AU2011326562B2 - Methods for organ regeneration - Google Patents

Methods for organ regeneration Download PDF

Info

Publication number
AU2011326562B2
AU2011326562B2 AU2011326562A AU2011326562A AU2011326562B2 AU 2011326562 B2 AU2011326562 B2 AU 2011326562B2 AU 2011326562 A AU2011326562 A AU 2011326562A AU 2011326562 A AU2011326562 A AU 2011326562A AU 2011326562 B2 AU2011326562 B2 AU 2011326562B2
Authority
AU
Australia
Prior art keywords
lsecs
liver
vegfr2
cells
regeneration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2011326562A
Other languages
English (en)
Other versions
AU2011326562A1 (en
Inventor
Bi-Sen Ding
Sina Y. Rabbany
Shahin Rafii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cornell University
Original Assignee
Cornell University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornell University filed Critical Cornell University
Publication of AU2011326562A1 publication Critical patent/AU2011326562A1/en
Application granted granted Critical
Publication of AU2011326562B2 publication Critical patent/AU2011326562B2/en
Priority to AU2017202119A priority Critical patent/AU2017202119B2/en
Priority to AU2018282248A priority patent/AU2018282248A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AU2011326562A 2010-11-09 2011-11-09 Methods for organ regeneration Active AU2011326562B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2017202119A AU2017202119B2 (en) 2010-11-09 2017-03-30 Methods for organ regeneration
AU2018282248A AU2018282248A1 (en) 2010-11-09 2018-12-17 Methods for organ regeneration

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41173210P 2010-11-09 2010-11-09
US61/411,732 2010-11-09
US201161545851P 2011-10-11 2011-10-11
US61/545,851 2011-10-11
PCT/US2011/059960 WO2012064834A2 (en) 2010-11-09 2011-11-09 Methods for organ regeneration

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017202119A Division AU2017202119B2 (en) 2010-11-09 2017-03-30 Methods for organ regeneration

Publications (2)

Publication Number Publication Date
AU2011326562A1 AU2011326562A1 (en) 2013-06-06
AU2011326562B2 true AU2011326562B2 (en) 2017-02-23

Family

ID=46051533

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2011326562A Active AU2011326562B2 (en) 2010-11-09 2011-11-09 Methods for organ regeneration
AU2017202119A Active AU2017202119B2 (en) 2010-11-09 2017-03-30 Methods for organ regeneration
AU2018282248A Abandoned AU2018282248A1 (en) 2010-11-09 2018-12-17 Methods for organ regeneration

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2017202119A Active AU2017202119B2 (en) 2010-11-09 2017-03-30 Methods for organ regeneration
AU2018282248A Abandoned AU2018282248A1 (en) 2010-11-09 2018-12-17 Methods for organ regeneration

Country Status (9)

Country Link
US (2) US10946066B2 (cg-RX-API-DMAC7.html)
EP (2) EP3721897B1 (cg-RX-API-DMAC7.html)
JP (3) JP6189216B2 (cg-RX-API-DMAC7.html)
AU (3) AU2011326562B2 (cg-RX-API-DMAC7.html)
CA (1) CA2816593C (cg-RX-API-DMAC7.html)
DK (1) DK2637683T3 (cg-RX-API-DMAC7.html)
ES (1) ES2788300T3 (cg-RX-API-DMAC7.html)
SG (2) SG190206A1 (cg-RX-API-DMAC7.html)
WO (1) WO2012064834A2 (cg-RX-API-DMAC7.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2816593C (en) * 2010-11-09 2021-05-25 Shahin Rafii Methods for organ regeneration
AU2013267422B2 (en) 2012-05-30 2018-07-26 Cornell University Generation of functional and durable endothelial cells from human amniotic fluid-derived cells
JP6076076B2 (ja) * 2012-12-21 2017-02-08 日東電工株式会社 組織再生促進剤
CN106574243B (zh) 2014-06-27 2021-02-23 安吉克莱茵生物科学有限公司 表达腺病毒e4orf1的神经细胞及其制备方法和应用
WO2016069897A1 (en) * 2014-10-30 2016-05-06 Massachusetts Institute Of Technology Materials and methods for rescue of ischemic tissue and regeneration of tissue integrity during restriction, engraftment and transplantation
CA2971439A1 (en) * 2014-12-19 2016-06-23 Angiocrine Bioscience, Inc. Biocompatible implants comprising engineered endothelial cells
HK1258452A1 (zh) 2015-07-20 2019-11-15 Angiocrine Bioscience, Inc. 表达ets转录因子的工程化的内皮细胞
CN105213230A (zh) * 2015-09-22 2016-01-06 薇碧生物科技（上海）有限公司 一种基于不可见光和酶抑制物来促进胶原蛋白再生的方法
AU2017326174B2 (en) 2016-09-13 2024-02-22 Angiocrine Bioscience, Inc. Blood-brain barrier comprising engineered endothelial cells
EP3576756A4 (en) 2017-02-03 2020-12-16 Cornell University STABLE THREE-DIMENSIONAL BLOOD VESSELS AND THEIR FORMATION PROCESSES
US20200155648A1 (en) * 2017-06-28 2020-05-21 Children's Medical Center Corporation Promoting lung growth
EP4380601A4 (en) * 2021-08-06 2025-06-25 Trujillo, Charles, Nathan SYSTEM AND METHOD FOR TREATING OR PREVENTING RESPIRATORY FAILURE WITH AEROSOLIZED COLLAGENASE
US12385002B1 (en) * 2022-01-21 2025-08-12 Sahar M. H. Jaffal Automated primary cells' triturator

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003103581A2 (en) * 2002-06-05 2003-12-18 Genentech, Inc. Compositions and methods for liver growth and liver protection
CN101275121A (zh) * 2007-03-26 2008-10-01 芦银雪 体外培养扩增的人肝脏祖先细胞及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06284883A (ja) * 1992-07-10 1994-10-11 Sanyo Chem Ind Ltd 肝細胞培養方法
US9585916B2 (en) * 1999-03-26 2017-03-07 Northern Therapeutics Inc. Cell based therapy for the pulmonary system
WO2002062971A1 (en) 2001-02-07 2002-08-15 Korea Atomic Energy Research Institute Method of isolating epithelial cells, method of preconditioning cells, and methods of preparing bioartificial skin and dermis with the epithelial cells or the preconditioned cells
EP1815244A4 (en) 2004-11-11 2009-07-22 Agency Science Tech & Res CELL CULTURE DEVICE
JP4916159B2 (ja) 2005-11-09 2012-04-11 国立大学法人東北大学 生体管路ステント
US20080176206A1 (en) 2007-01-18 2008-07-24 Toshiharu Shinoka Cardiovascular tissue culture substrate
WO2008089448A2 (en) * 2007-01-19 2008-07-24 Cornell Presearch Foundation, Inc. Methods and compositions for promoting survival & proliferation of endothelial cells & stimulating angiogenesis
MX2013003522A (es) 2010-10-01 2013-05-22 Cipla Ltd Composicion farmaceutica.
CA2816593C (en) * 2010-11-09 2021-05-25 Shahin Rafii Methods for organ regeneration

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003103581A2 (en) * 2002-06-05 2003-12-18 Genentech, Inc. Compositions and methods for liver growth and liver protection
CN101275121A (zh) * 2007-03-26 2008-10-01 芦银雪 体外培养扩增的人肝脏祖先细胞及其制备方法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BENTEN D, et al., Hepatology, (2005), Vol 42, pp 140-148. *
FOLLENZI A, et al, Hepatology, (2007), Vol 46 Suppl 1, pp 785A. *
FOLLENZI A, et al., J Clin Invest, (2008), Vol 118 pp 935-945. *
GREENE, AK, et al., Annals of Surgery, (2003), Vol 437 No 4, pp 530-535. *
LeCOUTER J, et al., Science, (2003), Vol 299, pp 890-893. *
WIRZ W, et al., Differentiation, (2008), Vol 76, pp784-794. *

Also Published As

Publication number Publication date
WO2012064834A3 (en) 2012-07-19
CA2816593A1 (en) 2012-05-18
EP2637683A2 (en) 2013-09-18
EP3721897B1 (en) 2025-10-08
US20210236598A1 (en) 2021-08-05
JP6189216B2 (ja) 2017-08-30
WO2012064834A2 (en) 2012-05-18
JP2013543760A (ja) 2013-12-09
SG10201509096SA (en) 2015-12-30
SG190206A1 (en) 2013-06-28
EP2637683B1 (en) 2020-03-04
US20130224161A1 (en) 2013-08-29
JP2020023565A (ja) 2020-02-13
US10946066B2 (en) 2021-03-16
CA2816593C (en) 2021-05-25
DK2637683T3 (da) 2020-05-25
EP3721897A1 (en) 2020-10-14
EP2637683A4 (en) 2015-10-28
AU2018282248A1 (en) 2019-01-17
AU2017202119A1 (en) 2017-04-20
AU2017202119B2 (en) 2019-01-03
ES2788300T3 (es) 2020-10-21
JP2018012704A (ja) 2018-01-25
AU2011326562A1 (en) 2013-06-06

Similar Documents

Publication Publication Date Title
US20210236598A1 (en) Methods for organ regeneration
US7135171B2 (en) Endothelial precursor cells for enhancing and restoring vascular function
US8747905B2 (en) Therapeutic use of CD31 expressing cells
AU2014262590B2 (en) Wound healing and tissue engineering
US20080194023A1 (en) Generating vascular smooth muscle cells in vitro from ES cells
CA2940691C (en) Method for generating endothelial colony forming cell-like cells
US20100143476A1 (en) Composition for stimulating formation of vascular structures
US20190352601A1 (en) Engineering blood vessel cells for transplantation
WO2019098264A1 (ja) Ｃｄ３１陽性ｃｄ４５陰性ｃｄ２００陽性の哺乳動物細胞からなる細胞集団、およびその利用
US20250019649A1 (en) Generation of thyroid and lung organoids from stem cells
KR20110102788A (ko) 합토글로빈 유전자가 도입된 혈관내피 전구세포 및 이를 포함하는 혈관형성 촉진용 조성물
Tedeschi Mesoangioblast promote regeneration of a stable and organised vasculature in a decellularised intestinal graft
Xie et al. Cardiac Derived CD51-Positive Mesenchymal Stem Cells Enhance the Repair of Infarcted Heart in Mice Through SCF-Mediated Angiogenesis
US20130287745A1 (en) Compositions and methods to stimulate vascular structure formation
JP2017514523A (ja) 細胞培養方法
DYM et al. HYNDA K. KLEINMAN,* MAURA C. KIBBEY,* H. WILLIAM SCHNAPER,* MARK A. HADLEY

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)