AU2012201303B2 - Met inhibitors for enhancing radiotherapy efficacy - Google Patents

Met inhibitors for enhancing radiotherapy efficacy Download PDF

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Publication number
AU2012201303B2
AU2012201303B2 AU2012201303A AU2012201303A AU2012201303B2 AU 2012201303 B2 AU2012201303 B2 AU 2012201303B2 AU 2012201303 A AU2012201303 A AU 2012201303A AU 2012201303 A AU2012201303 A AU 2012201303A AU 2012201303 B2 AU2012201303 B2 AU 2012201303B2
Authority
AU
Australia
Prior art keywords
met
met inhibitor
monoclonal antibody
cdrs
nucleotide sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2012201303A
Other languages
English (en)
Other versions
AU2012201303A1 (en
Inventor
Carla Boccaccio
Paolo Maria Comoglio
Rita De Santis
Fiorella Petronzelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertical Bio AG
Original Assignee
Vertical Bio AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertical Bio AG filed Critical Vertical Bio AG
Publication of AU2012201303A1 publication Critical patent/AU2012201303A1/en
Application granted granted Critical
Publication of AU2012201303B2 publication Critical patent/AU2012201303B2/en
Assigned to VERTICAL BIO AG reassignment VERTICAL BIO AG Request for Assignment Assignors: METHERESIS TRANSLATIONAL RESEARCH S.A.
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AU2012201303A 2011-03-18 2012-03-02 Met inhibitors for enhancing radiotherapy efficacy Active AU2012201303B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11158861.2 2011-03-18
EP11158861.2A EP2500036B1 (en) 2011-03-18 2011-03-18 MET inhibitors for enhancing radiotherapy efficacy

Publications (2)

Publication Number Publication Date
AU2012201303A1 AU2012201303A1 (en) 2012-10-04
AU2012201303B2 true AU2012201303B2 (en) 2013-11-07

Family

ID=44260211

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012201303A Active AU2012201303B2 (en) 2011-03-18 2012-03-02 Met inhibitors for enhancing radiotherapy efficacy

Country Status (22)

Country Link
US (1) US20120237524A1 (show.php)
EP (1) EP2500036B1 (show.php)
JP (1) JP5671487B2 (show.php)
KR (1) KR101540838B1 (show.php)
CN (1) CN102688491A (show.php)
AU (1) AU2012201303B2 (show.php)
BR (1) BR102012006063B1 (show.php)
CA (1) CA2769991C (show.php)
CY (1) CY1115374T1 (show.php)
DK (1) DK2500036T3 (show.php)
EA (1) EA028590B1 (show.php)
ES (1) ES2489475T3 (show.php)
HR (1) HRP20140729T1 (show.php)
IL (1) IL218293A (show.php)
MX (1) MX2012003084A (show.php)
PL (1) PL2500036T3 (show.php)
PT (1) PT2500036E (show.php)
RS (1) RS53468B (show.php)
SG (1) SG184637A1 (show.php)
SI (1) SI2500036T1 (show.php)
SM (1) SMT201400106B (show.php)
ZA (1) ZA201201992B (show.php)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法
IT201800009282A1 (it) * 2018-10-09 2020-04-09 Metis Prec Medicine Sb Srl Nuovo agente terapeutico per il trattamento di un tumore e/o metastasi
CN110320365B (zh) * 2019-07-06 2022-07-22 湖南莱拓福生物科技有限公司 NF-κB RelA/p65蛋白位点特异性磷酸化诊断试剂盒
CN121015920A (zh) 2019-09-16 2025-11-28 瑞泽恩制药公司 用于免疫pet成像的放射性标记的met结合蛋白
EP4687905A1 (en) 2023-03-30 2026-02-11 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
WO2024229406A1 (en) 2023-05-04 2024-11-07 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
WO2025034702A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005016382A1 (en) * 2003-08-04 2005-02-24 Pfizer Products Inc. Antibodies to c-met

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI310684B (en) * 2000-03-27 2009-06-11 Bristol Myers Squibb Co Synergistic pharmaceutical kits for treating cancer
EP1592713A2 (en) * 2003-02-13 2005-11-09 Pharmacia Corporation Antibodies to c-met for the treatment of cancers
BRPI0412885A (pt) * 2003-07-18 2006-10-03 Amgen Inc polipeptìdios, agentes de ligação especìficos, moléculas de ácido nucleico e linhas de células isoladas, células hospedeiras, composições e anticorpo ou domìnio de ligação de antìgeno e métodos de tratamento de cáncer e de tumor sólido num paciente, de detecção do nìvel do fator de crescimento hepatócito (hgf) numa amostra, de obtenção de anticorpo e de inibição da ligação de hgf a met e de diminuição ou prevenção da ligação de qualquer um dos agentes de ligação especìficos ao fator de crescimento hepatócito (hgf)
PT1981981E (pt) * 2006-02-06 2011-10-04 Metheresis Translational Res Sa Anticorpos monoclonais anti-met, fragmentos e vectores destes, para o tratamento de tumores e produtos correspondentes
EP2019116A1 (en) * 2007-07-26 2009-01-28 Helmholtz-Zentrum für Infektionsforschung GmbH Inhibitor of the met-receptor and its use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005016382A1 (en) * 2003-08-04 2005-02-24 Pfizer Products Inc. Antibodies to c-met

Also Published As

Publication number Publication date
MX2012003084A (es) 2012-09-17
EA028590B1 (ru) 2017-12-29
SMT201400106B (it) 2014-11-10
HRP20140729T1 (hr) 2014-08-29
CN102688491A (zh) 2012-09-26
JP5671487B2 (ja) 2015-02-18
KR20120106582A (ko) 2012-09-26
ES2489475T3 (es) 2014-09-02
BR102012006063B1 (pt) 2023-03-07
BR102012006063A2 (pt) 2021-11-16
EP2500036A1 (en) 2012-09-19
EA201200329A3 (ru) 2013-01-30
SI2500036T1 (sl) 2014-09-30
SG184637A1 (en) 2012-10-30
BR102012006063A8 (pt) 2022-11-08
IL218293A (en) 2016-06-30
AU2012201303A1 (en) 2012-10-04
KR101540838B1 (ko) 2015-08-06
CA2769991A1 (en) 2012-09-18
HK1174539A1 (en) 2013-06-14
EA201200329A2 (ru) 2012-09-28
PL2500036T3 (pl) 2014-10-31
US20120237524A1 (en) 2012-09-20
CA2769991C (en) 2018-05-15
CY1115374T1 (el) 2017-01-04
RS53468B (sr) 2014-12-31
IL218293A0 (en) 2012-07-31
EP2500036B1 (en) 2014-05-07
PT2500036E (pt) 2014-08-25
ZA201201992B (en) 2015-05-27
JP2012196206A (ja) 2012-10-18
DK2500036T3 (da) 2014-08-04

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Legal Events

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DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ BOCCACCIO, CARLA; COMOGLIO, PAOLO MARIA; PETRONZELLI, FIORELLA AND DE SANTIS, RITA

FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: VERTICAL BIO AG

Free format text: FORMER OWNER(S): METHERESIS TRANSLATIONAL RESEARCH S.A.