AU2007254148B2 - Method for the treatment and prevention of ocular disorders - Google Patents
Method for the treatment and prevention of ocular disorders Download PDFInfo
- Publication number
- AU2007254148B2 AU2007254148B2 AU2007254148A AU2007254148A AU2007254148B2 AU 2007254148 B2 AU2007254148 B2 AU 2007254148B2 AU 2007254148 A AU2007254148 A AU 2007254148A AU 2007254148 A AU2007254148 A AU 2007254148A AU 2007254148 B2 AU2007254148 B2 AU 2007254148B2
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- Australia
- Prior art keywords
- cyclosporin
- compound
- ethoxy
- certain embodiments
- agent
- Prior art date
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- 238000011282 treatment Methods 0.000 title claims abstract description 46
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Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
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- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Prostheses (AREA)
- Laser Surgery Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US80220806P | 2006-05-19 | 2006-05-19 | |
| US60/802,208 | 2006-05-19 | ||
| PCT/US2007/011919 WO2007136759A2 (en) | 2006-05-19 | 2007-05-18 | Method for the treatment and prevention of ocular disorders |
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| AU2007254148A1 AU2007254148A1 (en) | 2007-11-29 |
| AU2007254148B2 true AU2007254148B2 (en) | 2013-02-07 |
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| EP (1) | EP2023918B1 (https=) |
| JP (1) | JP5377293B2 (https=) |
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| CA (1) | CA2652662C (https=) |
| DE (1) | DE602007013391D1 (https=) |
| DK (1) | DK2023918T3 (https=) |
| ES (1) | ES2361635T3 (https=) |
| WO (1) | WO2007136759A2 (https=) |
| ZA (1) | ZA200810113B (https=) |
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| US7196161B2 (en) | 2004-10-01 | 2007-03-27 | Scynexis Inc. | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
| SI1802650T1 (sl) * | 2004-10-01 | 2012-03-30 | Scynexis Inc | Eter in tioeter substituirani ciklosporinski derivati za zdravljenje in preventivo pred infekcijami s hepatitisom c |
| US7202209B2 (en) * | 2005-07-13 | 2007-04-10 | Allergan, Inc. | Cyclosporin compositions |
| EP1931696B1 (en) | 2005-09-30 | 2011-02-16 | Scynexis, Inc. | Arylalkyl and heteroarylalkyl derivatives of cyclosporine a for the treatment and prevention of viral infection |
| JP5517454B2 (ja) | 2005-09-30 | 2014-06-11 | スシネキス インク | Ｃ型肝炎感染の治療及び予防のための方法及び医薬組成物 |
| EP2023918B1 (en) | 2006-05-19 | 2011-03-23 | Scynexis, Inc. | Cyclosporins for the treatment and prevention of ocular disorders |
| US10265265B2 (en) | 2007-03-15 | 2019-04-23 | Drug Delivery Solutions Limited | Topical composition |
| EP2008651A1 (en) | 2007-06-26 | 2008-12-31 | Drug Delivery Solutions Limited | A bioerodible patch |
| US20090306033A1 (en) * | 2008-06-06 | 2009-12-10 | Keqiang Li | Novel cyclic peptides |
| CN102083852A (zh) | 2008-06-06 | 2011-06-01 | 西尼克斯公司 | 环孢菌素类似物及其在治疗hcv感染中的应用 |
| EP2376524B1 (en) * | 2008-12-31 | 2017-03-15 | Cypralis Limited | Derivatives of cyclosporin a |
| US8685917B2 (en) * | 2009-07-09 | 2014-04-01 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US20110144005A1 (en) * | 2009-12-09 | 2011-06-16 | Scynexis, Inc. | Novel cyclic peptides |
| CA2814191A1 (en) * | 2010-10-12 | 2012-04-19 | Allergan, Inc. | Cyclosporin analogs |
| JP5805774B2 (ja) * | 2010-10-12 | 2015-11-10 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | シクロスポリンアナログ |
| HRP20191711T1 (hr) * | 2011-03-14 | 2019-12-13 | Drug Delivery Solutions Ltd | Oftalmološki pripravak |
| US10429712B2 (en) | 2012-04-20 | 2019-10-01 | View, Inc. | Angled bus bar |
| JP2015519368A (ja) | 2012-06-01 | 2015-07-09 | アラーガン インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | シクロスポリンａ類似体 |
| EP3011387A4 (en) | 2013-06-18 | 2016-11-30 | View Inc | ELECTROCHROMIC DEVICES WITH NON-RECTANGULAR SHAPES |
| CN107430118A (zh) * | 2013-06-27 | 2017-12-01 | 广东盛泽康华生物医药有限公司 | 对自身免疫状况的分类与管理的方法与仪器 |
| MX364310B (es) | 2013-11-05 | 2019-04-22 | Gustavo A Garcia Sanchez | Método para preparar una formulación inmunosupresora. |
| US9914755B2 (en) | 2015-01-08 | 2018-03-13 | Allergan, Inc. | Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized |
| TWI675851B (zh) * | 2015-12-14 | 2019-11-01 | 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 | 短合成胜肽及其用途 |
| GB201711749D0 (en) * | 2017-07-21 | 2017-09-06 | Cypralis Ltd | Cyclosporin analogues and uses thereof |
| EP3542788A1 (en) | 2018-03-19 | 2019-09-25 | MC2 Therapeutics Limited | Topical composition comprising calcipotriol and betamethasone dipropionate |
| CN111449050A (zh) * | 2019-01-20 | 2020-07-28 | 睿诺医疗科技（上海）有限公司 | 环孢菌素类似物及其用途 |
| US20200366476A1 (en) * | 2019-05-17 | 2020-11-19 | Panasonic Avionics Corporation | Transient key negotiation for passenger accessible peripherals |
| AU2020363688A1 (en) | 2019-10-12 | 2022-04-21 | Farsight Medical Technology (Shanghai) Co., Ltd. | Treatment and prevention of nephrotoxin-induced kidney injuries |
| CN111920940B (zh) * | 2020-09-16 | 2022-04-05 | 易舟(上海)生物医药有限公司 | 一种眼用制剂及其制备方法和应用 |
| IL296586B1 (en) | 2020-03-26 | 2026-04-01 | Farsight Medical Tech Shanghai Co Ltd | Cyclophilin inhibitors and their uses |
| AU2021256222A1 (en) * | 2020-04-15 | 2022-10-06 | Farsight Medical Technology (Shanghai) Co., Ltd. | Prevention and treatment of organ injuries |
| US11564909B2 (en) * | 2020-11-30 | 2023-01-31 | Romeg Therapeutics Llc | Methods and compositions for oral pilocarpine liquid |
| KR20260018851A (ko) * | 2023-06-02 | 2026-02-09 | 파사이트 메디컬 테크놀로지 (상하이) 컴퍼니 리미티드 | 사이클로필린 저해제 및 그 용도 |
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- 2007-05-18 ES ES07795039T patent/ES2361635T3/es active Active
- 2007-05-18 CN CN2007800267754A patent/CN101511357B/zh active Active
- 2007-05-18 US US12/301,210 patent/US8188052B2/en active Active
- 2007-05-18 CA CA2652662A patent/CA2652662C/en active Active
- 2007-05-18 AU AU2007254148A patent/AU2007254148B2/en active Active
- 2007-05-18 DK DK07795039.2T patent/DK2023918T3/da active
- 2007-05-18 DE DE602007013391T patent/DE602007013391D1/de active Active
- 2007-05-18 AT AT07795039T patent/ATE502633T1/de active
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2008
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Also Published As
| Publication number | Publication date |
|---|---|
| ATE502633T1 (de) | 2011-04-15 |
| ES2361635T3 (es) | 2011-06-20 |
| CN101511357A (zh) | 2009-08-19 |
| WO2007136759A2 (en) | 2007-11-29 |
| CA2652662C (en) | 2015-11-03 |
| JP2009537550A (ja) | 2009-10-29 |
| DE602007013391D1 (de) | 2011-05-05 |
| CN101511357B (zh) | 2011-11-02 |
| CA2652662A1 (en) | 2007-11-29 |
| JP5377293B2 (ja) | 2013-12-25 |
| WO2007136759A3 (en) | 2009-04-16 |
| US20120270804A1 (en) | 2012-10-25 |
| AU2007254148A1 (en) | 2007-11-29 |
| US20100062975A1 (en) | 2010-03-11 |
| EP2023918A2 (en) | 2009-02-18 |
| EP2023918B1 (en) | 2011-03-23 |
| DK2023918T3 (da) | 2011-04-26 |
| US8551952B2 (en) | 2013-10-08 |
| US8188052B2 (en) | 2012-05-29 |
| ZA200810113B (en) | 2010-02-24 |
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