AU2009302371B2 - Atropisomers of (hydroxyalkyl) pyrrole derivatives - Google Patents

Atropisomers of (hydroxyalkyl) pyrrole derivatives Download PDF

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Publication number
AU2009302371B2
AU2009302371B2 AU2009302371A AU2009302371A AU2009302371B2 AU 2009302371 B2 AU2009302371 B2 AU 2009302371B2 AU 2009302371 A AU2009302371 A AU 2009302371A AU 2009302371 A AU2009302371 A AU 2009302371A AU 2009302371 B2 AU2009302371 B2 AU 2009302371B2
Authority
AU
Australia
Prior art keywords
group
compound
phenyl
atropisomer
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009302371A
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English (en)
Other versions
AU2009302371A1 (en
Inventor
Kazumasa Aoki
Noriyuki Hayashi
Tsuyoshi Homma
Richard Martin
Raju Mohan
John Nuss
Hiroyuki Tsuruoka
Tie-Lin Wang
Matthew Williams
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Exelixis Inc
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Exelixis Inc
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Filing date
Publication date
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Publication of AU2009302371A1 publication Critical patent/AU2009302371A1/en
Application granted granted Critical
Publication of AU2009302371B2 publication Critical patent/AU2009302371B2/en
Assigned to EXELIXIS, INC. reassignment EXELIXIS, INC. Request for Assignment Assignors: DAIICHI SANKYO COMPANY, LIMITED, EXELIXIS, INC.
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AU2009302371A 2008-10-08 2009-10-07 Atropisomers of (hydroxyalkyl) pyrrole derivatives Ceased AU2009302371B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10371508P 2008-10-08 2008-10-08
US61/103,715 2008-10-08
PCT/US2009/059847 WO2010042622A1 (en) 2008-10-08 2009-10-07 Atropisomers of (hydroxyalkyl) pyrrole derivatives

Publications (2)

Publication Number Publication Date
AU2009302371A1 AU2009302371A1 (en) 2010-04-15
AU2009302371B2 true AU2009302371B2 (en) 2015-02-12

Family

ID=41360127

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009302371A Ceased AU2009302371B2 (en) 2008-10-08 2009-10-07 Atropisomers of (hydroxyalkyl) pyrrole derivatives

Country Status (12)

Country Link
US (1) US8487117B2 (enExample)
EP (1) EP2349997B1 (enExample)
JP (2) JP5767586B2 (enExample)
KR (1) KR101643285B1 (enExample)
CN (1) CN102186817B (enExample)
AU (1) AU2009302371B2 (enExample)
BR (1) BRPI0920459B1 (enExample)
CA (1) CA2736923C (enExample)
ES (1) ES2547697T3 (enExample)
IL (1) IL212170A (enExample)
TW (2) TWI547479B (enExample)
WO (1) WO2010042622A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE037007T2 (hu) * 2013-08-27 2018-08-28 Daiichi Sankyo Co Ltd Eljárás pirrol származék elõállítására és annak intermediere
AU2020371836B2 (en) * 2019-10-25 2026-01-29 Sunshine Lake Pharma Co., Ltd. Pyrrole amide compound and use thereof
EP4317133B1 (en) * 2021-03-30 2026-04-15 Sunshine Lake Pharma Co., Ltd. Crystalline form of pyrrole amide compound, preparation method therefor and use thereof
CN115784961B (zh) * 2021-09-10 2026-03-31 上海鼎雅药物化学科技有限公司 埃沙西林酮及其中间体的合成方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006012642A2 (en) * 2004-07-30 2006-02-02 Exelixis, Inc. Pyrrole derivatives as pharmaceutical agents
WO2008126831A1 (ja) * 2007-04-09 2008-10-23 Daiichi Sankyo Company, Limited ピロール誘導体のアトロプ異性体

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006012642A2 (en) * 2004-07-30 2006-02-02 Exelixis, Inc. Pyrrole derivatives as pharmaceutical agents
WO2008126831A1 (ja) * 2007-04-09 2008-10-23 Daiichi Sankyo Company, Limited ピロール誘導体のアトロプ異性体

Also Published As

Publication number Publication date
JP5767586B2 (ja) 2015-08-19
IL212170A0 (en) 2011-06-30
US20110263673A1 (en) 2011-10-27
JP2012505225A (ja) 2012-03-01
JP6121952B2 (ja) 2017-04-26
EP2349997B1 (en) 2015-08-12
KR20110091663A (ko) 2011-08-12
HK1155163A1 (zh) 2012-05-11
TWI593674B (zh) 2017-08-01
US8487117B2 (en) 2013-07-16
CN102186817A (zh) 2011-09-14
KR101643285B1 (ko) 2016-07-29
BRPI0920459B1 (pt) 2021-12-14
ES2547697T3 (es) 2015-10-08
TW201627283A (zh) 2016-08-01
JP2014196365A (ja) 2014-10-16
AU2009302371A1 (en) 2010-04-15
IL212170A (en) 2016-03-31
TW201028377A (en) 2010-08-01
CN102186817B (zh) 2017-05-17
CA2736923C (en) 2016-11-22
CA2736923A1 (en) 2010-04-15
TWI547479B (zh) 2016-09-01
BRPI0920459A2 (pt) 2020-08-11
WO2010042622A1 (en) 2010-04-15
EP2349997A1 (en) 2011-08-03

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FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: EXELIXIS, INC.

Free format text: FORMER OWNER(S): EXELIXIS, INC.; DAIICHI SANKYO COMPANY, LIMITED

MK14 Patent ceased section 143(a) (annual fees not paid) or expired