AU2010330813B2 - Methods and compositions for treating peripheral vascular disease - Google Patents

Methods and compositions for treating peripheral vascular disease Download PDF

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Publication number
AU2010330813B2
AU2010330813B2 AU2010330813A AU2010330813A AU2010330813B2 AU 2010330813 B2 AU2010330813 B2 AU 2010330813B2 AU 2010330813 A AU2010330813 A AU 2010330813A AU 2010330813 A AU2010330813 A AU 2010330813A AU 2010330813 B2 AU2010330813 B2 AU 2010330813B2
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AU
Australia
Prior art keywords
inhibitor
nitric oxide
phosphodiesterase type
oxide donor
arginine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010330813A
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English (en)
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AU2010330813A1 (en
AU2010330813A2 (en
Inventor
Crist J. Frangakis
Harry J. Leighton
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Exodos Life Sciences LP
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Exodos Life Sciences LP
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Publication of AU2010330813A1 publication Critical patent/AU2010330813A1/en
Publication of AU2010330813A2 publication Critical patent/AU2010330813A2/en
Application granted granted Critical
Publication of AU2010330813B2 publication Critical patent/AU2010330813B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2010330813A 2009-12-18 2010-12-17 Methods and compositions for treating peripheral vascular disease Ceased AU2010330813B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28796709P 2009-12-18 2009-12-18
US61/287,967 2009-12-18
PCT/US2010/061054 WO2011075655A1 (en) 2009-12-18 2010-12-17 Methods and compositions for treating peripheral vascular disease

Publications (3)

Publication Number Publication Date
AU2010330813A1 AU2010330813A1 (en) 2012-08-09
AU2010330813A2 AU2010330813A2 (en) 2012-08-09
AU2010330813B2 true AU2010330813B2 (en) 2016-04-28

Family

ID=44167718

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010330813A Ceased AU2010330813B2 (en) 2009-12-18 2010-12-17 Methods and compositions for treating peripheral vascular disease

Country Status (7)

Country Link
US (3) US20130053393A1 (https=)
EP (1) EP2512479B1 (https=)
JP (2) JP5960061B2 (https=)
AU (1) AU2010330813B2 (https=)
CA (1) CA2784788A1 (https=)
DK (1) DK2512479T3 (https=)
WO (1) WO2011075655A1 (https=)

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WO2011075691A1 (en) 2009-12-18 2011-06-23 Exodos Life Sciences Limited Partnership Methods and compositions for stable liquid drug formulations
HRP20150987T1 (hr) * 2010-05-26 2015-10-23 Adverio Pharma Gmbh UPORABA sGC STIMULATORA, sGC AKTIVATORA, SAMOSTALNO I U KOMBINACIJAMA S INHIBITORIMA PDE5 ZA LIJEÄŚENJE SISTEMSKE SKLEROZE (SSc)
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
JP2014526461A (ja) * 2011-09-09 2014-10-06 エスケー ケミカルズ カンパニー,リミテッド Pde5抑制剤を含む皮膚しわ改善用組成物
EP3024455A1 (en) 2013-07-25 2016-06-01 Bayer Pharma Aktiengesellschaft Sgc stimulators or sgc activators and pde5 inhibitors in combination with additional treatment for the therapy of cystic fibrosis
CN104644579A (zh) * 2013-11-25 2015-05-27 天津市汉康医药生物技术有限公司 一种阿伐那非药物组合物
JP6211406B2 (ja) * 2013-12-04 2017-10-11 ライオン株式会社 ムスカリン受容体活性化剤及び唾液分泌促進剤
JP6236304B2 (ja) * 2013-12-04 2017-11-22 ライオン株式会社 涙液分泌促進剤
US20160317542A1 (en) 2013-12-09 2016-11-03 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
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WO2016089893A1 (en) 2014-12-01 2016-06-09 Achelios Therapeutics Inc. Methods and compositions for treating migraine and conditions associated with pain
MX2017014057A (es) * 2015-05-06 2018-04-10 Bayer Pharma AG El uso de estimuladores sgc, activadores gc, solos y combinaciones con inhibidores pde5 para el tratamiento de ulceras digitales (du) concomitante con esclerosis sistemica (ssc).
US9993447B2 (en) * 2015-09-14 2018-06-12 JW Nutritional, LLC Systems and methods for increasing agmatine cellular uptake by oral administration
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EP4166129A1 (en) 2017-03-14 2023-04-19 Atir Holding S.A. Use of heterocyclic compounds in the treatment of aged skin
CA3055882A1 (en) 2017-03-14 2018-09-20 Atir Holding S.A. Topical formulation for the treatment of pigmented skin
MX2019013626A (es) 2017-05-22 2020-01-13 Topadur Pharma Ag Modo de accion dual novedoso de activadores de guanilato ciclasa solubles e inhibidores de fosfodiesterasa y usos de los mismos.
US11117808B2 (en) * 2017-08-01 2021-09-14 University Of Georgia Research Foundation, Inc. Mesoporous nitric oxide-releasing silica particles, methods of making, and uses thereof
KR20190043369A (ko) * 2017-10-18 2019-04-26 주식회사 코아팜바이오 유데나필의 신규한 반고형 제제
MX2017016930A (es) * 2017-12-19 2019-06-20 Malesil Research & Tech Llc Uso del maleato de sildenafil en el tratamiento de ulceras de pie diabetico.
CR20200630A (es) 2018-06-01 2021-05-26 Tavanta Therapeutics Hungary Incorporated Sales tópicas de amlodipino para el tratamiento de enfermedades anorrectales
EP3833395A1 (en) * 2018-08-06 2021-06-16 Nicox S.A. Nitric oxide releasing phosphodiesterase type 5 inhibitor
BR112021009958A2 (pt) 2018-11-28 2021-08-17 Topadur Pharma Ag modo duplo de ação de ativadores de guanilato ciclase solúveis e inibidores de fosfodiesterase e seus usos
WO2020123312A1 (en) 2018-12-09 2020-06-18 Weinberg Assa Method to prevent and treat macular degeneration by vasodilators
AU2020356193A1 (en) 2019-09-24 2022-05-19 Children's Hospital Of Philadelphia Methods of improving exercise performance, single ventricular performance, and myocardial performance index (MPI) in single ventricle heart disease, using udenafil compositions
WO2021245192A1 (en) 2020-06-04 2021-12-09 Topadur Pharma Ag Novel dual mode of action soluble guanylate cyclase activators and phosphodiesterase inhibitors and uses thereof
AU2021388141A1 (en) * 2020-11-25 2023-06-22 Aisa Pharma, Inc. Treatment of raynaud's disease
US11185513B1 (en) * 2021-05-07 2021-11-30 King Abdulaziz University Transfersome-containing transdermal film formulations and methods of use
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Also Published As

Publication number Publication date
US20150031704A1 (en) 2015-01-29
AU2010330813A1 (en) 2012-08-09
US20130053393A1 (en) 2013-02-28
JP5960061B2 (ja) 2016-08-02
HK1169941A1 (zh) 2013-02-15
CA2784788A1 (en) 2011-06-23
EP2512479A4 (en) 2013-07-17
EP2512479A1 (en) 2012-10-24
DK2512479T3 (en) 2016-06-06
AU2010330813A2 (en) 2012-08-09
US20180036314A1 (en) 2018-02-08
JP2013514995A (ja) 2013-05-02
WO2011075655A1 (en) 2011-06-23
JP2016166178A (ja) 2016-09-15
EP2512479B1 (en) 2016-03-30

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