AU2007245496A1 - Amino-ethyl-amino-aryl (AEAA) compounds and their use - Google Patents
Amino-ethyl-amino-aryl (AEAA) compounds and their use Download PDFInfo
- Publication number
- AU2007245496A1 AU2007245496A1 AU2007245496A AU2007245496A AU2007245496A1 AU 2007245496 A1 AU2007245496 A1 AU 2007245496A1 AU 2007245496 A AU2007245496 A AU 2007245496A AU 2007245496 A AU2007245496 A AU 2007245496A AU 2007245496 A1 AU2007245496 A1 AU 2007245496A1
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- Prior art keywords
- independently
- ring
- substituent
- alkyl
- compound according
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/46—Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- AIDS & HIV (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74563006P | 2006-04-26 | 2006-04-26 | |
| US60/745,630 | 2006-04-26 | ||
| GB0608269A GB0608269D0 (en) | 2006-04-26 | 2006-04-26 | Therapeutic compounds |
| GB0608269.7 | 2006-04-26 | ||
| PCT/GB2007/001537 WO2007125331A2 (en) | 2006-04-26 | 2007-04-26 | Amino-ethyl-amino-aryl (aeaa) compounds and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2007245496A1 true AU2007245496A1 (en) | 2007-11-08 |
Family
ID=38581449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2007245496A Abandoned AU2007245496A1 (en) | 2006-04-26 | 2007-04-26 | Amino-ethyl-amino-aryl (AEAA) compounds and their use |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20090247519A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2024333A2 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2009534458A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2007245496A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2649995A1 (cg-RX-API-DMAC10.html) |
| IL (1) | IL194899A0 (cg-RX-API-DMAC10.html) |
| MX (1) | MX2008013718A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2007125331A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008069976A2 (en) * | 2006-12-01 | 2008-06-12 | President And Fellows Of Harvard College | Compounds and methods for enzyme-mediated tumor imaging and therapy |
| KR20090129488A (ko) | 2007-03-22 | 2009-12-16 | 버텍스 파마슈티칼스 인코포레이티드 | 야누스 키나아제의 억제제로서 유용한 n-헤테로사이클릭 화합물 |
| KR20110040818A (ko) | 2008-06-10 | 2011-04-20 | 노파르티스 아게 | 상피 나트륨 채널 차단제로서의 피라진 유도체 |
| BRPI0915105A2 (pt) * | 2008-06-13 | 2019-09-24 | Novartis Ag | composto de 2,4'-biripidinila como inibidores da proteína cinase d úteis para o tratamento de ia insuficiência cardíaca e cancer |
| EP2440533B1 (en) | 2009-06-12 | 2015-09-23 | Socpra-Sciences Et Génie S.E.C. | Guanine riboswitch binding compounds and their use as antibiotics |
| EP2480537A1 (en) * | 2009-09-24 | 2012-08-01 | Basf Se | Aminoquinazoline compounds for combating invertebrate pests |
| EP2528606B1 (en) * | 2010-01-28 | 2014-09-24 | Alexander Levitzki | Quinazoline-based t cell proliferation inhibitors |
| EP2550361B1 (en) | 2010-03-25 | 2017-02-08 | The J. David Gladstone Institutes | Compositions and methods for treating neurological disorders |
| CA3056970A1 (en) | 2017-03-21 | 2018-09-27 | Bayer Pharma Aktiengesellschaft | 2-methyl-quinazolines |
| EP3781565A1 (en) | 2018-04-18 | 2021-02-24 | Bayer Pharma Aktiengesellschaft | 2-methyl-aza-quinazolines |
| EP3787612A4 (en) | 2018-05-04 | 2021-11-17 | Remedy Plan, Inc. | CANCER TREATMENTS AGAINST CANCER STEM CELLS |
| JP2022544700A (ja) * | 2019-08-22 | 2022-10-20 | バイオヘイブン・セラピューティクス・リミテッド | 筋萎縮性側索硬化症および関連障害の治療のためにtdp-43に結合する分子 |
| PH12022551081A1 (en) | 2019-11-06 | 2024-06-19 | Remedy Plan Inc | Cancer treatments targeting cancer stem cells |
| EP4192826A4 (en) * | 2020-08-07 | 2024-09-04 | Athos Therapeutics, Inc. | SMALL MOLECULES FOR THE TREATMENT OF AUTOIMMUNE DISEASES AND CANCER |
| WO2022185253A1 (en) | 2021-03-03 | 2022-09-09 | Instytut Biologii doswiadczalnej imienia Marcelego Nenckiego Polskiej Akademii Nauk | Inhibitor of protein kinase d for use in prevention or treatment of hyperlipidemia |
| EP4052700A1 (en) * | 2021-03-03 | 2022-09-07 | Instytut Biologii doswiadczalnej imienia Marcelego Nenckiego Polskiej Akademii Nauk | Inhibitor of protein kinase d (pkd) for use in prevention or treatment of obesity and a pharmaceutical composition for such use |
| CN117062599A (zh) * | 2021-03-03 | 2023-11-14 | 波兰国家科学院专业生物学研究所 | 用于预防或治疗高脂血症的蛋白激酶d抑制剂 |
| CN117924190B (zh) * | 2024-01-19 | 2026-07-17 | 重庆医科大学 | 2-苯基-4-胺基喹唑啉类化合物或其可药用盐及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2412345A1 (en) * | 1999-06-16 | 2000-12-21 | University Of Iowa Research Foundation | Antagonism of immunostimulatory cpg-oligonucleotides by 4-aminoquinolines and other weak bases |
| JP4272338B2 (ja) * | 2000-09-22 | 2009-06-03 | バイエル アクチェンゲゼルシャフト | ピリジン誘導体 |
| ATE466581T1 (de) * | 2001-12-07 | 2010-05-15 | Vertex Pharma | Verbindungen auf pyrimidin-basis als gsk-3-hemmer |
| AU2003255482A1 (en) * | 2002-10-02 | 2004-04-23 | Merck Patent Gmbh | Use of 4 amino-quinazolines as anti cancer agents |
| CL2004000409A1 (es) * | 2003-03-03 | 2005-01-07 | Vertex Pharma | Compuestos derivados de 2-(cilo sustituido)-1-(amino u oxi sustituido)-quinazolina, inhibidores de canales ionicos de sodio y calcio dependientes de voltaje; composicion farmaceutica; y uso del compuesto en el tratamiento de dolor agudo, cronico, neu |
| CA2531061A1 (en) * | 2003-07-02 | 2005-01-13 | Vertex Pharmaceuticals Incorporated | Pyrimidines useful as modulators of voltage-gated ion channels |
| CR9465A (es) * | 2005-03-25 | 2008-06-19 | Surface Logix Inc | Compuestos mejorados farmacocineticamente |
-
2007
- 2007-04-26 CA CA002649995A patent/CA2649995A1/en not_active Abandoned
- 2007-04-26 WO PCT/GB2007/001537 patent/WO2007125331A2/en not_active Ceased
- 2007-04-26 AU AU2007245496A patent/AU2007245496A1/en not_active Abandoned
- 2007-04-26 MX MX2008013718A patent/MX2008013718A/es not_active Application Discontinuation
- 2007-04-26 EP EP07732574A patent/EP2024333A2/en not_active Withdrawn
- 2007-04-26 JP JP2009507166A patent/JP2009534458A/ja not_active Withdrawn
- 2007-04-26 US US12/298,311 patent/US20090247519A1/en not_active Abandoned
-
2008
- 2008-10-23 IL IL194899A patent/IL194899A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007125331A2 (en) | 2007-11-08 |
| WO2007125331A3 (en) | 2008-01-03 |
| EP2024333A2 (en) | 2009-02-18 |
| CA2649995A1 (en) | 2007-11-08 |
| US20090247519A1 (en) | 2009-10-01 |
| MX2008013718A (es) | 2008-11-06 |
| JP2009534458A (ja) | 2009-09-24 |
| IL194899A0 (en) | 2009-08-03 |
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| MK4 | Application lapsed section 142(2)(d) - no continuation fee paid for the application |