AU2010277554B2 - Combination of a chemotherapeutic agent and an inhibitor of the TGF-beta system - Google Patents

Combination of a chemotherapeutic agent and an inhibitor of the TGF-beta system Download PDF

Info

Publication number
AU2010277554B2
AU2010277554B2 AU2010277554A AU2010277554A AU2010277554B2 AU 2010277554 B2 AU2010277554 B2 AU 2010277554B2 AU 2010277554 A AU2010277554 A AU 2010277554A AU 2010277554 A AU2010277554 A AU 2010277554A AU 2010277554 B2 AU2010277554 B2 AU 2010277554B2
Authority
AU
Australia
Prior art keywords
carcinoma
cancer
tgf
beta
antisense oligonucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010277554A
Other languages
English (en)
Other versions
AU2010277554A1 (en
Inventor
Frank Jaschinski
Tanja Rothammer
Karl-Hermann Schlingensiepen
Anneliese Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Isarna Therapeutics GmbH
Original Assignee
Antisense Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41278403&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2010277554(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Antisense Pharma GmbH filed Critical Antisense Pharma GmbH
Publication of AU2010277554A1 publication Critical patent/AU2010277554A1/en
Application granted granted Critical
Publication of AU2010277554B2 publication Critical patent/AU2010277554B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
AU2010277554A 2009-07-30 2010-07-30 Combination of a chemotherapeutic agent and an inhibitor of the TGF-beta system Ceased AU2010277554B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09166893 2009-07-30
EP09166893.9 2009-07-30
PCT/EP2010/061152 WO2011012713A1 (en) 2009-07-30 2010-07-30 Combination of a chemotherapeutic agent and an inhibitor of the tgf-beta system

Publications (2)

Publication Number Publication Date
AU2010277554A1 AU2010277554A1 (en) 2012-03-01
AU2010277554B2 true AU2010277554B2 (en) 2015-02-19

Family

ID=41278403

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010277554A Ceased AU2010277554B2 (en) 2009-07-30 2010-07-30 Combination of a chemotherapeutic agent and an inhibitor of the TGF-beta system

Country Status (17)

Country Link
US (1) US8476246B2 (forum.php)
EP (1) EP2340308B1 (forum.php)
JP (1) JP2013500313A (forum.php)
KR (1) KR20120107456A (forum.php)
CN (1) CN102712924A (forum.php)
AU (1) AU2010277554B2 (forum.php)
BR (1) BR112012002102A2 (forum.php)
CA (1) CA2769618A1 (forum.php)
CL (1) CL2012000247A1 (forum.php)
CO (1) CO6511199A2 (forum.php)
EC (1) ECSP12011689A (forum.php)
IL (1) IL217821A0 (forum.php)
IN (1) IN2012DN00969A (forum.php)
MX (1) MX2012001244A (forum.php)
PE (1) PE20121495A1 (forum.php)
RU (1) RU2012107535A (forum.php)
WO (1) WO2011012713A1 (forum.php)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE402999T1 (de) * 2002-01-17 2008-08-15 Univ British Columbia Bispezifische antisense oligonukleotide die igfbp-2 und igfbp-5 inhibieren und deren verwendung
CN103517990A (zh) 2010-10-07 2014-01-15 通用医疗公司 癌症生物标志物
TWI454281B (zh) * 2011-10-06 2014-10-01 Nat Univ Tsing Hua 硼酸於硼中子捕獲治療肝癌之用途
WO2013124869A2 (en) * 2012-02-21 2013-08-29 Amrita Vishwa Vidyapeetham University The art, method,manner process and system of fibrous bio-degradable polymeric wafers for the local delivery of therapeutic agents in combinations
WO2014159774A1 (en) * 2013-03-14 2014-10-02 Teva Pharmaceutical Industries Ltd. Custirsen treatment with reduced toxicity
CA2949574C (en) * 2014-05-23 2022-06-07 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for determining whether a patient will achieve a response after radiation therapy
US10301624B2 (en) 2014-06-25 2019-05-28 The General Hospital Corporation Targeting human satellite II (HSATII)
US11759530B2 (en) * 2014-11-17 2023-09-19 City Of Hope TKI permeability enhancers
US20180161429A1 (en) 2015-06-26 2018-06-14 Beth Israel Deaconess Medical Center Inc. Cancer therapy targeting tetraspanin 33 (tspan33) in myeloid derived suppressor cells
WO2017138924A1 (en) 2016-02-09 2017-08-17 Autotelic Llc Compositions and methods for treating pancreatic cancer
WO2017138925A1 (en) 2016-02-09 2017-08-17 Autotelic Llc Antitumour combinations of antisense oligonucleotides and anticancer agents
US9758786B2 (en) 2016-02-09 2017-09-12 Autotelic, Llc Compositions and methods for treating pancreatic cancer
CA3037046A1 (en) 2016-10-31 2018-05-03 University Of Massachusetts Targeting microrna-101-3p in cancer therapy
WO2018089688A1 (en) 2016-11-09 2018-05-17 Jinjun Shi Restoration of tumor suppression using mrna-based delivery system
CN112533613A (zh) 2018-02-06 2021-03-19 通用医疗公司 作为肿瘤免疫应答的生物标志物的重复rna
KR20210139237A (ko) * 2019-03-14 2021-11-22 더 리서치 파운데이션 포 더 스테이트 유니버시티 오브 뉴욕 변형된 마이크로rna 및 암 치료에 있어서의 이의 용도
GB201908012D0 (en) * 2019-06-05 2019-07-17 Io Biotech Aps TGF-Beta vaccine
CN112933238A (zh) * 2021-02-02 2021-06-11 石河子大学 抑制TGF-βR1基因表达的物质与顺铂在治疗和/或预防食管癌中的应用
CN113425855B (zh) * 2021-06-28 2023-11-07 深圳瑞吉生物科技有限公司 一种mRNA剂型的骨关节炎药物制剂及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005059133A2 (en) * 2003-12-19 2005-06-30 Antisense Pharma Gmbh Combination therapy associating a tgf-breta antagonist with a chemiotherapeutic agent
US20050272644A1 (en) * 2002-07-25 2005-12-08 Yih-Lin Chung Method for increasing therapeutic gain in radiotherapy and chemotherapy

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3854480A (en) 1969-04-01 1974-12-17 Alza Corp Drug-delivery system
US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4675189A (en) 1980-11-18 1987-06-23 Syntex (U.S.A.) Inc. Microencapsulation of water soluble active polypeptides
WO1983001451A1 (en) 1981-10-23 1983-04-28 Molecular Biosystems Inc Oligonucleotide therapeutic agent and methods of making same
US5023243A (en) 1981-10-23 1991-06-11 Molecular Biosystems, Inc. Oligonucleotide therapeutic agent and method of making same
US4452775A (en) 1982-12-03 1984-06-05 Syntex (U.S.A.) Inc. Cholesterol matrix delivery system for sustained release of macromolecules
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US5133974A (en) 1989-05-05 1992-07-28 Kv Pharmaceutical Company Extended release pharmaceutical formulations
US5539082A (en) 1993-04-26 1996-07-23 Nielsen; Peter E. Peptide nucleic acids
US5714331A (en) 1991-05-24 1998-02-03 Buchardt, Deceased; Ole Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5407686A (en) 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
US5736152A (en) 1995-10-27 1998-04-07 Atrix Laboratories, Inc. Non-polymeric sustained release delivery system
EP0856579A1 (en) * 1997-01-31 1998-08-05 BIOGNOSTIK GESELLSCHAFT FÜR BIOMOLEKULARE DIAGNOSTIK mbH An antisense oligonucleotide preparation method
US7795232B1 (en) 2000-08-25 2010-09-14 Genta Incorporated Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers
JP4682312B2 (ja) * 2003-09-04 2011-05-11 学校法人日本大学 ＴＧＦ−β遺伝子発現抑制剤
JP2007515949A (ja) * 2003-11-13 2007-06-21 ジェネンテック・インコーポレーテッド スクリーニングアッセイ及び腫瘍治療の方法
CN1902488A (zh) * 2003-11-13 2007-01-24 健泰科生物技术公司 肿瘤治疗的筛选实验和方法
US20070155685A1 (en) * 2004-02-27 2007-07-05 Karl-Hermann Schlingensiepen Pharmaceutical composition
US20090186076A1 (en) * 2006-02-01 2009-07-23 Kazunori Kataoka Combined Use of TGF-Beta Signaling Inhibitor and Antitumor Agent
JP5322476B2 (ja) * 2008-03-31 2013-10-23 テルモ株式会社 リポソームの製造装置およびリポソームの製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050272644A1 (en) * 2002-07-25 2005-12-08 Yih-Lin Chung Method for increasing therapeutic gain in radiotherapy and chemotherapy
WO2005059133A2 (en) * 2003-12-19 2005-06-30 Antisense Pharma Gmbh Combination therapy associating a tgf-breta antagonist with a chemiotherapeutic agent
US20070196269A1 (en) * 2003-12-19 2007-08-23 Karl-Hermann Schlingensiepen Pharmaceutical composition

Also Published As

Publication number Publication date
EP2340308A1 (en) 2011-07-06
US8476246B2 (en) 2013-07-02
CL2012000247A1 (es) 2013-07-05
WO2011012713A1 (en) 2011-02-03
CO6511199A2 (es) 2012-08-31
BR112012002102A2 (pt) 2017-05-02
IN2012DN00969A (forum.php) 2015-04-10
EP2340308B1 (en) 2014-12-24
MX2012001244A (es) 2012-03-26
PE20121495A1 (es) 2012-11-19
IL217821A0 (en) 2012-03-29
RU2012107535A (ru) 2013-09-10
KR20120107456A (ko) 2012-10-02
JP2013500313A (ja) 2013-01-07
US20120027873A1 (en) 2012-02-02
CN102712924A (zh) 2012-10-03
AU2010277554A1 (en) 2012-03-01
CA2769618A1 (en) 2011-02-03
ECSP12011689A (es) 2012-06-29

Similar Documents

Publication Publication Date Title
AU2010277554B2 (en) Combination of a chemotherapeutic agent and an inhibitor of the TGF-beta system
AU2004299670B2 (en) Combination therapy associating a TGF-beta antagonist with a chemotherapeutic agent
US20030055014A1 (en) Inhibition of angiogenesis by nucleic acids
CA2255637C (en) Conjugates of cis-docosahexaenoic acid and paclitaxel
US12303494B2 (en) Compositions and methods for monitoring, diagnosis, prognosis, detection, and treatment of cancer
US20040097463A1 (en) Use of asiatic acid or asiaticoside for treatment of cancer
US20080125380A1 (en) Fatty acid-anticancer conjugates and uses thereof
US20090143418A1 (en) Compositions and Methods for Preventing and Treating Hair Growth Cycle-Related Conditions
CN117343965B (zh) 核酸载体、核酸药及其制备方法和应用
US20050267027A1 (en) Use of erythropoietin for treatment of cancer
WO2000067802A1 (en) Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof
JP2022506958A (ja) Ｍｉｒ－１０ｂ活性を調節するためのマイクロｒｎａ化合物及び方法
EP2248895A2 (en) Combination therapy associating a TGF-beta antagonist with a chemotherapeutic agent
AU2020216444A1 (en) Modulators of YAP1 expression
US20200181711A1 (en) Compositions and methods for monitoring, diagnosis, prognosis, detection, and treatment of cancer
US20220233539A1 (en) Compositions and methods for inhibiting hedgehog pathway
HK40059024A (en) Modulators of foxp3 expression

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired