mycobacteria infections and lung disease
CA2987798A1 (en) * 2015-06-18 2016-12-22 Matinas Biopharma Nanotechnologies, Inc. Compositions and methods for treating inflammatory disease or conditions
WO2017205550A1 (en) * 2016-05-24 2017-11-30 Matinas Biopharma Nanotechnologies, Inc. Immunogenic cochleates and methods of use
CA3027668A1 (en) * 2016-07-12 2018-01-18 Matinas Biopharma Nanotechnologies, Inc. Encochleated antifungal compounds for central nervous system delivery and treatment of cryptococcus infections
CA3076336A1 (en) * 2017-09-20 2019-03-28 Atopic Medical, LLC Compositions and methods for treating and ameliorating respiratory conditions and inflammation of mucosa
KR101989789B1 (ko) * 2017-11-30 2019-06-18 (주) 에이치엔에이파마켐 포스파티딜세린/음이온계면활성제/염화칼슘을 이용한 코킬레이트
KR102019589B1 (ko) * 2018-01-23 2019-11-04 가톨릭대학교 산학협력단 내이에서의 약물전달용 나노입자
MX2022001871A (es) * 2019-08-13 2022-03-11 Matinas Biopharma Nanotechnologies Inc Metodos de tratamiento de las infecciones por criptococo.
WO2024039733A1 (en) 2022-08-16 2024-02-22 Matinas Biopharma Nanotechnologies, Inc. Methods of controlling lipid nanocrystal particle size and lipid nanocrystals produced by such methods
WO2024039729A1 (en) 2022-08-16 2024-02-22 Matinas Biopharma Nanotechnologies, Inc. Antifungal agent encapsulated in a lipid nanocrystal for treating mucormycosis
WO2026010571A1 (en) * 2024-07-05 2026-01-08 Nanyang Technological University Preparation of perfect, pure and uniform cochleates for drug delivery

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WO2005110361A2 (en) * 2004-04-09 2005-11-24 Biodelivery Sciences International, Inc. Nucleotide-cochleate compositions and methods of use
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CA2834788A1 (en) 2012-11-08
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