AU2007267392A1 - Pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them - Google Patents
Pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them Download PDFInfo
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- AU2007267392A1 AU2007267392A1 AU2007267392A AU2007267392A AU2007267392A1 AU 2007267392 A1 AU2007267392 A1 AU 2007267392A1 AU 2007267392 A AU2007267392 A AU 2007267392A AU 2007267392 A AU2007267392 A AU 2007267392A AU 2007267392 A1 AU2007267392 A1 AU 2007267392A1
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- Prior art keywords
- pyrido
- imidazo
- pyrazine
- methoxy
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80924206P | 2006-05-30 | 2006-05-30 | |
| US60/809,242 | 2006-05-30 | ||
| PCT/EP2007/004748 WO2007137820A1 (en) | 2006-05-30 | 2007-05-29 | PYRIDO[3,2-e]PYRAZINES, THEIR USE AS INHIBITORS OF PHOSPHODIESTERASE 10, AND PROCESSES FOR PREPARING THEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2007267392A1 true AU2007267392A1 (en) | 2007-12-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2007267392A Abandoned AU2007267392A1 (en) | 2006-05-30 | 2007-05-29 | Pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7550465B2 (https=) |
| EP (1) | EP2021342A1 (https=) |
| JP (1) | JP2009538853A (https=) |
| KR (1) | KR20090013834A (https=) |
| CN (1) | CN101454324A (https=) |
| AR (1) | AR061206A1 (https=) |
| AU (1) | AU2007267392A1 (https=) |
| BR (1) | BRPI0712132A2 (https=) |
| CA (1) | CA2651849A1 (https=) |
| CL (1) | CL2007001554A1 (https=) |
| CR (1) | CR10358A (https=) |
| GT (1) | GT200800265A (https=) |
| IL (1) | IL193740A0 (https=) |
| MX (1) | MX2008014569A (https=) |
| NO (1) | NO20085326L (https=) |
| PE (1) | PE20080711A1 (https=) |
| RU (1) | RU2008152440A (https=) |
| SV (1) | SV2009003048A (https=) |
| TW (1) | TW200817400A (https=) |
| WO (1) | WO2007137820A1 (https=) |
| ZA (1) | ZA200807517B (https=) |
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| TW200815436A (en) * | 2006-05-30 | 2008-04-01 | Elbion Ag | 4-amino-pyrido[3,2-e]pyrazines, their use as inhibitors of phosphodiesterase 10, and processes for preparing them |
| US8299080B2 (en) | 2006-12-13 | 2012-10-30 | Aska Pharmaceutical Co., Ltd. | Substituted imidazo[1,5-A] quinoxalines as a PDE9 inhibitor |
| US20090143392A1 (en) * | 2007-11-30 | 2009-06-04 | Elbion Gmbh | Methods of Treating Obesity and Metabolic Disorders |
| KR20100110804A (ko) * | 2007-11-30 | 2010-10-13 | 와이어쓰 엘엘씨 | 포스포디에스테라제 10의 저해물질로서의 아릴 및 헤테로아릴 융합된 이미다조[1,5-ａ]피라진 |
| US20090143361A1 (en) * | 2007-11-30 | 2009-06-04 | Elbion Gmbh | Pyrido[3,2-E]Pyrazines, Process For Preparing The Same, And Their Use As Inhibitors Of Phosphodiesterase 10 |
| CN102065861B (zh) * | 2008-05-07 | 2013-10-16 | H.隆德贝克有限公司 | 反式-4-((1r，3s)-6-氯-3-苯基茚满-1-基)-1，2，2-三甲基哌嗪用于改善认知的用途 |
| WO2010054253A1 (en) * | 2008-11-07 | 2010-05-14 | Biotie Therapies Gmbh | Triazine derivatives as inhibitors of phosphodiesterases |
| TWI520949B (zh) * | 2010-07-20 | 2016-02-11 | 錫蘭尼克藥物有限公司 | 使用環醯胺衍生物治療σ受體介導之病症的方法 |
| RS64819B1 (sr) * | 2010-07-20 | 2023-12-29 | Minerva Neurosciences Inc | Metode upotrebe derivata cikličnih amida za lečenje šizofrenije i njenih simptoma |
| US9540379B2 (en) | 2011-01-31 | 2017-01-10 | Boehringer Ingelheim International Gmbh | (1,2,4)triazolo[4,3-A]quinoxaline derivatives as inhibitors of phosphodiesterases |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5055465A (en) * | 1989-05-31 | 1991-10-08 | Berlex Laboratories, Inc. | Imidazoquinoxalinones, their aza analogs and process for their preparation |
| KR100207360B1 (ko) * | 1991-06-14 | 1999-07-15 | 돈 더블유. 슈미츠 | 이미다조[1,5,-a]퀸옥살린 |
| DE19510965A1 (de) * | 1995-03-24 | 1996-09-26 | Asta Medica Ag | Neue Pyrido/3,2-e/pyrazinone mit antiasthmatischer Wirksamkeit und Verfahren zu deren Herstellung |
| US20030032579A1 (en) * | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
| IL149106A0 (en) | 2001-04-20 | 2002-11-10 | Pfizer Prod Inc | Therapeutic use of selective pde10 inhibitors |
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| PE20080711A1 (es) | 2008-06-14 |
| IL193740A0 (en) | 2009-05-04 |
| US20090239874A1 (en) | 2009-09-24 |
| US20080027064A1 (en) | 2008-01-31 |
| CA2651849A1 (en) | 2007-12-06 |
| CL2007001554A1 (es) | 2008-01-18 |
| CR10358A (es) | 2009-01-07 |
| EP2021342A1 (en) | 2009-02-11 |
| CN101454324A (zh) | 2009-06-10 |
| NO20085326L (no) | 2008-12-19 |
| SV2009003048A (es) | 2009-02-11 |
| RU2008152440A (ru) | 2010-07-10 |
| AR061206A1 (es) | 2008-08-13 |
| TW200817400A (en) | 2008-04-16 |
| KR20090013834A (ko) | 2009-02-05 |
| JP2009538853A (ja) | 2009-11-12 |
| GT200800265A (es) | 2010-07-22 |
| US7550465B2 (en) | 2009-06-23 |
| WO2007137820A1 (en) | 2007-12-06 |
| BRPI0712132A2 (pt) | 2012-01-17 |
| ZA200807517B (en) | 2009-06-24 |
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