AU2009316629B2 - Antiviral vaccines with improved cellular immunogenicity - Google Patents

Antiviral vaccines with improved cellular immunogenicity Download PDF

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Publication number
AU2009316629B2
AU2009316629B2 AU2009316629A AU2009316629A AU2009316629B2 AU 2009316629 B2 AU2009316629 B2 AU 2009316629B2 AU 2009316629 A AU2009316629 A AU 2009316629A AU 2009316629 A AU2009316629 A AU 2009316629A AU 2009316629 B2 AU2009316629 B2 AU 2009316629B2
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Prior art keywords
vaccine
seq
nos
optimized
responses
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AU2009316629A
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AU2009316629A1 (en
Inventor
Dan H. Barouch
William M. Fischer
Bette T. Korber
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Beth Israel Deaconess Medical Center Inc
Los Alamos National Security LLC
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Beth Israel Deaconess Medical Center Inc
Los Alamos National Security LLC
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Assigned to BETH ISRAEL DEACONESS MEDICAL CENTER, LOS ALAMOS NATIONAL SECURITY, LLC reassignment BETH ISRAEL DEACONESS MEDICAL CENTER Amend patent request/document other than specification (104) Assignors: BETH ISRAEL DEACONESS MEDICAL CENTER, LOS ALAMOS NATIONAL LABORATORY
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/12Viral antigens
    • A61K39/235Adenoviridae
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
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    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
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    • C12N2740/16211Human Immunodeficiency Virus, HIV concerning HIV gagpol
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    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
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    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
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    • C12N2740/16011Human Immunodeficiency Virus, HIV
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    • C12N2740/16334Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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AU2009316629A 2008-11-18 2009-11-18 Antiviral vaccines with improved cellular immunogenicity Ceased AU2009316629B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US11570308P 2008-11-18 2008-11-18
US61/115,703 2008-11-18
US15218409P 2009-02-12 2009-02-12
US61/152,184 2009-02-12
US24818809P 2009-10-02 2009-10-02
US61/248,188 2009-10-02
PCT/US2009/064999 WO2010059732A1 (en) 2008-11-18 2009-11-18 Antiviral vaccines with improved cellular immunogenicity

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AU2009316629A1 AU2009316629A1 (en) 2011-07-07
AU2009316629B2 true AU2009316629B2 (en) 2016-02-04

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AU2009316629A Ceased AU2009316629B2 (en) 2008-11-18 2009-11-18 Antiviral vaccines with improved cellular immunogenicity

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US (5) US9017691B2 (OSRAM)
EP (2) EP3470437A1 (OSRAM)
JP (4) JP5694945B2 (OSRAM)
CN (1) CN102282175B (OSRAM)
AP (1) AP3719A (OSRAM)
AU (1) AU2009316629B2 (OSRAM)
BR (2) BR122021004758B1 (OSRAM)
CY (1) CY1121215T1 (OSRAM)
DK (1) DK2358757T3 (OSRAM)
ES (1) ES2699685T3 (OSRAM)
HR (1) HRP20181776T1 (OSRAM)
HU (1) HUE042397T2 (OSRAM)
IL (2) IL212984A (OSRAM)
LT (1) LT2358757T (OSRAM)
NZ (2) NZ593598A (OSRAM)
PL (1) PL2358757T3 (OSRAM)
PT (1) PT2358757T (OSRAM)
SG (1) SG10201408784SA (OSRAM)
SI (1) SI2358757T1 (OSRAM)
SM (1) SMT201800631T1 (OSRAM)
WO (1) WO2010059732A1 (OSRAM)
ZA (2) ZA201104538B (OSRAM)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3227814B2 (ja) 1992-07-29 2001-11-12 三菱マテリアル株式会社 スクラッププレス装置
SMT202000101T1 (it) 2008-10-10 2020-03-13 Childrens Medical Center Vaccino con trimero di env di hiv-1 stabilizzato biochimicamente
LT2358757T (lt) 2008-11-18 2018-11-26 Beth Israel Deaconess Medical Center Pagerinto ląstelinio imunogeniškumo priešvirusinės vakcinos
EP2620446A1 (en) 2012-01-27 2013-07-31 Laboratorios Del Dr. Esteve, S.A. Immunogens for HIV vaccination
NZ708144A (en) 2012-11-16 2020-03-27 Beth Israel Deaconess Medical Ct Inc Recombinant adenoviruses and use thereof
AP2015008634A0 (en) * 2013-01-07 2015-07-31 Beth Israel Hospital Stabilized human immunodeficiency virus 'hiv' env elope 'env' trimer vaccines and methods of using same
US10376583B2 (en) 2013-09-30 2019-08-13 Beth Israel Deaconess Medical Center, Inc. Human immunodeficiency virus therapies utilizing N332-glycan-dependent antibodies and a reservoir activator
US10716845B2 (en) 2013-10-04 2020-07-21 Beth Israel Deaconess Medical Center, Inc. Stabilized human immunodeficiency virus (HIV) clade C envelope (Env) trimer vaccines and methods of using same
KR20230093536A (ko) 2013-10-07 2023-06-27 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 어쥬번트로서 인터류킨-33을 갖는 백신
US9920305B2 (en) * 2013-10-16 2018-03-20 New England Biolabs, Inc. Reverse transcriptase with enhanced properties
WO2015128421A1 (en) * 2014-02-28 2015-09-03 Crucell Holland B.V. Replicating recombinant adenovirus vectors, compositions, and methods of use thereof
CN112121160A (zh) 2014-09-26 2020-12-25 贝斯以色列护理医疗中心有限公司 诱导针对人免疫缺陷病毒感染的保护性免疫性的方法和组合物
MA40783A (fr) * 2014-10-03 2017-08-08 Los Alamos Nat Security Llc Vaccins contre le vih comprenant un ou plusieurs antigènes episensus de population
US10306895B2 (en) * 2014-10-27 2019-06-04 Academia Sinica Plant defense signaling peptides and applications thereof
WO2016196471A1 (en) 2015-06-02 2016-12-08 Cooper Human Systems Llc Methods and compositions for treatment of hiv infection
US10542961B2 (en) 2015-06-15 2020-01-28 The Research Foundation For The State University Of New York System and method for infrasonic cardiac monitoring
BR112018005728A2 (pt) * 2015-09-25 2018-10-09 Univ Florida epítopos de célula t de reatividade cruzada de hiv, siv e fiv para vacinas em humanos e gatos
TWI707039B (zh) 2015-12-15 2020-10-11 荷蘭商傑森疫苗防護公司 人類免疫缺陷病毒抗原、載體、組成物、及其使用方法
AU2017286375B2 (en) 2016-06-16 2019-04-18 Janssen Vaccines & Prevention B.V. HIV vaccine formulation
CA3035759A1 (en) 2016-09-02 2018-03-08 Janssen Vaccines & Prevention B.V. Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment
MD3512543T2 (ro) 2016-09-15 2020-11-30 Janssen Vaccines & Prevention Bv Mutații de stabilizare a trimerului proteinei de înveliș HIV
US11230572B2 (en) 2016-10-17 2022-01-25 Beth Israel Deaconess Medical Center, Inc. Signature-based human immunodeficiency virus (HIV) envelope (Env) trimer vaccines and methods of using the same
BR112019026126A2 (pt) 2017-06-15 2020-06-30 Janssen Vaccines & Prevention B.V. vetores de poxvírus que codificam antígenos do hiv e métodos de uso dos mesmos
MY200554A (en) 2017-07-19 2024-01-03 Janssen Vaccines & Prevention Bv Trimer stabilizing hiv envelope protein mutations
US20190022212A1 (en) 2017-07-21 2019-01-24 Beth Israel Deaconess Medical Center, Inc. Methods for safe induction of cross-clade immunity against human immunodeficiency virus infection in human
US20190083620A1 (en) 2017-09-18 2019-03-21 Janssen Vaccines & Prevention B.V. Methods for inducing an immune response against human immunodeficiency virus infection in subjects undergoing antiretroviral treatment
US11773142B2 (en) 2017-12-11 2023-10-03 Beth Israel Deaconess Medical Center, Inc. Recombinant adenoviruses and uses thereof
US11845788B2 (en) 2018-05-22 2023-12-19 Beth Israel Deaconess Medical Center, Inc. Antibody therapies for human immunodeficiency virus (HIV)
CN112770770A (zh) 2018-09-25 2021-05-07 扬森疫苗与预防公司 共定位施用疫苗组分诱导针对人类免疫缺陷病毒的免疫应答的方法
EP3883962A4 (en) 2018-11-21 2023-04-12 Beth Israel Deaconess Medical Center, Inc. ANTIBODY THERAPIES FOR HUMAN IMMUNODEFICIENCY VIRUS (HIV)
TW202110476A (zh) 2019-05-22 2021-03-16 荷蘭商傑森疫苗防護公司 於接受抗反轉錄病毒治療之個體中誘發抗人類免疫缺乏病毒感染之免疫反應的方法
EP3999107A1 (en) 2019-07-16 2022-05-25 Gilead Sciences, Inc. Hiv vaccines and methods of making and using
AU2020384323A1 (en) 2019-11-14 2022-06-02 Aelix Therapeutics, S.L. Dosage regimens for vaccines
US20230075527A1 (en) 2020-01-31 2023-03-09 Janssen Pharmaceuticals, Inc Compositions and Methods for Preventing and Treating Coronavirus Infection - Sars-Cov-2 Vaccines
WO2021211760A1 (en) * 2020-04-14 2021-10-21 The Regents Of The University Of California Large sequence pan-coronavirus vaccine compositions
CN115605224A (zh) 2020-05-12 2023-01-13 扬森疫苗与预防公司(Nl) 同源腺病毒载体的施用
US20220118081A1 (en) 2020-10-20 2022-04-21 Janssen Vaccines & Prevention B.V. HIV vaccine regimens
JP7693813B2 (ja) 2021-01-14 2025-06-17 ギリアード サイエンシーズ, インコーポレイテッド Hivワクチン及び使用方法
US20220265813A1 (en) 2021-02-23 2022-08-25 Janssen Vaccines & Prevention B.V. Trimer Stabilizing HIV Envelope Protein Mutation
WO2023156505A1 (en) 2022-02-17 2023-08-24 Janssen Vaccines & Prevention B.V. Trimer stabilizing hiv envelope protein mutations r304v, n302m and t320l
WO2023198815A1 (en) 2022-04-14 2023-10-19 Janssen Vaccines & Prevention B.V. Sequential administration of adenoviruses
WO2024167803A2 (en) * 2023-02-07 2024-08-15 Merck Sharp & Dohme Llc Adjuvant formulations including low viscosity chitosan or chitosan derivatives

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603112A (en) 1981-12-24 1986-07-29 Health Research, Incorporated Modified vaccinia virus
US5298416A (en) 1989-01-18 1994-03-29 British Technology Group Ltd. Attenuated polioviruses
WO1992015672A1 (en) 1991-03-07 1992-09-17 Virogenetics Corporation Genetically engineered vaccine strain
US5505947A (en) 1994-05-27 1996-04-09 The University Of North Carolina At Chapel Hill Attenuating mutations in Venezuelan Equine Encephalitis virus
US6479258B1 (en) * 1995-12-07 2002-11-12 Diversa Corporation Non-stochastic generation of genetic vaccines
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
US20050232900A1 (en) 1999-05-18 2005-10-20 Crucell Holland B.V. Serotype of adenovirus and uses thereof
CA2422882A1 (en) * 2000-09-15 2002-03-21 Merck & Co., Inc. Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol, nef and modifications
US20040101957A1 (en) * 2001-09-14 2004-05-27 Emini Emilio A. Enhanced first generation adenovirus vaccines expressing codon optimized hiv1-gag, pol.nef and modifications
AU2002363436A1 (en) 2001-11-07 2003-05-19 Duke University Polyvalent immunogen of hiv
US7195768B2 (en) 2001-11-07 2007-03-27 Duke University Polyvalent immunogen
US7172761B2 (en) 2001-11-07 2007-02-06 Duke University Polyvalent immunogen
US20030219452A1 (en) 2001-11-27 2003-11-27 Haynes Barton F. HIV envelope V3-CCR5 binding site immunogen
JP4495588B2 (ja) 2002-04-25 2010-07-07 クルセル ホランド ベー ヴェー 安定なアデノウイルスベクターおよびその増殖方法
WO2004037294A2 (en) 2002-10-23 2004-05-06 Crucell Holland B.V. New settings for recombinant adenoviral-based vaccines
US20080153083A1 (en) 2003-10-23 2008-06-26 Crucell Holland B.V. Settings for recombinant adenoviral-based vaccines
US20050221493A1 (en) 2002-12-04 2005-10-06 Crucell Holland B.V. Recombinant virus production for the manufacturing of vaccines
BRPI0414443A (pt) 2003-09-17 2006-11-21 Univ Duke imunógenos consensuais/ancestrais
US20070298051A1 (en) 2003-11-19 2007-12-27 Beth Israel Deaconess Medical Center Adjuvants Of Immune Response
NZ553889A (en) 2004-10-13 2009-11-27 Crucell Holland Bv Replication-defective adenovirus comprising a chimeric hexon protein and replaced hypervariable ragions HVR1-7
JP4838259B2 (ja) 2004-11-16 2011-12-14 クルセル ホランド ベー ヴェー 組み換えウイルスベクターを含む多価ワクチン
EP1917040A4 (en) 2005-08-23 2012-12-12 Univ California POLYVALENT VACCINE
US7951377B2 (en) 2005-08-23 2011-05-31 Los Alamos National Security, Llc Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens
WO2007104792A2 (en) 2006-03-16 2007-09-20 Crucell Holland B.V. Recombinant adenoviruses based on serotype 26 and 48, and use thereof
US20080279879A1 (en) * 2006-11-17 2008-11-13 New York University INDUCTION OF BROADLY REACTIVE NEUTRALIZING ANTIBODIES BY FOCUSING THE IMMUNE RESPONSE ON V3 EPITOPES OF THE HIV-1 gp120 ENVELOPE
EP2129395A4 (en) 2007-03-27 2012-05-09 Univ California ACUTE, TRANSFERRED HIV ENVELOPMENT SIGNATURES
WO2010042817A1 (en) 2008-10-10 2010-04-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Use of hiv mosaic envelope proteins to optimize t-cell responses against hiv envelope
LT2358757T (lt) 2008-11-18 2018-11-26 Beth Israel Deaconess Medical Center Pagerinto ląstelinio imunogeniškumo priešvirusinės vakcinos
WO2010096561A1 (en) 2009-02-18 2010-08-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Synthetic hiv/siv gag proteins and uses thereof
US9017961B2 (en) 2012-03-05 2015-04-28 E.I. Du Pont De Nemours And Company Recombinant bacteria comprising novel sucrose transporters

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FISCHER, W., et al., "Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants," Nature Medicine, 2007, Vol. 13, No. 1, pages 100-106 *

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