AU2010245933B2 - Methods of delivering oligonucleotides to immune cells - Google Patents

Methods of delivering oligonucleotides to immune cells Download PDF

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Publication number
AU2010245933B2
AU2010245933B2 AU2010245933A AU2010245933A AU2010245933B2 AU 2010245933 B2 AU2010245933 B2 AU 2010245933B2 AU 2010245933 A AU2010245933 A AU 2010245933A AU 2010245933 A AU2010245933 A AU 2010245933A AU 2010245933 B2 AU2010245933 B2 AU 2010245933B2
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AU
Australia
Prior art keywords
lipid
peg
nucleic acid
dsrna
cell
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010245933A
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English (en)
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AU2010245933A1 (en
Inventor
Akin Akinc
Tatiana Novobrantseva
Tsukasa Sugo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arbutus Biopharma Corp
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Arbutus Biopharma Corp
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Publication of AU2010245933A1 publication Critical patent/AU2010245933A1/en
Assigned to TEKMIRA PHARMACEUTICALS CORPORATION reassignment TEKMIRA PHARMACEUTICALS CORPORATION Request for Assignment Assignors: ALNYLAM PHARMACEUTICALS, INC.
Application granted granted Critical
Publication of AU2010245933B2 publication Critical patent/AU2010245933B2/en
Priority to AU2016225873A priority Critical patent/AU2016225873A1/en
Assigned to ARBUTUS BIOPHARMA CORPORATION reassignment ARBUTUS BIOPHARMA CORPORATION Alteration of Name(s) of Applicant(s) under S113 Assignors: TEKMIRA PHARMACEUTICALS CORPORATION
Priority to AU2018200923A priority patent/AU2018200923A1/en
Priority to AU2019250141A priority patent/AU2019250141A1/en
Priority to AU2022200873A priority patent/AU2022200873A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2010245933A 2009-05-05 2010-05-05 Methods of delivering oligonucleotides to immune cells Ceased AU2010245933B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2016225873A AU2016225873A1 (en) 2009-05-05 2016-09-08 Methods of delivering oligonucleotides to immune cells
AU2018200923A AU2018200923A1 (en) 2009-05-05 2018-02-08 Methods of delivering oligonucleotides to immune cells
AU2019250141A AU2019250141A1 (en) 2009-05-05 2019-10-16 Methods of delivering oligonucleotides to immune cells
AU2022200873A AU2022200873A1 (en) 2009-05-05 2022-02-10 Methods of delivering oligonucleotides to immune cells

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US17577709P 2009-05-05 2009-05-05
US61/175,777 2009-05-05
US23404509P 2009-08-14 2009-08-14
US61/234,045 2009-08-14
US24276109P 2009-09-15 2009-09-15
US61/242,761 2009-09-15
US25199109P 2009-10-15 2009-10-15
US61/251,991 2009-10-15
US25884809P 2009-11-06 2009-11-06
US61/258,848 2009-11-06
PCT/US2010/033747 WO2010129687A1 (en) 2009-05-05 2010-05-05 Methods of delivering oligonucleotides to immune cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2016225873A Division AU2016225873A1 (en) 2009-05-05 2016-09-08 Methods of delivering oligonucleotides to immune cells

Publications (2)

Publication Number Publication Date
AU2010245933A1 AU2010245933A1 (en) 2011-11-24
AU2010245933B2 true AU2010245933B2 (en) 2016-06-16

Family

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Family Applications (5)

Application Number Title Priority Date Filing Date
AU2010245933A Ceased AU2010245933B2 (en) 2009-05-05 2010-05-05 Methods of delivering oligonucleotides to immune cells
AU2016225873A Abandoned AU2016225873A1 (en) 2009-05-05 2016-09-08 Methods of delivering oligonucleotides to immune cells
AU2018200923A Abandoned AU2018200923A1 (en) 2009-05-05 2018-02-08 Methods of delivering oligonucleotides to immune cells
AU2019250141A Abandoned AU2019250141A1 (en) 2009-05-05 2019-10-16 Methods of delivering oligonucleotides to immune cells
AU2022200873A Abandoned AU2022200873A1 (en) 2009-05-05 2022-02-10 Methods of delivering oligonucleotides to immune cells

Family Applications After (4)

Application Number Title Priority Date Filing Date
AU2016225873A Abandoned AU2016225873A1 (en) 2009-05-05 2016-09-08 Methods of delivering oligonucleotides to immune cells
AU2018200923A Abandoned AU2018200923A1 (en) 2009-05-05 2018-02-08 Methods of delivering oligonucleotides to immune cells
AU2019250141A Abandoned AU2019250141A1 (en) 2009-05-05 2019-10-16 Methods of delivering oligonucleotides to immune cells
AU2022200873A Abandoned AU2022200873A1 (en) 2009-05-05 2022-02-10 Methods of delivering oligonucleotides to immune cells

Country Status (6)

Country Link
US (3) US20100285112A1 (https=)
EP (3) EP2416652B1 (https=)
JP (6) JP5889783B2 (https=)
AU (5) AU2010245933B2 (https=)
CA (2) CA3045126A1 (https=)
WO (1) WO2010129687A1 (https=)

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