AU2007232297B2 - Amide substituted indazole and benzotriazole derivatives as poly(ADP-ribose)polymerase (PARP) inhibitors - Google Patents

Amide substituted indazole and benzotriazole derivatives as poly(ADP-ribose)polymerase (PARP) inhibitors Download PDF

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AU2007232297B2
AU2007232297B2 AU2007232297A AU2007232297A AU2007232297B2 AU 2007232297 B2 AU2007232297 B2 AU 2007232297B2 AU 2007232297 A AU2007232297 A AU 2007232297A AU 2007232297 A AU2007232297 A AU 2007232297A AU 2007232297 B2 AU2007232297 B2 AU 2007232297B2
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alkyl
indazol
aminocarbonyl
compound
trifluoroacetate
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AU2007232297A1 (en
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Julia Kay Boueres
Danila Branca
Federica Ferrigno
Philip Jones
Ester Muraglia
Jesus Maria Ontoria Ontoria
Federica Orvieto
Rita Scarpelli
Carsten Schultz-Fademrecht
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MSD Italia SRL
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Priority claimed from GB0615907A external-priority patent/GB0615907D0/en
Priority claimed from GBGB0700432.8A external-priority patent/GB0700432D0/en
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Assigned to MSD ITALIA S.R.L. reassignment MSD ITALIA S.R.L. Request for Assignment Assignors: ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA
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    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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AU2007232297A 2006-04-03 2007-04-02 Amide substituted indazole and benzotriazole derivatives as poly(ADP-ribose)polymerase (PARP) inhibitors Active 2032-04-02 AU2007232297B2 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0606663.3 2006-04-03
GB0606663A GB0606663D0 (en) 2006-04-03 2006-04-03 Therapeutic compounds
GB0615907A GB0615907D0 (en) 2006-08-11 2006-08-11 Therapeutic Compounds
GB0615907.3 2006-08-11
GBGB0700432.8A GB0700432D0 (en) 2007-01-10 2007-01-10 Therapeutic compounds
GB0700432.8 2007-01-10
PCT/GB2007/050177 WO2007113596A1 (en) 2006-04-03 2007-04-02 Amide substituted indazole and benzotriazole derivatives as poly(adp-ribose)polymerase (parp) inhibitors

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AU2007232297A1 AU2007232297A1 (en) 2007-10-11
AU2007232297B2 true AU2007232297B2 (en) 2012-09-20

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US (2) US20090275619A1 (enExample)
EP (1) EP2007733B1 (enExample)
JP (1) JP4611441B2 (enExample)
AU (1) AU2007232297B2 (enExample)
CA (1) CA2647545C (enExample)
WO (1) WO2007113596A1 (enExample)

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GB0610680D0 (en) * 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
GEP20115337B (en) * 2007-01-10 2011-11-25 St Di Ricerche Di Biologia Molecolare P Angeletti Spa Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
KR20100020487A (ko) * 2007-05-24 2010-02-22 와이어쓰 엘엘씨 히스타민-3 길항제로서 아자시클릴벤즈아미드 유도체
KR20100102609A (ko) * 2007-11-12 2010-09-24 바이파 사이언스 인코포레이티드 Ｐａｒｐ 억제제를 단독으로 사용하거나 항종양제와 병용하여 유방암을 치료하는 방법
NZ586675A (en) * 2008-01-08 2012-04-27 Merck Sharp & Dohme Pharmaceutically acceptable salts of 2-{ 4-[(3s)-piperidin-3- yl]phenyl} -2h-indazole-7-carboxamide
JP2011511078A (ja) * 2008-02-06 2011-04-07 レアド トヘラペウトイクス，インコーポレーテッド ポリ（ａｄｐリボース）ポリメラーゼ（ｐａｒｐ）のベンズオキサゾールカルボキサミド阻害剤
GB0804755D0 (en) 2008-03-14 2008-04-16 Angeletti P Ist Richerche Bio Therapeutic compounds
ITFI20090005A1 (it) * 2009-01-19 2010-07-20 Alberto Chiarugi Formulazioni farmaceutiche per indurre immunosoppressione attraverso l'inibizione del fenomeno dell'epitope spreading e loro uso.
ES2604305T3 (es) * 2009-07-14 2017-03-06 Nerviano Medical Sciences S.R.L. 3-oxo-2,3-dihidro-1H-isoindol-4-carboxamida con inhibición selectiva de PARP-1
US8877944B2 (en) * 2009-07-14 2014-11-04 Nerviano Medical Sciences S.R.L. 3-oxo-2,3-dihydro-1H-isoindole-4-carboxamides as PARP inhibitors
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WO2011141909A2 (en) 2010-05-10 2011-11-17 Radikal Therapeutics Inc. Lipoic acid and nitroxide derivatives and uses thereof
WO2012006958A1 (en) * 2010-07-14 2012-01-19 Zhejiang Beta Pharma Inc. Amids substituted indazole derivativees as ploy(adp-ribose)polymerase inhibitors
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