AU2008255387B2 - Recombinant non glycosylated monovalent half-antibodies obtained by molecular engineering - Google Patents
Recombinant non glycosylated monovalent half-antibodies obtained by molecular engineering Download PDFInfo
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- AU2008255387B2 AU2008255387B2 AU2008255387A AU2008255387A AU2008255387B2 AU 2008255387 B2 AU2008255387 B2 AU 2008255387B2 AU 2008255387 A AU2008255387 A AU 2008255387A AU 2008255387 A AU2008255387 A AU 2008255387A AU 2008255387 B2 AU2008255387 B2 AU 2008255387B2
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C07K2317/00—Immunoglobulins specific features
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- C07K2317/71—Decreased effector function due to an Fc-modification
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- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
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| US20160279239A1 (en) | 2011-05-02 | 2016-09-29 | Immunomedics, Inc. | Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease |
| EP1973576B1 (en) * | 2005-11-28 | 2019-05-15 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
| EP2167669A2 (en) | 2007-05-31 | 2010-03-31 | Genmab A/S | Transgenic animals producing monovalent human antibodies and antibodies obtainable from these animals |
| JP5746040B2 (ja) * | 2008-12-03 | 2015-07-08 | ゲンマブ エー／エス | 定常領域の中に改変を有する抗体変種 |
| EP2389392A1 (en) * | 2009-01-26 | 2011-11-30 | Genmab A/S | Methods for producing mixtures of antibodies |
| DE102009047243A1 (de) * | 2009-11-27 | 2011-06-01 | Orgentec Diagnostika Gmbh | Monospezifische Polypeptidreagenzien |
| LT3904391T (lt) * | 2010-03-10 | 2024-10-10 | Genmab A/S | Monokloniniai antikūnai prieš c-met |
| JP2014522843A (ja) | 2011-06-30 | 2014-09-08 | ジェネンテック， インコーポレイテッド | 抗ｃ−ｍｅｔ抗体製剤 |
| CN104066748A (zh) | 2011-11-21 | 2014-09-24 | 霍夫曼-拉罗奇有限公司 | 抗c-met抗体的纯化 |
| TWI682941B (zh) | 2013-02-01 | 2020-01-21 | 美商再生元醫藥公司 | 含嵌合恆定區之抗體 |
| CA2940242A1 (en) | 2014-02-20 | 2015-08-27 | Alder Biopharmaceuticals, Inc. | Anti-acth antibodies and use thereof |
| TWI754319B (zh) | 2014-03-19 | 2022-02-01 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| PL3139948T3 (pl) * | 2014-05-07 | 2020-08-10 | Novo Nordisk A/S | Leczenie cukrzycy z zastosowaniem glp-1 i anty-il-21 |
| ES2809455T3 (es) | 2014-11-17 | 2021-03-04 | Regeneron Pharma | Métodos para tratamiento tumoral usando anticuerpo biespecífico CD3xCD20 |
| US10544220B2 (en) * | 2015-01-08 | 2020-01-28 | Genmab A/S | Bispecific antibodies against CD3 and CD20 |
| CA2981312C (en) | 2015-03-30 | 2023-09-26 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
| EP3960760A1 (en) * | 2015-11-16 | 2022-03-02 | Ubiprotein, Corp. | A method for extending half-life of a protein |
| WO2018187074A1 (en) | 2017-04-03 | 2018-10-11 | Immunomedics, Inc. | Subcutaneous administration of antibody-drug conjugates for cancer therapy |
| TW202021618A (zh) | 2018-08-17 | 2020-06-16 | 美商２３與我有限公司 | 抗ｉｌ１ｒａｐ抗體及其使用方法 |
| JP7605734B2 (ja) | 2018-08-31 | 2024-12-24 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｃｄ３／ｃ２０二重特異性抗体のサイトカイン放出症候群を軽減する投与戦略 |
| AR117327A1 (es) | 2018-12-20 | 2021-07-28 | 23Andme Inc | Anticuerpos anti-cd96 y métodos de uso de estos |
| EA202191656A1 (ru) | 2018-12-21 | 2021-10-26 | 23Эндми, Инк. | Анти-il-36 антитела и способы их применения |
| JP2023524149A (ja) | 2020-05-08 | 2023-06-08 | ジェンマブ エー／エス | Ｃｄ３およびｃｄ２０に対する二重特異性抗体 |
| JP2023528375A (ja) | 2020-05-29 | 2023-07-04 | ２３アンドミー・インコーポレイテッド | 抗ｃｄ２００ｒ１抗体及びその使用方法 |
| CN116234824A (zh) | 2020-06-22 | 2023-06-06 | 阿尔米雷尔有限公司 | 抗il-36抗体及其使用方法 |
| EP4211165A1 (en) | 2020-09-14 | 2023-07-19 | Ichnos Sciences SA | Antibodies that bind to il1rap and uses thereof |
| WO2024123558A2 (en) * | 2022-12-05 | 2024-06-13 | The Scripps Research Institute | Engineered lassa viral immunogens and vaccine compositions |
| WO2024146458A1 (zh) * | 2023-01-06 | 2024-07-11 | 广东东阳光药业股份有限公司 | 抗il-11细胞因子人源化抗体 |
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| US20050048572A1 (en) * | 2002-10-31 | 2005-03-03 | Genentech, Inc. | Methods and compositions for increasing antibody production |
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| DE3883899T3 (de) * | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
| GB9206422D0 (en) * | 1992-03-24 | 1992-05-06 | Bolt Sarah L | Antibody preparation |
| WO1997033617A1 (en) * | 1996-03-13 | 1997-09-18 | Protein Design Labs, Inc. | Fas ligand fusion proteins and their uses |
| US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
| US7754208B2 (en) * | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7300916B2 (en) * | 2001-02-27 | 2007-11-27 | Yoshiko Yasuda | Preventives/remedies for thickened scar, keloid or chronic arthritic diseases |
| WO2003000176A2 (en) * | 2001-06-20 | 2003-01-03 | Molecular Staging, Inc. | Conjugates of reduced antibodies and biomolecules |
| GB2380127A (en) * | 2001-09-26 | 2003-04-02 | Isis Innovation | Treatment of chronic joint inflammation |
| US7053202B2 (en) * | 2001-10-19 | 2006-05-30 | Millennium Pharmaceuticals, Inc. | Immunoglobulin DNA cassette molecules, monobody constructs, methods of production, and methods of use therefor |
| US7317091B2 (en) * | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
| EP2298805A3 (en) * | 2002-09-27 | 2011-04-13 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
| DK1718677T3 (da) * | 2003-12-19 | 2012-07-09 | Genentech Inc | Monovalente antistoffragmenter egnede som terapeutiske midler |
| RU2007108538A (ru) * | 2004-08-11 | 2008-09-20 | Трабьон Фармасьютикалз, Инк. (Us) | Слитые со связывающим доменом белки |
| AR056142A1 (es) * | 2005-10-21 | 2007-09-19 | Amgen Inc | Metodos para generar el anticuerpo igg monovalente |
| EP1973576B1 (en) * | 2005-11-28 | 2019-05-15 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
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| US20050048572A1 (en) * | 2002-10-31 | 2005-03-03 | Genentech, Inc. | Methods and compositions for increasing antibody production |
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| EP2170951A2 (en) | 2010-04-07 |
| JP2010527621A (ja) | 2010-08-19 |
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