AU2009212319B2 - Oral care product and methods of use and manufacture thereof - Google Patents
Oral care product and methods of use and manufacture thereof Download PDFInfo
- Publication number
- AU2009212319B2 AU2009212319B2 AU2009212319A AU2009212319A AU2009212319B2 AU 2009212319 B2 AU2009212319 B2 AU 2009212319B2 AU 2009212319 A AU2009212319 A AU 2009212319A AU 2009212319 A AU2009212319 A AU 2009212319A AU 2009212319 B2 AU2009212319 B2 AU 2009212319B2
- Authority
- AU
- Australia
- Prior art keywords
- calcium
- reduce
- teeth
- oral care
- oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 title claims abstract description 28
- 238000004519 manufacturing process Methods 0.000 title description 4
- 239000000203 mixture Substances 0.000 claims abstract description 225
- 150000001413 amino acids Chemical class 0.000 claims abstract description 48
- 150000003839 salts Chemical group 0.000 claims abstract description 45
- 159000000007 calcium salts Chemical class 0.000 claims abstract description 19
- 229940024606 amino acid Drugs 0.000 claims description 47
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 46
- 229940091249 fluoride supplement Drugs 0.000 claims description 43
- 210000000214 mouth Anatomy 0.000 claims description 33
- 241000894006 Bacteria Species 0.000 claims description 27
- 239000004475 Arginine Substances 0.000 claims description 24
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 24
- 239000002253 acid Substances 0.000 claims description 22
- 230000036541 health Effects 0.000 claims description 16
- 239000011575 calcium Substances 0.000 claims description 15
- 239000002324 mouth wash Substances 0.000 claims description 15
- 229960005069 calcium Drugs 0.000 claims description 14
- 229910052791 calcium Inorganic materials 0.000 claims description 14
- 208000002925 dental caries Diseases 0.000 claims description 14
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 13
- 230000003902 lesion Effects 0.000 claims description 13
- 230000009885 systemic effect Effects 0.000 claims description 13
- 230000001013 cariogenic effect Effects 0.000 claims description 12
- 230000015572 biosynthetic process Effects 0.000 claims description 11
- 210000003298 dental enamel Anatomy 0.000 claims description 11
- 238000005115 demineralization Methods 0.000 claims description 10
- 230000002328 demineralizing effect Effects 0.000 claims description 10
- 239000000551 dentifrice Substances 0.000 claims description 10
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical group OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 8
- 230000036996 cardiovascular health Effects 0.000 claims description 8
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 8
- 150000001735 carboxylic acids Chemical class 0.000 claims description 7
- 230000000694 effects Effects 0.000 claims description 7
- 208000007565 gingivitis Diseases 0.000 claims description 7
- 230000008439 repair process Effects 0.000 claims description 7
- 206010020751 Hypersensitivity Diseases 0.000 claims description 6
- 208000026935 allergic disease Diseases 0.000 claims description 6
- 230000003628 erosive effect Effects 0.000 claims description 6
- 230000035876 healing Effects 0.000 claims description 6
- 230000009610 hypersensitivity Effects 0.000 claims description 6
- 230000000813 microbial effect Effects 0.000 claims description 6
- 230000007406 plaque accumulation Effects 0.000 claims description 6
- 206010013781 dry mouth Diseases 0.000 claims description 5
- 230000032770 biofilm formation Effects 0.000 claims description 4
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 4
- 239000001527 calcium lactate Substances 0.000 claims description 4
- 235000011086 calcium lactate Nutrition 0.000 claims description 4
- 229960002401 calcium lactate Drugs 0.000 claims description 4
- RWYRUDPAALLKPX-UHFFFAOYSA-N 2,2-difluoro-n-methylethanamine;hydrochloride Chemical compound Cl.CNCC(F)F RWYRUDPAALLKPX-UHFFFAOYSA-N 0.000 claims description 3
- OPSXJNAGCGVGOG-DKWTVANSSA-L Calcium L-aspartate Chemical compound [Ca+2].[O-]C(=O)[C@@H](N)CC([O-])=O OPSXJNAGCGVGOG-DKWTVANSSA-L 0.000 claims description 3
- CBOCVOKPQGJKKJ-UHFFFAOYSA-L Calcium formate Chemical compound [Ca+2].[O-]C=O.[O-]C=O CBOCVOKPQGJKKJ-UHFFFAOYSA-L 0.000 claims description 3
- 239000001749 Calcium fumarate Substances 0.000 claims description 3
- BCZXFFBUYPCTSJ-UHFFFAOYSA-L Calcium propionate Chemical compound [Ca+2].CCC([O-])=O.CCC([O-])=O BCZXFFBUYPCTSJ-UHFFFAOYSA-L 0.000 claims description 3
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 3
- 229940034055 calcium aspartate Drugs 0.000 claims description 3
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical group [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 claims description 3
- 239000001354 calcium citrate Substances 0.000 claims description 3
- 229960004256 calcium citrate Drugs 0.000 claims description 3
- 229940044172 calcium formate Drugs 0.000 claims description 3
- 239000004281 calcium formate Substances 0.000 claims description 3
- 235000019255 calcium formate Nutrition 0.000 claims description 3
- 235000019296 calcium fumarate Nutrition 0.000 claims description 3
- 239000004227 calcium gluconate Substances 0.000 claims description 3
- 235000013927 calcium gluconate Nutrition 0.000 claims description 3
- 229960004494 calcium gluconate Drugs 0.000 claims description 3
- PWKNEBQRTUXXLT-ZBHRUSISSA-L calcium lactate gluconate Chemical compound [Ca+2].CC(O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O PWKNEBQRTUXXLT-ZBHRUSISSA-L 0.000 claims description 3
- 229940041131 calcium lactate gluconate Drugs 0.000 claims description 3
- OLOZVPHKXALCRI-UHFFFAOYSA-L calcium malate Chemical compound [Ca+2].[O-]C(=O)C(O)CC([O-])=O OLOZVPHKXALCRI-UHFFFAOYSA-L 0.000 claims description 3
- 239000001362 calcium malate Substances 0.000 claims description 3
- 229940016114 calcium malate Drugs 0.000 claims description 3
- 235000011038 calcium malates Nutrition 0.000 claims description 3
- 239000004330 calcium propionate Substances 0.000 claims description 3
- 235000010331 calcium propionate Nutrition 0.000 claims description 3
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims description 3
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 3
- 235000013337 tricalcium citrate Nutrition 0.000 claims description 3
- 235000001014 amino acid Nutrition 0.000 description 45
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 44
- -1 fluoride ions Chemical class 0.000 description 44
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 23
- 235000009697 arginine Nutrition 0.000 description 23
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- 239000000377 silicon dioxide Substances 0.000 description 21
- 239000011734 sodium Substances 0.000 description 21
- 229910052708 sodium Inorganic materials 0.000 description 19
- 239000003795 chemical substances by application Substances 0.000 description 18
- 238000009472 formulation Methods 0.000 description 16
- 239000000606 toothpaste Substances 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 15
- 229940034610 toothpaste Drugs 0.000 description 15
- 239000003945 anionic surfactant Substances 0.000 description 14
- 229920000642 polymer Polymers 0.000 description 14
- 239000004094 surface-active agent Substances 0.000 description 14
- 239000003082 abrasive agent Substances 0.000 description 13
- 239000002245 particle Substances 0.000 description 13
- 239000003906 humectant Substances 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 11
- 102000004190 Enzymes Human genes 0.000 description 11
- 108090000790 Enzymes Proteins 0.000 description 11
- 229940088598 enzyme Drugs 0.000 description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 11
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 10
- 239000000463 material Substances 0.000 description 10
- 229960003500 triclosan Drugs 0.000 description 10
- 239000001506 calcium phosphate Substances 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 8
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 8
- 239000000796 flavoring agent Substances 0.000 description 8
- 150000004673 fluoride salts Chemical class 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- 229910052700 potassium Inorganic materials 0.000 description 8
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 8
- 230000008901 benefit Effects 0.000 description 7
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- 239000003921 oil Substances 0.000 description 7
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- 210000001519 tissue Anatomy 0.000 description 7
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 7
- 125000004429 atom Chemical group 0.000 description 6
- 229910000389 calcium phosphate Inorganic materials 0.000 description 6
- 235000011010 calcium phosphates Nutrition 0.000 description 6
- 235000011180 diphosphates Nutrition 0.000 description 6
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- 229910052500 inorganic mineral Inorganic materials 0.000 description 6
- 235000010755 mineral Nutrition 0.000 description 6
- 239000011707 mineral Substances 0.000 description 6
- 239000011591 potassium Substances 0.000 description 6
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- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 5
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
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- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 4
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- MPNNOLHYOHFJKL-UHFFFAOYSA-K peroxyphosphate Chemical compound [O-]OP([O-])([O-])=O MPNNOLHYOHFJKL-UHFFFAOYSA-K 0.000 description 1
- JRKICGRDRMAZLK-UHFFFAOYSA-L persulfate group Chemical group S(=O)(=O)([O-])OOS(=O)(=O)[O-] JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
- 238000010419 pet care Methods 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- CCTIOCVIZPCTGO-BYPYZUCNSA-N phosphoarginine Chemical compound OC(=O)[C@@H](N)CCCNC(=N)NP(O)(O)=O CCTIOCVIZPCTGO-BYPYZUCNSA-N 0.000 description 1
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 1
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
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- 238000005498 polishing Methods 0.000 description 1
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- 229920005646 polycarboxylate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
- 229940099402 potassium metaphosphate Drugs 0.000 description 1
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
- 229960001621 povidone-iodine Drugs 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- CIBMHJPPKCXONB-UHFFFAOYSA-N propane-2,2-diol Chemical compound CC(C)(O)O CIBMHJPPKCXONB-UHFFFAOYSA-N 0.000 description 1
- 229940069949 propolis Drugs 0.000 description 1
- XEYBRNLFEZDVAW-UHFFFAOYSA-N prostaglandin E2 Natural products CCCCCC(O)C=CC1C(O)CC(=O)C1CC=CCCCC(O)=O XEYBRNLFEZDVAW-UHFFFAOYSA-N 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- GRJJQCWNZGRKAU-UHFFFAOYSA-N pyridin-1-ium;fluoride Chemical compound F.C1=CC=NC=C1 GRJJQCWNZGRKAU-UHFFFAOYSA-N 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000000395 remineralizing effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229940092258 rosemary extract Drugs 0.000 description 1
- 235000020748 rosemary extract Nutrition 0.000 description 1
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical compound OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 description 1
- 229950000975 salicylanilide Drugs 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 229940045990 sodium laureth-2 sulfate Drugs 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- 229960001922 sodium perborate Drugs 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- GUQPDKHHVFLXHS-UHFFFAOYSA-M sodium;2-(2-dodecoxyethoxy)ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOS([O-])(=O)=O GUQPDKHHVFLXHS-UHFFFAOYSA-M 0.000 description 1
- YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- WSWCOQWTEOXDQX-MQQKCMAXSA-N sorbic acid group Chemical group C(\C=C\C=C\C)(=O)O WSWCOQWTEOXDQX-MQQKCMAXSA-N 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- DIORMHZUUKOISG-UHFFFAOYSA-N sulfoformic acid Chemical compound OC(=O)S(O)(=O)=O DIORMHZUUKOISG-UHFFFAOYSA-N 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- MSLRPWGRFCKNIZ-UHFFFAOYSA-J tetrasodium;hydrogen peroxide;dicarbonate Chemical compound [Na+].[Na+].[Na+].[Na+].OO.OO.OO.[O-]C([O-])=O.[O-]C([O-])=O MSLRPWGRFCKNIZ-UHFFFAOYSA-J 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 230000036347 tooth sensitivity Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- SYMVZGYNJDKIPL-UHFFFAOYSA-H tricalcium;oxido phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]OP([O-])([O-])=O.[O-]OP([O-])([O-])=O SYMVZGYNJDKIPL-UHFFFAOYSA-H 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
- WBGSMIRITKHZNA-UHFFFAOYSA-M trisodium;dioxido(oxidooxy)borane Chemical compound [Na+].[Na+].[Na+].[O-]OB([O-])[O-] WBGSMIRITKHZNA-UHFFFAOYSA-M 0.000 description 1
- VBIJGJLWKWLWHQ-UHFFFAOYSA-K trisodium;oxido phosphate Chemical compound [Na+].[Na+].[Na+].[O-]OP([O-])([O-])=O VBIJGJLWKWLWHQ-UHFFFAOYSA-K 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
- 229940117958 vinyl acetate Drugs 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2743208P | 2008-02-08 | 2008-02-08 | |
| US2743108P | 2008-02-08 | 2008-02-08 | |
| US2743508P | 2008-02-08 | 2008-02-08 | |
| US2742008P | 2008-02-08 | 2008-02-08 | |
| US61/027,432 | 2008-02-08 | ||
| US61/027,435 | 2008-02-08 | ||
| US61/027,431 | 2008-02-08 | ||
| US61/027,420 | 2008-02-08 | ||
| US2744408P | 2008-02-09 | 2008-02-09 | |
| US2744208P | 2008-02-09 | 2008-02-09 | |
| US61/027,442 | 2008-02-09 | ||
| US61/027,444 | 2008-02-09 | ||
| PCT/US2009/033289 WO2009100263A2 (en) | 2008-02-08 | 2009-02-06 | Oral care product and methods of use and manufacture thereof |
Publications (2)
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| AU2009212319A1 AU2009212319A1 (en) | 2009-08-13 |
| AU2009212319B2 true AU2009212319B2 (en) | 2012-11-15 |
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| AU2009212319A Active AU2009212319B2 (en) | 2008-02-08 | 2009-02-06 | Oral care product and methods of use and manufacture thereof |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20110014136A1 (enExample) |
| EP (1) | EP2217202A4 (enExample) |
| JP (1) | JP2011515332A (enExample) |
| CN (1) | CN101938982B (enExample) |
| AR (1) | AR070357A1 (enExample) |
| AU (1) | AU2009212319B2 (enExample) |
| BR (1) | BRPI0906453A2 (enExample) |
| CA (1) | CA2707085C (enExample) |
| MX (1) | MX2010005006A (enExample) |
| RU (1) | RU2013124842A (enExample) |
| TW (1) | TWI374753B (enExample) |
| WO (1) | WO2009100263A2 (enExample) |
| ZA (1) | ZA201003687B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI420722B (zh) | 2008-01-30 | 2013-12-21 | 歐斯朗奧托半導體股份有限公司 | 具有封裝單元之裝置 |
| WO2012064338A1 (en) | 2010-11-12 | 2012-05-18 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| DE102011003882A1 (de) * | 2011-02-09 | 2012-08-09 | Sb Limotive Company Ltd. | Zusammensetzung zum Löschen und/oder Hemmen von Fluor- und/oder Phosphor-haltigen Bränden |
| US9877929B2 (en) | 2011-10-13 | 2018-01-30 | Premier Dental Products Company | Topical vitamin D and ubiquinol oral supplement compositions |
| AU2011383326B2 (en) | 2011-12-15 | 2016-01-28 | Colgate-Palmolive Company | Aqueous oral care compositions |
| US9724542B2 (en) | 2012-10-12 | 2017-08-08 | Premier Dental Products Company | Remineralizing and desensitizing compositions, treatments and methods of manufacture |
| US9877930B2 (en) * | 2012-10-12 | 2018-01-30 | Premier Dental Products Company | Topical ubiquinol oral supplement compositions with amorphous calcium phosphate |
| KR20150090136A (ko) | 2012-12-03 | 2015-08-05 | 콜게이트-파아므올리브캄파니 | 치아 우식증을 치료하는 조성물 및 방법 |
| BR112015012959B1 (pt) * | 2012-12-06 | 2018-12-11 | Colgate-Palmolive Company | composição para cuidado oral |
| JP2015096473A (ja) * | 2013-11-15 | 2015-05-21 | 第一三共ヘルスケア株式会社 | 唾液分泌促進剤及びそれを含有する口腔用組成物 |
| CA2927611C (en) | 2013-12-03 | 2020-11-17 | Colgate-Palmolive Company | Oral care compositions |
| US20170157003A1 (en) * | 2014-07-11 | 2017-06-08 | Koninklijke Philips N.V. | Oral care formulation system providing amorphous calcium phosphate |
| WO2016105389A1 (en) | 2014-12-23 | 2016-06-30 | Colgate-Palmolive Company | Oral care compositions |
| BR112017012629B1 (pt) | 2014-12-23 | 2021-06-08 | Colgate-Palmolive Company | composição para higiene bucal e uso da mesma |
| JP6795316B2 (ja) * | 2015-03-18 | 2020-12-02 | 第一三共ヘルスケア株式会社 | Ｌ−アスパラギン酸またはその塩、及びニコチンアミドを含有する口腔ケア用組成物 |
| JP2018104302A (ja) * | 2016-12-22 | 2018-07-05 | 花王株式会社 | 歯磨剤用顆粒の製造方法 |
| EP3597175A4 (en) * | 2017-03-16 | 2020-12-16 | Ezaki Glico Co., Ltd. | ORAL COMPOSITION TO PROMOTE DENTAL REMINERALIZATION |
| WO2020016713A1 (en) | 2018-07-16 | 2020-01-23 | 3M Innovative Properties Company | Amino acid containing oral care composition for treating caries by reducing lactic acid release in oral biofilms |
| EP3930666A1 (en) | 2019-03-29 | 2022-01-05 | Colgate-Palmolive Company | Oral care product |
| MX2021011552A (es) | 2019-03-29 | 2021-10-26 | Colgate Palmolive Co | Producto para el cuidado bucal y metodos para uso y fabricacion de este. |
| AU2020299514B2 (en) | 2019-07-01 | 2023-05-18 | Colgate-Palmolive Company | Oral care compositions and methods |
| EP4072686A1 (en) | 2019-12-12 | 2022-10-19 | 3M Innovative Properties Company | Oral care composition with n-acetyl amino acid components for treating caries |
| EP3848017A1 (en) | 2020-01-08 | 2021-07-14 | 3M Innovative Properties Company | Oral care composition containing indole components for treating caries |
| US12083209B2 (en) | 2020-02-18 | 2024-09-10 | Sunstar Americas, Inc. | Oral care composition |
| CN114504646B (zh) * | 2022-02-18 | 2022-11-04 | 深圳南粤药业有限公司 | 一种含粘蛋白的人工唾液组合物及其制备方法与应用 |
| WO2023201001A1 (en) * | 2022-04-15 | 2023-10-19 | Zest Ip Holdings, Llc | Remineralization composition and application method thereof |
| CN115400039A (zh) * | 2022-10-17 | 2022-11-29 | 涌智(上海)生物科技有限公司 | 一种口腔酸碱平衡制剂及其应用 |
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| US5747004A (en) * | 1995-07-10 | 1998-05-05 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Self-heating dentifrice |
| US5801226A (en) * | 1995-04-05 | 1998-09-01 | Unilever Patent Holdings B.V. | Oral care compositions |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3538230A (en) | 1966-12-05 | 1970-11-03 | Lever Brothers Ltd | Oral compositions containing silica xerogels as cleaning and polishing agents |
| US3678154A (en) | 1968-07-01 | 1972-07-18 | Procter & Gamble | Oral compositions for calculus retardation |
| US3535421A (en) | 1968-07-11 | 1970-10-20 | Procter & Gamble | Oral compositions for calculus retardation |
| US4154815A (en) | 1970-04-01 | 1979-05-15 | Lever Brothers Company | Zinc and enzyme toothpowder dentifrice |
| US3696191A (en) | 1970-11-10 | 1972-10-03 | Monsanto Co | Dental creams containing enzymes |
| US4058595A (en) | 1971-10-13 | 1977-11-15 | Colgate-Palmolive Company | Stabilized toothpastes containing an enzyme |
| US3959458A (en) | 1973-02-09 | 1976-05-25 | The Procter & Gamble Company | Oral compositions for calculus retardation |
| US3937807A (en) | 1973-03-06 | 1976-02-10 | The Procter & Gamble Company | Oral compositions for plaque, caries, and calculus retardation with reduced staining tendencies |
| US3862307A (en) | 1973-04-09 | 1975-01-21 | Procter & Gamble | Dentifrices containing a cationic therapeutic agent and improved silica abrasive |
| US3991177A (en) | 1973-11-27 | 1976-11-09 | Colgate-Palmolive Company | Oral compositions containing dextranase |
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2009
- 2009-02-06 CA CA2707085A patent/CA2707085C/en active Active
- 2009-02-06 WO PCT/US2009/033289 patent/WO2009100263A2/en not_active Ceased
- 2009-02-06 JP JP2010546014A patent/JP2011515332A/ja active Pending
- 2009-02-06 EP EP20090708692 patent/EP2217202A4/en not_active Ceased
- 2009-02-06 CN CN200980104885.7A patent/CN101938982B/zh active Active
- 2009-02-06 MX MX2010005006A patent/MX2010005006A/es active IP Right Grant
- 2009-02-06 BR BRPI0906453-2A patent/BRPI0906453A2/pt not_active IP Right Cessation
- 2009-02-06 US US12/866,622 patent/US20110014136A1/en not_active Abandoned
- 2009-02-06 TW TW098103765A patent/TWI374753B/zh not_active IP Right Cessation
- 2009-02-06 AR ARP090100429A patent/AR070357A1/es unknown
- 2009-02-06 AU AU2009212319A patent/AU2009212319B2/en active Active
-
2010
- 2010-05-24 ZA ZA2010/03687A patent/ZA201003687B/en unknown
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2013
- 2013-05-28 RU RU2013124842/15A patent/RU2013124842A/ru not_active Application Discontinuation
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| US5801226A (en) * | 1995-04-05 | 1998-09-01 | Unilever Patent Holdings B.V. | Oral care compositions |
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Also Published As
| Publication number | Publication date |
|---|---|
| US20110014136A1 (en) | 2011-01-20 |
| CA2707085C (en) | 2013-11-26 |
| RU2013124842A (ru) | 2014-12-10 |
| CN101938982B (zh) | 2014-06-04 |
| JP2011515332A (ja) | 2011-05-19 |
| WO2009100263A3 (en) | 2009-10-22 |
| TWI374753B (en) | 2012-10-21 |
| MX2010005006A (es) | 2010-05-27 |
| WO2009100263A2 (en) | 2009-08-13 |
| EP2217202A4 (en) | 2014-01-08 |
| BRPI0906453A2 (pt) | 2015-07-14 |
| TW200946133A (en) | 2009-11-16 |
| EP2217202A2 (en) | 2010-08-18 |
| AU2009212319A1 (en) | 2009-08-13 |
| CN101938982A (zh) | 2011-01-05 |
| AR070357A1 (es) | 2010-03-31 |
| ZA201003687B (en) | 2015-06-24 |
| CA2707085A1 (en) | 2009-08-13 |
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