AU2011326562B2 - Methods for organ regeneration - Google Patents

Methods for organ regeneration Download PDF

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Publication number
AU2011326562B2
AU2011326562B2 AU2011326562A AU2011326562A AU2011326562B2 AU 2011326562 B2 AU2011326562 B2 AU 2011326562B2 AU 2011326562 A AU2011326562 A AU 2011326562A AU 2011326562 A AU2011326562 A AU 2011326562A AU 2011326562 B2 AU2011326562 B2 AU 2011326562B2
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AU
Australia
Prior art keywords
lsecs
liver
vegfr2
cells
regeneration
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AU2011326562A
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English (en)
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AU2011326562A1 (en
Inventor
Bi-Sen Ding
Sina Y. Rabbany
Shahin Rafii
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Cornell University
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Cornell University
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Publication date
Application filed by Cornell University filed Critical Cornell University
Publication of AU2011326562A1 publication Critical patent/AU2011326562A1/en
Application granted granted Critical
Publication of AU2011326562B2 publication Critical patent/AU2011326562B2/en
Priority to AU2017202119A priority Critical patent/AU2017202119B2/en
Priority to AU2018282248A priority patent/AU2018282248A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2011326562A 2010-11-09 2011-11-09 Methods for organ regeneration Active AU2011326562B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2017202119A AU2017202119B2 (en) 2010-11-09 2017-03-30 Methods for organ regeneration
AU2018282248A AU2018282248A1 (en) 2010-11-09 2018-12-17 Methods for organ regeneration

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41173210P 2010-11-09 2010-11-09
US61/411,732 2010-11-09
US201161545851P 2011-10-11 2011-10-11
US61/545,851 2011-10-11
PCT/US2011/059960 WO2012064834A2 (en) 2010-11-09 2011-11-09 Methods for organ regeneration

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017202119A Division AU2017202119B2 (en) 2010-11-09 2017-03-30 Methods for organ regeneration

Publications (2)

Publication Number Publication Date
AU2011326562A1 AU2011326562A1 (en) 2013-06-06
AU2011326562B2 true AU2011326562B2 (en) 2017-02-23

Family

ID=46051533

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2011326562A Active AU2011326562B2 (en) 2010-11-09 2011-11-09 Methods for organ regeneration
AU2017202119A Active AU2017202119B2 (en) 2010-11-09 2017-03-30 Methods for organ regeneration
AU2018282248A Abandoned AU2018282248A1 (en) 2010-11-09 2018-12-17 Methods for organ regeneration

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2017202119A Active AU2017202119B2 (en) 2010-11-09 2017-03-30 Methods for organ regeneration
AU2018282248A Abandoned AU2018282248A1 (en) 2010-11-09 2018-12-17 Methods for organ regeneration

Country Status (9)

Country Link
US (2) US10946066B2 (https=)
EP (2) EP2637683B1 (https=)
JP (3) JP6189216B2 (https=)
AU (3) AU2011326562B2 (https=)
CA (1) CA2816593C (https=)
DK (1) DK2637683T3 (https=)
ES (1) ES2788300T3 (https=)
SG (2) SG190206A1 (https=)
WO (1) WO2012064834A2 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2788300T3 (es) * 2010-11-09 2020-10-21 Univ Cornell Regeneración hepática
CA2874764C (en) * 2012-05-30 2022-11-01 Cornell University Generation of functional and durable endothelial cells from human amniotic fluid-derived cells
JP6076076B2 (ja) * 2012-12-21 2017-02-08 日東電工株式会社 組織再生促進剤
AU2015279552B2 (en) 2014-06-27 2021-01-21 Angiocrine Bioscience, Inc. Neural cells expressing adenovirus E4ORF1, and methods of making and using the same
US20160121023A1 (en) * 2014-10-30 2016-05-05 Massachusetts Institute Of Technology Materials and Methods for Rescue of Ischemic Tissue and Regeneration of Tissue Integrity During Resection, Engraftment and Transplantation
KR102571649B1 (ko) * 2014-12-19 2023-08-25 앤지오크린 바이오사이언스 인코포레이티드 조작된 내피 세포를 포함하는 생체적합성 임플란트
CN108291196B (zh) 2015-07-20 2021-08-27 安吉克莱茵生物科学有限公司 表达ets转录因子的工程化的内皮细胞
CN105213230A (zh) * 2015-09-22 2016-01-06 薇碧生物科技（上海）有限公司 一种基于不可见光和酶抑制物来促进胶原蛋白再生的方法
EP3512937B1 (en) 2016-09-13 2024-10-09 Angiocrine Bioscience, Inc. Blood-brain barrier comprising engineered endothelial cells
WO2018144860A1 (en) 2017-02-03 2018-08-09 Cornell University Stable three-dimensional blood vessels and methods for forming the same
US20200155648A1 (en) * 2017-06-28 2020-05-21 Children's Medical Center Corporation Promoting lung growth
WO2023014680A1 (en) * 2021-08-06 2023-02-09 Trujillo Charles Nathan System and method of treating or preventing respiratory failure with aerosolized collagenase
US12385002B1 (en) * 2022-01-21 2025-08-12 Sahar M. H. Jaffal Automated primary cells' triturator

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003103581A2 (en) * 2002-06-05 2003-12-18 Genentech, Inc. Compositions and methods for liver growth and liver protection
CN101275121A (zh) * 2007-03-26 2008-10-01 芦银雪 体外培养扩增的人肝脏祖先细胞及其制备方法

Family Cites Families (9)

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JPH06284883A (ja) * 1992-07-10 1994-10-11 Sanyo Chem Ind Ltd 肝細胞培養方法
US9585916B2 (en) * 1999-03-26 2017-03-07 Northern Therapeutics Inc. Cell based therapy for the pulmonary system
US20050164388A1 (en) 2001-02-07 2005-07-28 Young-Sook Son Method of isolating epithelial cells, method of preconditioning cells, and methods of preparing bioartificial skin and dermis with the epithelial cells and preconditioned cells
WO2006052223A1 (en) 2004-11-11 2006-05-18 Agency For Science, Technology And Research Cell culture device
JP4916159B2 (ja) 2005-11-09 2012-04-11 国立大学法人東北大学 生体管路ステント
US20080176206A1 (en) 2007-01-18 2008-07-24 Toshiharu Shinoka Cardiovascular tissue culture substrate
WO2008089448A2 (en) * 2007-01-19 2008-07-24 Cornell Presearch Foundation, Inc. Methods and compositions for promoting survival & proliferation of endothelial cells & stimulating angiogenesis
MY165826A (en) 2010-10-01 2018-05-17 Cipla Ltd Pharmaceutical composition
ES2788300T3 (es) * 2010-11-09 2020-10-21 Univ Cornell Regeneración hepática

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003103581A2 (en) * 2002-06-05 2003-12-18 Genentech, Inc. Compositions and methods for liver growth and liver protection
CN101275121A (zh) * 2007-03-26 2008-10-01 芦银雪 体外培养扩增的人肝脏祖先细胞及其制备方法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BENTEN D, et al., Hepatology, (2005), Vol 42, pp 140-148. *
FOLLENZI A, et al, Hepatology, (2007), Vol 46 Suppl 1, pp 785A. *
FOLLENZI A, et al., J Clin Invest, (2008), Vol 118 pp 935-945. *
GREENE, AK, et al., Annals of Surgery, (2003), Vol 437 No 4, pp 530-535. *
LeCOUTER J, et al., Science, (2003), Vol 299, pp 890-893. *
WIRZ W, et al., Differentiation, (2008), Vol 76, pp784-794. *

Also Published As

Publication number Publication date
EP3721897A1 (en) 2020-10-14
JP2013543760A (ja) 2013-12-09
EP2637683A4 (en) 2015-10-28
US10946066B2 (en) 2021-03-16
JP6189216B2 (ja) 2017-08-30
EP2637683B1 (en) 2020-03-04
SG10201509096SA (en) 2015-12-30
WO2012064834A3 (en) 2012-07-19
EP2637683A2 (en) 2013-09-18
SG190206A1 (en) 2013-06-28
AU2011326562A1 (en) 2013-06-06
CA2816593A1 (en) 2012-05-18
JP2020023565A (ja) 2020-02-13
CA2816593C (en) 2021-05-25
AU2018282248A1 (en) 2019-01-17
AU2017202119B2 (en) 2019-01-03
JP2018012704A (ja) 2018-01-25
WO2012064834A2 (en) 2012-05-18
DK2637683T3 (da) 2020-05-25
EP3721897B1 (en) 2025-10-08
US20130224161A1 (en) 2013-08-29
US20210236598A1 (en) 2021-08-05
ES2788300T3 (es) 2020-10-21
AU2017202119A1 (en) 2017-04-20

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