AU2011228703A1 - Spirocyclic compounds and their use as therapeutic agents and diagnostic probes - Google Patents
Spirocyclic compounds and their use as therapeutic agents and diagnostic probes Download PDFInfo
- Publication number
- AU2011228703A1 AU2011228703A1 AU2011228703A AU2011228703A AU2011228703A1 AU 2011228703 A1 AU2011228703 A1 AU 2011228703A1 AU 2011228703 A AU2011228703 A AU 2011228703A AU 2011228703 A AU2011228703 A AU 2011228703A AU 2011228703 A1 AU2011228703 A1 AU 2011228703A1
- Authority
- AU
- Australia
- Prior art keywords
- oxa
- heptan
- morpholino
- azaspiro
- triazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000001257 hydrogen Substances 0.000 claims description 32
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Classifications
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1004200.0 | 2010-03-15 | ||
| GBGB1004200.0A GB201004200D0 (en) | 2010-03-15 | 2010-03-15 | Spirocyclic compounds and their use as therapeutic agents and diagnostic probes |
| PCT/IB2011/051047 WO2011114275A1 (en) | 2010-03-15 | 2011-03-11 | Spirocyclic compounds and their use as therapeutic agents and diagnostic probes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2011228703A1 true AU2011228703A1 (en) | 2012-09-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2011228703A Abandoned AU2011228703A1 (en) | 2010-03-15 | 2011-03-11 | Spirocyclic compounds and their use as therapeutic agents and diagnostic probes |
Country Status (15)
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| TWI547493B (zh) | 2011-09-27 | 2016-09-01 | 諾華公司 | 作為突變ｉｄｈ之抑制劑之３－嘧啶－４－基－唑啶－２－酮 |
| UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
| US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
| WO2014141104A1 (en) | 2013-03-14 | 2014-09-18 | Novartis Ag | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| UY35464A (es) | 2013-03-15 | 2014-10-31 | Araxes Pharma Llc | Inhibidores covalentes de kras g12c. |
| MA42164B1 (fr) | 2013-05-01 | 2019-12-31 | Hoffmann La Roche | Composes biheteroaryle et leurs utilisations |
| CN103483345B (zh) * | 2013-09-25 | 2016-07-06 | 中山大学 | Pi3k激酶抑制剂、包含其的药物组合物及其应用 |
| TWI659021B (zh) | 2013-10-10 | 2019-05-11 | 亞瑞克西斯製藥公司 | Ｋｒａｓ ｇ１２ｃ之抑制劑 |
| CN104557871B (zh) * | 2013-10-28 | 2017-05-03 | 上海汇伦生命科技有限公司 | 具有螺环取代基的芳基吗啉类化合物，其制备方法和用途 |
| KR102161927B1 (ko) | 2014-04-25 | 2020-10-06 | 블루버드 바이오, 인코포레이티드. | 양자 세포 치료제를 제조하는 개선된 방법 |
| MX382565B (es) | 2014-04-25 | 2025-03-13 | 2Seventy Bio Inc | Receptores de antigenos quimericos del promotor mnd. |
| ES2846811T3 (es) | 2014-06-06 | 2021-07-29 | Bluebird Bio Inc | Composiciones de células T mejoradas |
| SG10201900455YA (en) | 2014-07-24 | 2019-02-27 | Bluebird Bio Inc | Bcma chimeric antigen receptors |
| DK3212637T3 (da) | 2014-10-31 | 2021-07-12 | Indivior Uk Ltd | Dopamin-d3-receptorantagonistforbindelser |
| WO2016094304A2 (en) | 2014-12-12 | 2016-06-16 | Bluebird Bio, Inc. | Bcma chimeric antigen receptors |
| US11479755B2 (en) | 2015-12-07 | 2022-10-25 | 2Seventy Bio, Inc. | T cell compositions |
| EP3231799A1 (en) * | 2016-04-14 | 2017-10-18 | Universität Basel | 4-(azetidin-1-yl)pyrimidine derivatives with anti-mitotic and anti-proliferative activity |
| CN110022906A (zh) | 2016-11-04 | 2019-07-16 | 蓝鸟生物公司 | 抗bcma car t细胞组合物 |
| JP2020502224A (ja) * | 2016-12-21 | 2020-01-23 | 日本たばこ産業株式会社 | ヤヌスキナーゼ阻害剤の結晶形 |
| US11136308B2 (en) | 2017-01-26 | 2021-10-05 | Araxes Pharma Llc | Substituted quinazoline and quinazolinone compounds and methods of use thereof |
| JP7327802B2 (ja) | 2017-01-26 | 2023-08-16 | アラクセス ファーマ エルエルシー | 縮合ヘテロ－ヘテロ二環式化合物およびその使用方法 |
| EP3573971A1 (en) | 2017-01-26 | 2019-12-04 | Araxes Pharma LLC | 1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer |
| US11274093B2 (en) | 2017-01-26 | 2022-03-15 | Araxes Pharma Llc | Fused bicyclic benzoheteroaromatic compounds and methods of use thereof |
| WO2018140599A1 (en) | 2017-01-26 | 2018-08-02 | Araxes Pharma Llc | Benzothiophene and benzothiazole compounds and methods of use thereof |
| US10745385B2 (en) | 2017-05-25 | 2020-08-18 | Araxes Pharma Llc | Covalent inhibitors of KRAS |
| JP2020521740A (ja) | 2017-05-25 | 2020-07-27 | アラクセス ファーマ エルエルシー | 変異体ｋｒａｓ、ｈｒａｓまたはｎｒａｓの調節因子としてのキナゾリン誘導体 |
| EP3712157A4 (en) * | 2017-11-06 | 2021-04-28 | Medshine Discovery Inc. | PYRIDOPYRIMIDINE COMPOUNDS ACTING AS DOUBLE KINASE MTORC 1/2 INHIBITORS |
| CN108191837A (zh) * | 2018-01-10 | 2018-06-22 | 贵州医科大学 | PI3Kα/mTOR双激酶抑制剂及其药物组合物和应用 |
| BR112021001709A2 (pt) * | 2018-08-01 | 2021-05-04 | Araxes Pharma Llc | compostos espiro heterocíclicos e métodos de uso dos mesmos para o tratamento de câncer |
| EP4069366B1 (en) * | 2019-12-04 | 2025-03-19 | CHDI Foundation, Inc. | Atm kinase inhibitors and compositions and methods of use thereof |
| UA129208C2 (uk) * | 2019-12-19 | 2025-02-05 | Янссен Фармацевтика Нв | Заміщені спіропохідні з прямим ланцюгом |
| CA3198809A1 (en) * | 2020-10-20 | 2022-04-28 | Amgen Inc. | Heterocyclic spiro compounds and methods of use |
| WO2025137105A1 (en) * | 2023-12-22 | 2025-06-26 | Deciphera Pharmaceuticals, Llc | Dual raf and tubulin inhibitors and methods of use thereof |
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| KR100833371B1 (ko) | 2001-04-27 | 2008-05-28 | 젠야쿠코교가부시키가이샤 | 헤테로시클릭 화합물 및 이를 유효 성분으로 하는 항종양제 |
| EP1877388A2 (en) | 2005-02-25 | 2008-01-16 | Kudos Pharmaceuticals Ltd | Hydrazinomethyl, hydrazonomethyl and 5-membered heterocylic compounds which act as mtor inhibitors and their use as anti cancer agents |
| GB0525081D0 (en) | 2005-12-09 | 2006-01-18 | Astrazeneca Ab | Pyrimidine derivatives |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| WO2008032033A1 (en) | 2006-09-14 | 2008-03-20 | Astrazeneca Ab | 4-benzimidazolyl-2-morpholino-6-piperazinylpyrimidine derivatives as pi3k and mtor inhibitors for the treatment of proliferative disorders |
| JP2010503650A (ja) * | 2006-09-14 | 2010-02-04 | アストラゼネカ アクチボラグ | 増殖性疾患の治療のための、ｐｉ３ｋおよびｍｔｏｒ阻害剤としての２−ベンズイミダゾリル−６−モルホリノ−４−ピペリジン−４−イルピリミジン誘導体 |
| US8173647B2 (en) * | 2007-02-06 | 2012-05-08 | Gordana Atallah | PI 3-kinase inhibitors and methods of their use |
| GB0721095D0 (en) * | 2007-10-26 | 2007-12-05 | Piramed Ltd | Pharmaceutical compounds |
| EP2300469B1 (en) * | 2008-05-13 | 2015-06-24 | Novartis AG | Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors |
| AU2009248997A1 (en) * | 2008-05-23 | 2009-11-26 | Wyeth Llc | Triazine compounds as PI3 kinase and mTOR inhibitors |
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2011
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- 2011-03-11 CA CA2791737A patent/CA2791737A1/en not_active Abandoned
- 2011-03-11 JP JP2012557645A patent/JP2013522286A/ja active Pending
- 2011-03-11 CN CN2011800239958A patent/CN102939292A/zh active Pending
- 2011-03-11 KR KR1020127026689A patent/KR20130086520A/ko not_active Withdrawn
- 2011-03-11 US US13/635,016 patent/US20130040934A1/en not_active Abandoned
- 2011-03-11 WO PCT/IB2011/051047 patent/WO2011114275A1/en not_active Ceased
- 2011-03-11 MX MX2012010655A patent/MX2012010655A/es not_active Application Discontinuation
- 2011-03-11 BR BR112012023320A patent/BR112012023320A2/pt not_active IP Right Cessation
- 2011-03-11 RU RU2012143689/04A patent/RU2012143689A/ru not_active Application Discontinuation
- 2011-03-11 AU AU2011228703A patent/AU2011228703A1/en not_active Abandoned
- 2011-03-11 SG SG2012068094A patent/SG184062A1/en unknown
- 2011-03-11 NZ NZ602292A patent/NZ602292A/en not_active IP Right Cessation
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2012
- 2012-09-03 ZA ZA2012/06580A patent/ZA201206580B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2791737A1 (en) | 2011-09-22 |
| SG184062A1 (en) | 2012-10-30 |
| EP2547684A1 (en) | 2013-01-23 |
| BR112012023320A2 (pt) | 2016-05-24 |
| CN102939292A (zh) | 2013-02-20 |
| WO2011114275A1 (en) | 2011-09-22 |
| ZA201206580B (en) | 2013-05-29 |
| RU2012143689A (ru) | 2014-04-20 |
| MX2012010655A (es) | 2012-10-05 |
| KR20130086520A (ko) | 2013-08-02 |
| GB201004200D0 (en) | 2010-04-28 |
| NZ602292A (en) | 2014-08-29 |
| US20130040934A1 (en) | 2013-02-14 |
| JP2013522286A (ja) | 2013-06-13 |
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