AU2009226266A1 - Composite implant having porous structure filled with biodegradable alloy and method of magnesium-based manufacturing the same - Google Patents
Composite implant having porous structure filled with biodegradable alloy and method of magnesium-based manufacturing the same Download PDFInfo
- Publication number
- AU2009226266A1 AU2009226266A1 AU2009226266A AU2009226266A AU2009226266A1 AU 2009226266 A1 AU2009226266 A1 AU 2009226266A1 AU 2009226266 A AU2009226266 A AU 2009226266A AU 2009226266 A AU2009226266 A AU 2009226266A AU 2009226266 A1 AU2009226266 A1 AU 2009226266A1
- Authority
- AU
- Australia
- Prior art keywords
- porous structure
- magnesium
- composite implant
- based alloy
- pores
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000011777 magnesium Substances 0.000 title claims description 136
- 229910052749 magnesium Inorganic materials 0.000 title claims description 124
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title claims description 123
- 239000007943 implant Substances 0.000 title claims description 89
- 229910045601 alloy Inorganic materials 0.000 title claims description 71
- 239000000956 alloy Substances 0.000 title claims description 71
- 238000000034 method Methods 0.000 title claims description 54
- 239000002131 composite material Substances 0.000 title claims description 46
- 238000004519 manufacturing process Methods 0.000 title claims description 24
- 239000011148 porous material Substances 0.000 claims description 52
- 229910052751 metal Inorganic materials 0.000 claims description 42
- 239000002184 metal Substances 0.000 claims description 42
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 31
- 239000010936 titanium Substances 0.000 claims description 30
- 229920000642 polymer Polymers 0.000 claims description 28
- 230000008569 process Effects 0.000 claims description 27
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 26
- 229910052719 titanium Inorganic materials 0.000 claims description 23
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 16
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims description 16
- 239000000919 ceramic Substances 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 11
- 238000011049 filling Methods 0.000 claims description 10
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 claims description 8
- 210000004204 blood vessel Anatomy 0.000 claims description 7
- 239000011651 chromium Substances 0.000 claims description 7
- CPLXHLVBOLITMK-UHFFFAOYSA-N Magnesium oxide Chemical compound [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 6
- 229920000954 Polyglycolide Polymers 0.000 claims description 6
- 239000011572 manganese Substances 0.000 claims description 6
- 229910052759 nickel Inorganic materials 0.000 claims description 6
- 239000010955 niobium Substances 0.000 claims description 6
- 239000004633 polyglycolic acid Substances 0.000 claims description 6
- 239000011669 selenium Substances 0.000 claims description 6
- 239000000126 substance Substances 0.000 claims description 6
- 229910000861 Mg alloy Inorganic materials 0.000 claims description 5
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- 239000001506 calcium phosphate Substances 0.000 claims description 4
- 229910052804 chromium Inorganic materials 0.000 claims description 4
- 230000000399 orthopedic effect Effects 0.000 claims description 4
- 229910052715 tantalum Inorganic materials 0.000 claims description 4
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 4
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 4
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims description 3
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 3
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 3
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 238000002316 cosmetic surgery Methods 0.000 claims description 3
- 239000004053 dental implant Substances 0.000 claims description 3
- 239000000395 magnesium oxide Substances 0.000 claims description 3
- 229910052748 manganese Inorganic materials 0.000 claims description 3
- 229910052750 molybdenum Inorganic materials 0.000 claims description 3
- 239000011733 molybdenum Substances 0.000 claims description 3
- 229910052758 niobium Inorganic materials 0.000 claims description 3
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 claims description 3
- 239000011574 phosphorus Substances 0.000 claims description 3
- 229910052698 phosphorus Inorganic materials 0.000 claims description 3
- -1 polyethylene Polymers 0.000 claims description 3
- 239000004626 polylactic acid Substances 0.000 claims description 3
- VSZWPYCFIRKVQL-UHFFFAOYSA-N selanylidenegallium;selenium Chemical compound [Se].[Se]=[Ga].[Se]=[Ga] VSZWPYCFIRKVQL-UHFFFAOYSA-N 0.000 claims description 3
- 229910052711 selenium Inorganic materials 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- 229910001220 stainless steel Inorganic materials 0.000 claims description 3
- 229910052712 strontium Inorganic materials 0.000 claims description 3
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 3
- JBQYATWDVHIOAR-UHFFFAOYSA-N tellanylidenegermanium Chemical compound [Te]=[Ge] JBQYATWDVHIOAR-UHFFFAOYSA-N 0.000 claims description 3
- 239000004698 Polyethylene Substances 0.000 claims description 2
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims description 2
- 235000011010 calcium phosphates Nutrition 0.000 claims description 2
- 239000000788 chromium alloy Substances 0.000 claims description 2
- 229920000573 polyethylene Polymers 0.000 claims description 2
- 229950008885 polyglycolic acid Drugs 0.000 claims 2
- 239000000843 powder Substances 0.000 description 26
- 239000000463 material Substances 0.000 description 17
- 210000000988 bone and bone Anatomy 0.000 description 13
- 239000000243 solution Substances 0.000 description 10
- 238000005245 sintering Methods 0.000 description 9
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 8
- 150000002739 metals Chemical class 0.000 description 8
- 239000000523 sample Substances 0.000 description 8
- 238000001125 extrusion Methods 0.000 description 7
- 238000002844 melting Methods 0.000 description 7
- 230000008018 melting Effects 0.000 description 7
- 230000011164 ossification Effects 0.000 description 7
- 229920002635 polyurethane Polymers 0.000 description 7
- 239000004814 polyurethane Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 238000006065 biodegradation reaction Methods 0.000 description 6
- 238000005755 formation reaction Methods 0.000 description 6
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 6
- 229910052742 iron Inorganic materials 0.000 description 6
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- 229920002988 biodegradable polymer Polymers 0.000 description 5
- 239000004621 biodegradable polymer Substances 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 229910052786 argon Inorganic materials 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000007797 corrosion Effects 0.000 description 4
- 238000005260 corrosion Methods 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 150000002500 ions Chemical class 0.000 description 4
- 238000005555 metalworking Methods 0.000 description 4
- 239000011259 mixed solution Substances 0.000 description 4
- 230000035882 stress Effects 0.000 description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 238000012669 compression test Methods 0.000 description 3
- 229910052802 copper Inorganic materials 0.000 description 3
- 239000010949 copper Substances 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000006261 foam material Substances 0.000 description 3
- 239000011261 inert gas Substances 0.000 description 3
- 229910021645 metal ion Inorganic materials 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 229910052790 beryllium Inorganic materials 0.000 description 2
- ATBAMAFKBVZNFJ-UHFFFAOYSA-N beryllium atom Chemical compound [Be] ATBAMAFKBVZNFJ-UHFFFAOYSA-N 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 239000010453 quartz Substances 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 2
- 235000019731 tricalcium phosphate Nutrition 0.000 description 2
- 229940078499 tricalcium phosphate Drugs 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229910021591 Copper(I) chloride Inorganic materials 0.000 description 1
- 229920005830 Polyurethane Foam Polymers 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 239000012300 argon atmosphere Substances 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229910001651 emery Inorganic materials 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 230000006355 external stress Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000004088 foaming agent Substances 0.000 description 1
- 238000005242 forging Methods 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000011874 heated mixture Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910001092 metal group alloy Inorganic materials 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 229920002037 poly(vinyl butyral) polymer Polymers 0.000 description 1
- 239000011496 polyurethane foam Substances 0.000 description 1
- 239000010970 precious metal Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- DQWPFSLDHJDLRL-UHFFFAOYSA-N triethyl phosphate Chemical compound CCOP(=O)(OCC)OCC DQWPFSLDHJDLRL-UHFFFAOYSA-N 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/427—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of other specific inorganic materials not covered by A61L27/422 or A61L27/425
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Composite Materials (AREA)
- Materials Engineering (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Dentistry (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020080024801A KR101289122B1 (ko) | 2008-03-18 | 2008-03-18 | 생체분해성 마그네슘계 합금으로 다공성 구조체의 기공이충진된 복합재 임플란트 및 이의 제조방법 |
| KR10-2008-0024801 | 2008-03-18 | ||
| PCT/KR2009/001361 WO2009116799A2 (en) | 2008-03-18 | 2009-03-18 | Composite implant having porous structure filled with biodegradable alloy and method of magnesium-based manufacturing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2009226266A1 true AU2009226266A1 (en) | 2009-09-24 |
Family
ID=41091394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009226266A Abandoned AU2009226266A1 (en) | 2008-03-18 | 2009-03-18 | Composite implant having porous structure filled with biodegradable alloy and method of magnesium-based manufacturing the same |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20110054629A1 (https=) |
| EP (1) | EP2278940A4 (https=) |
| JP (1) | JP2011515145A (https=) |
| KR (1) | KR101289122B1 (https=) |
| CN (1) | CN102014798A (https=) |
| AU (1) | AU2009226266A1 (https=) |
| IN (1) | IN2010DN07335A (https=) |
| WO (1) | WO2009116799A2 (https=) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9452001B2 (en) * | 2005-02-22 | 2016-09-27 | Tecres S.P.A. | Disposable device for treatment of infections of human limbs |
| DE102008037200B4 (de) * | 2008-08-11 | 2015-07-09 | Aap Implantate Ag | Verwendung eines Druckgussverfahrens zur Herstellung eines Implantats aus Magnesium sowie Magnesiumlegierung |
| CN102639158A (zh) * | 2009-12-07 | 2012-08-15 | 友和安股份公司 | 植入物 |
| WO2011071289A2 (ko) * | 2009-12-09 | 2011-06-16 | 서울대학교산학협력단 | 흡수성 재료 및 이를 이용한 식립체, 임플란트 |
| US11491257B2 (en) | 2010-07-02 | 2022-11-08 | University Of Florida Research Foundation, Inc. | Bioresorbable metal alloy and implants |
| WO2012003502A2 (en) * | 2010-07-02 | 2012-01-05 | University Of Florida Research Foundation, Inc. | Bioresorbable metal alloy and implants made of same |
| AU2011326525B2 (en) * | 2010-11-09 | 2015-06-18 | Transluminal Technologies, Llc | Specially designed magnesium-aluminum alloys and medical uses thereof in a hemodynamic environment |
| JP5819977B2 (ja) * | 2010-11-22 | 2015-11-24 | エレクトロマグネティクス コーポレーション | 物質をテーラリングするためのデバイス |
| KR101375473B1 (ko) * | 2011-04-15 | 2014-03-17 | 서울대학교산학협력단 | 생체 분해성 임플란트 및 이의 제조 방법 |
| CN103170013B (zh) * | 2011-12-26 | 2014-12-24 | 蔡淑芬 | 一种医用植入件 |
| CN108994296A (zh) * | 2012-02-20 | 2018-12-14 | 史密夫和内修有限公司 | 多孔结构及其制造方法 |
| RU2015101291A (ru) | 2012-06-26 | 2016-08-10 | Биотроник Аг | Магниевый сплав, способ его производства и использования |
| US10358709B2 (en) | 2012-06-26 | 2019-07-23 | Biotronik Ag | Magnesium-zinc-calcium alloy, method for production thereof, and use thereof |
| HK1200881A1 (en) | 2012-06-26 | 2015-08-14 | 百多力股份公司 | Magnesium alloy, method for the production thereof and use thereof |
| AU2013283433A1 (en) | 2012-06-26 | 2014-10-09 | Biotronik Ag | Magnesium-zinc-calcium alloy, method for production thereof, and use thereof |
| US9084843B2 (en) | 2012-08-14 | 2015-07-21 | The Board Of Trustees Of The University Of Alabama | Biodegradable medical device having an adjustable degradation rate and methods of making the same |
| US10246763B2 (en) | 2012-08-24 | 2019-04-02 | The Regents Of The University Of California | Magnesium-zinc-strontium alloys for medical implants and devices |
| US9469889B2 (en) * | 2012-08-31 | 2016-10-18 | DePuy Synthes Products, Inc. | Ultrapure magnesium alloy with adjustable degradation rate |
| CN102908672A (zh) * | 2012-10-30 | 2013-02-06 | 东南大学 | 高强度可吸收镁基复合骨科内固定器及其制备方法 |
| EP2730298B1 (de) * | 2012-11-09 | 2016-05-18 | Karl Leibinger Medizintechnik Gmbh & Co. Kg | Knochenimplantat aus mindestens zwei unterschiedlichen, resorbierbaren und biodegradierbaren Materialien, die als Hybrid- oder Composite-Material kombinierbar sind |
| CN103028148B (zh) * | 2012-12-28 | 2014-08-27 | 上海交通大学 | 医用可降解Fe-Mg-X合金材料及其制备方法 |
| CN103908328A (zh) * | 2013-01-06 | 2014-07-09 | 香港中文大学 | 骨植入物 |
| US9593397B2 (en) | 2013-03-14 | 2017-03-14 | DePuy Synthes Products, Inc. | Magnesium alloy with adjustable degradation rate |
| US10478529B2 (en) | 2013-03-14 | 2019-11-19 | DePuy Synthes Products, Inc. | Magnesium alloy with adjustable degradation rate |
| JP6408556B2 (ja) * | 2013-03-14 | 2018-10-17 | バイオ ディージー インコーポレイテッド | 向上した分解速度を有する生分解性合金を含む埋め込み型医療デバイス |
| WO2015003112A1 (en) | 2013-07-03 | 2015-01-08 | University Of Florida Research Foundation, Inc. | Biodegradable magnesium alloys, methods of manufacture thereof and articles comprising the same |
| US9795427B2 (en) | 2013-11-05 | 2017-10-24 | University Of Florida Research Foundation, Inc. | Articles comprising reversibly attached screws comprising a biodegradable composition, methods of manufacture thereof and uses thereof |
| KR101493752B1 (ko) * | 2013-11-18 | 2015-02-17 | 고려대학교 산학협력단 | 이중기공 합성골 웨지 및 이의 제조 방법 |
| TWI615136B (zh) * | 2013-12-06 | 2018-02-21 | 財團法人金屬工業研究發展中心 | 椎間植入物及其製備方法 |
| CN104707182B (zh) * | 2013-12-16 | 2017-08-11 | 财团法人金属工业研究发展中心 | 椎间植入物 |
| CN106061520A (zh) * | 2014-03-03 | 2016-10-26 | 医乐世医疗技术蒂默什达拉公司 | 用于刺激骨形成的复合物 |
| WO2016118444A1 (en) | 2015-01-23 | 2016-07-28 | University Of Florida Research Foundation, Inc. | Radiation shielding and mitigating alloys, methods of manufacture thereof and articles comprising the same |
| CN104710793A (zh) * | 2015-03-31 | 2015-06-17 | 苏州维泰生物技术有限公司 | 一种医用合金材料及其制备方法 |
| WO2016159493A1 (ko) * | 2015-03-31 | 2016-10-06 | (주)웹스 | 생분해성 임플란트 구조체 |
| EP3093030A1 (de) | 2015-05-12 | 2016-11-16 | Biotronik AG | Bioresorbierbares osteosynthese-implantat |
| US12023418B2 (en) * | 2016-09-09 | 2024-07-02 | University of Pittsburgh—of the Commonwealth System of Higher Education | Biocompatible polymer and magnesium for regeneration of articular surfaces in the temporomandibular joint |
| WO2018187756A1 (en) * | 2017-04-07 | 2018-10-11 | The Board Of Trustees Of The University Of Illinois | Bioresorbable magnesium-based sponge and foam materials, methods and devices |
| CN107397977B (zh) * | 2017-08-03 | 2021-01-26 | 广东工业大学 | 3d打印金属基体表面改性的方法、3d打印金属基生物陶瓷支架及其制备方法 |
| CN208823014U (zh) * | 2017-12-01 | 2019-05-07 | 广州市健齿生物科技有限公司 | 一种可降解镁离子的多孔牙种植体 |
| CN108159488B (zh) * | 2018-01-12 | 2020-08-07 | 杭州电子科技大学 | 一种能促进骨骼生长的多孔钛镁合金人工骨及其制备方法 |
| KR102059960B1 (ko) * | 2018-06-11 | 2019-12-30 | 장희지 | 생분해성 물질을 구비한 임플란트 |
| CN111068106A (zh) * | 2019-11-27 | 2020-04-28 | 东南大学 | 一种医用可降解抗菌复合材料及其制备方法和应用 |
| CN112168431A (zh) * | 2020-10-23 | 2021-01-05 | 中国人民解放军空军军医大学 | 一种功能仿生性多孔钛合金股骨头支撑棒及其制备方法 |
| JP7675189B2 (ja) * | 2020-12-28 | 2025-05-12 | 元心科技（深▲せん▼）有限公司 | 整形外科内固定インプラント医療機器 |
| TR202102040A2 (tr) * | 2021-02-12 | 2021-05-21 | Atatuerk Ueniversitesi Rektoerluegue Bilimsel Arastirma Projeleri Bap Koordinasyon Birimi | Ti̇tanyum esasli bi̇yokompozi̇t doku i̇skelesi̇ üreti̇m yöntemi̇ |
| CN113209366A (zh) * | 2021-04-23 | 2021-08-06 | 常州市第二人民医院 | 一种可降解局部万古霉素缓释系统及其制备方法 |
| US20220354488A1 (en) | 2021-05-10 | 2022-11-10 | Cilag Gmbh International | Absorbable surgical staples comprising sufficient structural properties during a tissue healing window |
| CN115671378B (zh) * | 2021-07-21 | 2024-03-15 | 北京大学口腔医学院 | 一种降解速率可控镁合金引导骨再生植入体 |
| KR20230074009A (ko) | 2021-11-19 | 2023-05-26 | 주식회사 도이프 | 생체친화형 마그네슘 메시의 제조방법 |
| CN114569223B (zh) * | 2022-01-25 | 2023-12-08 | 苏州卓恰医疗科技有限公司 | 具有填充物的身体植入物及其制备方法 |
| CN115501386A (zh) * | 2022-09-28 | 2022-12-23 | 北京科技大学 | 一种全降解高强韧仿生梯度复合材料及其增材制造方法 |
| PL445734A1 (pl) * | 2023-08-01 | 2025-02-03 | Wątrobiński Marcin | Hybrydowy implant bioresorbowalny, sposób jego wytwarzania i zastosowanie do implantacji ubytków kości w chirurgii szczękowej |
| CN118576376B (zh) * | 2024-06-24 | 2025-11-04 | 山东威高骨科材料股份有限公司 | 具有骨诱导性高强度椎间融合器及制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19731021A1 (de) | 1997-07-18 | 1999-01-21 | Meyer Joerg | In vivo abbaubares metallisches Implantat |
| GB0020734D0 (en) * | 2000-08-22 | 2000-10-11 | Dytech Corp Ltd | Bicontinuous composites |
| US6599323B2 (en) * | 2000-12-21 | 2003-07-29 | Ethicon, Inc. | Reinforced tissue implants and methods of manufacture and use |
| CA2489242A1 (en) * | 2002-07-12 | 2004-01-22 | Robert M. Pilliar | Method of manufacture of porous inorganic structures and infiltration with organic polymers |
| KR100487119B1 (ko) | 2002-11-26 | 2005-05-03 | 설영택 | 마그네슘 티타네이트 산화막 임플란트 및 그 제조방법 |
| WO2006077256A1 (en) * | 2005-01-24 | 2006-07-27 | Cinvention Ag | Metal containing composite materials |
| EA200702019A1 (ru) * | 2005-03-18 | 2008-02-28 | Синвеншен Аг | Способ изготовления пористых спечённых металлсодержащих материалов |
| WO2007003516A2 (en) * | 2005-07-01 | 2007-01-11 | Cinvention Ag | Medical devices comprising a reticulated composite material |
| CN100584390C (zh) * | 2006-03-08 | 2010-01-27 | 中国科学院金属研究所 | 一种骨组织工程支架材料 |
| DE102006015457A1 (de) | 2006-03-31 | 2007-10-04 | Biotronik Vi Patent Ag | Magnesiumlegierung und dazugehöriges Herstellungsverfahren |
| GB0610333D0 (en) * | 2006-05-24 | 2006-07-05 | Orthogem Ltd | Bone repair or augmentation device |
| WO2008122595A2 (en) * | 2007-04-05 | 2008-10-16 | Cinvention Ag | Biodegradable therapeutic implant for bone or cartilage repair |
| ES2712548T3 (es) * | 2009-04-22 | 2019-05-13 | U & I Corp | Implante biodegradable y procedimiento para fabricar el mismo |
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| KR101289122B1 (ko) | 2013-07-23 |
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| WO2009116799A3 (en) | 2009-12-23 |
| EP2278940A2 (en) | 2011-02-02 |
| KR20090099670A (ko) | 2009-09-23 |
| JP2011515145A (ja) | 2011-05-19 |
| US20110054629A1 (en) | 2011-03-03 |
| EP2278940A4 (en) | 2013-07-17 |
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