AU2009202685B1 - Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension - Google Patents

Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension Download PDF

Info

Publication number
AU2009202685B1
AU2009202685B1 AU2009202685A AU2009202685A AU2009202685B1 AU 2009202685 B1 AU2009202685 B1 AU 2009202685B1 AU 2009202685 A AU2009202685 A AU 2009202685A AU 2009202685 A AU2009202685 A AU 2009202685A AU 2009202685 B1 AU2009202685 B1 AU 2009202685B1
Authority
AU
Australia
Prior art keywords
patient
treatment
left ventricular
pulmonary
risk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2009202685A
Other languages
English (en)
Inventor
James S. Baldassarre
Ralf Rosskamp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
INO Therapeutics LLC
Original Assignee
INO Therapeutics LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42062590&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2009202685(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by INO Therapeutics LLC filed Critical INO Therapeutics LLC
Priority to AU2010202422A priority Critical patent/AU2010202422B2/en
Priority to AU2010206032A priority patent/AU2010206032B2/en
Publication of AU2009202685B1 publication Critical patent/AU2009202685B1/en
Assigned to IKARIA, INC. reassignment IKARIA, INC. Request to Amend Deed and Register Assignors: IKARIA HOLDINGS, INC.
Assigned to INO THERAPEUTICS LLC reassignment INO THERAPEUTICS LLC Request for Assignment Assignors: IKARIA, INC.
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/08—Measuring devices for evaluating the respiratory organs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7275—Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7271—Specific aspects of physiological measurement analysis
    • A61B5/7278—Artificial waveform generation or derivation, e.g. synthesizing signals from measured signals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Clinical applications
    • A61B8/0883—Clinical applications for diagnosis of the heart
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/48—Diagnostic techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/0057—Pumps therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/104—Preparation of respiratory gases or vapours specially adapted for anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
    • A61M16/10—Preparation of respiratory gases or vapours
    • A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/135—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting
    • A61M60/139—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel inside a blood vessel, e.g. using grafting inside the aorta, e.g. intra-aortic balloon pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/295—Balloon pumps for circulatory assistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving
    • A61M60/497—Details relating to driving for balloon pumps for circulatory assistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/841—Constructional details other than related to driving of balloon pumps for circulatory assistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/855—Constructional details other than related to driving of implantable pumps or pumping devices
    • A61M60/857—Implantable blood tubes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
    • G06Q99/00—Subject matter not provided for in other groups of this subclass
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2201/00—Vessel construction, in particular geometry, arrangement or size
    • F17C2201/05—Size
    • F17C2201/058—Size portable (<30 l)
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2203/00—Vessel construction, in particular walls or details thereof
    • F17C2203/06—Materials for walls or layers thereof; Properties or structures of walls or their materials
    • F17C2203/0634—Materials for walls or layers thereof
    • F17C2203/0636—Metals
    • F17C2203/0646—Aluminium
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2221/00—Handled fluid, in particular type of fluid
    • F17C2221/01—Pure fluids
    • F17C2221/014—Nitrogen
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2221/00—Handled fluid, in particular type of fluid
    • F17C2221/03—Mixtures
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2223/00—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel
    • F17C2223/01—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel characterised by the phase
    • F17C2223/0107—Single phase
    • F17C2223/0123—Single phase gaseous, e.g. CNG, GNC
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2223/00—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel
    • F17C2223/03—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel characterised by the pressure level
    • F17C2223/036—Very high pressure (>80 bar)
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
    • F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
    • F17C2270/00—Applications
    • F17C2270/02—Applications for medical applications
    • F17C2270/025—Breathing
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Physiology (AREA)
  • Mechanical Engineering (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Psychiatry (AREA)
  • Signal Processing (AREA)
  • Inorganic Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Business, Economics & Management (AREA)
  • General Business, Economics & Management (AREA)
AU2009202685A 2009-06-30 2009-07-02 Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension Active AU2009202685B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2010202422A AU2010202422B2 (en) 2009-06-30 2010-06-10 Methods of treating children having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension
AU2010206032A AU2010206032B2 (en) 2009-06-30 2010-07-29 Methods of treating patients having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49459809A 2009-06-30 2009-06-30
US12/494,598 2009-06-30

Related Child Applications (2)

Application Number Title Priority Date Filing Date
AU2010202422A Division AU2010202422B2 (en) 2009-06-30 2010-06-10 Methods of treating children having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension
AU2010206032A Division AU2010206032B2 (en) 2009-06-30 2010-07-29 Methods of treating patients having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension

Publications (1)

Publication Number Publication Date
AU2009202685B1 true AU2009202685B1 (en) 2010-08-19

Family

ID=42062590

Family Applications (3)

Application Number Title Priority Date Filing Date
AU2009202685A Active AU2009202685B1 (en) 2009-06-30 2009-07-02 Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension
AU2010202422A Active AU2010202422B2 (en) 2009-06-30 2010-06-10 Methods of treating children having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension
AU2010206032A Active AU2010206032B2 (en) 2009-06-30 2010-07-29 Methods of treating patients having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension

Family Applications After (2)

Application Number Title Priority Date Filing Date
AU2010202422A Active AU2010202422B2 (en) 2009-06-30 2010-06-10 Methods of treating children having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension
AU2010206032A Active AU2010206032B2 (en) 2009-06-30 2010-07-29 Methods of treating patients having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension

Country Status (7)

Country Link
US (12) US20100330193A1 (enExample)
EP (3) EP2269614A1 (enExample)
JP (3) JP2011010865A (enExample)
AU (3) AU2009202685B1 (enExample)
CA (2) CA2671029A1 (enExample)
MX (1) MX2010006055A (enExample)
WO (1) WO2011002606A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113557052A (zh) * 2019-03-12 2021-10-26 心脏器械股份有限公司 监测具有植入式血泵的患者的健康状况的方法

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7523752B2 (en) 2005-09-21 2009-04-28 Ino Therapeutics, Llc System and method of administering a pharmaceutical gas to a patient
CA2671029A1 (en) 2009-06-30 2010-12-30 James S. Baldassarre Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension
JP2012100240A (ja) 2010-03-09 2012-05-24 Ricoh Co Ltd 画像処理装置、及び、画像処理方法
EP2600837A1 (en) * 2010-08-03 2013-06-12 G. Pohl-Boskamp GmbH & Co. KG Use of glyceryl trinitrate for treating hematomas
RU2495493C2 (ru) * 2010-10-25 2013-10-10 Государственное образовательное учреждение высшего профессионального образования "Московский государственный университет геодезии и картографии" (МИИГАиК) Способ прогнозирования риска смертности населения в зоне возникновения и нарастания концентрации загрязняющих веществ в атмосферном воздухе
MX378823B (es) 2011-01-06 2025-03-10 Mallinckrodt Hospital Products Ip Ltd Dispositivo y sistema de entrega de gas.
PL2678006T3 (pl) 2011-02-25 2016-06-30 G Pohl Boskamp Gmbh & Co Kg Pakowanie stałych preparatów farmaceutycznych zawierających substancję aktywną triazotan glicerolu
US20130054264A1 (en) * 2011-03-04 2013-02-28 Sterling Point Research, Llc Systems and methods for optimizing medical care through data monitoring and feedback treatment
JP2014527025A (ja) * 2011-05-27 2014-10-09 ゲノ エルエルシー 吸入用一酸化窒素を用いて血管反応性を決定する方法
FR2976259B1 (fr) * 2011-06-09 2013-07-05 Air Liquide Procede de conditionnement d'un melange gazeux no/n2
FR2976260B1 (fr) † 2011-06-09 2013-07-05 Air Liquide Procede de conditionnement de melanges no/n2 avec etapes de purge et rincage gazeux prealable
FR2976258B1 (fr) * 2011-06-09 2014-09-05 Air Liquide Installation de conditionnement de no a debitmetres massiques
FR2977298B1 (fr) * 2011-06-29 2015-02-06 Air Liquide Bouteille en aluminium pour melange gazeux no/azote
JP2014532523A (ja) 2011-11-07 2014-12-08 アイ・エヌ・オー セラピューティクス エル・エル・シーＩＮＯ Ｔｈｅｒａｐｅｕｔｉｃｓ ＬＬＣ 一酸化窒素送出を監視する装置および方法
US10426913B2 (en) 2011-11-07 2019-10-01 Mallinckrodt Hospital Products IP Limited Apparatus and method for monitoring nitric oxide delivery
DK3421042T3 (da) 2012-03-07 2024-07-22 Beyond Air Ltd Indånding af nitrogenoxid til behandling af luftvejssygdomme
US8944051B2 (en) 2012-04-05 2015-02-03 Ino Therapeutics Llc Breathing apparatus detection and purging
FR2991025B1 (fr) * 2012-05-24 2014-07-04 Air Liquide Sante Int Conditionnement d'un melange gazeux no/azote a haute concentration en no
FR2991026B1 (fr) * 2012-05-24 2014-07-04 Air Liquide Sante Int Conditionnement a haute pression d'un melange gazeux no/azote
PL2668947T3 (pl) 2012-05-31 2017-06-30 G. Pohl-Boskamp Gmbh & Co. Kg Indukcja arteriogenezy donorem NO, takim jak nitrogliceryna
US9248099B2 (en) 2012-05-31 2016-02-02 Desmoid Aktiengesellschaft Use of stabilized granules containing glyceryl trinitrate for arteriogenesis
IL277164B2 (en) 2012-12-04 2023-12-01 Mallinckrodt Hospital Products Ip Ltd A system for providing oxygenated nitrogen
US9795756B2 (en) 2012-12-04 2017-10-24 Mallinckrodt Hospital Products IP Limited Cannula for minimizing dilution of dosing during nitric oxide delivery
US20160022731A1 (en) 2013-03-07 2016-01-28 Advanced Inhalation Therapies (Ait) Ltd. Inhalation of nitric oxide for treating respiratory diseases
EP3653119A1 (en) * 2013-03-13 2020-05-20 Ino Therapeutics LLC Devices for monitoring oxygenation during treatment with delivery of nitric oxide
PL2968827T3 (pl) 2013-03-15 2019-08-30 The General Hospital Corporation Synteza gazowego tlenku azotu do inhalacji
ES2981406T3 (es) 2013-03-15 2024-10-08 Mallinckrodt Pharmaceuticals Ireland Ltd Administración y monitorización de óxido nítrico en fluidos ex vivo
WO2014144151A1 (en) 2013-03-15 2014-09-18 The General Hospital Corporation Inspiratory synthesis of nitric oxide
AU2014227790B2 (en) 2013-03-15 2019-03-14 Mallinckrodt Hospital Products IP Limited Therapeutic gas delivery device with pulsed and continuous flow control
US9629358B2 (en) 2013-03-15 2017-04-25 Mallinckrodt Hospital Products IP Limited Administration and monitoring of nitric oxide in ex vivo fluids
US10342948B2 (en) 2013-03-18 2019-07-09 Mallinckrodt Hospital Products IP Limited Therapeutic gas delivery device with pulsed and continuous flow control
WO2014210030A2 (en) * 2013-06-25 2014-12-31 Ino Therapeutics Llc Methods of reducing the risk of mortality associated with a medical treatment
US10512741B2 (en) 2013-09-13 2019-12-24 Mallinckrodt Hospital Products IP Limited Clinical decision support system and methods
EP2878310B1 (en) 2013-11-29 2017-01-11 G. Pohl-Boskamp GmbH & Co. KG Sprayable aqueous composition comprising glyceryl trinitrate
CA2936490C (en) 2014-01-10 2022-10-04 Ino Therapeutics Llc Methods of using inhaled nitric oxide gas for treatment of acute respiratory distress syndrome in children
US10188822B2 (en) 2014-03-13 2019-01-29 Mallinckrodt Hospital Products IP Limited Gas delivery device and system for use in magnetic resonance imaging
US10226592B2 (en) 2014-04-01 2019-03-12 Mallinckrodt Hospital Product Ip Limited Systems and method for delivery of therapeutic gas to patients in need thereof using enhanced breathing circuit gas (BCG) flow measurement
US10071213B2 (en) 2014-05-02 2018-09-11 Mallinckrodt Hospital Products IP Limited Systems and method for delivery of therapeutic gas to patients, in need thereof, receiving breathing gas from a ventilator that varies at least pressure and/or flow using enhanced therapeutic gas (NO) flow measurement
CA3225876A1 (en) 2014-05-09 2015-11-12 Ino Therapeutics Llc Systems and methods for intelligent gas source management and/or systems and methods for delivery of therapeutic gas and/or enhanced performance verification for therapeutic gas delivery
US10384031B1 (en) 2014-06-20 2019-08-20 Mallinckrodt Hospital Products IP Limited Systems and methods for manufacturing and safety of an NO2-to-NO reactor cartridge used to deliver NO for inhalation therapy to a patient
JP6317206B2 (ja) * 2014-07-30 2018-04-25 日本光電工業株式会社 生体情報測定装置、作動方法、及びプログラム
US10758703B2 (en) 2014-10-17 2020-09-01 Mallinckrodt Hospital Products IP Limited Systems and methods for providing a pulse of a therapeutic gas with a desired flow profile to maximize therapeutic effectiveness
CN116177503A (zh) 2014-10-20 2023-05-30 通用医疗公司 用于合成一氧化氮的系统和方法
EP4186548A1 (en) 2015-04-02 2023-05-31 Hill-Rom Services PTE. LTD. Mask leakage detection for a respiratory device
US10912872B2 (en) 2015-07-22 2021-02-09 Viaderm Llc Cardiac assist device
BR112018006600B1 (pt) 2015-10-01 2022-05-17 Mallinckrodt Hospital Products IP Limited Dispositivo e método para difusão de no de alta concentração com gás para terapia de inalação
CN113633868A (zh) 2016-02-02 2021-11-12 马林克罗特医疗产品知识产权公司 补偿呼吸气体流量测量中的破坏
EP3970730B1 (en) * 2016-02-12 2024-05-01 Mallinckrodt Pharmaceuticals Ireland Limited System for use and monitoring of inhaled nitric oxide with left ventricular assist devices
KR20190005839A (ko) 2016-03-25 2019-01-16 더 제너럴 하스피탈 코포레이션 산화질소의 전기 플라즈마 합성을 위한 전달 시스템 및 방법
CN113456966A (zh) 2017-02-27 2021-10-01 第三极股份有限公司 用于移动生成一氧化氮的系统和方法
KR102354762B1 (ko) 2017-02-27 2022-01-25 써드 폴, 아이엔씨. 산화 질소 발생 시스템 및 방법
MX2020010523A (es) 2017-02-27 2021-02-09 Third Pole Inc Sistemas y metodos para generar oxido nitrico.
CN110475562A (zh) 2017-03-31 2019-11-19 通用医疗公司 用于冷却一氧化氮发生器的系统和方法
JP2020532531A (ja) * 2017-08-30 2020-11-12 ベレロフォン パルス テクノロジーズ エルエルシー 肺疾患に関連付けられる肺高血圧症の治療のための吸入用一酸化窒素の使用
CN114375284A (zh) 2019-05-15 2022-04-19 第三极股份有限公司 用于生成一氧化氮的系统和方法
EP3969415A4 (en) 2019-05-15 2023-08-16 Third Pole, Inc. ELECTRODES FOR NITRIC OXIDE GENERATION
EP3980373A1 (en) * 2019-06-04 2022-04-13 Thirty Holdings Limited Methods and compositions for generating nitric oxide and uses thereof
CN115151183A (zh) 2020-01-11 2022-10-04 第三极股份有限公司 具有湿度控制的用于一氧化氮生成的系统和方法
US20210395905A1 (en) 2020-06-18 2021-12-23 Third Pole, Inc. Systems and methods for preventing and treating infections with nitric oxide
EP4405019A4 (en) 2021-09-23 2025-07-16 Third Pole Inc SYSTEMS AND METHODS FOR PROVIDING NITRIC OXIDE
USD1069817S1 (en) 2023-02-14 2025-04-08 Mallinckrodt Pharmaceuticals Ireland Limited Display screen or portion thereof with graphical user interface
USD1073017S1 (en) 2023-02-14 2025-04-29 Mallinckrodt Pharmaceuticals Ireland Limited Gas cylinder
USD1060405S1 (en) 2023-02-14 2025-02-04 Mallinckrodt Pharmaceuticals Ireland Limited Display screen or portion thereof with graphical user interface
USD1064285S1 (en) 2023-02-14 2025-02-25 Mallinckrodt Pharmaceuticals Ireland Limited Therapeutic gas delivery cart
USD1061594S1 (en) 2023-02-14 2025-02-11 Mallinckrodt Pharmaceuticals Ireland Limited Display screen or portion thereof with graphical user interface
USD1092742S1 (en) 2023-02-14 2025-09-09 Mallinckrodt Pharmaceuticals Ireland Limited Therapeutic gas cylinder bay
USD1092732S1 (en) 2023-02-14 2025-09-09 Mallinckrodt Pharmaceuticals Ireland Limited Injector module
USD1087129S1 (en) 2023-02-14 2025-08-05 Mallinckrodt Pharmaceuticals Ireland Limited Display screen or portion thereof with graphical user interface
USD1084322S1 (en) 2023-08-15 2025-07-15 Becton, Dickinson And Company Disinfecting unit label for a medical device
USD1081795S1 (en) 2023-08-15 2025-07-01 Becton, Dickinson And Company Medical device label
CN117379683B (zh) * 2023-12-12 2024-02-27 苏州晟智医疗科技有限公司 反搏辅助装置、计算设备、存储介质及反搏系统

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5570683A (en) 1990-12-05 1996-11-05 The General Hospital Corporation Methods and devices for treating pulmonary vasoconstriction and asthma
DE10299002I1 (de) 1990-12-05 2012-07-05 Gen Hospital Corp Verwendung von No zur Behandlung oder Praevention der Bronchokonstriktion
FR2695831B1 (fr) 1992-09-24 1994-11-10 Air Liquide Installation et procédé de fourniture d'un mélange gazeux aux voies respiratoires d'un utilisateur.
US5670125A (en) 1993-09-30 1997-09-23 The Boc Group, Inc. Process for the purification of nitric oxide
US5728705A (en) 1993-10-04 1998-03-17 The Trustees Of Columbia University In The City Of New York Method of inducing vasorelaxation to treat pulmonary hypertension
GB9320978D0 (en) 1993-10-12 1993-12-01 Higenbottam Timohy W Nitric oxide treatment
US5558083A (en) 1993-11-22 1996-09-24 Ohmeda Inc. Nitric oxide delivery system
US5417950A (en) 1994-07-07 1995-05-23 The Boc Group, Inc. Process for the purification of nitric oxide
US5514204A (en) 1994-07-07 1996-05-07 The Boc Group, Inc. Process for the purification of nitric oxide
US6063407A (en) 1995-02-16 2000-05-16 The General Hospital Corporation Treatment of vascular thrombosis and restenosis with inhaled nitric oxide
US5670127A (en) 1995-09-26 1997-09-23 The Boc Group, Inc. Process for the manufacture of nitric oxide
US5699790A (en) 1996-03-21 1997-12-23 Ohmeda Inc. System for predicting NO2 concentrations
US5692495A (en) 1996-04-02 1997-12-02 The Boc Group, Inc. Method and apparatus for the production of nitric oxide gas mixture
ATE331505T1 (de) 1996-04-05 2006-07-15 Gen Hospital Corp Behandlung einer hämoglobinstörung
US5732694A (en) 1996-12-13 1998-03-31 Ohmeda Inc. System for correcting NO2 monitor
US5732693A (en) 1996-10-02 1998-03-31 Ohmeda Inc. Pause control of nitric oxide therapy
US5752504A (en) 1996-12-13 1998-05-19 Ohmeda Inc. System for monitoring therapy during calibration
US5890490A (en) 1996-11-29 1999-04-06 Aylsworth; Alonzo C. Therapeutic gas flow monitoring system
US6259654B1 (en) 1997-03-28 2001-07-10 Telaric, L.L.C. Multi-vial medication organizer and dispenser
CA2278053C (en) 1997-01-17 2010-03-23 Messer Griesheim Austria Ges.Mbh Controlled gas supply system
US5918596A (en) 1997-04-22 1999-07-06 Instrumentarium Corp. Special gas dose delivery apparatus for respiration equipment
US6164276A (en) 1997-05-16 2000-12-26 Datex-Ohmeda, Inc. Accurate dose nitric oxide pulse delivery device with monitoring and alarms
US6125846A (en) 1997-05-16 2000-10-03 Datex-Ohmeda, Inc. Purge system for nitric oxide administration apparatus
US5846973A (en) 1997-05-23 1998-12-08 Eli Lilly And Company Methods of treating pulmonary hypertension
US6109260A (en) 1998-02-18 2000-08-29 Datex-Ohmeda, Inc. Nitric oxide administration device with timed pulse
US6142147A (en) 1998-03-31 2000-11-07 The General Hospital Corporation Nasal delivery system for inhaled nitric oxide
US6089229A (en) 1998-05-26 2000-07-18 Datex-Ohmeda, Inc. High concentration no pulse delivery device
US7678390B2 (en) 1999-04-01 2010-03-16 Yale University Carbon monoxide as a biomarker and therapeutic agent
US6581599B1 (en) 1999-11-24 2003-06-24 Sensormedics Corporation Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients
US6601580B1 (en) 2000-06-28 2003-08-05 The General Hospital Corporation Enhancing therapeutic effectiveness of nitric oxide inhalation
US7114510B2 (en) 2000-11-17 2006-10-03 Ino Therapeutics, Inc. Valve with smart handle
EP1404811B1 (en) 2001-06-21 2008-11-12 Beth Israel Deaconess Medical Center, Inc. Carbon monoxide improves outcomes in tissue and organ transplants and suppresses apoptosis
CA2459891C (en) 2001-09-05 2014-02-04 Cyterra Corporation Method and apparatus for nitric oxide generation
CA2475963A1 (en) 2002-02-13 2003-09-04 Beth Israel Deaconess Medical Center, Inc. Methods of treating vascular disease
ES2546280T3 (es) 2002-04-15 2015-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Monóxido de carbono para su uso en un método para tratar íleo
EP1499328B1 (en) 2002-04-15 2015-09-16 University of Pittsburgh - Of the Commonwealth System of Higher Education Methods of treating necrotizing enterocolitis
EP1505990B1 (en) 2002-05-17 2011-08-24 Yale University Methods of treating hepatitis
DE10230165A1 (de) 2002-07-04 2004-01-15 Ino Therapeutics Gmbh Verfahren und Vorrichtung zur Administration von Kohlenmonoxid
US20040106954A1 (en) 2002-11-15 2004-06-03 Whitehurst Todd K. Treatment of congestive heart failure
AU2004255268B2 (en) 2003-07-09 2010-04-01 Loma Linda University Use of nitrite salts for the treatment of cardiovascular conditions
EP1682672B1 (en) 2003-11-14 2009-10-14 Council of Scientific and Industrial Research Method of detecting predisposition to high altitude pulmonary edema
CA2557814A1 (en) 2004-03-01 2005-09-15 Lumen Therapeutics, Llc Compositions and methods for treating diseases
CN101072562A (zh) 2004-11-09 2007-11-14 Cv医药有限公司 在心力衰竭治疗中雷诺嗪与至少一种（抗）重塑剂联合用于逆转左室重塑
US20100130500A1 (en) 2004-12-08 2010-05-27 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of pulmonary hypertension of the newborn
CA2609456C (en) 2005-05-25 2014-04-29 Massachusetts Institute Of Technology Localized delivery of cardiac inotropic agents
US7523752B2 (en) 2005-09-21 2009-04-28 Ino Therapeutics, Llc System and method of administering a pharmaceutical gas to a patient
AU2006321942A1 (en) 2005-12-05 2007-06-14 Biomarin Pharmaceutical Inc. Methods and compositions for the treatment of disease
US20090029371A1 (en) 2005-12-05 2009-01-29 Ihc Intellectual Asset Management, Llc Method for determining vasoreactivity
US8790715B2 (en) 2006-02-16 2014-07-29 Ino Therapeutics Llc Method and apparatus for generating nitric oxide for medical use
US20080193566A1 (en) 2007-02-09 2008-08-14 Miller Christopher C Use of high dose concentrations of gaseous nitric oxide
US7943667B2 (en) 2007-10-11 2011-05-17 Duke University Potentiating the effect of compound comprising nitric oxide
AU2008330093A1 (en) 2007-11-28 2009-06-04 Yeda Research And Development Co., Ltd. Method of delaying the onset of clinically definite multiple sclerosis
AU2009282104A1 (en) 2008-08-13 2010-02-18 Novartis Ag Treatment of pulmonary arterial hypertension
CA2671029A1 (en) 2009-06-30 2010-12-30 James S. Baldassarre Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ARGENZIANO, M. et al. THE JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1998, vol.115: 700-704 *
BOCCHI, E. et al. THE AMERICAN JOURNAL OF CARDIOLOGY, 1994, vol.74: 70-71 *
CUJEC, B. et al. CANADIAN JOURNAL OF CARDIOLOGY, 1997, vol.13(9): 816-824. *
LOH, E. et al. "Cardiovascular Effects of Inhaled Nitric Oxide in Patients with Left Ventricular Dysfunction". CIRCULATION, 1994, vol.90: 2780-2785. *
ROSALES, A et al. PEDIATRIC CARDIOLOGY, 1999, vol.20: 224-226. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113557052A (zh) * 2019-03-12 2021-10-26 心脏器械股份有限公司 监测具有植入式血泵的患者的健康状况的方法
CN113557052B (zh) * 2019-03-12 2024-05-28 心脏器械股份有限公司 监测具有植入式血泵的患者的健康状况的方法

Also Published As

Publication number Publication date
US11931377B2 (en) 2024-03-19
EP2269614A1 (en) 2011-01-05
US20190231814A1 (en) 2019-08-01
JP2011010865A (ja) 2011-01-20
US8293284B2 (en) 2012-10-23
US20130078321A1 (en) 2013-03-28
US20100330193A1 (en) 2010-12-30
US20140348955A1 (en) 2014-11-27
EP2448572A1 (en) 2012-05-09
US20100330207A1 (en) 2010-12-30
AU2010202422B2 (en) 2010-10-21
AU2010206032B2 (en) 2011-12-08
JP2011251155A (ja) 2011-12-15
JP2011011059A (ja) 2011-01-20
US8431163B2 (en) 2013-04-30
MX2010006055A (es) 2011-03-16
US20100331405A1 (en) 2010-12-30
US8795741B2 (en) 2014-08-05
AU2010206032A1 (en) 2010-09-02
US20140377378A1 (en) 2014-12-25
US8846112B2 (en) 2014-09-30
CA2671029A1 (en) 2010-12-30
US20130040000A1 (en) 2013-02-14
CA3130908A1 (en) 2010-12-30
WO2011002606A1 (en) 2011-01-06
US20100330206A1 (en) 2010-12-30
WO2011002606A8 (en) 2011-08-11
US20140338665A1 (en) 2014-11-20
EP2540304A1 (en) 2013-01-02
US20130068223A1 (en) 2013-03-21
US8282966B2 (en) 2012-10-09
AU2010202422A1 (en) 2010-09-02
US20130074839A1 (en) 2013-03-28

Similar Documents

Publication Publication Date Title
US11931377B2 (en) Methods of administering inhaled nitric oxide gas
AU2015100638B4 (en) Methods of treating patients having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: INO THERAPEUTICS LLC

Free format text: FORMER OWNER WAS: IKARIA, INC.

GD Licence registered

Name of requester: IKARIA AUSTRALIA PTY LTD