AU2009336040B2 - Tricyclic azaindoles - Google Patents

Tricyclic azaindoles Download PDF

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Publication number
AU2009336040B2
AU2009336040B2 AU2009336040A AU2009336040A AU2009336040B2 AU 2009336040 B2 AU2009336040 B2 AU 2009336040B2 AU 2009336040 A AU2009336040 A AU 2009336040A AU 2009336040 A AU2009336040 A AU 2009336040A AU 2009336040 B2 AU2009336040 B2 AU 2009336040B2
Authority
AU
Australia
Prior art keywords
tetrahydro
dipyrido
chloro
pyrrol
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009336040A
Other languages
English (en)
Other versions
AU2009336040A1 (en
Inventor
Benny C. Askew Jr.
Nadia Brugger
Bayard R. Huck
Christopher Charles Victor Jones
Garry R. Smith
Amanda E. Sutton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU2009336040A1 publication Critical patent/AU2009336040A1/en
Application granted granted Critical
Publication of AU2009336040B2 publication Critical patent/AU2009336040B2/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AU2009336040A 2008-12-18 2009-12-03 Tricyclic azaindoles Ceased AU2009336040B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20302208P 2008-12-18 2008-12-18
US61/203,022 2008-12-18
PCT/US2009/066534 WO2010080253A1 (en) 2008-12-18 2009-12-03 Tricyclic azaindoles

Publications (2)

Publication Number Publication Date
AU2009336040A1 AU2009336040A1 (en) 2011-06-30
AU2009336040B2 true AU2009336040B2 (en) 2015-07-16

Family

ID=41682740

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009336040A Ceased AU2009336040B2 (en) 2008-12-18 2009-12-03 Tricyclic azaindoles

Country Status (8)

Country Link
US (1) US8853391B2 (cg-RX-API-DMAC10.html)
EP (1) EP2367822B1 (cg-RX-API-DMAC10.html)
JP (2) JP2012512871A (cg-RX-API-DMAC10.html)
AU (1) AU2009336040B2 (cg-RX-API-DMAC10.html)
CA (1) CA2745085C (cg-RX-API-DMAC10.html)
ES (1) ES2603208T3 (cg-RX-API-DMAC10.html)
IL (1) IL213589A (cg-RX-API-DMAC10.html)
WO (1) WO2010080253A1 (cg-RX-API-DMAC10.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2734552T3 (es) 2010-04-16 2019-12-10 Ac Immune Sa Compuestos novedosos para el tratamiento de enfermedades asociadas a proteínas amiloides o de tipo amiloide
BR112015021386A2 (pt) * 2013-03-14 2017-07-18 Bristol Myers Squibb Co moduladores de ácido biciclo [2.2.2] gpr120
GB201704325D0 (en) * 2017-03-17 2017-05-03 Argonaut Therapeutics Ltd Compounds
CN111757882B (zh) 2018-01-05 2023-08-22 Ac免疫有限公司 用于治疗、减轻或预防与Tau聚集体相关的病症的化合物
CN112313230B (zh) * 2018-06-04 2024-03-15 Ac免疫有限公司 用于治疗、缓解或预防与Tau聚集体相关的病症的新型化合物
EA202091395A1 (ru) * 2018-06-04 2020-10-01 Ас Иммьюн Са ПРОИЗВОДНЫЕ 1,3,4,5-ТЕТРАГИДРО-2Н-ПИРИДО[4,3-b]ИНДОЛА ДЛЯ ЛЕЧЕНИЯ, ОБЛЕГЧЕНИЯ ИЛИ ПРОФИЛАКТИКИ РАССТРОЙСТВ, СВЯЗАННЫХ С АГРЕГАТАМИ ТАУ, ТАКИХ КАК БОЛЕЗНЬ АЛЬЦГЕЙМЕРА
EP3836919A4 (en) 2018-08-16 2022-05-18 Recreo Pharmaceuticals Inc. 1,3,4,9-tetrahydro-2h-pyrido[3,4-b]indole derivative compounds and uses thereof
CA3131805C (en) 2019-03-01 2023-11-21 Ac Immune Sa Novel compounds for the treatment, alleviation or prevention of disorders associated with tau aggregates

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008016184A1 (en) * 2006-08-02 2008-02-07 Takeda Pharmaceutical Company Limited Alpha-carboline derivatives and methods for preparation thereof
WO2009001129A1 (en) * 2007-06-26 2008-12-31 Astrazeneca Ab 1-cyanocyclopropyl-derivatives as cathepsin k inhibitors
WO2009055828A1 (en) * 2007-10-25 2009-04-30 Medivation Technologies, Inc. New tetracyclic compounds

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1268771A (en) * 1968-03-15 1972-03-29 Glaxo Lab Ltd Azacarbazoles
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
CA2242425C (en) 1996-02-13 2006-07-18 Zeneca Limited Quinazoline derivatives as vegf inhibitors
NZ331191A (en) 1996-03-05 2000-03-27 Zeneca Ltd 4-anilinoquinazoline derivatives and pharmaceutical compositions thereof
GB9718972D0 (en) 1996-09-25 1997-11-12 Zeneca Ltd Chemical compounds
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
US6589954B1 (en) * 1998-05-22 2003-07-08 Scios, Inc. Compounds and methods to treat cardiac failure and other disorders
GB9900334D0 (en) 1999-01-07 1999-02-24 Angiogene Pharm Ltd Tricylic vascular damaging agents
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
BR0111230A (pt) 2000-05-31 2003-06-10 Astrazeneca Ab Composto, e, uso e processo para a preparação do mesmo
KR20030014425A (ko) 2000-07-07 2003-02-17 앤지오젠 파마슈티칼스 리미티드 혈관 손상제인 콜치놀 유도체
EE200300015A (et) 2000-07-07 2004-10-15 Angiogene Pharmaceuticals Limited Kolhinooli derivaadid kui angiogeneesi inhibiitorid
US20040014676A1 (en) * 2001-07-09 2004-01-22 Ramalinga Dharanipragada SRC kinase inhibitors useful for treating osteoporosis
FR2891459B1 (fr) * 2005-09-30 2007-12-28 Flamel Technologies Sa Microparticules a liberation modifiee d'au moins un principe actif et forme galenique orale en comprenant
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008016184A1 (en) * 2006-08-02 2008-02-07 Takeda Pharmaceutical Company Limited Alpha-carboline derivatives and methods for preparation thereof
WO2009001129A1 (en) * 2007-06-26 2008-12-31 Astrazeneca Ab 1-cyanocyclopropyl-derivatives as cathepsin k inhibitors
WO2009055828A1 (en) * 2007-10-25 2009-04-30 Medivation Technologies, Inc. New tetracyclic compounds

Also Published As

Publication number Publication date
WO2010080253A1 (en) 2010-07-15
US20120022060A1 (en) 2012-01-26
EP2367822B1 (en) 2016-10-05
US8853391B2 (en) 2014-10-07
JP2015187155A (ja) 2015-10-29
JP6109880B2 (ja) 2017-04-05
JP2012512871A (ja) 2012-06-07
IL213589A (en) 2016-02-29
AU2009336040A1 (en) 2011-06-30
CA2745085C (en) 2018-03-06
CA2745085A1 (en) 2010-07-15
EP2367822A1 (en) 2011-09-28
IL213589A0 (en) 2011-07-31
ES2603208T3 (es) 2017-02-24

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Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired