AU2007311019B2 - Diclofenac gel - Google Patents
Diclofenac gel Download PDFInfo
- Publication number
- AU2007311019B2 AU2007311019B2 AU2007311019A AU2007311019A AU2007311019B2 AU 2007311019 B2 AU2007311019 B2 AU 2007311019B2 AU 2007311019 A AU2007311019 A AU 2007311019A AU 2007311019 A AU2007311019 A AU 2007311019A AU 2007311019 B2 AU2007311019 B2 AU 2007311019B2
- Authority
- AU
- Australia
- Prior art keywords
- present
- composition
- diclofenac
- gel
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 title claims description 61
- 229960001259 diclofenac Drugs 0.000 title claims description 55
- 239000000203 mixture Substances 0.000 claims abstract description 275
- 238000009472 formulation Methods 0.000 claims abstract description 152
- 229960001193 diclofenac sodium Drugs 0.000 claims abstract description 88
- JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 claims abstract description 88
- 230000004907 flux Effects 0.000 claims abstract description 82
- 201000008482 osteoarthritis Diseases 0.000 claims abstract description 47
- 238000011282 treatment Methods 0.000 claims abstract description 25
- 208000002193 Pain Diseases 0.000 claims abstract description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 117
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 115
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 114
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 97
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- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 29
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- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 21
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- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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Landscapes
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- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
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| US82975606P | 2006-10-17 | 2006-10-17 | |
| US60/829,756 | 2006-10-17 | ||
| PCT/US2007/081674 WO2008049020A2 (en) | 2006-10-17 | 2007-10-17 | Diclofenac gel |
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| AU2007311019A1 AU2007311019A1 (en) | 2008-04-24 |
| AU2007311019A8 AU2007311019A8 (en) | 2009-06-18 |
| AU2007311019B2 true AU2007311019B2 (en) | 2013-05-16 |
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| US (14) | US8252838B2 (OSRAM) |
| EP (2) | EP2086504B1 (OSRAM) |
| JP (1) | JP5432716B2 (OSRAM) |
| CN (2) | CN101588791A (OSRAM) |
| AU (1) | AU2007311019B2 (OSRAM) |
| BR (1) | BRPI0717769A2 (OSRAM) |
| CA (1) | CA2666398C (OSRAM) |
| DK (1) | DK2086504T3 (OSRAM) |
| IL (1) | IL198161A (OSRAM) |
| MX (1) | MX2009004038A (OSRAM) |
| NZ (1) | NZ577020A (OSRAM) |
| RU (1) | RU2463038C2 (OSRAM) |
| WO (1) | WO2008049020A2 (OSRAM) |
| ZA (1) | ZA200903135B (OSRAM) |
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| US8480797B2 (en) | 2005-09-12 | 2013-07-09 | Abela Pharmaceuticals, Inc. | Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors |
| WO2007033180A1 (en) | 2005-09-12 | 2007-03-22 | Abela Pharmaceuticals, Inc. | Materials for facilitating administration of dimethyl sulfoxide (dmso) and related compounds |
| EP1937286B1 (en) | 2005-09-12 | 2016-03-09 | Abela Pharmaceuticals, Inc. | Compositions comprising dimethyl sulfoxide (dmso) |
| AU2006291134C1 (en) | 2005-09-12 | 2013-08-15 | Abela Pharmaceuticals, Inc. | Systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same |
| BRPI0717769A2 (pt) | 2006-10-17 | 2013-11-05 | Nuvo Res | Formulação de gel, método para o tratamento da osteoartrite em um indivíduo sofrendo de dor articular, e, uso de diclofenac de sódio |
| US20100100060A1 (en) * | 2008-10-17 | 2010-04-22 | Novartis Ag | Applicator for pharmaceutical product and method of using same |
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- 2007-10-17 CN CNA2007800464038A patent/CN101588791A/zh active Pending
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