AU2011308893B2 - Method for removing residual organic solvent from microparticles - Google Patents

Method for removing residual organic solvent from microparticles Download PDF

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Publication number
AU2011308893B2
AU2011308893B2 AU2011308893A AU2011308893A AU2011308893B2 AU 2011308893 B2 AU2011308893 B2 AU 2011308893B2 AU 2011308893 A AU2011308893 A AU 2011308893A AU 2011308893 A AU2011308893 A AU 2011308893A AU 2011308893 B2 AU2011308893 B2 AU 2011308893B2
Authority
AU
Australia
Prior art keywords
microparticles
organic solvent
residual organic
lactide
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011308893A
Other languages
English (en)
Other versions
AU2011308893A1 (en
Inventor
Brenda H. Perkins
Adrian T. Raiche
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Corp
Original Assignee
Evonik Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Corp filed Critical Evonik Corp
Publication of AU2011308893A1 publication Critical patent/AU2011308893A1/en
Application granted granted Critical
Publication of AU2011308893B2 publication Critical patent/AU2011308893B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
AU2011308893A 2010-09-30 2011-09-28 Method for removing residual organic solvent from microparticles Ceased AU2011308893B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38805010P 2010-09-30 2010-09-30
US61/388,050 2010-09-30
PCT/US2011/053655 WO2012044671A2 (en) 2010-09-30 2011-09-28 Method for removing residual organic solvent from microparticles

Publications (2)

Publication Number Publication Date
AU2011308893A1 AU2011308893A1 (en) 2013-05-09
AU2011308893B2 true AU2011308893B2 (en) 2015-04-23

Family

ID=45094869

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011308893A Ceased AU2011308893B2 (en) 2010-09-30 2011-09-28 Method for removing residual organic solvent from microparticles

Country Status (8)

Country Link
EP (1) EP2621473A2 (ja)
JP (1) JP5808413B2 (ja)
CN (1) CN103370057A (ja)
AU (1) AU2011308893B2 (ja)
CA (1) CA2813301A1 (ja)
IL (1) IL225254A0 (ja)
RU (1) RU2013119811A (ja)
WO (1) WO2012044671A2 (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104382848B (zh) * 2014-10-20 2017-04-26 齐鲁制药有限公司 一种他克莫司混悬型滴眼液及其制备方法
CN109718209B (zh) * 2017-10-30 2021-03-05 浙江圣兆药物科技股份有限公司 一种低乙醇残留的利培酮微球冻干方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976761A (en) * 1995-09-20 1999-11-02 Clariant Finance (Bvi) Limited Fractionation of phenol formaldehyde condensate and photoresist compositions produced therefrom

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4637905A (en) * 1982-03-04 1987-01-20 Batelle Development Corporation Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones
CA2050911C (en) 1989-05-04 1997-07-15 Thomas R. Tice Encapsulation process and products therefrom
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
PH30995A (en) * 1989-07-07 1997-12-23 Novartis Inc Sustained release formulations of water soluble peptides.
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
WO2005032511A2 (en) * 2003-09-30 2005-04-14 Spherics, Inc. Nanoparticulate therapeutic biologically active agents
US20080317865A1 (en) * 2007-06-20 2008-12-25 Alkermes, Inc. Quench liquids and washing systems for production of microparticles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976761A (en) * 1995-09-20 1999-11-02 Clariant Finance (Bvi) Limited Fractionation of phenol formaldehyde condensate and photoresist compositions produced therefrom

Also Published As

Publication number Publication date
WO2012044671A3 (en) 2013-03-14
WO2012044671A2 (en) 2012-04-05
JP2013538854A (ja) 2013-10-17
EP2621473A2 (en) 2013-08-07
JP5808413B2 (ja) 2015-11-10
CA2813301A1 (en) 2012-04-05
AU2011308893A1 (en) 2013-05-09
CN103370057A (zh) 2013-10-23
RU2013119811A (ru) 2014-11-10
IL225254A0 (en) 2013-06-27

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired