AU2008334941B2 - Advantageous salts of mu-opiate receptor peptides - Google Patents
Advantageous salts of mu-opiate receptor peptides Download PDFInfo
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- AU2008334941B2 AU2008334941B2 AU2008334941A AU2008334941A AU2008334941B2 AU 2008334941 B2 AU2008334941 B2 AU 2008334941B2 AU 2008334941 A AU2008334941 A AU 2008334941A AU 2008334941 A AU2008334941 A AU 2008334941A AU 2008334941 B2 AU2008334941 B2 AU 2008334941B2
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- 239000008103 glucose Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 150000004677 hydrates Chemical group 0.000 description 1
- 235000011167 hydrochloric acid Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 102000048260 kappa Opioid Receptors Human genes 0.000 description 1
- 229940001447 lactate Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 208000020442 loss of weight Diseases 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229940099273 magnesium trisilicate Drugs 0.000 description 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
- 235000019793 magnesium trisilicate Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 230000000945 opiatelike Effects 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 210000003254 palate Anatomy 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- IWZKICVEHNUQTL-UHFFFAOYSA-M potassium hydrogen phthalate Chemical compound [K+].OC(=O)C1=CC=CC=C1C([O-])=O IWZKICVEHNUQTL-UHFFFAOYSA-M 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 229920001592 potato starch Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002953 preparative HPLC Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000006798 ring closing metathesis reaction Methods 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
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- 238000006467 substitution reaction Methods 0.000 description 1
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- 239000003826 tablet Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000000825 ultraviolet detection Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US761707P | 2007-12-13 | 2007-12-13 | |
| US61/007,617 | 2007-12-13 | ||
| PCT/US2008/086838 WO2009076672A1 (en) | 2007-12-13 | 2008-12-15 | Advantageous salts of mu-opiate receptor peptides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2008334941A1 AU2008334941A1 (en) | 2009-06-18 |
| AU2008334941B2 true AU2008334941B2 (en) | 2013-02-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2008334941A Ceased AU2008334941B2 (en) | 2007-12-13 | 2008-12-15 | Advantageous salts of mu-opiate receptor peptides |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US20110190214A1 (enExample) |
| EP (2) | EP2229400B1 (enExample) |
| JP (1) | JP5647002B2 (enExample) |
| AU (1) | AU2008334941B2 (enExample) |
| CA (2) | CA2707733C (enExample) |
| ES (1) | ES2550604T3 (enExample) |
| WO (1) | WO2009076672A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110065648A1 (en) * | 2009-09-15 | 2011-03-17 | Maione Theodore E | Advantageous mu-opiate receptor peptide compounds |
| EP2574172A4 (en) | 2010-05-21 | 2013-10-30 | Cytogel Pharma Llc | MATERIALS AND METHOD FOR TREATING INFLAMMATION |
| US20150126455A1 (en) * | 2012-05-18 | 2015-05-07 | Cytogel Pharma, Llc. | Novel Therapeutic Uses of Mu-Opiate Receptor Peptides |
| WO2018231838A1 (en) * | 2017-06-12 | 2018-12-20 | Board Of Regents Of The University Of Nebraska | Hydrochloride salts of c5a receptor agonist peptides |
| US10975121B2 (en) | 2017-06-24 | 2021-04-13 | Cytogel Pharma, Llc | Analgesic mu-opioid receptor binding peptide pharmaceutical formulations and uses thereof |
| JP2021503481A (ja) * | 2017-11-17 | 2021-02-12 | サイトジェル ファーマ リミテッド ライアビリティ カンパニー | μオピオイド受容体のポリマーアゴニスト |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998042732A1 (en) * | 1997-03-25 | 1998-10-01 | The Administrators Of The Tulane Educational Fund | Mu-opiate receptor peptides |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6235496B1 (en) * | 1993-03-08 | 2001-05-22 | Advanced Research & Technology Institute | Nucleic acid encoding mammalian mu opioid receptor |
| US5942492A (en) * | 1996-11-12 | 1999-08-24 | Angstrom Pharmaceuticals, Inc. | Cyclic peptides that bind to urokinase-type plasminogen activator receptor |
| JPH10330398A (ja) * | 1997-05-28 | 1998-12-15 | Asahi Glass Co Ltd | 新規環状ペプチド |
| SE9800865D0 (sv) * | 1998-03-16 | 1998-03-16 | Astra Ab | New Process |
| JPWO2002102833A1 (ja) * | 2001-06-15 | 2004-09-30 | 千寿製薬株式会社 | 新規エンドモルフィン誘導体 |
| AU2002324133A1 (en) | 2001-09-03 | 2003-03-18 | The University Of Bristol | Inflammation modulatory compound comprising an endomorphin |
| WO2003066593A2 (en) * | 2001-11-29 | 2003-08-14 | Schering Corporation | Preparation of pharmaceutical salts of 4 ( (z) - (4-bromophenyl) (ethoxyimino) methyl )-1'-( (2,4-dimethyl-1-oxido-3-pyridinyl) carbonyl) -4'-methyl-1,4' bipiperidine as ccr5-antagonists for the treatment of aids and related hiv infections |
-
2008
- 2008-12-15 AU AU2008334941A patent/AU2008334941B2/en not_active Ceased
- 2008-12-15 ES ES14189232.3T patent/ES2550604T3/es active Active
- 2008-12-15 CA CA2707733A patent/CA2707733C/en not_active Expired - Fee Related
- 2008-12-15 CA CA2984218A patent/CA2984218C/en not_active Expired - Fee Related
- 2008-12-15 EP EP08858817.3A patent/EP2229400B1/en not_active Not-in-force
- 2008-12-15 JP JP2010538227A patent/JP5647002B2/ja not_active Expired - Fee Related
- 2008-12-15 US US12/744,859 patent/US20110190214A1/en not_active Abandoned
- 2008-12-15 EP EP14189232.3A patent/EP2826786B1/en active Active
- 2008-12-15 WO PCT/US2008/086838 patent/WO2009076672A1/en not_active Ceased
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2013
- 2013-10-17 US US14/056,496 patent/US8940704B2/en active Active
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2014
- 2014-12-15 US US14/570,432 patent/US20150152137A1/en not_active Abandoned
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2018
- 2018-06-22 US US16/016,165 patent/US20180291060A1/en not_active Abandoned
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2020
- 2020-07-15 US US16/929,994 patent/US20200339628A1/en not_active Abandoned
-
2021
- 2021-12-17 US US17/554,421 patent/US20220324908A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998042732A1 (en) * | 1997-03-25 | 1998-10-01 | The Administrators Of The Tulane Educational Fund | Mu-opiate receptor peptides |
Non-Patent Citations (2)
| Title |
|---|
| CARDILLO, G. et al. J. Med. Chem. (2002), 45(9), 2571-2578 * |
| CARDILLO, G. et al. Org. Biomol. Chem. (2003), 1, 1498-1502 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2826786B1 (en) | 2015-09-23 |
| US20150152137A1 (en) | 2015-06-04 |
| HK1206363A1 (en) | 2016-01-08 |
| US20200339628A1 (en) | 2020-10-29 |
| US20140142050A1 (en) | 2014-05-22 |
| JP5647002B2 (ja) | 2014-12-24 |
| CA2984218C (en) | 2019-12-31 |
| EP2229400A4 (en) | 2012-01-04 |
| US20110190214A1 (en) | 2011-08-04 |
| WO2009076672A1 (en) | 2009-06-18 |
| CA2984218A1 (en) | 2009-06-18 |
| AU2008334941A1 (en) | 2009-06-18 |
| EP2229400A1 (en) | 2010-09-22 |
| US20220324908A1 (en) | 2022-10-13 |
| US20180291060A1 (en) | 2018-10-11 |
| EP2826786A1 (en) | 2015-01-21 |
| CA2707733C (en) | 2018-01-02 |
| CA2707733A1 (en) | 2009-06-18 |
| EP2229400B1 (en) | 2014-11-19 |
| US8940704B2 (en) | 2015-01-27 |
| ES2550604T3 (es) | 2015-11-11 |
| JP2011508727A (ja) | 2011-03-17 |
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| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |