AU2011221229B2 - Anti-angiogenesis therapy for the treatment of ovarian cancer - Google Patents

Anti-angiogenesis therapy for the treatment of ovarian cancer Download PDF

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Publication number
AU2011221229B2
AU2011221229B2 AU2011221229A AU2011221229A AU2011221229B2 AU 2011221229 B2 AU2011221229 B2 AU 2011221229B2 AU 2011221229 A AU2011221229 A AU 2011221229A AU 2011221229 A AU2011221229 A AU 2011221229A AU 2011221229 B2 AU2011221229 B2 AU 2011221229B2
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AU
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Prior art keywords
cancer
vegf
antibody
patient
day
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AU2011221229A
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AU2011221229A1 (en
Inventor
Jakob Dupont
Cornelia Irl
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F Hoffmann La Roche AG
Genentech Inc
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F Hoffmann La Roche AG
Genentech Inc
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Application filed by F Hoffmann La Roche AG, Genentech Inc filed Critical F Hoffmann La Roche AG
Publication of AU2011221229A1 publication Critical patent/AU2011221229A1/en
Application granted granted Critical
Publication of AU2011221229B2 publication Critical patent/AU2011221229B2/en
Priority to AU2015210479A priority Critical patent/AU2015210479A1/en
Priority to AU2017204320A priority patent/AU2017204320B2/en
Priority to AU2019203466A priority patent/AU2019203466A1/en
Priority to AU2019210484A priority patent/AU2019210484A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
    • G06Q99/00—Subject matter not provided for in other groups of this subclass
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • General Business, Economics & Management (AREA)
  • Business, Economics & Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Cell Biology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2011221229A 2010-02-23 2011-02-22 Anti-angiogenesis therapy for the treatment of ovarian cancer Active AU2011221229B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2015210479A AU2015210479A1 (en) 2010-02-23 2015-08-10 Anti-angiogenesis therapy for the treatment of ovarian cancer
AU2017204320A AU2017204320B2 (en) 2010-02-23 2017-06-26 Anti-angiogenesis therapy for the treatment of ovarian cancer
AU2019203466A AU2019203466A1 (en) 2010-02-23 2019-05-17 Anti-angiogenesis therapy for the treatment of ovarian cancer
AU2019210484A AU2019210484A1 (en) 2010-02-23 2019-07-29 Anti-angiogenesis therapy for the treatment of ovarian cancer

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US30709510P 2010-02-23 2010-02-23
US61/307,095 2010-02-23
US35123110P 2010-06-03 2010-06-03
US61/351,231 2010-06-03
US36005910P 2010-06-30 2010-06-30
US61/360,059 2010-06-30
US201161439819P 2011-02-04 2011-02-04
US61/439,819 2011-02-04
PCT/US2011/025651 WO2011106300A2 (en) 2010-02-23 2011-02-22 Anti-angiogenesis therapy for the treatment of ovarian cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2015210479A Division AU2015210479A1 (en) 2010-02-23 2015-08-10 Anti-angiogenesis therapy for the treatment of ovarian cancer

Publications (2)

Publication Number Publication Date
AU2011221229A1 AU2011221229A1 (en) 2012-08-16
AU2011221229B2 true AU2011221229B2 (en) 2015-06-18

Family

ID=44476669

Family Applications (5)

Application Number Title Priority Date Filing Date
AU2011221229A Active AU2011221229B2 (en) 2010-02-23 2011-02-22 Anti-angiogenesis therapy for the treatment of ovarian cancer
AU2015210479A Abandoned AU2015210479A1 (en) 2010-02-23 2015-08-10 Anti-angiogenesis therapy for the treatment of ovarian cancer
AU2017204320A Active AU2017204320B2 (en) 2010-02-23 2017-06-26 Anti-angiogenesis therapy for the treatment of ovarian cancer
AU2019203466A Abandoned AU2019203466A1 (en) 2010-02-23 2019-05-17 Anti-angiogenesis therapy for the treatment of ovarian cancer
AU2019210484A Abandoned AU2019210484A1 (en) 2010-02-23 2019-07-29 Anti-angiogenesis therapy for the treatment of ovarian cancer

Family Applications After (4)

Application Number Title Priority Date Filing Date
AU2015210479A Abandoned AU2015210479A1 (en) 2010-02-23 2015-08-10 Anti-angiogenesis therapy for the treatment of ovarian cancer
AU2017204320A Active AU2017204320B2 (en) 2010-02-23 2017-06-26 Anti-angiogenesis therapy for the treatment of ovarian cancer
AU2019203466A Abandoned AU2019203466A1 (en) 2010-02-23 2019-05-17 Anti-angiogenesis therapy for the treatment of ovarian cancer
AU2019210484A Abandoned AU2019210484A1 (en) 2010-02-23 2019-07-29 Anti-angiogenesis therapy for the treatment of ovarian cancer

Country Status (20)

Country Link
US (8) US8778340B2 (enExample)
EP (3) EP3064509A3 (enExample)
JP (6) JP2013520442A (enExample)
KR (4) KR102104197B1 (enExample)
CN (3) CN110227154A (enExample)
AR (1) AR080244A1 (enExample)
AU (5) AU2011221229B2 (enExample)
BR (1) BR112012020700A8 (enExample)
CA (2) CA2930248A1 (enExample)
CL (1) CL2012002326A1 (enExample)
CO (1) CO6592072A2 (enExample)
IL (2) IL221058B (enExample)
MA (1) MA34059B1 (enExample)
MX (3) MX2012009554A (enExample)
PH (2) PH12012501681A1 (enExample)
RU (1) RU2012140447A (enExample)
SG (2) SG10201401123VA (enExample)
TW (2) TWI457135B (enExample)
UA (1) UA114277C2 (enExample)
WO (1) WO2011106300A2 (enExample)

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