CN102448961B - 作为用于治疗生育力病症的fsh受体激动剂的(二氢)咪唑并异[5,1-a]喹啉 - Google Patents

作为用于治疗生育力病症的fsh受体激动剂的(二氢)咪唑并异[5,1-a]喹啉 Download PDF

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Publication number
CN102448961B
CN102448961B CN201080023361.8A CN201080023361A CN102448961B CN 102448961 B CN102448961 B CN 102448961B CN 201080023361 A CN201080023361 A CN 201080023361A CN 102448961 B CN102448961 B CN 102448961B
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China
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alkyl
amino
vacuo
heteroatoms selected
heteroaryl
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Chinese (zh)
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CN102448961A (zh
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H.J.J.卢津
C.M.蒂默斯
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Organic Agricultural Biological Sciences Holland Co ltd
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MSD Oss BV
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pregnancy & Childbirth (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN201080023361.8A 2009-05-27 2010-05-25 作为用于治疗生育力病症的fsh受体激动剂的(二氢)咪唑并异[5,1-a]喹啉 Expired - Fee Related CN102448961B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09161274 2009-05-27
EP09161274.7 2009-05-27
PCT/EP2010/057134 WO2010136438A1 (en) 2009-05-27 2010-05-25 (dihydro) imidazoiso (5, 1-a) quinolines as fsh receptor agonists for the treatment of fertility disorders

Publications (2)

Publication Number Publication Date
CN102448961A CN102448961A (zh) 2012-05-09
CN102448961B true CN102448961B (zh) 2016-01-06

Family

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Family Applications (1)

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CN201080023361.8A Expired - Fee Related CN102448961B (zh) 2009-05-27 2010-05-25 作为用于治疗生育力病症的fsh受体激动剂的(二氢)咪唑并异[5,1-a]喹啉

Country Status (8)

Country Link
EP (1) EP2435433B1 (https=)
JP (1) JP5647675B2 (https=)
CN (1) CN102448961B (https=)
AR (1) AR076703A1 (https=)
AU (1) AU2010252007B2 (https=)
CA (1) CA2763118A1 (https=)
TW (1) TWI461426B (https=)
WO (1) WO2010136438A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2837524C (en) 2011-07-01 2019-08-20 Merck Patent Gmbh Dihydropyrazoles
EP2734517B1 (en) 2011-07-18 2017-08-30 Merck Patent GmbH Benzamides
WO2013106409A1 (en) 2012-01-10 2013-07-18 Merck Patent Gmbh Benzamide derivatives as modulators of the follicle stimulating hormone
EP2812320B1 (en) * 2012-02-08 2018-03-07 Merck Patent GmbH Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor
JP6523267B2 (ja) * 2013-06-24 2019-05-29 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｆｓｈｒの調節剤としてのイミダゾール化合物及びその使用
WO2014209980A1 (en) * 2013-06-24 2014-12-31 Merck Patent Gmbh Pyrazole compounds as modulators of fshr and uses thereof
SI3105218T1 (sl) 2014-02-13 2019-11-29 Incyte Corp Ciklopropilamini kot inhibitorji LSD1
MX373103B (es) 2014-02-13 2020-04-17 Incyte Holdings Corp Ciclopropilaminas como inhibidores de desmetilasa específica de lisina 1 (lsd1).
EP3105219B9 (en) 2014-02-13 2018-10-03 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
WO2015196335A1 (en) * 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof
TW201613925A (en) 2014-07-10 2016-04-16 Incyte Corp Imidazopyrazines as LSD1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
WO2016007727A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
EP3277689B1 (en) 2015-04-03 2019-09-04 Incyte Corporation Heterocyclic compounds as lsd1 inhibitors
LT3334709T (lt) 2015-08-12 2025-03-10 Incyte Holdings Corporation Lsd1 inhibitoriaus druskos
JP6999574B2 (ja) 2016-04-22 2022-01-18 インサイト・コーポレイション Ｌｓｄ１阻害剤の製剤
CN106866692A (zh) * 2017-03-30 2017-06-20 毛阿龙 具有苯并1,4‑二氧杂环己二烯酮结构的fshr拮抗剂的制备方法
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same
JP2025535050A (ja) * 2022-10-05 2025-10-22 ラディオネティクス オンコロジー，インク． 卵胞刺激ホルモン受容体（ｆｓｈｒ）を標的とした治療薬およびその使用
EP4676591A2 (en) 2023-03-08 2026-01-14 Ferring B.V. Small molecule fsh receptor modulators

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000008015A2 (en) * 1998-08-07 2000-02-17 Applied Research Systems Ars Holding N.V. Fsh mimetics for the treatment of infertility
WO2003004028A1 (en) * 2001-07-02 2003-01-16 Akzo Nobel N.V. Tetrahydroquinoline derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RO66801A (fr) * 1973-05-25 1979-08-15 Lepetit Spa Procede pour obtenir des derives des triazoloizoquinolines
PH15001A (en) * 1977-07-25 1982-03-22 Sandoz Ag Prolactin secretion inhibitors
MXPA05010373A (es) * 2003-04-01 2005-12-05 Applied Research Systems Inhibidores de fosfodiesterasas en infertilidad.
RS20050945A (sr) * 2003-06-30 2008-06-05 Altana Pharma Ag., Novi pirolodihidroizohinolini koji se mogu upotrebiti u tretmanu kancera
TW200944523A (en) * 2008-02-08 2009-11-01 Organon Nv (Dihydro)pyrrolo[2,1-a]isoquinolines

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000008015A2 (en) * 1998-08-07 2000-02-17 Applied Research Systems Ars Holding N.V. Fsh mimetics for the treatment of infertility
WO2003004028A1 (en) * 2001-07-02 2003-01-16 Akzo Nobel N.V. Tetrahydroquinoline derivatives

Also Published As

Publication number Publication date
CN102448961A (zh) 2012-05-09
WO2010136438A1 (en) 2010-12-02
AU2010252007A1 (en) 2011-12-22
JP2012528105A (ja) 2012-11-12
TW201107322A (en) 2011-03-01
CA2763118A1 (en) 2010-12-02
EP2435433A1 (en) 2012-04-04
EP2435433B1 (en) 2013-08-28
AU2010252007B2 (en) 2014-06-05
AR076703A1 (es) 2011-06-29
TWI461426B (zh) 2014-11-21
JP5647675B2 (ja) 2015-01-07

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