AU2009272280B2 - Sustained-release drug carrier composition - Google Patents

Sustained-release drug carrier composition Download PDF

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Publication number
AU2009272280B2
AU2009272280B2 AU2009272280A AU2009272280A AU2009272280B2 AU 2009272280 B2 AU2009272280 B2 AU 2009272280B2 AU 2009272280 A AU2009272280 A AU 2009272280A AU 2009272280 A AU2009272280 A AU 2009272280A AU 2009272280 B2 AU2009272280 B2 AU 2009272280B2
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Prior art keywords
another embodiment
substrate
matrix composition
matrix
bone
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AU2009272280A
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AU2009272280A1 (en
Inventor
Shlomo Barak
Noam Emanuel
Moshe Neuman
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Polypid Ltd
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Polypid Ltd
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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  • Health & Medical Sciences (AREA)
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AU2009272280A 2008-07-14 2009-07-14 Sustained-release drug carrier composition Active AU2009272280B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8028908P 2008-07-14 2008-07-14
US61/080,289 2008-07-14
US15478509P 2009-02-24 2009-02-24
US61/154,785 2009-02-24
PCT/IL2009/000701 WO2010007623A1 (en) 2008-07-14 2009-07-14 Sustained-release drug carrier composition

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AU2009272280A1 AU2009272280A1 (en) 2010-01-21
AU2009272280B2 true AU2009272280B2 (en) 2015-08-06

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EP (1) EP2299953B1 (cg-RX-API-DMAC7.html)
JP (3) JP5681626B2 (cg-RX-API-DMAC7.html)
CN (2) CN104274866B (cg-RX-API-DMAC7.html)
AU (1) AU2009272280B2 (cg-RX-API-DMAC7.html)
CA (1) CA2730340C (cg-RX-API-DMAC7.html)
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Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5738856B2 (ja) 2009-07-14 2015-06-24 ポリピッド リミテッド 徐放性薬物担体組成物
AU2011208374B2 (en) 2010-01-19 2016-09-08 Polypid Ltd. Sustained-release nucleic acid matrix compositions
US9119793B1 (en) 2011-06-28 2015-09-01 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for doxycycline
AU2012288422B2 (en) * 2011-07-27 2016-08-11 Polypid Ltd. Matrix compositions for controlled release of peptide and polypeptide molecules
CN102362861B (zh) * 2011-11-04 2014-03-26 无锡中科光远生物材料有限公司 一种空心核壳结构复合纳米粒子及其制备方法
US20130288951A1 (en) * 2012-04-27 2013-10-31 Biomet Manufacturing Corp. Compositions and methods for coating implant surfaces to inhibit surgical infections
EA201492145A1 (ru) * 2012-05-18 2015-03-31 Ой Филана Лтд. Препарат пролонгированного действия на основе доцетаксела для лечения рака
EA027543B1 (ru) 2012-08-02 2017-08-31 Полипид Лтд. Композиции и способы для лечения участков отсутствующей костной ткани и открытых переломов
US10842802B2 (en) 2013-03-15 2020-11-24 Medicis Pharmaceutical Corporation Controlled release pharmaceutical dosage forms
US20160317560A1 (en) * 2013-11-07 2016-11-03 The University Of North Carolina At Chapel Hill Particles containing phospholipids or bioactive fatty acids and uses thereof
WO2015114633A1 (en) 2014-01-30 2015-08-06 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. Actin binding peptides and compositions comprising same for inhibiting angiogenes is and treating medical conditions associated with same
AU2015280417B2 (en) 2014-06-24 2020-01-30 The Trustees Of Princeton University Process for encapsulating soluble biologics, therapeutics, and imaging agents
WO2016020901A1 (en) 2014-08-07 2016-02-11 Acerta Pharma B.V. Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on btk occupancy and btk resynthesis rate
JP2017531461A (ja) * 2014-10-02 2017-10-26 ポリピッド リミテッド インプラント周囲炎の治療法
ES2900816T3 (es) 2014-10-02 2022-03-18 Polypid Ltd Composiciones y métodos para el tratamiento y la profilaxis de las infecciones del sitio quirúrgico
US10695168B2 (en) * 2015-04-17 2020-06-30 Massachusetts Eye And Ear Infirmary Prosthetic devices for semicircular canal defects
CN107921179B (zh) 2015-07-10 2020-12-22 高丽大学校产学协力团 医疗伤口愈合促进器和骨髓炎治疗装置
KR101773287B1 (ko) * 2016-03-10 2017-08-31 고려대학교 산학협력단 골수염 치료 장치
US11103461B2 (en) 2015-12-22 2021-08-31 The Trustees Of Princeton University Process for encapsulating soluble biologics, therapeutics, and imaging agents
CA3047157A1 (en) * 2016-12-16 2018-06-21 Field Orthopaedics Pty Ltd A medical implant and a method of coating a medical implant
WO2019055539A1 (en) 2017-09-12 2019-03-21 Prudhomme Robert K CELLULOSIC POLYMER NANOPARTICLES AND METHODS OF FORMING THE SAME
EP3703667A4 (en) 2017-11-03 2021-08-04 The Trustees of Princeton University PAIRING OF HYDROPHOBIC IONS AND FLASH NANOPRECIPITATION FOR FORMULATIONS OF CONTROLLED RELEASE NANOVECTORS
US12186436B2 (en) 2018-07-19 2025-01-07 The Trustees Of Princeton University Triblock copolymer stabilizers for the formation of nanoparticles encapsulating soluble biologics, therapeutics, and imaging agents
US11731099B2 (en) 2018-07-20 2023-08-22 The Trustees Of Princeton University Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation
US20200147032A1 (en) 2018-11-14 2020-05-14 Robert K. Prud'homme Dihydromyricetin hot melt extrusion formulations and methods for forming them
EP4009998A4 (en) 2019-08-08 2023-05-24 Avidence Therapeutics, Inc. INJECTABLE CELECOXIB MICROBALL BASED FORMULATION
TWI754876B (zh) * 2019-12-31 2022-02-11 財團法人工業技術研究院 含藥多層薄膜與其形成方法
WO2022137126A1 (en) 2020-12-21 2022-06-30 Polypid Ltd. Compositions and methods for the treatment of solid tumors
US20220296524A1 (en) 2021-01-29 2022-09-22 Tionlab Therapeutics Initial burst release controlled depot composition and a method thereof
KR102442807B1 (ko) 2021-01-29 2022-09-15 주식회사 티온랩테라퓨틱스 초기 방출 제어된 데포 조성물 및 이의 제조방법
KR20230115591A (ko) 2022-01-27 2023-08-03 주식회사 티온랩테라퓨틱스 초기 방출 제어된 지질 융합 데포 조성물 및 이의 제조방법
KR20250110749A (ko) 2024-01-12 2025-07-21 주식회사 티온랩테라퓨틱스 소르비탄 포화지방산을 포함하는 서방성 지질 전구 제제 및 이의 제조방법
KR20250118174A (ko) 2024-01-29 2025-08-05 주식회사 티온랩테라퓨틱스 세마글루타이드의 개선된 의료 요법 제공을 위한 비만 및 당뇨 치료용로써, 소수성 이온 페어링 겔레이션을 통한 초기 방출이 제어된 데포 조성물 및 이의 제조방법

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040115240A1 (en) * 2001-03-16 2004-06-17 Timo Narhi Composite for attaching, growing and/or repairing of living tissues and use of said composite
US20040247624A1 (en) * 2003-06-05 2004-12-09 Unger Evan Charles Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US20050208100A1 (en) * 2004-03-19 2005-09-22 Jan Weber Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release
US20050249697A1 (en) * 2003-09-24 2005-11-10 Uhrich Kathryn E Compositions and methods for the inhibition of bone growth and resorption
US20050287180A1 (en) * 2004-06-15 2005-12-29 Chen Andrew X Phospholipid compositions and methods for their preparation and use
US20060147520A1 (en) * 2004-07-26 2006-07-06 Curtis Ruegg Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
US7160557B2 (en) * 1998-04-30 2007-01-09 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US20090006311A1 (en) * 2007-06-28 2009-01-01 Yahoo! Inc. Automated system to improve search engine optimization on web pages

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4882167A (en) * 1983-05-31 1989-11-21 Jang Choong Gook Dry direct compression compositions for controlled release dosage forms
US4578384A (en) * 1984-02-15 1986-03-25 The United States Of America As Represented By The Secretary Of The Army Polylactic-polyglycolic acids combined with an acidic phospholipid-lysozyme complex for healing osseous tissue
US4522863A (en) 1984-06-21 1985-06-11 Kimberly-Clark Corporation Soft nonwoven laminate bonded by adhesive on reinforcing scrim
JPS6163613A (ja) 1984-09-04 1986-04-01 Mitsui Toatsu Chem Inc 顆粒状に調整された徐放性製剤
US5043166A (en) * 1987-01-09 1991-08-27 Hadasit Medical Research, Inc. Liposome/anthraquinone drug composition and method
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
ES2085465T3 (es) 1989-11-13 1996-06-01 Abraham J Domb Lipoesferas para la administracion controlada de sustancias.
US6120805A (en) * 1990-04-06 2000-09-19 Rhone-Poulenc Rorer Sa Microspheres, process for their preparation and their use
JPH046115A (ja) 1990-04-25 1992-01-10 Olympus Optical Co Ltd 光学素子成形用型
DK166600B1 (da) 1991-01-17 1993-06-21 Therkel Bisgaard Vaerktoejssaet til brug ved suturering i dybe operationsaabninger eller legemshulrum
US5922340A (en) * 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US6180134B1 (en) * 1993-03-23 2001-01-30 Sequus Pharmaceuticals, Inc. Enhanced ciruclation effector composition and method
WO1995024929A2 (en) 1994-03-15 1995-09-21 Brown University Research Foundation Polymeric gene delivery system
US6156337A (en) * 1994-07-08 2000-12-05 Opperbas Holding B.V. Method for high loading of vesicles with biopolymeric substances
US6333021B1 (en) * 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US6040295A (en) 1995-01-13 2000-03-21 Genemedicine, Inc. Formulated nucleic acid compositions and methods of administering the same for gene therapy
US5919480A (en) * 1996-06-24 1999-07-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal influenza vaccine composition and method
JPH108035A (ja) 1996-06-25 1998-01-13 Akebono Brake Ind Co Ltd 非石綿系摩擦材
US5837221A (en) * 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
WO1998007412A1 (en) 1996-08-21 1998-02-26 Alkermes Controlled Therapeutics, Inc. Controlled release microparticles with a hydrophobic material
DE69737915T2 (de) * 1996-09-11 2008-03-13 Bristol-Myers Squibb Medical Imaging, Inc. Verfahren zur diagnostischen Bilderzeugung der Nierenregion unter Verwendung eines Kontrastmittels und eines Vasodilators
US6048551A (en) * 1997-03-27 2000-04-11 Hilfinger; John M. Microsphere encapsulation of gene transfer vectors
IL129951A0 (en) * 1997-07-02 2000-02-29 Euro Celtique Sa Prolonged anesthesia in joints and body spaces
US6287587B2 (en) 1997-07-15 2001-09-11 Takeda Chemical Industries, Ltd. Process for producing sustained-release preparation by in-water drying
US6787132B1 (en) * 1997-12-04 2004-09-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combined chemo-immunotherapy with liposomal drugs and cytokines
ES2233036T3 (es) 1998-04-27 2005-06-01 Opperbas Holding B.V. Composicion farmaceutica que comprende factor viii y liposomas neutros.
WO2000003660A1 (en) * 1998-07-17 2000-01-27 Skyepharma, Inc. Biodegradable compositions for the controlled release of encapsulated substances
ATE355827T1 (de) * 1998-08-12 2007-03-15 Yissum Res Dev Co Mittels ammoniumsulfatgradient hergestellte liposomale therapeutische zusammensetzungen
US6153217A (en) 1999-01-22 2000-11-28 Biodelivery Sciences, Inc. Nanocochleate formulations, process of preparation and method of delivery of pharmaceutical agents
US6083482A (en) * 1999-05-11 2000-07-04 Icn Pharmaceuticals, Inc. Conformationally locked nucleosides and oligonucleotides
WO2000078358A2 (en) 1999-06-18 2000-12-28 The Collaborative Group, Ltd. Hyaluronic acid microspheres for sustained gene transfer
DE10001172A1 (de) * 2000-01-13 2001-07-26 Max Planck Gesellschaft Templatieren von Feststoffpartikeln mit Polymermultischichten
US6267587B1 (en) * 2000-07-06 2001-07-31 Johnson & Johnson Vision Care, Inc. Thermal curing oven and thermal curing process
US6967028B2 (en) * 2000-07-31 2005-11-22 Mainelab Prolonged release microspheres for injectable administration
MXPA03002918A (es) * 2000-10-02 2004-04-20 Arizeke Pharmaceuticals Inc Composiciones y metodos para el transporte de agentes biologicamente activos a traves de barreras celulares.
US7749539B2 (en) * 2000-11-30 2010-07-06 Efrat Biopolymers Ltd. Polymeric formulations for drug delivery
MXPA04002891A (es) * 2001-09-28 2005-06-20 Johnson & Johnson Composicion farmaceutica a base de pasta de azucar.
TWI226249B (en) * 2001-12-19 2005-01-11 Ind Tech Res Inst Biodegradable composite matrix for enhancing angiogenesis
US20040086885A1 (en) * 2002-02-22 2004-05-06 Purdue Research Foundation Magnetic nanomaterials and methods for detection of biological materials
EP1509203B1 (en) * 2002-05-15 2016-04-13 California Pacific Medical Center Delivery of nucleic acid-like compounds
US7144430B2 (en) * 2002-07-12 2006-12-05 Motion Control, Inc. Wrist device for use with a prosthetic limb
SE0202619D0 (sv) * 2002-09-05 2002-09-05 Fredrik Nederberg New Polymers and Applications
AU2004211991B2 (en) * 2003-02-12 2011-03-31 Syncera, Inc. Random and non-random alkylene oxide polymer alloy compositions
GB0305941D0 (en) * 2003-03-14 2003-04-23 Camurus Ab Composition
CA2521916C (en) * 2003-04-10 2013-06-25 Teijin Limited Biodegradable film having a honeycomb structure for the prevention of postoperative tissue adhesion
US20060188573A1 (en) * 2003-06-10 2006-08-24 Anna Imberg Composite materials and particles
JP2005154514A (ja) * 2003-11-21 2005-06-16 Univ Waseda 機能性生分解性材料およびその製造方法
US7915028B2 (en) * 2003-11-21 2011-03-29 Teijin Limited Tissue regeneration substrate, complex thereof with cells, and method for its production
CA2553426A1 (en) * 2004-01-15 2005-08-04 Alza Corporation Liposome composition for delivery of therapeutic agents
US8277831B2 (en) * 2004-02-17 2012-10-02 Advanced Technologies And Regenerative Medicine, Llc. Drug-enhanced adhesion prevention
NZ551990A (en) * 2004-06-04 2011-01-28 Camurus Ab Liquid depot formulations
CN101005828B (zh) * 2004-06-17 2012-01-11 维尔恩公司 用于经粘膜递送活性成分的包含粘膜粘附蛋白和所述活性物质的组合物
WO2006116565A2 (en) * 2005-04-25 2006-11-02 Amgen Inc. Biodegradable peptide sustained release compositions containing porogens
US20070141134A1 (en) * 2005-12-16 2007-06-21 Kosak Matthew K Shielded micelles for polynucleotide delivery
EP1976460A4 (en) * 2006-01-19 2012-06-20 Warsaw Orthopedic Inc INJECTABLE AND FORMABLE BONE REPLACEMENT MATERIALS
US20090318355A1 (en) * 2006-02-15 2009-12-24 Chen Thomas T Compositions and methods for promoting tissue repair and wound healing
JP2009534309A (ja) * 2006-03-31 2009-09-24 マサチューセッツ インスティテュート オブ テクノロジー 治療剤の標的化送達のためのシステム
US8703167B2 (en) * 2006-06-05 2014-04-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug
CN101621999B (zh) 2007-03-02 2012-09-26 帝化制药株式会社 经皮吸收医药组合物、医药组合物储存单元以及利用了该储存单元的经皮吸收制剂
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
WO2009006311A2 (en) 2007-06-29 2009-01-08 Wisconsin Alumni Research Foundation Structuring effect of cholesterol in peg-phospholipid micelles, drug delivery of amphotericin b, and combination antifungals
US20090110713A1 (en) 2007-10-31 2009-04-30 Florencia Lim Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices
WO2009061515A1 (en) 2007-11-09 2009-05-14 Northeastern University Self-assembling micelle-like nanoparticles for systemic gene delivery
US20110027172A1 (en) 2007-12-10 2011-02-03 Zhuang Wang Drug delivery system for pharmaceuticals and radiation
TWI373474B (en) 2007-12-31 2012-10-01 Univ Kaohsiung Medical Stem cell transfection method
US8685432B2 (en) * 2008-03-25 2014-04-01 University Of Utah Research Foundation Controlled release tissue graft combination biomaterials
US8128983B2 (en) * 2008-04-11 2012-03-06 Abbott Cardiovascular Systems Inc. Coating comprising poly(ethylene glycol)-poly(lactide-glycolide-caprolactone) interpenetrating network
CA2721333C (en) 2008-04-15 2020-12-01 Protiva Biotherapeutics, Inc. Novel lipid formulations for nucleic acid delivery
JP5738856B2 (ja) 2009-07-14 2015-06-24 ポリピッド リミテッド 徐放性薬物担体組成物
KR101114771B1 (ko) 2009-09-23 2012-03-05 유영환 석쇠
AU2011208374B2 (en) 2010-01-19 2016-09-08 Polypid Ltd. Sustained-release nucleic acid matrix compositions

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7160557B2 (en) * 1998-04-30 2007-01-09 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US20040115240A1 (en) * 2001-03-16 2004-06-17 Timo Narhi Composite for attaching, growing and/or repairing of living tissues and use of said composite
US20040247624A1 (en) * 2003-06-05 2004-12-09 Unger Evan Charles Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US20050249697A1 (en) * 2003-09-24 2005-11-10 Uhrich Kathryn E Compositions and methods for the inhibition of bone growth and resorption
US20050208100A1 (en) * 2004-03-19 2005-09-22 Jan Weber Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release
US20050287180A1 (en) * 2004-06-15 2005-12-29 Chen Andrew X Phospholipid compositions and methods for their preparation and use
US20060147520A1 (en) * 2004-07-26 2006-07-06 Curtis Ruegg Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
US20090006311A1 (en) * 2007-06-28 2009-01-01 Yahoo! Inc. Automated system to improve search engine optimization on web pages

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