AU2010252007B2 - (Dihydro) imidazoiso [5, 1-a] quinolines as FSH receptor agonists for the treatment of fertility disorders - Google Patents

(Dihydro) imidazoiso [5, 1-a] quinolines as FSH receptor agonists for the treatment of fertility disorders Download PDF

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Publication number
AU2010252007B2
AU2010252007B2 AU2010252007A AU2010252007A AU2010252007B2 AU 2010252007 B2 AU2010252007 B2 AU 2010252007B2 AU 2010252007 A AU2010252007 A AU 2010252007A AU 2010252007 A AU2010252007 A AU 2010252007A AU 2010252007 B2 AU2010252007 B2 AU 2010252007B2
Authority
AU
Australia
Prior art keywords
alkyl
amino
vacuo
concentrated
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010252007A
Other languages
English (en)
Other versions
AU2010252007A1 (en
Inventor
Hubert Jan Jozef Loozen
Cornelis Marius Timmers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme BV
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp and Dohme BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd, Merck Sharp and Dohme BV filed Critical Merck Sharp and Dohme Ltd
Publication of AU2010252007A1 publication Critical patent/AU2010252007A1/en
Assigned to MSD OSS B.V. reassignment MSD OSS B.V. Alteration of Name(s) of Applicant(s) under S113 Assignors: N.V. ORGANON
Assigned to MERCK SHARP & DOHME B.V. reassignment MERCK SHARP & DOHME B.V. Alteration of Name(s) of Applicant(s) under S113 Assignors: MSD OSS B.V.
Application granted granted Critical
Publication of AU2010252007B2 publication Critical patent/AU2010252007B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pregnancy & Childbirth (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AU2010252007A 2009-05-27 2010-05-25 (Dihydro) imidazoiso [5, 1-a] quinolines as FSH receptor agonists for the treatment of fertility disorders Ceased AU2010252007B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09161274.7 2009-05-27
EP09161274 2009-05-27
PCT/EP2010/057134 WO2010136438A1 (en) 2009-05-27 2010-05-25 (dihydro) imidazoiso (5, 1-a) quinolines as fsh receptor agonists for the treatment of fertility disorders

Publications (2)

Publication Number Publication Date
AU2010252007A1 AU2010252007A1 (en) 2011-12-22
AU2010252007B2 true AU2010252007B2 (en) 2014-06-05

Family

ID=42315817

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010252007A Ceased AU2010252007B2 (en) 2009-05-27 2010-05-25 (Dihydro) imidazoiso [5, 1-a] quinolines as FSH receptor agonists for the treatment of fertility disorders

Country Status (8)

Country Link
EP (1) EP2435433B1 (https=)
JP (1) JP5647675B2 (https=)
CN (1) CN102448961B (https=)
AR (1) AR076703A1 (https=)
AU (1) AU2010252007B2 (https=)
CA (1) CA2763118A1 (https=)
TW (1) TWI461426B (https=)
WO (1) WO2010136438A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013006308A2 (en) 2011-07-01 2013-01-10 Merck Patent Gmbh Dihydropyrazoles
WO2013012848A1 (en) 2011-07-18 2013-01-24 Merck Patent Gmbh Benzamides
WO2013106409A1 (en) 2012-01-10 2013-07-18 Merck Patent Gmbh Benzamide derivatives as modulators of the follicle stimulating hormone
HK1201837A1 (en) 2012-02-08 2015-09-11 默克专利有限公司 Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor
WO2014209978A1 (en) 2013-06-24 2014-12-31 Merck Patent Gmbh Imidazole compounds as modulators of fshr and uses thereof
KR102318498B1 (ko) * 2013-06-24 2021-10-27 메르크 파텐트 게엠베하 Fshr의 조절인자로서의 피라졸 화합물 및 이의 용도
JP6602779B2 (ja) 2014-02-13 2019-11-06 インサイト・コーポレイション Ｌｓｄ１阻害剤としてのシクロプロピルアミン類
EP3105219B9 (en) 2014-02-13 2018-10-03 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
EP3105218B1 (en) 2014-02-13 2019-09-25 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
WO2015196335A1 (en) * 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof
WO2016007731A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyridines and imidazopyrazines as lsd1 inhibitors
US9758523B2 (en) 2014-07-10 2017-09-12 Incyte Corporation Triazolopyridines and triazolopyrazines as LSD1 inhibitors
US9695167B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
US9695180B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
EP3277689B1 (en) 2015-04-03 2019-09-04 Incyte Corporation Heterocyclic compounds as lsd1 inhibitors
MY189367A (en) 2015-08-12 2022-02-08 Incyte Corp Salts of an lsd1 inhibitor
TWI833686B (zh) 2016-04-22 2024-03-01 美商英塞特公司 Lsd1 抑制劑之調配物
CN106866692A (zh) * 2017-03-30 2017-06-20 毛阿龙 具有苯并1,4‑二氧杂环己二烯酮结构的fshr拮抗剂的制备方法
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same
JP2025535050A (ja) * 2022-10-05 2025-10-22 ラディオネティクス オンコロジー，インク． 卵胞刺激ホルモン受容体（ｆｓｈｒ）を標的とした治療薬およびその使用
IL322905A (en) 2023-03-08 2025-10-01 Ferring Bv Small molecule FSH receptor modulators

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004028A1 (en) * 2001-07-02 2003-01-16 Akzo Nobel N.V. Tetrahydroquinoline derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO66801A (fr) * 1973-05-25 1979-08-15 Lepetit Spa Procede pour obtenir des derives des triazoloizoquinolines
PH15001A (en) * 1977-07-25 1982-03-22 Sandoz Ag Prolactin secretion inhibitors
US6235755B1 (en) * 1998-08-07 2001-05-22 Applied Research Systems Ars Holding N.A. FSH mimetics for the treatment of infertility
US7153824B2 (en) * 2003-04-01 2006-12-26 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
RS20050945A (sr) * 2003-06-30 2008-06-05 Altana Pharma Ag., Novi pirolodihidroizohinolini koji se mogu upotrebiti u tretmanu kancera
TW200944523A (en) * 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004028A1 (en) * 2001-07-02 2003-01-16 Akzo Nobel N.V. Tetrahydroquinoline derivatives

Also Published As

Publication number Publication date
TWI461426B (zh) 2014-11-21
CA2763118A1 (en) 2010-12-02
EP2435433A1 (en) 2012-04-04
CN102448961B (zh) 2016-01-06
TW201107322A (en) 2011-03-01
CN102448961A (zh) 2012-05-09
JP2012528105A (ja) 2012-11-12
EP2435433B1 (en) 2013-08-28
JP5647675B2 (ja) 2015-01-07
AR076703A1 (es) 2011-06-29
AU2010252007A1 (en) 2011-12-22
WO2010136438A1 (en) 2010-12-02

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