AU2012238208A1 - Flexible nonlinear laser scanning microscope for noninvasive three-dimensional detection - Google Patents

Flexible nonlinear laser scanning microscope for noninvasive three-dimensional detection Download PDF

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Publication number
AU2012238208A1
AU2012238208A1 AU2012238208A AU2012238208A AU2012238208A1 AU 2012238208 A1 AU2012238208 A1 AU 2012238208A1 AU 2012238208 A AU2012238208 A AU 2012238208A AU 2012238208 A AU2012238208 A AU 2012238208A AU 2012238208 A1 AU2012238208 A1 AU 2012238208A1
Authority
AU
Australia
Prior art keywords
measuring head
imaging
scanning microscope
laser scanning
excitation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2012238208A
Other languages
English (en)
Inventor
Karsten Konig
Martin Weinigel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JenLab GmbH
Original Assignee
JenLab GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JenLab GmbH filed Critical JenLab GmbH
Publication of AU2012238208A1 publication Critical patent/AU2012238208A1/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0068—Confocal scanning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
    • G01J1/4257—Photometry, e.g. photographic exposure meter using electric radiation detectors applied to monitoring the characteristics of a beam, e.g. laser beam, headlamp beam
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0028—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04—Constructional details of apparatus
    • A61B2560/0437—Trolley or cart-type apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683—Means for maintaining contact with the body
    • A61B5/6835—Supports or holders, e.g., articulated arms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/42—Photometry, e.g. photographic exposure meter using electric radiation detectors
    • G01J2001/4238—Pulsed light

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Surgery (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microscoopes, Condenser (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
AU2012238208A 2011-10-08 2012-10-05 Flexible nonlinear laser scanning microscope for noninvasive three-dimensional detection Abandoned AU2012238208A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102011115944A DE102011115944B4 (de) 2011-10-08 2011-10-08 Flexibles nichtlineares Laserscanning-Mikroskop zur nicht-invasiven dreidimensionalen Detektion
DE102011115944.8 2011-10-08

Publications (1)

Publication Number Publication Date
AU2012238208A1 true AU2012238208A1 (en) 2013-05-02

Family

ID=47263017

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012238208A Abandoned AU2012238208A1 (en) 2011-10-08 2012-10-05 Flexible nonlinear laser scanning microscope for noninvasive three-dimensional detection

Country Status (8)

Country Link
US (1) US9176309B2 (enExample)
EP (1) EP2579085B1 (enExample)
JP (1) JP5377738B2 (enExample)
CN (1) CN103033917B (enExample)
AU (1) AU2012238208A1 (enExample)
DE (1) DE102011115944B4 (enExample)
ES (1) ES2712799T3 (enExample)
RU (1) RU2524742C2 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102012223533A1 (de) * 2012-12-18 2014-06-18 Carl Zeiss Microscopy Gmbh Digitales Mikroskopsystem
CN104116510B (zh) * 2014-08-11 2016-03-30 西华大学 一种用于帕金森病人震颤的传感装置及检测方法
US20160209330A1 (en) * 2015-01-21 2016-07-21 Protrustech Co., Ltd Integrated raman spectrometer and modularized laser module
CN113834567A (zh) 2015-08-21 2021-12-24 阿尔特勒法斯特系统公司 自动化的延迟线对准
JP7194723B2 (ja) * 2017-08-07 2022-12-22 イエーノプティーク オプティカル システムズ ゲーエムベーハー 光電子チップを接触させるための位置公差に無感応な接触モジュール
US20200233196A1 (en) 2017-08-18 2020-07-23 Leica Microsystems Cms Gmbh Microscopy arrangement with microscope system and holding apparatus, and method for examining a specimen with a microscope
CN107450180A (zh) * 2017-10-12 2017-12-08 凝辉(天津)科技有限责任公司 一种自适应光学传像用柔性光路
CN108464814B (zh) * 2018-02-27 2021-02-02 中国人民解放军陆军军医大学 一种防脱落实验动物用可穿戴经目光刺激装置
EP3542710A1 (de) 2018-03-23 2019-09-25 JenLab GmbH Multimodales bildgebungssystem und verfahren zur nicht-invasiven untersuchung eines untersuchungsobjekts
CN110623636A (zh) * 2018-06-22 2019-12-31 凝辉(天津)科技有限责任公司 三维扫描微型光学探头
CN108613968B (zh) * 2018-08-17 2020-11-24 山东省科学院激光研究所 一种基于空芯管液体光纤拉曼探头及拉曼测试系统
CN109662696B (zh) * 2019-01-31 2024-05-24 北京超维景生物科技有限公司 可设置光纤束的定位式吸附装置及激光扫描显微镜
US11322343B2 (en) * 2019-07-09 2022-05-03 IonQ, Inc. Optical alignment using reflective dove prisms
JP7313221B2 (ja) * 2019-07-26 2023-07-24 ロベルト・ボッシュ・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 測定装置及び測定方法
CN111277002B (zh) * 2020-03-19 2022-03-11 国网浙江省电力有限公司电力科学研究院 一种柔性励磁功率单元并联拓扑结构及其控制方法
EP4184231B1 (en) * 2020-07-17 2025-11-12 Sony Group Corporation Endoscope system, endoscope control method, and program
EP3944807A1 (en) 2020-07-28 2022-02-02 Prospective Instruments GmbH Multimodal microscopic systems
CN113925504B (zh) * 2021-10-21 2024-02-13 浙江澍源智能技术有限公司 一种基于脉搏波的动脉血液拉曼光谱检测装置及方法
CN115629468B (zh) * 2022-11-02 2026-01-27 北京大学 光学成像系统
CN115598780B (zh) * 2022-11-02 2025-08-19 北京大学 激光适配器及光学系统
WO2024094229A2 (zh) * 2022-11-02 2024-05-10 北京大学 激光适配器，多光子显微镜主机和光学系统
DE102023123483B3 (de) * 2023-08-31 2025-01-23 Histolution GmbH Lasermikroskop zur histologischen Untersuchung einer Gewebeprobe und histologisches Untersuchungsverfahren
DE102024200638A1 (de) * 2024-01-24 2025-07-24 Siemens Healthineers Ag Laserbasierte Ausrichtungsunterstützungsvorrichtung, Laserbasiertes Ausrichtungsunterstützungssystem, sowie ein Röntgenbildgebungssystem
HUP2400333A1 (hu) * 2024-06-25 2025-12-28 Femtonics Kft Optikai kar és optikai kart tartalmazó mikroszkóp rendszer szabadon mozgó kísérleti állat vizsgálatára
CN119147464A (zh) * 2024-08-21 2024-12-17 北京超维景生物科技有限公司 一种基于多光子深度成像的成像设备

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4349732A (en) * 1980-01-07 1982-09-14 The Singer Company Laser spatial stabilization transmission system
US4481418A (en) * 1982-09-30 1984-11-06 Vanzetti Systems, Inc. Fiber optic scanning system for laser/thermal inspection
DE3406677A1 (de) * 1984-02-24 1985-09-05 Fa. Carl Zeiss, 7920 Heidenheim Einrichtung zur kompensation der auswanderung eines laserstrahls
DE3406676A1 (de) 1984-02-24 1985-09-05 Fa. Carl Zeiss, 7920 Heidenheim Einrichtung zur lagekorrektur eines ueber eine gelenkoptik gefuehrten laserstrahls
JP2606227B2 (ja) * 1987-09-04 1997-04-30 株式会社ニコン 送光装置
US5034613A (en) 1989-11-14 1991-07-23 Cornell Research Foundation, Inc. Two-photon laser microscopy
FR2698182B1 (fr) 1992-11-13 1994-12-16 Commissariat Energie Atomique Dispositif de contrôle du centrage d'un faisceau lumineux, application à l'introduction de ce faisceau dans une fibre optique.
RU2145109C1 (ru) * 1999-03-09 2000-01-27 Левин Геннадий Генрихович Способ оптической томографии трехмерных микрообъектов и микроскоп для его осуществления
DE20117294U1 (de) 2001-10-19 2003-02-27 JenLab GmbH, 07745 Jena Scansystem
US7148683B2 (en) * 2001-10-25 2006-12-12 Intematix Corporation Detection with evanescent wave probe
DE20306122U1 (de) 2003-04-13 2003-10-02 JenLab GmbH, 07745 Jena Kompaktes Laser-Scanning-Mikroskop
JP2005140981A (ja) * 2003-11-06 2005-06-02 Nikon Corp 顕微鏡装置
JP4681834B2 (ja) * 2004-07-29 2011-05-11 オリンパス株式会社 生体観察装置
US8049135B2 (en) * 2004-06-18 2011-11-01 Electro Scientific Industries, Inc. Systems and methods for alignment of laser beam(s) for semiconductor link processing
ATE517365T1 (de) * 2004-08-27 2011-08-15 Koninkl Philips Electronics Nv Ausrichtungssystem für spektroskopische analysen
DE102006046925A1 (de) 2006-09-28 2008-04-03 Jenlab Gmbh Verfahren und Anordnung zur Laser-Endoskopie für die Mikrobearbeitung
JP5307629B2 (ja) * 2009-05-22 2013-10-02 オリンパス株式会社 走査型顕微鏡装置
DE102009029831A1 (de) 2009-06-17 2011-01-13 W.O.M. World Of Medicine Ag Vorrichtung und Verfahren für die Mehr-Photonen-Fluoreszenzmikroskopie zur Gewinnung von Informationen aus biologischem Gewebe
JP5054072B2 (ja) * 2009-07-28 2012-10-24 キヤノン株式会社 光断層画像撮像装置
DE202010009249U1 (de) * 2010-06-17 2010-09-16 Jenlab Gmbh Flexibles Scansystem für die Diagnostik humaner Haut
DE102010047578A1 (de) 2010-10-07 2012-04-12 Jenlab Gmbh Verwendung einer Kombination von Auswertungsverfahren in einer Vorrichtung zur Detektion von Tumoren sowie Vorrichtung zur Detektion von Tumoren

Also Published As

Publication number Publication date
US9176309B2 (en) 2015-11-03
RU2012140513A (ru) 2014-03-27
DE102011115944A1 (de) 2013-04-11
ES2712799T3 (es) 2019-05-14
CN103033917B (zh) 2016-08-03
EP2579085A1 (de) 2013-04-10
RU2524742C2 (ru) 2014-08-10
JP2013083980A (ja) 2013-05-09
EP2579085B1 (de) 2019-02-13
JP5377738B2 (ja) 2013-12-25
CN103033917A (zh) 2013-04-10
US20130088709A1 (en) 2013-04-11
DE102011115944B4 (de) 2013-06-06

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MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted