AU2007306361A1 - RNA antagonist compounds for the modulation of PCSK9 - Google Patents
RNA antagonist compounds for the modulation of PCSK9 Download PDFInfo
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- AU2007306361A1 AU2007306361A1 AU2007306361A AU2007306361A AU2007306361A1 AU 2007306361 A1 AU2007306361 A1 AU 2007306361A1 AU 2007306361 A AU2007306361 A AU 2007306361A AU 2007306361 A AU2007306361 A AU 2007306361A AU 2007306361 A1 AU2007306361 A1 AU 2007306361A1
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- seq
- oligomer
- pcsk9
- nucleobases
- sequence
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21112—Site-1 protease (3.4.21.112), i.e. subtilisin kexin isozyme-1
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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Applications Claiming Priority (7)
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| US82873506P | 2006-10-09 | 2006-10-09 | |
| US60/828,735 | 2006-10-09 | ||
| US97293207P | 2007-09-17 | 2007-09-17 | |
| US60/972,932 | 2007-09-17 | ||
| US97740907P | 2007-10-04 | 2007-10-04 | |
| US60/977,409 | 2007-10-04 | ||
| PCT/EP2007/060703 WO2008043753A2 (en) | 2006-10-09 | 2007-10-09 | Rna antagonist compounds for the modulation of pcsk9 |
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| AU2007306361A1 true AU2007306361A1 (en) | 2008-04-17 |
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| JP (1) | JP2010505432A (enExample) |
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| MX (1) | MX2009003729A (enExample) |
| WO (1) | WO2008043753A2 (enExample) |
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| WO2008113830A1 (en) | 2007-03-22 | 2008-09-25 | Santaris Pharma A/S | Rna antagonist compounds for the inhibition of apo-b100 expression |
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| US20110224280A1 (en) * | 2008-04-16 | 2011-09-15 | Niels Fisker Nielsen | Pharmaceutical Composition Comprising Anti PCSK9 Oligomers |
| WO2009143367A2 (en) * | 2008-05-22 | 2009-11-26 | Schering Corporation | Egf-a domain-mediated modulation of pcsk9 |
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| GB2481373A (en) * | 2010-06-21 | 2011-12-28 | Weiming Xu | Treatment of hypercholesterolaemia by ubiquitination of PCSK9 |
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| CA2823913C (en) | 2011-01-10 | 2023-10-03 | The Regents Of The University Of Michigan | Stem cell factor inhibitor |
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| RU2748426C2 (ru) * | 2013-10-11 | 2021-05-25 | Ионис Фармасьютикалз, Инк. | Композиции для модуляции экспрессии c90rf72 |
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| KR20170123345A (ko) * | 2015-03-20 | 2017-11-07 | 오르후스 우니베르시테트 | 지질단백질 대사 장애의 치료를 위한 pcsk9의 억제제 |
| EP3283012A4 (en) * | 2015-04-15 | 2018-11-21 | Concievalve LLC | Devices and methods for inhibiting stenosis, obstruction, or calcification of a native heart valve, stented heart valve or bioprosthesis |
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| EP2444494B1 (en) | 2016-09-28 |
| EP2076597A2 (en) | 2009-07-08 |
| WO2008043753A3 (en) | 2008-09-25 |
| ES2603379T3 (es) | 2017-02-27 |
| CA2666191A1 (en) | 2008-04-17 |
| CA2666191C (en) | 2017-07-11 |
| EP2444494A1 (en) | 2012-04-25 |
| WO2008043753A2 (en) | 2008-04-17 |
| WO2008043753A8 (en) | 2008-06-26 |
| JP2010505432A (ja) | 2010-02-25 |
| IL197668A0 (en) | 2011-08-01 |
| MX2009003729A (es) | 2009-04-22 |
| US20100216864A1 (en) | 2010-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CB4 | Opposition filed under section 104(4) |
Opponent name: PREFERENCE MANUFACTURING (AUST) PTY LTD |
|
| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |