AU2010308306A1 - Combination cancer therapy with HSP90 inhibitory compounds - Google Patents
Combination cancer therapy with HSP90 inhibitory compounds Download PDFInfo
- Publication number
- AU2010308306A1 AU2010308306A1 AU2010308306A AU2010308306A AU2010308306A1 AU 2010308306 A1 AU2010308306 A1 AU 2010308306A1 AU 2010308306 A AU2010308306 A AU 2010308306A AU 2010308306 A AU2010308306 A AU 2010308306A AU 2010308306 A1 AU2010308306 A1 AU 2010308306A1
- Authority
- AU
- Australia
- Prior art keywords
- optionally substituted
- triazole
- phenyl
- indol
- mercapto
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- OPIIJJPPFNOILK-HVOOWIBXSA-N CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@@H](CCN2CCOCC2)C([C@](C)([C@H](C[C@H]2OC3)OC)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)C(C)(C)[C@@]14O)=O)O)c1ccccc1)=O Chemical compound CC(C)(C)OC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@@H](CCN2CCOCC2)C([C@](C)([C@H](C[C@H]2OC3)OC)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)C(C)(C)[C@@]14O)=O)O)c1ccccc1)=O OPIIJJPPFNOILK-HVOOWIBXSA-N 0.000 description 1
- 0 CC(C)(C)SC(N[C@]([C@](C(O[C@@](C1)C(C)=C([C@](C([C@](C)([C@](C[C@]2OC3)O)[C@]([C@@]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=*)OC(C)=O)C(C)(C)[C@@]14O)=O)O)c1ccc[o]1)=O Chemical compound CC(C)(C)SC(N[C@]([C@](C(O[C@@](C1)C(C)=C([C@](C([C@](C)([C@](C[C@]2OC3)O)[C@]([C@@]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=*)OC(C)=O)C(C)(C)[C@@]14O)=O)O)c1ccc[o]1)=O 0.000 description 1
- KSXQJJHMTRFIQU-UWWCWNIOSA-N CC(C)CSC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C([C@](C)([C@H](CC2OC3)O)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)OC(C)O)C(C)(C)[C@@]14O)=O)O)C1OC=CC1)=O Chemical compound CC(C)CSC(N[C@H]([C@H](C(O[C@@H](C1)C(C)=C([C@H](C([C@](C)([C@H](CC2OC3)O)[C@H]([C@@H]4OC(c5ccccc5)=O)[C@@]23OC(C)=O)=O)OC(C)O)C(C)(C)[C@@]14O)=O)O)C1OC=CC1)=O KSXQJJHMTRFIQU-UWWCWNIOSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27933009P | 2009-10-19 | 2009-10-19 | |
| US61/279,330 | 2009-10-19 | ||
| US33577810P | 2010-01-11 | 2010-01-11 | |
| US61/335,778 | 2010-01-11 | ||
| PCT/US2010/053199 WO2011049946A1 (en) | 2009-10-19 | 2010-10-19 | Combination cancer therapy with hsp90 inhibitory compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2010308306A1 true AU2010308306A1 (en) | 2012-05-10 |
Family
ID=43218142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2010308306A Abandoned AU2010308306A1 (en) | 2009-10-19 | 2010-10-19 | Combination cancer therapy with HSP90 inhibitory compounds |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20120245186A1 (enExample) |
| EP (1) | EP2490688B1 (enExample) |
| JP (2) | JP2013508378A (enExample) |
| KR (1) | KR20120093970A (enExample) |
| CN (1) | CN102695504A (enExample) |
| AU (1) | AU2010308306A1 (enExample) |
| BR (1) | BR112012009215A2 (enExample) |
| CA (1) | CA2779233A1 (enExample) |
| CY (1) | CY1115902T1 (enExample) |
| DK (1) | DK2490688T3 (enExample) |
| EA (1) | EA022119B1 (enExample) |
| ES (1) | ES2526566T3 (enExample) |
| HR (1) | HRP20141150T1 (enExample) |
| MX (1) | MX2012004577A (enExample) |
| NZ (2) | NZ599445A (enExample) |
| PH (1) | PH12012500748A1 (enExample) |
| PL (1) | PL2490688T3 (enExample) |
| PT (1) | PT2490688E (enExample) |
| RS (1) | RS53716B1 (enExample) |
| SI (1) | SI2490688T1 (enExample) |
| WO (1) | WO2011049946A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007021966A1 (en) | 2005-08-12 | 2007-02-22 | Synta Pharmaceuticals Corp. | Pyrazole compounds that modulate hsp90 activity |
| US20070250391A1 (en) * | 2006-04-05 | 2007-10-25 | Prade Hendrik D | Merchandising system and method for food and non-food items for a meal kit |
| DK2035396T3 (da) | 2006-05-25 | 2014-06-02 | Synta Pharmaceuticals Corp | Triazolforbindelser der modulerer hsp90-aktivitet |
| WO2007140002A2 (en) | 2006-05-25 | 2007-12-06 | Synta Pharmaceuticals Corp. | Method for treating non-hodgkin's lymphoma |
| US8034834B2 (en) | 2006-05-25 | 2011-10-11 | Synta Pharmaceuticals Corp. | Method for treating proliferative disorders with HSP90 inhibitors |
| WO2009139916A1 (en) * | 2008-05-16 | 2009-11-19 | Synta Pharmaceuticals Corp. | Tricyclic triazole compounds that modulate hsp90 activity |
| WO2009148599A1 (en) | 2008-06-04 | 2009-12-10 | Synta Pharmaceuticals Corp. | Pyrrole compunds that modulate hsp90 activity |
| ES2415234T3 (es) * | 2008-08-08 | 2013-07-24 | Synta Pharmaceuticals Corp. | Compuestos de triazol que modulan la actividad Hsp90 |
| TW201011003A (en) | 2008-08-08 | 2010-03-16 | Synta Pharmaceuticals Corp | Triazole compounds that modulate HSP90 activity |
| CN102844313B (zh) | 2010-01-28 | 2016-10-05 | 哈佛大学校长及研究员协会 | 提高蛋白酶体活性的组合物和方法 |
| EP2560640A1 (en) | 2010-04-19 | 2013-02-27 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor |
| AU2011255438A1 (en) * | 2010-05-20 | 2013-01-10 | Synta Pharmaceuticals Corp. | Method of treating lung adenocarcinoma with Hsp90 inhibitory compounds |
| US20130172333A1 (en) * | 2010-05-20 | 2013-07-04 | Synta Pharmaceuticals Corp. | Formulation and dosing of hsp90 inhibitory compounds |
| EP2575810A1 (en) * | 2010-05-24 | 2013-04-10 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of a hsp90 inhibitory compound and a topoisomerase ii inhibitor |
| AU2011302344B2 (en) * | 2010-09-13 | 2015-01-15 | Synta Pharmaceuticals Corp. | HSP90 inhibitors for treating non-small cell lung cancers in wild-type EGFR and/or KRAS patients |
| US9556166B2 (en) | 2011-05-12 | 2017-01-31 | Proteostasis Therapeutics, Inc. | Proteostasis regulators |
| US20140228418A1 (en) * | 2011-05-23 | 2014-08-14 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with mek inhibitors |
| EP2714038A1 (en) * | 2011-05-24 | 2014-04-09 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with mtor/pi3k inhibitors |
| US20140194388A1 (en) * | 2011-05-26 | 2014-07-10 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitory compounds with chk inhibitors |
| EP2729144A2 (en) * | 2011-07-07 | 2014-05-14 | Synta Pharmaceuticals Corp. | Treating cancer with hsp90 inhibitory compounds |
| CA2853799A1 (en) * | 2011-11-02 | 2013-05-10 | Synta Pharmaceuticals Corp. | Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors |
| AU2012332424A1 (en) * | 2011-11-02 | 2014-06-05 | Synta Pharmaceuticals Corp. | Combination therapy of Hsp90 inhibitors with platinum-containing agents |
| WO2013074594A1 (en) * | 2011-11-14 | 2013-05-23 | Synta Pharmaceuticals Corp. | Combination therapy of hsp90 inhibitors with braf inhibitors |
| WO2014116228A1 (en) | 2013-01-25 | 2014-07-31 | President And Fellows Of Harvard College | Usp14 inhibitors for treating or preventing viral infections |
| CA2928568A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
| WO2015073528A1 (en) | 2013-11-12 | 2015-05-21 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
| SG11201700777VA (en) | 2014-08-04 | 2017-02-27 | Nuevolution As | Optionally fused heterocyclyl-substituted derivatives of pyrimidine useful for the treatment of inflammatory, metabolic, oncologic and autoimmune diseases |
| BR112018002399A2 (pt) | 2015-08-06 | 2018-09-25 | Chimerix, Inc. | nucleosídeos de pirrolopirimidina e análogos dos mesmos, úteis como agentes antivirais |
| CN105237533B (zh) * | 2015-10-26 | 2017-03-22 | 中国药科大学 | 四氢吡啶并[4,3‑d]嘧啶类Hsp90抑制剂及其医药用途 |
| EP3684771B1 (en) | 2017-09-21 | 2024-11-27 | Chimerix, Inc. | Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7h-pyrrolo(2,3-d)pyrimidine-5-carboxamide and uses thereof |
| EP4076657A1 (en) | 2019-12-20 | 2022-10-26 | Nuevolution A/S | Compounds active towards nuclear receptors |
| EP4076661A1 (en) | 2019-12-20 | 2022-10-26 | Nuevolution A/S | Compounds active towards nuclear receptors |
| EP4126875A1 (en) | 2020-03-31 | 2023-02-08 | Nuevolution A/S | Compounds active towards nuclear receptors |
| WO2021198955A1 (en) | 2020-03-31 | 2021-10-07 | Nuevolution A/S | Compounds active towards nuclear receptors |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| US6274171B1 (en) | 1996-03-25 | 2001-08-14 | American Home Products Corporation | Extended release formulation of venlafaxine hydrochloride |
| EP1817295B1 (en) | 2004-11-18 | 2012-11-07 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| US8034834B2 (en) * | 2006-05-25 | 2011-10-11 | Synta Pharmaceuticals Corp. | Method for treating proliferative disorders with HSP90 inhibitors |
| DE102007002715A1 (de) * | 2007-01-18 | 2008-07-24 | Merck Patent Gmbh | Triazolderivat |
| CN101641117B (zh) * | 2007-03-05 | 2012-06-13 | 协和发酵麒麟株式会社 | 药物组合物 |
| WO2009002321A1 (en) | 2007-06-27 | 2008-12-31 | Thomson Licensing | Enhancing image quality |
| EP2193135A1 (en) * | 2007-08-13 | 2010-06-09 | Synta Pharmaceuticals Corp. | Triazole compounds that modulate hsp90 activity |
| EP2729144A2 (en) * | 2011-07-07 | 2014-05-14 | Synta Pharmaceuticals Corp. | Treating cancer with hsp90 inhibitory compounds |
-
2010
- 2010-10-19 RS RS20140705A patent/RS53716B1/sr unknown
- 2010-10-19 CN CN201080056689XA patent/CN102695504A/zh active Pending
- 2010-10-19 NZ NZ599445A patent/NZ599445A/en not_active IP Right Cessation
- 2010-10-19 BR BR112012009215A patent/BR112012009215A2/pt not_active IP Right Cessation
- 2010-10-19 WO PCT/US2010/053199 patent/WO2011049946A1/en not_active Ceased
- 2010-10-19 HR HRP20141150AT patent/HRP20141150T1/hr unknown
- 2010-10-19 SI SI201030832T patent/SI2490688T1/sl unknown
- 2010-10-19 EP EP10768357.5A patent/EP2490688B1/en active Active
- 2010-10-19 PH PH1/2012/500748A patent/PH12012500748A1/en unknown
- 2010-10-19 KR KR1020127012977A patent/KR20120093970A/ko not_active Ceased
- 2010-10-19 NZ NZ622713A patent/NZ622713A/en not_active IP Right Cessation
- 2010-10-19 EA EA201270570A patent/EA022119B1/ru not_active IP Right Cessation
- 2010-10-19 MX MX2012004577A patent/MX2012004577A/es active IP Right Grant
- 2010-10-19 DK DK10768357.5T patent/DK2490688T3/en active
- 2010-10-19 JP JP2012535301A patent/JP2013508378A/ja not_active Ceased
- 2010-10-19 CA CA2779233A patent/CA2779233A1/en not_active Abandoned
- 2010-10-19 PT PT107683575T patent/PT2490688E/pt unknown
- 2010-10-19 US US13/501,608 patent/US20120245186A1/en not_active Abandoned
- 2010-10-19 ES ES10768357.5T patent/ES2526566T3/es active Active
- 2010-10-19 AU AU2010308306A patent/AU2010308306A1/en not_active Abandoned
- 2010-10-19 PL PL10768357T patent/PL2490688T3/pl unknown
-
2014
- 2014-12-31 CY CY20141101097T patent/CY1115902T1/el unknown
-
2015
- 2015-10-08 JP JP2015199844A patent/JP2016041715A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20120093970A (ko) | 2012-08-23 |
| MX2012004577A (es) | 2012-06-13 |
| ES2526566T3 (es) | 2015-01-13 |
| PH12012500748A1 (en) | 2012-10-29 |
| WO2011049946A1 (en) | 2011-04-28 |
| US20120245186A1 (en) | 2012-09-27 |
| HRP20141150T1 (hr) | 2015-01-30 |
| DK2490688T3 (en) | 2014-12-08 |
| RS53716B1 (sr) | 2015-04-30 |
| JP2013508378A (ja) | 2013-03-07 |
| SI2490688T1 (sl) | 2015-01-30 |
| CA2779233A1 (en) | 2011-04-28 |
| JP2016041715A (ja) | 2016-03-31 |
| HK1175112A1 (en) | 2013-06-28 |
| EA201270570A1 (ru) | 2012-09-28 |
| EP2490688A1 (en) | 2012-08-29 |
| NZ599445A (en) | 2014-04-30 |
| CY1115902T1 (el) | 2017-01-25 |
| BR112012009215A2 (pt) | 2019-09-24 |
| NZ622713A (en) | 2015-07-31 |
| PT2490688E (pt) | 2014-12-29 |
| EA022119B1 (ru) | 2015-11-30 |
| CN102695504A (zh) | 2012-09-26 |
| PL2490688T3 (pl) | 2015-03-31 |
| EP2490688B1 (en) | 2014-10-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |