AU2010252007B2 - (Dihydro) imidazoiso [5, 1-a] quinolines as FSH receptor agonists for the treatment of fertility disorders - Google Patents

(Dihydro) imidazoiso [5, 1-a] quinolines as FSH receptor agonists for the treatment of fertility disorders Download PDF

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Publication number
AU2010252007B2
AU2010252007B2 AU2010252007A AU2010252007A AU2010252007B2 AU 2010252007 B2 AU2010252007 B2 AU 2010252007B2 AU 2010252007 A AU2010252007 A AU 2010252007A AU 2010252007 A AU2010252007 A AU 2010252007A AU 2010252007 B2 AU2010252007 B2 AU 2010252007B2
Authority
AU
Australia
Prior art keywords
alkyl
amino
vacuo
concentrated
butyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010252007A
Other languages
English (en)
Other versions
AU2010252007A1 (en
Inventor
Hubert Jan Jozef Loozen
Cornelis Marius Timmers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme BV
Original Assignee
Merck Sharp and Dohme Ltd
Merck Sharp and Dohme BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme Ltd, Merck Sharp and Dohme BV filed Critical Merck Sharp and Dohme Ltd
Publication of AU2010252007A1 publication Critical patent/AU2010252007A1/en
Assigned to MSD OSS B.V. reassignment MSD OSS B.V. Alteration of Name(s) of Applicant(s) under S113 Assignors: N.V. ORGANON
Assigned to MERCK SHARP & DOHME B.V. reassignment MERCK SHARP & DOHME B.V. Alteration of Name(s) of Applicant(s) under S113 Assignors: MSD OSS B.V.
Application granted granted Critical
Publication of AU2010252007B2 publication Critical patent/AU2010252007B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pregnancy & Childbirth (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2010252007A 2009-05-27 2010-05-25 (Dihydro) imidazoiso [5, 1-a] quinolines as FSH receptor agonists for the treatment of fertility disorders Ceased AU2010252007B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09161274 2009-05-27
EP09161274.7 2009-05-27
PCT/EP2010/057134 WO2010136438A1 (en) 2009-05-27 2010-05-25 (dihydro) imidazoiso (5, 1-a) quinolines as fsh receptor agonists for the treatment of fertility disorders

Publications (2)

Publication Number Publication Date
AU2010252007A1 AU2010252007A1 (en) 2011-12-22
AU2010252007B2 true AU2010252007B2 (en) 2014-06-05

Family

ID=42315817

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010252007A Ceased AU2010252007B2 (en) 2009-05-27 2010-05-25 (Dihydro) imidazoiso [5, 1-a] quinolines as FSH receptor agonists for the treatment of fertility disorders

Country Status (8)

Country Link
EP (1) EP2435433B1 (https=)
JP (1) JP5647675B2 (https=)
CN (1) CN102448961B (https=)
AR (1) AR076703A1 (https=)
AU (1) AU2010252007B2 (https=)
CA (1) CA2763118A1 (https=)
TW (1) TWI461426B (https=)
WO (1) WO2010136438A1 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2837524C (en) 2011-07-01 2019-08-20 Merck Patent Gmbh Dihydropyrazoles
EP2734517B1 (en) 2011-07-18 2017-08-30 Merck Patent GmbH Benzamides
WO2013106409A1 (en) 2012-01-10 2013-07-18 Merck Patent Gmbh Benzamide derivatives as modulators of the follicle stimulating hormone
EP2812320B1 (en) * 2012-02-08 2018-03-07 Merck Patent GmbH Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor
JP6523267B2 (ja) * 2013-06-24 2019-05-29 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｆｓｈｒの調節剤としてのイミダゾール化合物及びその使用
WO2014209980A1 (en) * 2013-06-24 2014-12-31 Merck Patent Gmbh Pyrazole compounds as modulators of fshr and uses thereof
SI3105218T1 (sl) 2014-02-13 2019-11-29 Incyte Corp Ciklopropilamini kot inhibitorji LSD1
MX373103B (es) 2014-02-13 2020-04-17 Incyte Holdings Corp Ciclopropilaminas como inhibidores de desmetilasa específica de lisina 1 (lsd1).
EP3105219B9 (en) 2014-02-13 2018-10-03 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
WO2015196335A1 (en) * 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof
TW201613925A (en) 2014-07-10 2016-04-16 Incyte Corp Imidazopyrazines as LSD1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
WO2016007727A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
EP3277689B1 (en) 2015-04-03 2019-09-04 Incyte Corporation Heterocyclic compounds as lsd1 inhibitors
LT3334709T (lt) 2015-08-12 2025-03-10 Incyte Holdings Corporation Lsd1 inhibitoriaus druskos
JP6999574B2 (ja) 2016-04-22 2022-01-18 インサイト・コーポレイション Ｌｓｄ１阻害剤の製剤
CN106866692A (zh) * 2017-03-30 2017-06-20 毛阿龙 具有苯并1,4‑二氧杂环己二烯酮结构的fshr拮抗剂的制备方法
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same
JP2025535050A (ja) * 2022-10-05 2025-10-22 ラディオネティクス オンコロジー，インク． 卵胞刺激ホルモン受容体（ｆｓｈｒ）を標的とした治療薬およびその使用
EP4676591A2 (en) 2023-03-08 2026-01-14 Ferring B.V. Small molecule fsh receptor modulators

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004028A1 (en) * 2001-07-02 2003-01-16 Akzo Nobel N.V. Tetrahydroquinoline derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO66801A (fr) * 1973-05-25 1979-08-15 Lepetit Spa Procede pour obtenir des derives des triazoloizoquinolines
PH15001A (en) * 1977-07-25 1982-03-22 Sandoz Ag Prolactin secretion inhibitors
CA2339018A1 (en) * 1998-08-07 2000-02-17 Applied Research Systems Ars Holding N.V. Fsh mimetics for the treatment of infertility
MXPA05010373A (es) * 2003-04-01 2005-12-05 Applied Research Systems Inhibidores de fosfodiesterasas en infertilidad.
RS20050945A (sr) * 2003-06-30 2008-06-05 Altana Pharma Ag., Novi pirolodihidroizohinolini koji se mogu upotrebiti u tretmanu kancera
TW200944523A (en) * 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003004028A1 (en) * 2001-07-02 2003-01-16 Akzo Nobel N.V. Tetrahydroquinoline derivatives

Also Published As

Publication number Publication date
CN102448961A (zh) 2012-05-09
WO2010136438A1 (en) 2010-12-02
AU2010252007A1 (en) 2011-12-22
CN102448961B (zh) 2016-01-06
JP2012528105A (ja) 2012-11-12
TW201107322A (en) 2011-03-01
CA2763118A1 (en) 2010-12-02
EP2435433A1 (en) 2012-04-04
EP2435433B1 (en) 2013-08-28
AR076703A1 (es) 2011-06-29
TWI461426B (zh) 2014-11-21
JP5647675B2 (ja) 2015-01-07

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired