AU2007345673A1 - Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins - Google Patents

Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins Download PDF

Info

Publication number
AU2007345673A1
AU2007345673A1 AU2007345673A AU2007345673A AU2007345673A1 AU 2007345673 A1 AU2007345673 A1 AU 2007345673A1 AU 2007345673 A AU2007345673 A AU 2007345673A AU 2007345673 A AU2007345673 A AU 2007345673A AU 2007345673 A1 AU2007345673 A1 AU 2007345673A1
Authority
AU
Australia
Prior art keywords
infectious pathogen
vaccine
extracellular matrix
adjuvant
interest
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2007345673A
Other languages
English (en)
Inventor
Mark A. Suckow
William R. Wolter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Notre Dame
Original Assignee
University of Notre Dame
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Notre Dame filed Critical University of Notre Dame
Publication of AU2007345673A1 publication Critical patent/AU2007345673A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
AU2007345673A 2007-01-30 2007-05-25 Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins Abandoned AU2007345673A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/699,448 2007-01-30
US11/699,448 US9308252B2 (en) 2005-10-27 2007-01-30 Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins
PCT/US2007/069727 WO2008094276A1 (en) 2007-01-30 2007-05-25 Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins

Publications (1)

Publication Number Publication Date
AU2007345673A1 true AU2007345673A1 (en) 2008-08-07

Family

ID=39359947

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007345673A Abandoned AU2007345673A1 (en) 2007-01-30 2007-05-25 Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins

Country Status (6)

Country Link
US (3) US9308252B2 (https=)
EP (1) EP2114444B1 (https=)
JP (1) JP2010516763A (https=)
CN (1) CN101730541B (https=)
AU (1) AU2007345673A1 (https=)
WO (2) WO2008094276A1 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8257715B1 (en) 2004-08-26 2012-09-04 University Of Notre Dame Tissue vaccines and uses thereof
US8778360B2 (en) 2005-10-27 2014-07-15 University Of Notre Dame Extracellular matrix cancer vaccine adjuvant
US8802113B2 (en) 2005-10-27 2014-08-12 University Of Notre Dame Extracellular matrix cancer vaccine adjuvant
US9308252B2 (en) 2005-10-27 2016-04-12 Cook Biotech, Inc. Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8097419B2 (en) 2006-09-12 2012-01-17 Longhorn Vaccines & Diagnostics Llc Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009
US8080645B2 (en) 2007-10-01 2011-12-20 Longhorn Vaccines & Diagnostics Llc Biological specimen collection/transport compositions and methods
US8652782B2 (en) 2006-09-12 2014-02-18 Longhorn Vaccines & Diagnostics, Llc Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids
US9481912B2 (en) 2006-09-12 2016-11-01 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and identifying nucleic acid sequences in biological samples
US9683256B2 (en) 2007-10-01 2017-06-20 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system
US11041215B2 (en) 2007-08-24 2021-06-22 Longhorn Vaccines And Diagnostics, Llc PCR ready compositions and methods for detecting and identifying nucleic acid sequences
US10004799B2 (en) 2007-08-27 2018-06-26 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
AU2008293504B2 (en) 2007-08-27 2012-04-12 Longhorn Vaccines & Diagnostics, Llc Immunogenic compositions and methods
CA2861667C (en) 2007-10-01 2017-06-13 Longhorn Vaccines And Diagnostics, Llc Biological specimen collection and transport system and methods of use
US11041216B2 (en) 2007-10-01 2021-06-22 Longhorn Vaccines And Diagnostics, Llc Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples
US9283266B2 (en) * 2008-02-28 2016-03-15 University Of Notre Dame Metastasis inhibition preparations and methods
RU2572826C2 (ru) 2008-12-02 2016-01-20 Чиралджен, Лтд. Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
WO2010078478A1 (en) 2008-12-31 2010-07-08 Cook Biotech Incorporated Tissue adjuvants and medical products including the same
CA2767253A1 (en) 2009-07-06 2011-01-13 Ontorii, Inc. Novel nucleic acid prodrugs and methods of use thereof
US8846059B2 (en) 2009-12-08 2014-09-30 University Of Notre Dame Extracellular matrix adjuvant and methods for prevention and/or inhibition of ovarian tumors and ovarian cancer
US20110150934A1 (en) * 2009-12-18 2011-06-23 University Of Notre Dame Ovarian Tumor Tissue Cell Preparations/Vaccines for the Treatment/Inhibition of Ovarian Tumors and Ovarian Cancer
JP5868324B2 (ja) 2010-09-24 2016-02-24 株式会社Wave Life Sciences Japan 不斉補助基
AU2012284265B2 (en) 2011-07-19 2017-08-17 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
WO2013112916A1 (en) 2012-01-26 2013-08-01 Longhorn Vaccines And Diagnostics, Llc Composite antigenic sequences and vaccines
JP6453212B2 (ja) 2012-07-13 2019-01-16 ウェイブ ライフ サイエンシズ リミテッドＷａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｌｔｄ． キラル制御
SG11201500239VA (en) 2012-07-13 2015-03-30 Wave Life Sciences Japan Asymmetric auxiliary group
CN104684923B (zh) * 2012-07-13 2018-09-28 株式会社新日本科学 手性核酸佐剂
CN103110943B (zh) * 2013-03-11 2014-11-26 浙江普康生物技术股份有限公司 一种可替代氢氧化铝的新型疫苗佐剂
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
WO2015108047A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108046A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
ES2917473T3 (es) 2014-01-16 2022-07-08 Wave Life Sciences Ltd Diseño quiral
WO2016183292A1 (en) 2015-05-14 2016-11-17 Longhorn Vaccines And Diagnostics, Llc Rapid methods for the extraction of nucleic acids from biological samples
CN106860861B (zh) * 2017-03-03 2020-11-03 北京博辉瑞进生物科技有限公司 一种免疫增强组合物、制备方法及其应用
US12485166B2 (en) 2020-02-06 2025-12-02 Longhorn Vaccines And Diagnostics, Llc Vaccines for the treatment and prevention of zoonotic infections
EP4138781A1 (en) * 2020-04-22 2023-03-01 Fettech, Llc Compositions comprising extracellular material with antiviral activity and uses thereof
KR20230091978A (ko) 2020-10-20 2023-06-23 롱혼 백신즈 앤드 다이어그나스틱스, 엘엘씨 면역원성 항원
JP2022151753A (ja) * 2021-03-25 2022-10-07 国立大学法人 長崎大学 慢性感染症に対する免疫増強用組成物および慢性感染症治療用医薬
US20250375512A1 (en) * 2022-06-24 2025-12-11 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Use of matrix bound vesicles (mbv) as vaccine adjuvants

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2172903A (en) 1937-09-24 1939-09-12 Paul M Charping Electric lighting system
US3346401A (en) 1963-12-12 1967-10-10 Council Scient Ind Res Processing of raw intestines
AT261800B (de) 1966-08-22 1968-05-10 Braun Internat Gmbh B Verfahren zur Herstellung von röhrenförmigen, glatten bzw. mit einem Gewinde versehenen Gewebe-Blutgefäß-Prothesen
US3810473A (en) 1972-12-04 1974-05-14 Avicon Inc Liquid-laid, non-woven, fibrous collagen derived surgical web having hemostatic and wound sealing properties
US4578067A (en) 1982-04-12 1986-03-25 Alcon (Puerto Rico) Inc. Hemostatic-adhesive, collagen dressing for severed biological surfaces
US4502159A (en) 1982-08-12 1985-03-05 Shiley Incorporated Tubular prostheses prepared from pericardial tissue
ATE109491T1 (de) 1988-03-11 1994-08-15 Chemokol G B R Ing Buero Fuer Verfahren zur herstellung von kollagenmembranen für hämostase, wundbehandlung und implantate.
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
US4956178A (en) 1988-07-11 1990-09-11 Purdue Research Foundation Tissue graft composition
US5837269A (en) 1989-09-25 1998-11-17 University Of Utah Research Foundation Vaccine compositions and method for enhancing an immune response
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
US6120991A (en) * 1990-10-30 2000-09-19 Fred Hutchinson Cancer Research Center Epiligrin, an epithelial ligand for integrins
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5507810A (en) 1991-10-07 1996-04-16 Osteotech, Inc. Processing of fibrous connective tissue
US5437287A (en) 1992-08-17 1995-08-01 Carbomedics, Inc. Sterilization of tissue implants using iodine
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
US5480424A (en) 1993-11-01 1996-01-02 Cox; James L. Heart valve replacement using flexible tubes
US5460962A (en) 1994-01-04 1995-10-24 Organogenesis Inc. Peracetic acid sterilization of collagen or collagenous tissue
US6156305A (en) 1994-07-08 2000-12-05 Baxter International Inc. Implanted tumor cells for the prevention and treatment of cancer
US6218166B1 (en) 1994-12-09 2001-04-17 John Wayne Cancer Institute Adjuvant incorporation into antigen carrying cells: compositions and methods
US5695998A (en) * 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US7361332B2 (en) 1995-03-17 2008-04-22 The Regents Of The University Of California Treating tumors using implants comprising combinations of allogeneic cells
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
US5733337A (en) 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
JPH11508151A (ja) * 1995-04-07 1999-07-21 パーデュー・リサーチ・ファウンデーション 膀胱再建方法及び膀胱再建用組織グラフト
US6406689B1 (en) 1995-10-03 2002-06-18 Frank W. Falkenberg Compositions and methods for treatment of tumors and metastatic diseases
EP1382346B1 (en) 1996-04-03 2007-09-26 The Rogosin Institute Conditioned medium and diffusible biological product produced by incubating entrapped cells
US6277368B1 (en) 1996-07-25 2001-08-21 The Regents Of The University Of California Cancer immunotherapy using autologous tumor cells combined with cells expressing a membrane cytokine
WO1998022158A2 (en) 1996-08-23 1998-05-28 Cook Biotech, Incorporated Graft prosthesis, materials and methods
CN1237909A (zh) 1996-10-11 1999-12-08 加利福尼亚大学董事会 联合使用肿瘤细胞与混合淋巴细胞的癌症免疫治疗
US5782914A (en) 1996-11-29 1998-07-21 Bio-Vascular, Inc. Method for preparing heterogeneous tissue grafts
ES2227833T3 (es) 1997-05-12 2005-04-01 Aphton Corporation Composiciones inmunogenicas para el receptor cck-b/gastrina y metodos para el tratamiento de tumores.
US6264992B1 (en) 1998-02-27 2001-07-24 Purdue Research Foundation Submucosa as a growth substrate for cells
DE19916085A1 (de) * 1998-10-28 2000-05-04 Sonntag Hans Guenther Verfahren zur Herstellung eines antiviralen Mittels
GB9827103D0 (en) 1998-12-10 1999-02-03 Onyvax Ltd New cancer treatments
DE60031100T2 (de) 1999-03-16 2007-03-08 Thomas Jefferson University Hapten modifizierte tumorzellen und verfahren zur herstellung und deren verwendung
JP2000264900A (ja) 1999-03-16 2000-09-26 Hisamitsu Pharmaceut Co Inc 新規生理活性ペプチド
US6105775A (en) * 1999-04-20 2000-08-22 Pakon, Inc. Sleeving system for photographic film negatives
EP1180031A4 (en) 1999-04-26 2004-04-07 Univ Emory NOSCAPIN DERIVATIVES FOR USE AS ADJUVANT COMPOSITIONS AND METHODS OF USE THEREOF
US7015205B1 (en) 1999-10-18 2006-03-21 St. Vincent's Hospital And Medical Center Of New York Melanoma vaccine and methods of making and using same
IT1318663B1 (it) 2000-08-02 2003-08-27 Mediolanum Farmaceutici Srl Membrane di collagene a due facce di cui una organizzata a livellomacromolecolare.
WO2003002165A1 (en) * 2001-06-28 2003-01-09 Cook Biotech Incorporated Graft prosthesis devices containing renal capsule collagen
US6986739B2 (en) * 2001-08-23 2006-01-17 Sciperio, Inc. Architecture tool and methods of use
WO2003100034A2 (en) 2002-03-18 2003-12-04 Sciperio, Inc. Dentritic cell nodes
FR2842822B1 (fr) 2002-07-26 2004-10-01 Roussy Inst Gustave Procede de preparation d'une matrice extracellulaire et son utilisation pour la culture de cellules tumorales
US7175652B2 (en) 2002-08-20 2007-02-13 Cook Incorporated Stent graft with improved proximal end
US7550004B2 (en) 2002-08-20 2009-06-23 Cook Biotech Incorporated Endoluminal device with extracellular matrix material and methods
CA2536923C (en) * 2003-09-04 2012-10-09 Cook Biotech Incorporated Extracellular matrix composite materials, and manufacture and use thereof
US8257715B1 (en) 2004-08-26 2012-09-04 University Of Notre Dame Tissue vaccines and uses thereof
WO2006125055A2 (en) 2005-05-17 2006-11-23 Cook Incorporated Prosthetic valve devices and methods of making and using such devices
WO2007035843A2 (en) * 2005-09-21 2007-03-29 Dask Technologies, Llc Methods and compositions for organ and tissue functionality
US8802113B2 (en) 2005-10-27 2014-08-12 University Of Notre Dame Extracellular matrix cancer vaccine adjuvant
US8778360B2 (en) 2005-10-27 2014-07-15 University Of Notre Dame Extracellular matrix cancer vaccine adjuvant
US9308252B2 (en) 2005-10-27 2016-04-12 Cook Biotech, Inc. Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins
US7545569B2 (en) * 2006-01-13 2009-06-09 Avery Dennison Corporation Optical apparatus with flipped compound prism structures
CA2627364A1 (en) 2007-01-30 2008-07-30 University Of Notre Dame Du Lac Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins
US9283266B2 (en) 2008-02-28 2016-03-15 University Of Notre Dame Metastasis inhibition preparations and methods
US8846059B2 (en) 2009-12-08 2014-09-30 University Of Notre Dame Extracellular matrix adjuvant and methods for prevention and/or inhibition of ovarian tumors and ovarian cancer
US20110150934A1 (en) 2009-12-18 2011-06-23 University Of Notre Dame Ovarian Tumor Tissue Cell Preparations/Vaccines for the Treatment/Inhibition of Ovarian Tumors and Ovarian Cancer

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8257715B1 (en) 2004-08-26 2012-09-04 University Of Notre Dame Tissue vaccines and uses thereof
US8778360B2 (en) 2005-10-27 2014-07-15 University Of Notre Dame Extracellular matrix cancer vaccine adjuvant
US8802113B2 (en) 2005-10-27 2014-08-12 University Of Notre Dame Extracellular matrix cancer vaccine adjuvant
US9308252B2 (en) 2005-10-27 2016-04-12 Cook Biotech, Inc. Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins

Also Published As

Publication number Publication date
EP2114444A1 (en) 2009-11-11
US20080107665A1 (en) 2008-05-08
WO2008112344A2 (en) 2008-09-18
CN101730541A (zh) 2010-06-09
US9220770B2 (en) 2015-12-29
US9308252B2 (en) 2016-04-12
EP2114444A4 (en) 2010-09-29
US20100136050A1 (en) 2010-06-03
WO2008112344A3 (en) 2009-12-30
EP2114444B1 (en) 2014-10-22
US20110076305A1 (en) 2011-03-31
WO2008094276A1 (en) 2008-08-07
CN101730541B (zh) 2014-03-05
JP2010516763A (ja) 2010-05-20

Similar Documents

Publication Publication Date Title
US9308252B2 (en) Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins
JP2011190278A (ja) 粘膜体表面に接触させてワクチン抗原を包含する物質の効果を調節する新規非抗原性粘膜アジュバント処方
US9585955B2 (en) Lipid and nitrous oxide combination as adjuvant for the enhancement of the efficacy of vaccines
US8277778B2 (en) Vaccine adjuvants
CA2627364A1 (en) Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins
US10293041B2 (en) Multivalent stable vaccine composition and methods of making same
US20140322272A1 (en) Vaccine
AU2004235815A1 (en) Vaccinating against infectious diseases using proteosomes
Vogel et al. Immunologic Section 1: General 5 adjuvants
HK1118013B (en) Lipid and nitrous oxide combination as adjuvant for the enhancement of the efficacy of vaccines
WO2016007797A1 (en) Multivalent stable vaccine composition and methods of making same

Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted