AU2010306755B2 - Pharmaceutical formulations of nitrite and uses thereof - Google Patents

Pharmaceutical formulations of nitrite and uses thereof Download PDF

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Publication number
AU2010306755B2
AU2010306755B2 AU2010306755A AU2010306755A AU2010306755B2 AU 2010306755 B2 AU2010306755 B2 AU 2010306755B2 AU 2010306755 A AU2010306755 A AU 2010306755A AU 2010306755 A AU2010306755 A AU 2010306755A AU 2010306755 B2 AU2010306755 B2 AU 2010306755B2
Authority
AU
Australia
Prior art keywords
nitrite
pharmaceutical composition
human
pharmaceutically acceptable
release
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010306755A
Other languages
English (en)
Other versions
AU2010306755A1 (en
Inventor
Panayiotis P. Constantinides
Douglas R. Flanagan
Anthony Giordano
Christopher Kevil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TheraVasc Inc
Original Assignee
TheraVasc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by TheraVasc Inc filed Critical TheraVasc Inc
Publication of AU2010306755A1 publication Critical patent/AU2010306755A1/en
Application granted granted Critical
Publication of AU2010306755B2 publication Critical patent/AU2010306755B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2068Compounds of unknown constitution, e.g. material from plants or animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2010306755A 2009-10-14 2010-10-14 Pharmaceutical formulations of nitrite and uses thereof Ceased AU2010306755B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25148309P 2009-10-14 2009-10-14
US61/251,483 2009-10-14
PCT/US2010/052683 WO2011047161A1 (en) 2009-10-14 2010-10-14 Pharmaceutical formulations of nitrite and uses thereof

Publications (2)

Publication Number Publication Date
AU2010306755A1 AU2010306755A1 (en) 2012-05-03
AU2010306755B2 true AU2010306755B2 (en) 2015-12-24

Family

ID=43855036

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010306755A Ceased AU2010306755B2 (en) 2009-10-14 2010-10-14 Pharmaceutical formulations of nitrite and uses thereof

Country Status (10)

Country Link
US (4) US10463689B2 (cg-RX-API-DMAC7.html)
EP (1) EP2488035B1 (cg-RX-API-DMAC7.html)
JP (3) JP5758904B2 (cg-RX-API-DMAC7.html)
CN (2) CN107260756A (cg-RX-API-DMAC7.html)
AU (1) AU2010306755B2 (cg-RX-API-DMAC7.html)
CA (1) CA2777066C (cg-RX-API-DMAC7.html)
ES (1) ES2633618T3 (cg-RX-API-DMAC7.html)
IL (1) IL219155A0 (cg-RX-API-DMAC7.html)
IN (1) IN2012DN03428A (cg-RX-API-DMAC7.html)
WO (1) WO2011047161A1 (cg-RX-API-DMAC7.html)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009065142A2 (en) 2007-11-15 2009-05-22 Biomedical Research Foundation Of Northwest Louisiana Use of nitrite salts in chronic ischemia
US9241999B2 (en) * 2009-06-15 2016-01-26 Board Of Regents Of The University Of Texas System Method of producing physiological and therapeutic levels of nitric oxide through an oral delivery system
WO2010147742A2 (en) 2009-06-18 2010-12-23 Theravasc Inc. Use of nitrite salts in treating tissue damage
WO2011047161A1 (en) 2009-10-14 2011-04-21 TheraVasc, LLC Pharmaceutical formulations of nitrite and uses thereof
US8627204B2 (en) * 2011-10-18 2014-01-07 Microsoft Corporation Custom optimization of web pages
DK2958573T3 (da) * 2013-02-20 2019-08-05 The Board Of Supervisors Of The Louisiana State Univ Mechanical And Agricultural College Farmaceutiske formuleringer af nitrit og anvendelser deraf
EP2994165A4 (en) * 2013-05-10 2017-01-04 Nitromega Corp. Nutritional or dietary supplements containing fatty acids and nitrite
GB201309092D0 (en) * 2013-05-20 2013-07-03 Edixomed Ltd Transdermal delivery system
US11247902B2 (en) 2016-06-06 2022-02-15 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Pharmaceutical formulations of nitrite and uses thereof
JP2020508308A (ja) 2017-02-20 2020-03-19 ボード オブ スーパーバイザーズ オブ ルイジアナ ステート ユニバーシティ アンド アグリカルチュアル アンド メカニカル カレッジ 心房細動の治療及び予防における硫化水素及び/又は亜硝酸塩
US11850271B1 (en) * 2023-05-16 2023-12-26 King Faisal University Topical skin cream

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US20070154569A1 (en) * 2003-07-09 2007-07-05 The Govt. of the U.S.A. through The Dept. of Health and Human Services Use of nitrite salts for the treatment of cardiovascular conditions
US20090196930A1 (en) * 2007-12-27 2009-08-06 Aires Pharmaceuticals, Inc. Aerosolized nitrite and nitric oxide -donating compounds and uses thereof

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US4650484A (en) 1983-02-03 1987-03-17 Alza Corporation Method for treating ischemic conditions
IE64726B1 (en) 1987-11-20 1995-08-23 Elan Corp Plc Pharmaceutical formulations for preventing drug tolerance
US5122384A (en) 1989-05-05 1992-06-16 Kv Pharmaceutical Company Oral once-per-day organic nitrate formulation which does not induce tolerance
US5278192A (en) 1992-07-02 1994-01-11 The Research Foundation Of State University Of New York Method of vasodilator therapy for treating a patient with a condition
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US20110196039A9 (en) * 1994-10-05 2011-08-11 Kaesemeyer Wayne H Controlled release arginine formulations
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CA2379211A1 (fr) 2002-03-28 2003-09-28 Institut De Cardiologie De Montreal Utilisation du bleu de methylene pour renverser la reaction hemodynamique exageree induite par la combinaison d'un derive nitre et du sildenafil ou d'une molecule de meme classe (inhibiteur de la phosphodiesterase)
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WO2011047161A1 (en) 2009-10-14 2011-04-21 TheraVasc, LLC Pharmaceutical formulations of nitrite and uses thereof
US20130209584A1 (en) 2009-10-14 2013-08-15 Theravasc Inc. Pharmaceutical formulations of nitrite and uses thereof
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US5994444A (en) * 1997-10-16 1999-11-30 Medtronic, Inc. Polymeric material that releases nitric oxide
US20070154569A1 (en) * 2003-07-09 2007-07-05 The Govt. of the U.S.A. through The Dept. of Health and Human Services Use of nitrite salts for the treatment of cardiovascular conditions
US20090196930A1 (en) * 2007-12-27 2009-08-06 Aires Pharmaceuticals, Inc. Aerosolized nitrite and nitric oxide -donating compounds and uses thereof

Also Published As

Publication number Publication date
CA2777066C (en) 2020-02-18
IL219155A0 (en) 2012-06-28
EP2488035B1 (en) 2017-04-26
JP5758904B2 (ja) 2015-08-05
JP2017141275A (ja) 2017-08-17
IN2012DN03428A (cg-RX-API-DMAC7.html) 2015-10-23
CN102686111A (zh) 2012-09-19
CA2777066A1 (en) 2011-04-21
US20200085861A1 (en) 2020-03-19
US20200297756A1 (en) 2020-09-24
CN107260756A (zh) 2017-10-20
JP6125567B2 (ja) 2017-05-10
US20110086069A1 (en) 2011-04-14
WO2011047161A1 (en) 2011-04-21
US10463689B2 (en) 2019-11-05
ES2633618T3 (es) 2017-09-22
JP2013508289A (ja) 2013-03-07
US20160067279A1 (en) 2016-03-10
EP2488035A1 (en) 2012-08-22
AU2010306755A1 (en) 2012-05-03
JP2015180674A (ja) 2015-10-15
EP2488035A4 (en) 2013-07-31
US10307441B2 (en) 2019-06-04

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired