AU2010298141B2 - Compositions and methods for the prevention and treatment of metabolic diseases - Google Patents

Compositions and methods for the prevention and treatment of metabolic diseases Download PDF

Info

Publication number
AU2010298141B2
AU2010298141B2 AU2010298141A AU2010298141A AU2010298141B2 AU 2010298141 B2 AU2010298141 B2 AU 2010298141B2 AU 2010298141 A AU2010298141 A AU 2010298141A AU 2010298141 A AU2010298141 A AU 2010298141A AU 2010298141 B2 AU2010298141 B2 AU 2010298141B2
Authority
AU
Australia
Prior art keywords
bone
milk
derived
minerals
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010298141A
Other languages
English (en)
Other versions
AU2010298141A1 (en
Inventor
Rajan V. Vembu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of AU2010298141A1 publication Critical patent/AU2010298141A1/en
Application granted granted Critical
Publication of AU2010298141B2 publication Critical patent/AU2010298141B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20Milk; Whey; Colostrum
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/14Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
    • A23C9/142Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
    • A23C9/1425Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration by ultrafiltration, microfiltration or diafiltration of whey, e.g. treatment of the UF permeate
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/14Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
    • A23C9/142Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration
    • A23C9/1427Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by dialysis, reverse osmosis or ultrafiltration by dialysis, reverse osmosis or hyperfiltration, e.g. for concentrating or desalting
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/14Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment
    • A23C9/146Milk preparations; Milk powder or milk powder preparations in which the chemical composition of the milk is modified by non-chemical treatment by ion-exchange
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K10/00Animal feeding-stuffs
    • A23K10/20Animal feeding-stuffs from material of animal origin
    • A23K10/26Animal feeding-stuffs from material of animal origin from waste material, e.g. feathers, bones or skin
    • A23K10/28Animal feeding-stuffs from material of animal origin from waste material, e.g. feathers, bones or skin from waste dairy products
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K20/00Accessory food factors for animal feeding-stuffs
    • A23K20/10Organic substances
    • A23K20/142Amino acids; Derivatives thereof
    • A23K20/147Polymeric derivatives, e.g. peptides or proteins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/20Feeding-stuffs specially adapted for particular animals for horses
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/40Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A23K50/42Dry feed
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/70Feeding-stuffs specially adapted for particular animals for birds
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23KFODDER
    • A23K50/00Feeding-stuffs specially adapted for particular animals
    • A23K50/70Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75Feeding-stuffs specially adapted for particular animals for birds for poultry
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/19Dairy proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/01Hydrolysed proteins; Derivatives thereof
    • A61K38/012Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/018Hydrolysed proteins; Derivatives thereof from animals from milk
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/02Peptides of undefined number of amino acids; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87Re-use of by-products of food processing for fodder production

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Birds (AREA)
  • Animal Husbandry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Water Supply & Treatment (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physiology (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
AU2010298141A 2009-09-24 2010-09-24 Compositions and methods for the prevention and treatment of metabolic diseases Ceased AU2010298141B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24550509P 2009-09-24 2009-09-24
US61/245,505 2009-09-24
PCT/US2010/050202 WO2011038230A2 (en) 2009-09-24 2010-09-24 Compositions and methods for the prevention and treatment of metabolic diseases

Publications (2)

Publication Number Publication Date
AU2010298141A1 AU2010298141A1 (en) 2012-04-19
AU2010298141B2 true AU2010298141B2 (en) 2015-12-17

Family

ID=43796456

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010298141A Ceased AU2010298141B2 (en) 2009-09-24 2010-09-24 Compositions and methods for the prevention and treatment of metabolic diseases

Country Status (8)

Country Link
US (4) US8518453B2 (enExample)
EP (1) EP2480099B1 (enExample)
JP (1) JP2013505950A (enExample)
AU (1) AU2010298141B2 (enExample)
CA (1) CA2775276C (enExample)
NZ (1) NZ599184A (enExample)
RU (1) RU2565020C2 (enExample)
WO (2) WO2011037957A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011037957A2 (en) 2009-09-24 2011-03-31 U.S. Foods & Pharmaceuticals, Inc. Compositions and methods for bone repair, maintenance and regeneration
CN103599521A (zh) * 2013-11-08 2014-02-26 苏州冉新生物技术有限公司 一种复合维生素d冲剂
BE1027357B1 (nl) * 2019-06-12 2021-01-18 Vanlommel Maria Kristel Voedingssupplement voor versnelde genezing

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639501A (en) * 1995-01-31 1997-06-17 Vembu; Rajan Separation of minerals from whey permeate
US6740334B2 (en) * 1999-03-30 2004-05-25 Show Brand Products Co., Ltd. Bone resorption suppressing agent
EP0786473B1 (en) * 1996-01-23 2005-03-30 Snow Brand Milk Products Co., Ltd. Basic protein composition, basic peptide composition and application thereof
EP1602284A1 (en) * 2000-06-09 2005-12-07 Snow Brand Milk Products, Co., Ltd. Method of producing fractions containing a high concentration of milk basic cystatin and decomposition products thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3615664A (en) * 1969-12-05 1971-10-26 Foremost Mckesson Treatment of whey
US3896241A (en) * 1971-09-01 1975-07-22 Coca Cola Co Preparation of a whey protein concentrate
US4572837A (en) * 1984-06-28 1986-02-25 The British Food Manufacturing Industries Research Association Protein product
NL9001692A (nl) * 1990-04-26 1991-11-18 Cooeperatieve Melkproductenbed Werkwijze voor de bereiding van een olie-in-water emulsie.
EP0545946B1 (en) * 1990-07-13 2005-01-19 Gropep Limited Growth-promoting agent
US7033610B2 (en) * 1990-07-13 2006-04-25 Gropep Pty, Ltd. Growth-promoting agent
JP3604159B2 (ja) * 1992-05-07 2004-12-22 雪印乳業株式会社 乳清由来の骨芽細胞増殖促進及び骨強化因子ならびに該因子を含有せしめた骨強化食品、医薬および飼料
JP3693359B2 (ja) * 1993-07-21 2005-09-07 マルハ株式会社 骨強化促進剤
US5912032A (en) * 1995-05-11 1999-06-15 Meiji Milk Products Company, Limited Process of producing calcium-supplemented milk drinks
JP3454487B2 (ja) * 1995-06-29 2003-10-06 雪印乳業株式会社 乳由来カルシウム含有組成物及びその製造方法
US6139901A (en) * 1997-09-16 2000-10-31 New Zealand Milk Products (North Amerca) Inc. Membrane filtered milk proteins varying in composition and functional attributes
JP4701472B2 (ja) * 2000-04-21 2011-06-15 雪印乳業株式会社 乳カルシウム組成物の製造方法
JP2001346519A (ja) * 2000-06-09 2001-12-18 Snow Brand Milk Prod Co Ltd 乳塩基性シスタチン高含有画分及びその分解物の製造方法
JP4647750B2 (ja) * 2000-06-20 2011-03-09 雪印乳業株式会社 乳塩基性シスタチン高含有画分及びその分解物の製造法
NZ507335A (en) * 2000-10-05 2004-10-29 New Zealand Dairy Board Bone health compositions derived from milk comprising an acidic protein fraction but that does not contain CGMP
US20030026845A1 (en) * 2001-06-18 2003-02-06 Etzel Lisa R. Process for preparing protein isolate from milk, whey, colostrum, and the like
US20030118662A1 (en) * 2001-12-05 2003-06-26 Glanbia Foods, Inc. Therapeutic uses of milk mineral fortified food products
FR2841747B1 (fr) * 2002-07-02 2004-08-20 Cie Laitiere Europeenne Isolat de proteines de lait et procede pour sa preparation
JP2004115509A (ja) * 2002-09-05 2004-04-15 Snow Brand Milk Prod Co Ltd 破骨細胞分化抑制因子産生促進剤
KR100509177B1 (ko) * 2003-02-05 2005-08-22 롯데제과주식회사 골다공증 예방용 기능성 식품 조성물
JP4536341B2 (ja) * 2003-08-15 2010-09-01 雪印乳業株式会社 骨形成促進剤
US8895540B2 (en) * 2003-11-26 2014-11-25 DePuy Synthes Products, LLC Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor
US20050208638A1 (en) * 2004-03-22 2005-09-22 Chao Wu Process for preparing bioactive protein-enriched whey products
WO2006058083A2 (en) * 2004-11-24 2006-06-01 Cornell Research Foundation, Inc. Protein and calcium fortification system for clear and opaque beverages
ZA200804292B (en) * 2005-11-30 2009-09-30 Unilever Plc Calcium fortified food product and additive
DE102006009799A1 (de) * 2006-03-01 2007-09-06 Henkel Kgaa Vorwiegend plättchenförmige schwer wasserlösliche Calciumsalze und/oder deren Kompositmaterialien, umfassend diese
FR2901796A1 (fr) * 2006-05-31 2007-12-07 Lab Francais Du Fractionnement Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
WO2008028194A2 (en) * 2006-09-01 2008-03-06 Cornell Research Foundation, Inc. Calcium phosphate nanofibers
JP5657200B2 (ja) * 2008-09-05 2015-01-21 サントリー食品インターナショナル株式会社 乳清タンパク質の含有量が低減された乳組成物及び乳入り飲料
WO2011037957A2 (en) 2009-09-24 2011-03-31 U.S. Foods & Pharmaceuticals, Inc. Compositions and methods for bone repair, maintenance and regeneration

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639501A (en) * 1995-01-31 1997-06-17 Vembu; Rajan Separation of minerals from whey permeate
EP0786473B1 (en) * 1996-01-23 2005-03-30 Snow Brand Milk Products Co., Ltd. Basic protein composition, basic peptide composition and application thereof
US6740334B2 (en) * 1999-03-30 2004-05-25 Show Brand Products Co., Ltd. Bone resorption suppressing agent
EP1602284A1 (en) * 2000-06-09 2005-12-07 Snow Brand Milk Products, Co., Ltd. Method of producing fractions containing a high concentration of milk basic cystatin and decomposition products thereof

Also Published As

Publication number Publication date
JP2013505950A (ja) 2013-02-21
NZ599184A (en) 2013-04-26
CA2775276A1 (en) 2011-03-31
WO2011038230A2 (en) 2011-03-31
US20110189337A1 (en) 2011-08-04
WO2011037957A2 (en) 2011-03-31
EP2480099B1 (en) 2018-12-12
WO2011038230A3 (en) 2011-08-11
US20130029017A1 (en) 2013-01-31
US20140227409A1 (en) 2014-08-14
US8557296B2 (en) 2013-10-15
US20170027989A1 (en) 2017-02-02
EP2480099A2 (en) 2012-08-01
EP2480099A4 (en) 2015-05-27
RU2012114489A (ru) 2013-10-27
AU2010298141A1 (en) 2012-04-19
RU2565020C2 (ru) 2015-10-10
CA2775276C (en) 2021-07-06
WO2011037957A3 (en) 2012-02-23
US8518453B2 (en) 2013-08-27

Similar Documents

Publication Publication Date Title
Semler et al. First use of the RANKL antibody denosumab in osteogenesis imperfecta type VI
van Riet et al. Impact of nutrition on lameness and claw health in sows
Fujita et al. Effect of an intermittent weekly dose of human parathyroid hormone (1-34) on osteoporosis: a randomized double-masked prospective study using three dose levels
US20170027989A1 (en) Compositions and Methods for the Prevention and Treatment of Metabolic Diseases
LEE et al. Disorders of bone metabolism in severely handicapped children and young adults
Barr et al. Hypercalcemic nephropathy in three dogs: sonographic appearance
JP6203724B2 (ja) 骨疾患の予防又は治療用タンパク質素材及びその製造方法
Chinoy et al. Current status in therapeutic interventions of neonatal bone mineral metabolic disorders
CN115399370A (zh) 高钙鲜牛奶及其制备方法和应用
Tymczyna et al. Relationships between biochemical bone metabolism indices and morphometric, densitometric and mechanical properties of mandible in 6-month-old pigs
Evason et al. Suspect osteogenesis imperfecta in a male kitten
Uçaktürk et al. Enzyme replacement therapy in hypophosphatasia
Ghanem et al. Evaluation of Four Treatment Protocols on Experimentally Induced Nutritional Secondary Hyperparathyroidism in Kittens
Prentice The effects of silicon on skeletal integrity in poultry
JP6203723B2 (ja) 骨疾患の予防又は治療用タンパク質素材及びその製造方法
Shah et al. Evaluation of the efficacy and safety of lactoferrin combination in improving bone mineral density in healthy male dogs
Aithal et al. Effects of Nandrolone and TGF-β1 in growing rabbits with osteopenia induced by over-supplementation of calcium and vitamin D3
da Costa Hyperparathyroidism
O’Mara Hypophosphatemic Rickets: A Targeted Literature Review to
Cohen-Mivtach Renal Osteodystrophy in 2 Canine Patients
Liebross et al. Renal osteodystrophy
McKinnon Effect of goat milk on bone mass, morphology and biomechanics: a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Anatomy and Physiology at Massey University, Palmerston North, New Zealand
Behets et al. Gastrointestinal calcium absorption after ingestion of non calcium containing phosphate binders
Arundel et al. Evolution of the radiographic appearance of the metaphyses over the first year of life in type V osteogenesis imperfecta: clues to pathogenesis
Colburn Metabolic Bone Disorders

Legal Events

Date Code Title Description
MK4 Application lapsed section 142(2)(d) - no continuation fee paid for the application
NA Applications received for extensions of time, section 223

Free format text: AN APPLICATION TO EXTEND THE TIME FROM 24 SEP 2014 TO 24 APR 2015 IN WHICH TO PAY A CONTINUATION FEE HAS BEEN FILED .

NA Applications received for extensions of time, section 223

Free format text: AN APPLICATION TO EXTEND THE TIME FROM 27 JUN 2015 TO 27 DEC 2015 IN WHICH TO GAIN ACCEPTANCE HAS BEEN FILED .

NB Applications allowed - extensions of time section 223(2)

Free format text: THE TIME IN WHICH TO PAY A CONTINUATION FEE HAS BEEN EXTENDED TO 24 APR 2015 .

NB Applications allowed - extensions of time section 223(2)

Free format text: THE TIME IN WHICH TO GAIN ACCEPTANCE HAS BEEN EXTENDED TO 27 DEC 2015 .

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired