AU2012219322A1 - Technology for preventing abuse of solid dosage forms - Google Patents
Technology for preventing abuse of solid dosage forms Download PDFInfo
- Publication number
- AU2012219322A1 AU2012219322A1 AU2012219322A AU2012219322A AU2012219322A1 AU 2012219322 A1 AU2012219322 A1 AU 2012219322A1 AU 2012219322 A AU2012219322 A AU 2012219322A AU 2012219322 A AU2012219322 A AU 2012219322A AU 2012219322 A1 AU2012219322 A1 AU 2012219322A1
- Authority
- AU
- Australia
- Prior art keywords
- pellets
- water
- abuse
- carbopol
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- A61K9/2004—Excipients; Inactive ingredients
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- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
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- A—HUMAN NECESSITIES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| US61/443,966 | 2011-02-17 | ||
| PCT/US2012/025737 WO2012112952A1 (en) | 2011-02-17 | 2012-02-17 | Technology for preventing abuse of solid dosage forms |
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| AU2012219322A1 true AU2012219322A1 (en) | 2013-05-09 |
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| AU2012219322A Abandoned AU2012219322A1 (en) | 2011-02-17 | 2012-02-17 | Technology for preventing abuse of solid dosage forms |
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| EP1429744A1 (en) | 2001-09-21 | 2004-06-23 | Egalet A/S | Morphine polymer release system |
| EP1429739A1 (en) | 2001-09-21 | 2004-06-23 | Egalet A/S | Polymer release system |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| ES2570454T3 (es) | 2003-03-26 | 2016-05-18 | Egalet Ltd | Sistema de liberación controlada de morfina |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
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| AU2010211220B2 (en) | 2009-02-06 | 2013-08-01 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
| CA2766179A1 (en) | 2009-06-24 | 2010-12-29 | Egalet Ltd. | Controlled release formulations |
| EP2456427B1 (en) | 2009-07-22 | 2015-03-04 | Grünenthal GmbH | Hot-melt extruded controlled release dosage form |
| RU2555531C2 (ru) | 2009-07-22 | 2015-07-10 | Грюненталь Гмбх | Защищенная от применения не по назначению лекарственная форма для чувствительных к окислению опиоидов |
| US20120321674A1 (en) * | 2011-02-17 | 2012-12-20 | Michael Vachon | Technology for Preventing Abuse of Solid Dosage Forms |
| NZ608865A (en) | 2010-09-02 | 2015-03-27 | Gruenenthal Chemie | Tamper resistant dosage form comprising an anionic polymer |
| PE20131102A1 (es) | 2010-09-02 | 2013-10-12 | Gruenenthal Chemie | Forma de dosificacion resistente a manipulacion que comprende una sal inorganica |
| CN103857386A (zh) * | 2011-07-29 | 2014-06-11 | 格吕伦塔尔有限公司 | 提供药物立即释放的抗破碎片剂 |
| NO2736495T3 (cg-RX-API-DMAC7.html) | 2011-07-29 | 2018-01-20 | ||
| AR088875A1 (es) * | 2011-11-17 | 2014-07-16 | Gruenenthal Gmbh | Forma de dosis farmaceutica oral a prueba de manipulacion |
| FR2983409B1 (fr) * | 2011-12-06 | 2013-12-27 | Ethypharm Sa | Comprime susceptible de lutter contre le detournement par voie injectable |
| BR112014019988A8 (pt) | 2012-02-28 | 2017-07-11 | Gruenenthal Gmbh | Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico |
| AU2013204592A1 (en) * | 2012-04-09 | 2013-10-24 | QRxPharma Ltd. | Controlled release formulations of opioids |
| PL2838516T3 (pl) | 2012-04-18 | 2019-05-31 | SpecGx LLC | Zapobiegające nadużywaniu kompozycje farmaceutyczne o natychmiastowym uwalnianiu |
| AR090695A1 (es) | 2012-04-18 | 2014-12-03 | Gruenenthal Gmbh | Forma de dosificacion farmaceutica resistente a la adulteracion y resistente a la liberacion inmediata de la dosis |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
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| JP6208261B2 (ja) | 2013-02-05 | 2017-10-04 | パーデュー、ファーマ、リミテッド、パートナーシップＰｕｒｄｕｅ Ｐｈａｒｍａ Ｌ．Ｐ． | タンパリング抵抗性医薬製剤 |
| JP6255474B2 (ja) | 2013-03-15 | 2017-12-27 | マリンクロッド エルエルシー | 機能的割線を有する即時放出用の乱用抑止性固体剤形 |
| WO2014191397A1 (en) | 2013-05-29 | 2014-12-04 | Grünenthal GmbH | Tamper-resistant dosage form containing one or more particles |
| AR096439A1 (es) | 2013-05-29 | 2015-12-30 | Gruenenthal Gmbh | Forma de dosificación resistente al uso indebido que contiene una o más partículas |
| CA2917136C (en) | 2013-07-12 | 2022-05-31 | Grunenthal Gmbh | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
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| US9770514B2 (en) | 2013-09-03 | 2017-09-26 | ExxPharma Therapeutics LLC | Tamper-resistant pharmaceutical dosage forms |
| US20150118300A1 (en) | 2013-10-31 | 2015-04-30 | Cima Labs Inc. | Immediate Release Abuse-Deterrent Granulated Dosage Forms |
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| JP2017518980A (ja) | 2014-05-12 | 2017-07-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | タペンタドールを含む、改変防止即時放出カプセル製剤 |
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| US3773955A (en) | 1970-08-03 | 1973-11-20 | Bristol Myers Co | Analgetic compositions |
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| CN101703777B (zh) | 2000-02-08 | 2012-11-28 | 欧罗赛铁克股份有限公司 | 抗破坏口服阿片样激动剂 |
| EP1414418A1 (en) * | 2001-08-06 | 2004-05-06 | Euro-Celtique S.A. | Compositions and methods to prevent abuse of opioids |
| US7332182B2 (en) * | 2001-08-06 | 2008-02-19 | Purdue Pharma L.P. | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant |
| EP1414413A1 (en) * | 2001-08-06 | 2004-05-06 | Euro-Celtique S.A. | Compositions and methods to prevent abuse of opioids |
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| US20030091635A1 (en) * | 2001-09-26 | 2003-05-15 | Baichwal Anand R. | Opioid formulations having reduced potential for abuse |
| CA2483827C (en) * | 2002-04-29 | 2012-01-24 | Amir H. Shojaei | Pharmaceutical formulations with improved bioavailability |
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| EP1765292B1 (en) | 2004-06-12 | 2017-10-04 | Collegium Pharmaceutical, Inc. | Abuse-deterrent drug formulations |
| US20060110327A1 (en) * | 2004-11-24 | 2006-05-25 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
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-
2012
- 2012-02-17 AU AU2012219322A patent/AU2012219322A1/en not_active Abandoned
- 2012-02-17 US US13/400,004 patent/US20120321716A1/en not_active Abandoned
- 2012-02-17 BR BR112013021026A patent/BR112013021026A2/pt not_active IP Right Cessation
- 2012-02-17 CA CA2827273A patent/CA2827273A1/en not_active Abandoned
- 2012-02-17 WO PCT/US2012/025737 patent/WO2012112952A1/en not_active Ceased
- 2012-02-17 MX MX2013009492A patent/MX2013009492A/es not_active Application Discontinuation
- 2012-02-17 CN CN2012800187591A patent/CN103476401A/zh active Pending
- 2012-02-17 JP JP2013554661A patent/JP2014505736A/ja active Pending
- 2012-02-17 EP EP12712786.8A patent/EP2675436A1/en not_active Withdrawn
-
2013
- 2013-08-14 IL IL227962A patent/IL227962A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2827273A1 (en) | 2012-08-23 |
| US20120321716A1 (en) | 2012-12-20 |
| MX2013009492A (es) | 2014-07-30 |
| IL227962A0 (en) | 2013-09-30 |
| CN103476401A (zh) | 2013-12-25 |
| BR112013021026A2 (pt) | 2016-10-11 |
| JP2014505736A (ja) | 2014-03-06 |
| EP2675436A1 (en) | 2013-12-25 |
| WO2012112952A1 (en) | 2012-08-23 |
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